CGRP
Synonyms
Calcitonin gene-related peptide I, CGRP1, CGRP-I, PCT, CGRP-Alpha, Calcitonin 1, Katacalcin, CT, CALC1, Calcitonin/Calcitonin-Related Polypeptide, Alpha, Calcitonin, KC, CGRP, Calcitonin Related Polypeptide Alpha, Alpha-type CGRP
Description
CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP.
KO Status
RenMab: F0
Drug Information
Drug Name
Code
Phase
Company
Indications
Clinical Trials
anti-ILT3 CAR-T（Carbiogene）
Nidanilimab
CAN-04
Phase 2 Clinical
Lund University Foundation
Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma
HLX-71
HLX-71, SI-F019
Phase 1 Clinical
Hengenix Biotech Inc
Coronavirus Disease 2019 (COVID-19)
IO-202
IO-202
Phase 1 Clinical
Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute
GSK3903371
GSK3903371
Clinical
Glaxosmithkline Plc
Neoplasms
NKp46 NKCE
NKp46-NKCE, NKp46 NKCE
Preclinical
Neoplasms
SAR-443579
SAR-443579, SAR443579, IPH6101, IPH-6101
Preclinical
Neoplasms
BI-1910
BI-1910
Preclinical
Bioinvent International
Solid tumours
IPR-1110
IPR 1110
Preclinical
Neoplasms
MNPR-101
huATN-658, ATN-291 F(ab’)2
Preclinical
Monopar Therapeutics Inc
Neoplasms
References
Title
Authors
Source
Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin
Hubbard J.A.M., Martin S.R., Chaplin L.C., Bose C., Kelly S.M., Price N.C.,
Biochem. J. 275:785-788(1991)
Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression
Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J., Evans R.M., Rosenfeld M.G.,
Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985)
Structure and methylation of the human calcitonin/alpha-CGRP gene
Broad P.M., Symes A.J., Thakker R.V., Craig R.K.,
Nucleic Acids Res. 17:6999-7011(1989)
Human chromosome 11 DNA sequence and analysis including novel gene identification
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Sakaki Y.,
Nature 440:497-500(2006)
Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide
Nelkin B.D., Rosenfeld K.I., de Bustros A., Leong S.S., Roos B.A., Baylin S.B.,
Biochem. Biophys. Res. Commun. 123:648-655(1984)
Expression of the human calcitonin/CGRP gene in lung and thyroid carcinoma
Edbrooke M.R., Parker D., McVey J.H., Riley J.H., Sorenson G.D., Pettengill O.S., Craig R.K.,
EMBO J. 4:715-724(1985)
Calcitonin gene related peptide coding sequence is conserved in the human genome and is expressed in medullary thyroid carcinoma
Steenbergh P.H., Hoppener J.W., Zandberg J., de Ven W.J., Jansz H.S., Lips C.J.,
J. Clin. Endocrinol. Metab. 59:358-360(1984)
Expression and function of the human calcitonin/alpha-CGRP gene in health and disease
Craig R.K., Riley J.H., Edbrooke M.R., Broad P.M., Foord S.M., Al-Kazwini S.J., Holman J.J., Marshall I.,
Biochem. Soc. Symp. 52:91-105(1986)
Isolation and characterization of human calcitonin gene-related peptide
Morris H.R., Panico M., Etienne T., Tippins J., Girgis S.I., McIntyre I.,
Nature 308:746-748(1984)
Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord
Petermann J.B., Born W., Chang J.Y., Fischer J.A.,
J. Biol. Chem. 262:542-545(1987)