CD86

Synonyms

FUN-1, CTLA-4 counter-receptor B7.2, CD28LG2, Activation B7-2 antigen, CD86, CD86 Molecule, CD86 Antigen (CD28 Antigen Ligand 2, B7-2 Antigen), BU63, B70, B-Lymphocyte Activation Antigen B7-2, T-Lymphocyte Activation Antigen CD86, B-Lymphocyte Antigen B7-2, CD86 Antigen, LAB72, B7-2, B7.2, B7-2 Antigen

Description

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on dendritic cells, macrophages, B-cells, and other antigen-presenting cells. CD86 is the receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, also be involved in the regulation of B cells function, plays a role in regulating the level of IgG produced. Upon CD40 engagement, It activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.

KO Status

RenMab: F2 (-/-)

RenLite: F0

Drug Information

Launched drugs: 2
Drug in clinical trials: 1
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Abatacept

BMS-188667, BMS-188667SC, ONO-4164SC, ONO-4164

Approved

Bristol-Myers Squibb Company

Polymyositis, Myositis, Dermatomyositis, Coronavirus Disease 2019 (COVID-19), Arthritis, Rheumatoid, Sjogren's Syndrome, Arthritis, Juvenile, Lupus Nephritis, Multiple Sclerosis, Nephrosis, Lipoid, Lupus Erythematosus, Systemic, Psoriasis, Glomerulosclerosis, Focal Segmental, Arthritis, Psoriatic, Colitis, Ulcerative, Muscular Diseases, Nephrotic Syndrome, Crohn Disease

Belatacept

LEA29Y, LEA-029, BMS-224818, L104EA29YIg

Approved

Bristol-Myers Squibb Company

Rejection of renal transplantation, Rejection of organ transplantation

Chimeric antigen receptor T-cell therapy (Hunan Zhaotai Yongren Biotech)

Z-CTLs

Phase 1 Clinical

Hunan Zhaotai Yongren Biotech

Carcinoma, Non-Small-Cell Lung

Abatacept biosimilar (Momenta Pharmaceuticals)

M-834

Pending

Momenta

Autoimmune Diseases, Inflammation

Recombinant human CTLA4-Ig Fusion protein(Shanghai CP Guojian)

Pending

Shanghai Cp Guojian Pharmaceutical Co Ltd

Arthritis, Rheumatoid

APVO-210

ES-210, APVO-210

Discontinued

Aptevo

Psoriasis, Colitis, Ulcerative

Attenuated viral vector immunogene-based therapy and vaccine (Radient Pharmaceuticals)

Discontinued

Radient

Neoplasms

Abatacept biosimilar (Hanwha Biologics)

Discontinued

Hanwha Biologics

Arthritis

ASP-2408

ASP-2408

Discontinued

Maxygen

Arthritis, Rheumatoid

CTLA-4/FasL fusion protein (KAHR Medical)

KAHR-102

Discontinued

Kahr Medical

Lymphoma

References


Title

Authors

Source

B70 antigen is a second ligand for CTLA-4 and CD28

Azuma M., Ito D., Yagita K., Okumura K., Phillips J.H., Lanier L.L., Somoza C.,

Nature 366:76-79(1993)

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation

Freeman G.J., Gribben J.G., Boussiotis V.A., Ng J.W., Restivo V.A. Jr., Lombard L.A., Gray G.S., Nadler L.M.,

Science 262:909-911(1993)

Identification of an alternatively spliced variant of human CD86 mRNA

Magistrelli G., Caron G., Gauchat J.-F., Jeannin P., Bonnefoy J.-Y., Delneste Y.,

Biochem. Biophys. Res. Commun. 280:1211-1215(2001)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence, annotation and analysis of human chromosome 3

Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Gibbs R.A.,

Nature 440:1194-1198(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)

Jellis C.L., Wang S.S., Rennert P., Borriello F., Sharpe A.H., Green N.R., Gray G.S.,

Immunogenetics 42:85-89(1995)

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL

Lanier L.L., O'Fallon S., Somoza C., Phillips J.H., Linsley P.S., Okumura K., Ito D., Azuma M.,

J. Immunol. 154:97-105(1995)

The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen

Engel P., Gribben J.G., Freeman G.J., Zhou L.J., Nozawa Y., Abe M., Nadler L.M., Wakasa H., Tedder T.F.,

Blood 84:1402-1407(1994)

c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity

Goto E., Ishido S., Sato Y., Ohgimoto S., Ohgimoto K., Nagano-Fujii M., Hotta H.,

J. Biol. Chem. 278:14657-14668(2003)