CD62E

Synonyms

Leukocyte Endothelial Cell Adhesion Molecule 2, LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM-1, SELE, Selectin E, CD62 Antigen-Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte-Endothelial Cell Adhesion Molecule 2, CD62E Antigen, CD62E, ESEL, ELAM, E-Selectin

Description

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. It mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. And it may have a role in capillary morphogenesis.

KO Status

F1 (+/-)

Drug Information

Drugs in clinical trials: 4
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rivipansel Sodium

GM-1070, GMI-1070, PF-6460031, PF-06460031-02, PF-06460031 (free base)

Phase 3 Clinical

Glycomimetics Pharmaceutical

Pain, Kidney Diseases, Anemia, Sickle Cell

Uproleselan

GMI-1271, APL-106

Phase 3 Clinical

Glycomimetics Pharmaceutical

Hematopoietic stem cell transplantation (HSCT), Multiple Myeloma, Leukemia, Myeloid, Acute, Venous Thrombosis

E-selectin targeting humanized antibody (LifeArc)

Phase 1 Clinical

Lifearc

Sepsis, Respiratory Distress Syndrome, Adult

GMI-1359

GMI-1359

Phase 1 Clinical

Glycomimetics Pharmaceutical

Breast Neoplasms, Metastatic breast cancer

GMI-1687

GMI-1687

Preclinical

Glycomimetics Inc

Leukemia, Myeloid, Acute

GMI-1757

GMI-1757

Preclinical

Glycomimetics

Thrombosis

Bimosiamose

TBC-1269

Pending

Encysive

Psoriasis, Asthma, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic

CDP-850

CDP-850

Discontinued

Celltech

Psoriasis

Monoclonal antibody EP-5C7  (PDL BioPharma)

EP-5C7

Discontinued

Pdl Biopharma

Autoimmune Diseases, Stroke, Psoriasis, Asthma, Shock

GI-270384X

GI-270384, GI-270384X

Discontinued

Glaxosmithkline Plc

Inflammatory Bowel Diseases, Colitis, Ulcerative

References


Title

Authors

Source

Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins

Kerr S.C., Fieger C.B., Snapp K.R., Rosen S.D.,

J. Immunol. 181:1480-1490(2008)

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force

Mehta-D'souza P., Klopocki A.G., Oganesyan V., Terzyan S., Mather T., Li Z., Panicker S.R., Zhu C., McEver R.P.,

J. Biol. Chem. 292:2510-2518(2017)

Modelling the carbohydrate recognition domain of human E-selectin

Mills A.,

FEBS Lett. 319:5-11(1993)

Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains

Graves B.J., Crowther R.L., Chandran C., Rumberger J.M., Li S., Huang K.-S., Presky D.H., Familletti P.C., Wolitzky B.A., Burns D.K.,

Nature 367:532-538(1994)

Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1

Somers W.S., Tang J., Shaw G.D., Camphausen R.T.,

Cell 103:467-479(2000)

E-selectin ligand complexes adopt an extended high-affinity conformation

Preston R.C., Jakob R.P., Binder F.P., Sager C.P., Ernst B., Maier T.,

J. Mol. Cell Biol. 8:62-72(2016)

E-selectin polymorphism and atherosclerosis: an association study

Wenzel K., Felix S., Kleber F.X., Brachold R., Menke T., Schattke S., Schulte K.L., Glaser C., Rohde K., Baumann G., Speer A.,

Hum. Mol. Genet. 3:1935-1937(1994)

DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis

Wenzel K., Ernst M., Rohde K., Baumann G., Speer A.,

Hum. Genet. 97:15-20(1996)

A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease

Ye S.Q., Usher D., Virgil D., Zhang L.Q., Yochim S.E., Gupta R.,

J. Biomed. Sci. 6:18-21(1999)

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.,

Nat. Genet. 22:239-247(1999)