CFD

Synonyms

CFD, Properdin factor D, DF, Complement factor D, D Component Of Complement (Adipsin), PFD, Complement Factor D Preproprotein, Complement Factor D (Adipsin), EC 3.4.21.46, ADN, EC:3.4.21.46, EC 3.4.21');, EC 3.4.21, C3 Convertase Activator, ADIPSIN

Description

Complement Factor D (CFD) is a specific serine protease that cleaves its unique substrate.Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

KO Status

F1 (+/-)

Drug Information

Drugs in clinical trials: 4
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Danicopan

ACH-4471, ACH-0144471

Phase 3 Clinical

Achillion Pharmaceutical

Drug-Related Side Effects and Adverse Reactions, Hemoglobinuria, Paroxysmal, Glomerulonephritis, Membranoproliferative, Hepatic Insufficiency, Glomerulonephritis

BCX-9930

BCX-9930

Phase 2 Clinical

Biocryst Pharmaceuticals

Hemoglobinuria, Paroxysmal

ACH-5228

ACH-0145228, ACH-5228, ALXN-2050

Phase 2 Clinical

Achillion Pharmaceutical

Hemoglobinuria, Paroxysmal, Kidney Diseases

ACH-5548

ACH-5548, ACH-0145548

Phase 1 Clinical

Achillion Pharmaceutical

Autoimmune Diseases

A-01017

A-01017

Preclinical

Clearside Biomedical

Macular Degeneration

Lampalizumab

RG-7417, TNX-234, FCFD-4514S, RO-5490249

Discontinued

Genentech Inc

Geographic Atrophy, Macular Degeneration

References


Title

Authors

Source

Resveratrol-induced changes of the human adipocyte secretion profile

Rosenow A., Noben J.P., Jocken J., Kallendrusch S., Fischer-Posovszky P., Mariman E.C., Renes J.,

J. Proteome Res. 11:4733-4743(2012)

Structure of human factor D. A complement system protein at 2.0-A resolution

Narayana S.V.L., Carson M., El-Kabbani O., Kilpatrick J.M., Moore D., Chen X., Bugg C.E., Volanakis J.E., Delucas L.J.,

J. Mol. Biol. 235:695-708(1994)

Crystal structure of a complement factor D mutant expressing enhanced catalytic activity

Kim S., Narayana S.V., Volanakis J.E.,

J. Biol. Chem. 270:24399-24405(1995)

Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections

Sprong T., Roos D., Weemaes C., Neeleman C., Geesing C.L., Mollnes T.E., van Deuren M.,

Blood 107:4865-4870(2006)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue

White R.T., Damm D., Hancock N., Rosen B.S., Lowell B.B., Usher P., Flier J.S., Spiegelman B.M.,

J. Biol. Chem. 267:9210-9213(1992)

Amino acid sequence of human D of the alternative complement pathway

Niemann M.A., Bhown A.S., Bennett J.C., Volanakis J.E.,

Biochemistry 23:2482-2486(1984)

Amino acid sequence of human factor D of the complement system. Similarity in sequence between factor D and proteases of non-plasma origin

Johnson D.M.A., Gagnon J., Reid K.B.M.,

FEBS Lett. 166:347-351(1984)

Partial amino acid sequence of human factor D: homology with serine proteases

Volanakis J.E., Bhown A.S., Bennett J.C., Mole J.E.,

Proc. Natl. Acad. Sci. U.S.A. 77:1116-1119(1980)