CD48

Synonyms

Signaling lymphocytic activation molecule 2, BCM1 surface antigen, CD48, BCM1, CD48 Molecule, CD48 Antigen (B-Cell Membrane Protein), B-Lymphocyte Activation Marker BLAST-1, SLAM Family Member 2, CD48 Antigen, BLAST1, SLAMF2, TCT.1, MEM-102, BLAST, HCD48, MCD48, Leukocyte antigen MEM-102

Description

Cluster of differentiation 48 (CD48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene. CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244. CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells.

KO Status

F1 (+/-)

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 1 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

SGN-CD48A

SGN-CD48A

Phase 1 Clinical

Seattle Genetics

Multiple Myeloma

Anti-CD48 monoclonal antibody WM-63

Pending

Nonindustrial Source

Leukemia, Lymphocytic, Chronic, B-Cell

References


Title

Authors

Source

The isolation of cDNA clones for CD48

Vaughan H.A., Henning M.M., Purcell D.F.J., McKenzie I.F.C., Sandrin M.S.,

Immunogenetics 33:113-117(1991)

The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1

Korinek V., Stefanova I., Angelisova P., Hilbert I., Horejsi V.,

Immunogenetics 33:108-112(1991)

Molecular cloning of the lymphocyte activation marker Blast-1

Staunton D.E., Thorley-Lawson D.A.,

EMBO J. 6:3695-3701(1987)

The DNA sequence and biological annotation of human chromosome 1

Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Bentley D.R.,

Nature 441:315-321(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48)

Fisher R.C., Thorley-Lawson D.A.,

Mol. Cell. Biol. 11:1614-1623(1991)

TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1

del Porto P., Mami-Chouaib F., Bruneau J.-M., Jitsukawa S., Dumas J., Harnois M., Hercend T.,

J. Exp. Med. 173:1339-1344(1991)

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.,

Nat. Biotechnol. 27:378-386(2009)