Neural cell adhesion molecule 1, CD56, NCAM1, NCAM, Neural Cell Adhesion Molecule, NCAM, CD56 Antigen, N-CAM-1, MSK39, NCAM-1, Antigen Recognized By Monoclonal Antibody 5.1H11


Neural cell adhesion molecule 1 (NCAM1), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

KO Status

RenMab: Antibody Discovery

RenLite: F0

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name





Clinical Trials

Lorvotuzumab mertansine

BB-10901, IMGN-901, huN-901-DM1, IMGN-901-TAP, huN-901-SPP-DM1

Phase 2 Clinical

Immunogen Inc

Ovarian Neoplasms, Hematologic Neoplasms, Carcinoma, Merkel Cell, Small Cell Lung Carcinoma, Multiple Myeloma, Carcinoma, Small Cell





Small Cell Lung Carcinoma

Oncolysin S (ImmunoGen)


Immunogen Inc

Small Cell Lung Carcinoma





Splicing of the VASE exon of neural cell adhesion molecule (NCAM) in human small-cell lung carcinoma (SCLC)

van Duijnhoven H.L., Helfrich W., de Leij L., Roebroek A.J., van de Ven W.J., Healey K., Culverwell A., Rossell R.J., Kemshead J.T., Patel K.,

Int. J. Cancer 50:118-123(1992)

Human muscle neural cell adhesion molecule (N-CAM): identification of a muscle-specific sequence in the extracellular domain

Dickson G., Gower H.J., Barton C.H., Prentice H.M., Elsom V.L., Moore S.E., Cox R.D., Quinn C., Putt W., Walsh F.S.,

Cell 50:1119-1130(1987)

Alternative splicing generates a secreted form of N-CAM in muscle and brain

Gower H.J., Barton C.H., Elsom V.L., Thompson J., Moore S.E., Dickson G., Walsh F.S.,

Cell 55:955-964(1988)

The neural cell adhesion molecule is a receptor for rabies virus

Thoulouze M.I., Lafage M., Schachner M., Hartmann U., Cremer H., Lafon M.,

J. Virol. 72:7181-7190(1998)

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry

Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.,

J. Proteome Res. 4:2070-2080(2005)

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.,

J. Proteomics 96:253-262(2014)

Complete sequence and in vitro expression of a tissue-specific phosphatidylinositol-linked N-CAM isoform from skeletal muscle

Barton C.H., Dickson G., Gower H.J., Rowett L.H., Putt W., Elsom V., Moore S.E., Goridis C., Walsh F.S.,

Development 104:165-173(1988)

Molecular and functional analysis of human natural killer cell-associated neural cell adhesion molecule (N-CAM/CD56)

Lanier L.L., Chang C., Azuma M., Ruitenberg J.J., Hemperly J.J., Phillips J.H.,

J. Immunol. 146:4421-4426(1991)

Complementary DNA sequence encoding the major neural cell adhesion molecule isoform in a human small cell lung cancer cell line

Saito S., Tanio Y., Tachibana I., Hayashi S., Kishimoto T., Kawase I.,

Lung Cancer 10:307-318(1994)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)