CD6

Synonyms

T12, CD6, CD6 Molecule, TP120, T-Cell Differentiation Antigen CD6, CD6 Antigen

KO Status

RenMab: Antibody Discovery

Drug Information

Launched drug: 1
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Itolizumab

h-T1, T-1-h, Bmab-600, EQ-001, T-1-hT

Approved

Biocon, Center Of Molecular Immunology

Lupus Erythematosus, Cutaneous, Graft vs Host Disease, Lupus Nephritis, Psoriasis, Coronavirus Infections, Asthma, Plaque psoriasis

Oncolysin CD6 (Dana-Farber Cancer Institute)

Discontinued

Immunogen, Dana-Farber Cancer Institute

Rejection of renal transplantation, Leukemia, Lymphoid, Autoimmune Diseases, Lupus Erythematosus, Systemic, Lymphoma

References


Title

Authors

Source

Frontline: Optimal T cell activation requires the engagement of CD6 and CD166

Hassan N.J., Barclay A.N., Brown M.H.,

Eur. J. Immunol. 34:930-940(2004)

Relevance of CD6-mediated interactions in T cell activation and proliferation

Gimferrer I., Calvo M., Mittelbrunn M., Farnos M., Sarrias M.R., Enrich C., Vives J., Sanchez-Madrid F., Lozano F.,

J. Immunol. 173:2262-2270(2004)

Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells

Zimmerman A.W., Joosten B., Torensma R., Parnes J.R., van Leeuwen F.N., Figdor C.G.,

Blood 107:3212-3220(2006)

CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76

Hassan N.J., Simmonds S.J., Clarkson N.G., Hanrahan S., Puklavec M.J., Bomb M., Barclay A.N., Brown M.H.,

Mol. Cell. Biol. 26:6727-6738(2006)

CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock

Sarrias M.R., Farnos M., Mota R., Sanchez-Barbero F., Ibanez A., Gimferrer I., Vera J., Fenutria R., Casals C., Yelamos J., Lozano F.,

Proc. Natl. Acad. Sci. U.S.A. 104:11724-11729(2007)

Modulation of CD6 function through interaction with galectin-1 and -3

Escoda-Ferran C., Carrasco E., Caballero-Banos M., Miro-Julia C., Martinez-Florensa M., Consuegra-Fernandez M., Martinez V.G., Liu F.T., Lozano F.,

FEBS Lett. 588:2805-2813(2014)

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub

Roncagalli R., Hauri S., Fiore F., Liang Y., Chen Z., Sansoni A., Kanduri K., Joly R., Malzac A., Laehdesmaeki H., Lahesmaa R., Yamasaki S., Saito T., Malissen M., Aebersold R., Gstaiger M., Malissen B.,

Nat. Immunol. 15:384-392(2014)

Structures of CD6 and its ligand CD166 give insight into their interaction

Chappell P.E., Garner L.I., Yan J., Metcalfe C., Hatherley D., Johnson S., Robinson C.V., Lea S.M., Brown M.H.,

Structure 23:1426-1436(2015)

Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms

Bowen M.A., Whitney G.S., Neubauer M., Starling G.C., Palmer D., Zhang J., Nowak N.J., Shows T.B., Aruffo A.,

J. Immunol. 158:1149-1156(1997)

Human chromosome 11 DNA sequence and analysis including novel gene identification

Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,

Nature 440:497-500(2006)