CD54

Synonyms

Intercellular Adhesion Molecule 1, Cell Surface Glycoprotein P3.58, Major group rhinovirus receptor, Human Rhinovirus Receptor, CD54 Antigen, P3.58, CD54, BB2, Intercellular Adhesion Molecule-1, ICAM1, ICAM-1, Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor, Epididymis Secretory Sperm Binding Protein

Description

ICAM-1 (Intercellular adhesion molecule-1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. It acts as a receptor for major receptor group rhinovirus A-B capsid proteins and as a receptor for Coxsackievirus A21 capsid proteins. Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, it is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.

KO Status

RenMab: Antibody Discovery

RenLite: F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 4
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Tocopherol acetate

DSE-9912

Approved

Venous Thromboembolism, Atherosclerosis, Intermittent Claudication, Thrombosis, Diabetic Retinopathy

Alicaforsen sodium

AP-1007, AP-1431, AP-1450, AP-1451, ISIS-2302

NDA/BLA

Ionis Pharmaceuticals Inc

Inflammatory Bowel Diseases, Pouchitis, Colitis, Ulcerative, Crohn Disease

Bersanlimab

BI-505

Phase 2 Clinical

Bioinvent International

Smoldering Multiple Myeloma, Multiple Myeloma

Coxsackievirus A21 (Viralytics)

V-937, CVA-21

Phase 2 Clinical

Viralytics

Head and Neck Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Prostatic Neoplasms, Melanoma, Neoplasm Metastasis

AIC-100

AIC-100

Phase 1 Clinical

Affyimmune Therapeutics

Thyroid Carcinoma, Anaplastic, Thyroid Neoplasms

DNP-007

DNP-007

Preclinical

Dinona

Autoimmune Diseases

DZ-13

DZ13, DZ-13

Pending

University Of New South Wales, Royal Prince Alfred Hospital

Carcinoma, Basal Cell, Melanoma

BAY-Z-9700

BAY-Z-9700

Pending

Bayer Ag

Asthma, Rhinitis

ICM-3

ICM-3

Discontinued

Icos Corporation

Psoriasis

RhinoRx (Planet Biotechnology)

Discontinued

Planet Biotechnology

Rhinovirus infection

References


Title

Authors

Source

Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor

Kolatkar P.R., Bella J., Olson N.H., Bator C.M., Baker T.S., Rossmann M.G.,

EMBO J. 18:6249-6259(1999)

Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation

Shimaoka M., Xiao T., Liu J.H., Yang Y., Dong Y., Jun C.D., McCormack A., Zhang R., Joachimiak A., Takagi J., Wang J.H., Springer T.A.,

Cell 112:99-111(2003)

Structural basis for dimerization of ICAM-1 on the cell surface

Yang Y., Jun C.D., Liu J.H., Zhang R., Joachimiak A., Springer T.A., Wang J.H.,

Mol. Cell 14:269-276(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Structural characteristics of the 5' region of the human ICAM-1 gene

Stade B.G., Messer G., Riethmueller G., Johnson J.P.,

Immunobiology 182:79-87(1990)

The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)

Walter N.A.R., Stebbing J., Messier W.,

J. Theor. Biol. 232:339-346(2005)

The major human rhinovirus receptor is ICAM-1

Greve J.M., Davis G., Meyer A.M., Forte C.P., Yost S.C., Marlor C.W., Kamarck M.E., McClelland A.,

Cell 56:839-847(1989)

A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection

Marlin S.D., Staunton D.E., Springer T.A., Stratowa C., Sommergruber W., Merluzzi V.J.,

Nature 344:70-72(1990)

MUC1 mucin core protein binds to the domain 1 of ICAM-1

Hayashi T., Takahashi T., Motoya S., Ishida T., Itoh F., Adachi M., Hinoda Y., Imai K.,

Digestion 63 Suppl. 1:87-92(2001)

Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1

Xiao C., Bator C.M., Bowman V.D., Rieder E., He Y., Hebert B., Bella J., Baker T.S., Wimmer E., Kuhn R.J., Rossmann M.G.,

J. Virol. 75:2444-2451(2001)