CD49b

Synonyms

GPIa, ITGA2, Collagen receptor, VLA-2 subunit alpha, Integrin Subunit Alpha 2, Platelet Membrane Glycoprotein Ia, Alpha 2 Subunit Of VLA-2 Receptor, CD49 Antigen-Like Family Member B, CD49B, Human Platelet Alloantigen System 5, Platelet Glycoprotein GPIa, Platelet Antigen Br, Integrin Alpha-2, CD49b Antigen, HPA-5, VLA-2, VLAA2, BR, Integrin alpha2, Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor), Very Late Activation Protein 2 Receptor, Alpha-2 Subunit,

Description

Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene. The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling.It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 0
Latest Research Phase:Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

E-7820

E-7820, NSC-719239, ER-68203-00

Phase 2 Clinical

Eisai Co Ltd

Rectal Neoplasms, Colonic Neoplasms, Neoplasms, Colorectal Neoplasms, Lymphoma