CXCL10

Synonyms

Protein 10 From Interferon (Gamma)-Induced Cell Line, CXCL10, INP10, SCYB10, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, IP-10, C-X-C Motif Chemokine Ligand 10, Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10, Chemokine (C-X-C Motif) Ligand 10, Small-Inducible Cytokine B10, Chemokine CXCL10, Interferon-Inducible Cytokine IP-10, Gamma IP10, Gamma-IP10, GIP-10, IFI10, Crg-2, Mob-1, C7

Description

C-X-C motif chemokine ligand 10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene.C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects . Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization . In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation . Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.

KO Status

RenMab: Immunization

Drug Information

Drugs in clinical trials: 3
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

JT-02 (JYANT Technologies)

JT-02

Phase 2 Clinical

Jyant Technologies

Inflammatory Bowel Diseases

NG-641

NG-641, NG-aFAP, EnAd-FAP-Tac, EnAd-FAP-BiTE

Phase 1 Clinical

University Of Oxford, Psioxus Therapeutics

Carcinoma, Squamous Cell Carcinoma of Head and Neck, Neoplasms, Glandular and Epithelial, Neoplasm Metastasis

BMS-986184

BMS-986184

Phase 1 Clinical

Bristol-Myers Squibb Company

Colitis, Ulcerative

Eldelumab

MDX-1100, BMS-936557

Pending

Bristol-Myers Squibb Company, Medarex

Arthritis, Rheumatoid, Colitis, Ulcerative, Crohn Disease

NI-0801

Alpha-IP-10, NI-0801, α-IP-10

Discontinued

Novimmune

Liver Cirrhosis, Biliary, Dermatitis, Allergic Contact

References


Title

Authors

Source

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Luster A.D., Unkeless J.C., Ravetch J.V.,

Nature 315:672-676(1985)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8

Proost P., de Wolf-Peeters C., Conings R., Opdenakker G., Billiau A., van Damme J.,

J. Immunol. 150:1000-1010(1993)

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo

Angiolillo A.L., Sgadari C., Taub D.D., Liao F., Farber J.M., Maheshwari S., Kleinman H.K., Reaman G.H., Tosato G.,

J. Exp. Med. 182:155-162(1995)

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

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J. Exp. Med. 184:963-969(1996)

Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3)

Tensen C.P., Flier J., van der Raaij-Helmer E.M.H., Sampat-Sardjoepersad S., van der Schors R.C., Leurs R., Scheper R.J., Boorsma D.M., Willemze R.,

J. Invest. Dermatol. 112:716-722(1999)

Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity

Hensbergen P.J., van der Raaij-Helmer E.M.H., Dijkman R., van der Schors R.C., Werner-Felmayer G., Boorsma D.M., Scheper R.J., Willemze R., Tensen C.P.,

Eur. J. Biochem. 268:4992-4999(2001)

Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) alphabeta+ CD8+ single-positive T cells, TCRgammadelta+ T cells, and natural killer-type cells in human thymus

Romagnani P., Annunziato F., Lazzeri E., Cosmi L., Beltrame C., Lasagni L., Galli G., Francalanci M., Manetti R., Marra F., Vanini V., Maggi E., Romagnani S.,

Blood 97:601-607(2001)

CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase

Smit M.J., Verdijk P., van der Raaij-Helmer E.M., Navis M., Hensbergen P.J., Leurs R., Tensen C.P.,

Blood 102:1959-1965(2003)

CXCL10 production from cytomegalovirus-stimulated microglia is regulated by both human and viral interleukin-10

Cheeran M.C., Hu S., Sheng W.S., Peterson P.K., Lokensgard J.R.,

J. Virol. 77:4502-4515(2003)