CD6

Synonyms

T12, CD6, CD6 Molecule, TP120, T-Cell Differentiation Antigen CD6, CD6 Antigen,

Description

T-cell differentiation antigen CD6 is a human protein encoded by the CD6 gene.Contributes to signaling cascades triggered by activation of the TCR/CD3 complex . Functions as costimulatory molecule; promotes T-cell activation and proliferation . Contributes to the formation and maturation of the immunological synapse . Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria . LPS binding leads to the activation of signaling cascades and down-stream MAP kinases . Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS .

KO Status

F1 (+/-)

Drug Information

Launched drug: 1
Drugs in clinical trials: 0
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Itolizumab

h-T1, T-1-h, EQ-001, T-1-hT, Bmab-600

Approved

Biocon, Center Of Molecular Immunology

Lupus Erythematosus, Cutaneous, Graft vs Host Disease, Lupus Nephritis, Psoriasis, Coronavirus Infections, Asthma, Plaque psoriasis

Oncolysin CD6 (Dana-Farber Cancer Institute)

Discontinued

Immunogen, Dana-Farber Cancer Institute

Rejection of renal transplantation, Leukemia, Lymphoid, Autoimmune Diseases, Lupus Erythematosus, Systemic, Lymphoma