CD5

Synonyms

CD5, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5, CD5 Molecule, CD5 Antigen (P56-62), LEU1, CD5 Antigen, T1, CD5 Antigens, Epididymis Secretory Sperm Binding Protein

Description

CD5 is a cell surface molecule that is expressed on most circulating T cells and a small population of B cells, and is involved in modulation of antigen-specific receptor-mediated activation.

KO Status

RenMab: In Vitro

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 1 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

CD5 CAR T Cell Therapy (Beijing Boren Hospital)

Phase 1 Clinical

Beijing Boren Hospital

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

HY-010

HY-010

Preclinical

Heyuan Biotechnology (Tianjin) Co Ltd

Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin

Monoclonal antibody T101-Y-90 conjugate

Pending

Hybritech Incorporated, Nonindustrial Source

Hematologic Neoplasms

Zolimomab aritox

Discontinued

Cancer Research Uk

Rejection of renal transplantation, Arthritis, Rheumatoid, Graft vs Host Disease, Diabetes Mellitus

References


Title

Authors

Source

Isolation of complementary DNA clones encoding the human lymphocyte glycoprotein T1/Leu-1

Jones N.H., Clabby M.L., Dialynas D.P., Huag H.-J.S., Herzenberg L.A., Strominger J.L.,

Nature 323:346-349(1986)

Evolutionarily conserved transcription regulatory elements within the 5'-flanking region of the human CD5 gene

Calvo J., Sole J., Simarro M., Vives J., Lozano F.,

Tissue Antigens 47:257-261(1996)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Human chromosome 11 DNA sequence and analysis including novel gene identification

Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,

Nature 440:497-500(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The B-cell surface protein CD72/Lyb-2 is the ligand for CD5

van de Velde H., von Hoegen I., Luo W., Parnes J.R., Thielemans K.,

Nature 351:662-665(1991)

Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry

Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T., Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.,

Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003)

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry

Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.,

Anal. Chem. 76:2763-2772(2004)

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions

Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.,

Sci. Signal. 2:RA46-RA46(2009)

Crystal structure of the third extracellular domain of CD5 reveals the fold of a group B scavenger cysteine-rich receptor domain

Rodamilans B., Munoz I.G., Bragado-Nilsson E., Sarrias M.R., Padilla O., Blanco F.J., Lozano F., Montoya G.,

J. Biol. Chem. 282:12669-12677(2007)