CD6
Synonyms
T12, CD6, CD6 Molecule, TP120, T-Cell Differentiation Antigen CD6, CD6 Antigen
Description
T-cell differentiation antigen CD6 is a human protein encoded by the CD6 gene.Contributes to signaling cascades triggered by activation of the TCR/CD3 complex . Functions as costimulatory molecule; promotes T-cell activation and proliferation . Contributes to the formation and maturation of the immunological synapse . Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS .
KO Status
F2 (-/-)
Drug Information
Launched drug: 1
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Itolizumab
h-T1, T-1-h, EQ-001, T-1-hT, Bmab-600
Approved
Biocon, Center Of Molecular Immunology
Graft vs Host Disease, Lupus Erythematosus, Cutaneous, Lupus Nephritis, Psoriasis, Coronavirus Infections, Asthma, Plaque psoriasis
Oncolysin CD6 (Dana-Farber Cancer Institute)
Discontinued
Immunogen, Dana-Farber Cancer Institute
Rejection of renal transplantation, Leukemia, Lymphoid, Autoimmune Diseases, Lupus Erythematosus, Systemic, Lymphoma
References
Title
Authors
Source
Frontline: Optimal T cell activation requires the engagement of CD6 and CD166
Hassan N.J., Barclay A.N., Brown M.H.,
Eur. J. Immunol. 34:930-940(2004)
Relevance of CD6-mediated interactions in T cell activation and proliferation
Gimferrer I., Calvo M., Mittelbrunn M., Farnos M., Sarrias M.R., Enrich C., Vives J., Sanchez-Madrid F., Lozano F.,
J. Immunol. 173:2262-2270(2004)
Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells
Zimmerman A.W., Joosten B., Torensma R., Parnes J.R., van Leeuwen F.N., Figdor C.G.,
Blood 107:3212-3220(2006)
CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76
Hassan N.J., Simmonds S.J., Clarkson N.G., Hanrahan S., Puklavec M.J., Bomb M., Barclay A.N., Brown M.H.,
Mol. Cell. Biol. 26:6727-6738(2006)
CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock
Sarrias M.R., Farnos M., Mota R., Sanchez-Barbero F., Ibanez A., Gimferrer I., Vera J., Fenutria R., Casals C., Yelamos J., Lozano F.,
Proc. Natl. Acad. Sci. U.S.A. 104:11724-11729(2007)
Modulation of CD6 function through interaction with galectin-1 and -3
Escoda-Ferran C., Carrasco E., Caballero-Banos M., Miro-Julia C., Martinez-Florensa M., Consuegra-Fernandez M., Martinez V.G., Liu F.T., Lozano F.,
FEBS Lett. 588:2805-2813(2014)
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub
Roncagalli R., Hauri S., Fiore F., Liang Y., Chen Z., Sansoni A., Kanduri K., Joly R., Malzac A., Laehdesmaeki H., Lahesmaa R., Yamasaki S., Saito T., Malissen M., Aebersold R., Gstaiger M., Malissen B.,
Nat. Immunol. 15:384-392(2014)
Structures of CD6 and its ligand CD166 give insight into their interaction
Chappell P.E., Garner L.I., Yan J., Metcalfe C., Hatherley D., Johnson S., Robinson C.V., Lea S.M., Brown M.H.,
Structure 23:1426-1436(2015)
Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms
Bowen M.A., Whitney G.S., Neubauer M., Starling G.C., Palmer D., Zhang J., Nowak N.J., Shows T.B., Aruffo A.,
J. Immunol. 158:1149-1156(1997)
Human chromosome 11 DNA sequence and analysis including novel gene identification
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,
Nature 440:497-500(2006)