CGRP
Synonyms
Calcitonin gene-related peptide I, CGRP1, CGRP-I, PCT, CGRP-Alpha, Calcitonin 1, Katacalcin, CT, CALC1, Calcitonin/Calcitonin-Related Polypeptide, Alpha, Calcitonin, KC, CGRP, Calcitonin Related Polypeptide Alpha, Alpha-type CGRP
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
KO Status
RenMab: F0
Drug Information
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Nidanilimab
CAN-04
Phase 2 Clinical
Lund University Foundation
Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma
HLX-71
HLX-71, SI-F019
Phase 1 Clinical
Hengenix Biotech Inc
Coronavirus Disease 2019 (COVID-19)
GSK-6097608
GSK-6097608
Phase 1 Clinical
Glaxosmithkline Plc
Neoplasms
IO-202
IO-202
Phase 1 Clinical
Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute
XKH-001(Xinkanghe Biomedical)
XKH-001
Phase 1 Clinical
Beijing Xinkanghe Biomedical Technology Co Ltd
Inflammation
anti-ILT3 CAR-T（Carbiogene）
Phase 1 Clinical
Leukemia, Myeloid, Acute
GSK3903371
GSK3903371
Clinical
Glaxosmithkline Plc
Neoplasms
LBL-019
LBL-019
IND
Nanjing Leads Biolabs Co Ltd
Neoplasms
SIM1811-03
SIM1811-03, SIM0235
IND
Jiangsu Xiansheng Pharmaceutical Co Ltd
Solid tumours, Lymphoma, T-Cell, Cutaneous
ISB-880
ISB-880
Preclinical
Ichnos Sciences Sa
Autoimmune Diseases of the Nervous System
References
Title
Authors
Source
Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin
Hubbard J.A.M., Martin S.R., Chaplin L.C., Bose C., Kelly S.M., Price N.C.,
Biochem. J. 275:785-788(1991)
Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression
Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J., Evans R.M., Rosenfeld M.G.,
Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985)
Structure and methylation of the human calcitonin/alpha-CGRP gene
Broad P.M., Symes A.J., Thakker R.V., Craig R.K.,
Nucleic Acids Res. 17:6999-7011(1989)
Human chromosome 11 DNA sequence and analysis including novel gene identification
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,
Nature 440:497-500(2006)
Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide
Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A., Baylin S.B.,
Biochem. Biophys. Res. Commun. 123:648-655(1984)
Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma
Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K.,
EMBO J. 4:715-724(1985)
Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma
Steenbergh P.H., Hoppener J.W., Zandberg J., de Ven W.J., Jansz H.S., Lips C.J.,
J. Clin. Endocrinol. Metab. 59:358-360(1984)
Expression and function of the human calcitonin/alpha-CGRP gene in health and disease
Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M., Al-Kazwini S.J., Holman J.J., Marshall I.,
Biochem. Soc. Symp. 52:91-105(1986)
Isolation and characterization of human calcitonin gene-related peptide
Morris H.R., Panico M., Etienne T., Tippins J., Girgis S.I., McIntyre I.,
Nature 308:746-748(1984)
Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord
Petermann J.B., Born W., Chang J.Y., Fischer J.A.,
J. Biol. Chem. 262:542-545(1987)