CD62P

Synonyms

PADGEM, GRMP, Selectin P (Granule Membrane Protein 140kD, Antigen CD62), Platelet Alpha-Granule Membrane Protein, Granulocyte Membrane Protein, CD62P Antigen, Antigen CD62, P-Selectin, GMP140, CD62P, CD62, PSEL, Platelet Activation Dependent Granule-External Membrane Protein, Granule Membrane Protein 140kDa, LECAM3, CD62 antigen-like family member P, GMRP, GMP-140, Granule membrane protein 140, SELP, Selectin P, Selectin P (Granule Membrane Protein 140kDa, Antigen CD62), Leukocyte-Endothelial Cell Adhesion Molecule 3,

Description

P-selectin that in humans is encoded by the SELP gene,is a Ca-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. It mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG.

KO Status

F0

Drug Information

Launched drugs: 3
Drug in clinical trials: 1
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Crizanlizumab-tmca

Sel-G1, SEG-101, Sel-G-1

Approved

Selexys, Novartis Pharma Ag

Priapism, Primary Myelofibrosis, Anemia, Sickle Cell

Dociparstat sodium

ODSH, CX-01, PGX-100, PGX-ODSH-2013-AML-1

Phase 3 Clinical

Paringenix

Coronavirus Disease 2019 (COVID-19), Pancreatic Neoplasms, Leukemia, Myeloid, Acute, Protein-Losing Enteropathies, Pulmonary Disease, Chronic Obstructive, Acute Lung Injury

Rivipansel Sodium

GM-1070, GMI-1070, PF-6460031, PF-06460031-02, PF-06460031 (free base)

Phase 3 Clinical

Glycomimetics Pharmaceutical

Kidney Diseases, Anemia, Sickle Cell

Inclacumab

RG-1512, RO-4905417, LC-1004-002, DSM-ACC-2641, R-1512

Phase 2 Clinical

F. Hoffmann-La Roche Ltd, Genmab

Myocardial Infarction, Peripheral Vascular Diseases, Acute Coronary Syndrome, Graft Occlusion, Vascular, Peripheral Arterial Disease

Bimosiamose

TBC-1269

Pending

Encysive

Psoriasis, Asthma, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic

Monoclonal antibody EP-5C7  (PDL BioPharma)

EP-5C7

Discontinued

Pdl Biopharma

Autoimmune Diseases, Stroke, Psoriasis, Asthma, Shock

CY-1503

CY-1503

Discontinued

Epimmune Inc

Reperfusion Injury

Torapsel

YSPSL

Discontinued

Pfizer Inc

Reperfusion Injury, Myocardial Infarction, Kidney Diseases, Liver Diseases, Delayed Graft Function