EREG

Synonyms

Epiregulin, Ep, EREG, EPR, ER, Proepiregulin

Description

Epiregulin (EREG) is a novel family member of EGF-like ligands and have elevated expression in a variety of human cancers. EREG expression promotes tumor progression and metastasis and reduces patient survival. Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.

KO Status

F1 (+/-)

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

TGF-alpha/epiregulin monoclonal antibody

LY-3016859

Phase 2 Clinical

Eli Lilly And Company

Diabetic Neuropathies, Diabetic Nephropathies, Osteoarthritis, Low Back Pain

References


Title

Authors

Source

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family

Toyoda H., Komurasaki T., Uchida D., Morimoto S.,

Biochem. J. 326:69-75(1997)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4

Komurasaki T., Toyoda H., Uchida D., Morimoto S.,

Oncogene 15:2841-2848(1997)

Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity

Sato K., Nakamura T., Mizuguchi M., Miura K., Tada M., Aizawa T., Gomi T., Miyamoto K., Kawano K.,

FEBS Lett. 553:232-238(2003)

Epiregulin: roles in normal physiology and cancer

Riese D.J. II, Cullum R.L.,

Semin. Cell Dev. Biol. 28:49-56(2014)

The consensus coding sequences of human breast and colorectal cancers

Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Velculescu V.E.,

Science 314:268-274(2006)

Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family.

Toyoda H., Komurasaki T., Uchida D., Morimoto S.,

Biochem. J. 326:69-75(1997)

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

The MGC Project Team,

Genome Res. 14:2121-2127(2004)