CD62P

Synonyms

PADGEM, GRMP, Selectin P (Granule Membrane Protein 140kD, Antigen CD62), Platelet Alpha-Granule Membrane Protein, Granulocyte Membrane Protein, CD62P Antigen, Antigen CD62, P-Selectin, GMP140, CD62P, CD62, PSEL, Platelet Activation Dependent Granule-External Membrane Protein, Granule Membrane Protein 140kDa, LECAM3, CD62 antigen-like family member P, GMRP, GMP-140, Granule membrane protein 140, SELP, Selectin P, Selectin P (Granule Membrane Protein 140kDa, Antigen CD62), Leukocyte-Endothelial Cell Adhesion Molecule 3

Description

P-selectin that in humans is encoded by the SELP gene,is a Ca-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. It mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 3
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Crizanlizumab-tmca

Sel-G1, SEG-101, Sel-G-1

Approved

Selexys, Novartis Pharma Ag

Priapism, Primary Myelofibrosis, Anemia, Sickle Cell

Dociparstat sodium

ODSH, CX-01, PGX-100, PGX-ODSH-2013-AML-1

Phase 3 Clinical

Paringenix

Coronavirus Disease 2019 (COVID-19), Pancreatic Neoplasms, Leukemia, Myeloid, Acute, Protein-Losing Enteropathies, Pulmonary Disease, Chronic Obstructive, Acute Lung Injury

Rivipansel Sodium

GM-1070, GMI-1070, PF-6460031, PF-06460031-02, PF-06460031 (free base)

Phase 3 Clinical

Glycomimetics Pharmaceutical

Pain, Kidney Diseases, Anemia, Sickle Cell

Inclacumab

RG-1512, RO-4905417, LC-1004-002, DSM-ACC-2641, R-1512

Phase 2 Clinical

F. Hoffmann-La Roche Ltd, Genmab

Myocardial Infarction, Peripheral Vascular Diseases, Acute Coronary Syndrome, Graft Occlusion, Vascular, Peripheral Arterial Disease

Bimosiamose

TBC-1269

Pending

Encysive

Psoriasis, Asthma, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic

Monoclonal antibody EP-5C7  (PDL BioPharma)

EP-5C7

Discontinued

Pdl Biopharma

Autoimmune Diseases, Stroke, Psoriasis, Asthma, Shock

CY-1503

CY-1503

Discontinued

Epimmune Inc

Reperfusion Injury

Torapsel

YSPSL

Discontinued

Pfizer Inc

Reperfusion Injury, Myocardial Infarction, Kidney Diseases, Liver Diseases, Delayed Graft Function

References


Title

Authors

Source

The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction

Herrmann S.M., Ricard S., Nicaud V., Mallet C., Evans A., Ruidavets J.B., Arveiler D., Luc G., Cambien F.,

Hum. Mol. Genet. 7:1277-1284(1998)

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,

Nat. Genet. 22:231-238(1999)

Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis

Zee R.Y.L., Cook N.R., Cheng S., Reynolds R., Erlich H.A., Lindpaintner K., Ridker P.M.,

Hum. Mol. Genet. 13:389-396(2004)

Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation

Johnston G.I., Cook R.G., McEver R.P.,

Cell 56:1033-1044(1989)

The DNA sequence and biological annotation of human chromosome 1

Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Bentley D.R.,

Nature 441:315-321(2006)

P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage

Fujimoto T., Stroud E., Whatley R.E., Prescott S.M., Muszbek L., Laposata M., McEver R.P.,

J. Biol. Chem. 268:11394-11400(1993)

A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding

Sako D., Comess K.M., Barone K.M., Camphausen R.T., Cumming D.A., Shaw G.D.,

Cell 83:323-331(1995)

PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus

Pouyani T., Seed B.,

Cell 83:333-343(1995)

A new member of the sorting nexin family interacts with the C-terminus of P-selectin

Florian V., Schlueter T., Bohnensack R.,

Biochem. Biophys. Res. Commun. 281:1045-1050(2001)

Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking

Knauth P., Schlueter T., Czubayko M., Kirsch C., Florian V., Schreckenberger S., Hahn H., Bohnensack R.,

J. Mol. Biol. 347:813-825(2005)