CGRP

Synonyms

Calcitonin gene-related peptide I, CGRP1, CGRP-I, PCT, CGRP-Alpha, Calcitonin 1, Katacalcin, CT, CALC1, Calcitonin/Calcitonin-Related Polypeptide, Alpha, Calcitonin, KC, CGRP, Calcitonin Related Polypeptide Alpha, Alpha-type CGRP

Description

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.

KO Status

RenMab: F0

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

anti-ILT3 CAR-T(Carbiogene)

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71, SI-F019

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)

IO-202

IO-202

Phase 1 Clinical

Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute

GSK3903371

GSK3903371

Clinical

Glaxosmithkline Plc

Neoplasms

NKp46 NKCE

NKp46-NKCE, NKp46 NKCE

Preclinical

Neoplasms

SAR-443579

SAR-443579, SAR443579, IPH6101, IPH-6101

Preclinical

Neoplasms

BI-1910

BI-1910

Preclinical

Bioinvent International

Solid tumours

IPR-1110

IPR 1110

Preclinical

Neoplasms

MNPR-101

huATN-658, ATN-291 F(ab’)2

Preclinical

Monopar Therapeutics Inc

Neoplasms

References


Title

Authors

Source

Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin

Hubbard J.A.M., Martin S.R., Chaplin L.C., Bose C., Kelly S.M., Price N.C.,

Biochem. J. 275:785-788(1991)

Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression

Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J., Evans R.M., Rosenfeld M.G.,

Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985)

Structure and methylation of the human calcitonin/alpha-CGRP gene

Broad P.M., Symes A.J., Thakker R.V., Craig R.K.,

Nucleic Acids Res. 17:6999-7011(1989)

Human chromosome 11 DNA sequence and analysis including novel gene identification

Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,

Nature 440:497-500(2006)

Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide

Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A., Baylin S.B.,

Biochem. Biophys. Res. Commun. 123:648-655(1984)

Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma

Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K.,

EMBO J. 4:715-724(1985)

Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma

Steenbergh P.H., Hoppener J.W., Zandberg J., de Ven W.J., Jansz H.S., Lips C.J.,

J. Clin. Endocrinol. Metab. 59:358-360(1984)

Expression and function of the human calcitonin/alpha-CGRP gene in health and disease

Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M., Al-Kazwini S.J., Holman J.J., Marshall I.,

Biochem. Soc. Symp. 52:91-105(1986)

Isolation and characterization of human calcitonin gene-related peptide

Morris H.R., Panico M., Etienne T., Tippins J., Girgis S.I., McIntyre I.,

Nature 308:746-748(1984)

Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord

Petermann J.B., Born W., Chang J.Y., Fischer J.A.,

J. Biol. Chem. 262:542-545(1987)