EREG
Synonyms
Epiregulin, Ep, EREG, EPR, ER, Proepiregulin
Description
Epiregulin (EREG) is a novel family member of EGF-like ligands and have elevated expression in a variety of human cancers. EREG expression promotes tumor progression and metastasis and reduces patient survival. Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation.
KO Status
RenMab: Immunization
Drug Information
Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
TGF-alpha/epiregulin monoclonal antibody
LY-3016859
Phase 2 Clinical
Eli Lilly And Company
Diabetic Neuropathies, Diabetic Nephropathies, Osteoarthritis, Low Back Pain
References
Title
Authors
Source
Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family
Toyoda H., Komurasaki T., Uchida D., Morimoto S.,
Biochem. J. 326:69-75(1997)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4
Komurasaki T., Toyoda H., Uchida D., Morimoto S.,
Oncogene 15:2841-2848(1997)
Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity
Sato K., Nakamura T., Mizuguchi M., Miura K., Tada M., Aizawa T., Gomi T., Miyamoto K., Kawano K.,
FEBS Lett. 553:232-238(2003)
Epiregulin: roles in normal physiology and cancer
Riese D.J. II, Cullum R.L.,
Semin. Cell Dev. Biol. 28:49-56(2014)
The consensus coding sequences of human breast and colorectal cancers
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Velculescu V.E.,
Science 314:268-274(2006)