FGF21
Synonyms
FGF21
KO Status
RenMab: F2 (-/-)
Drug Information
Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical
Drug Name
Code
Phase
Company
Indications
Clinical Trials
BIO89-100
BIO89-100, TEV-47948
Phase 2 Clinical
Teva, 89bio
Hypertriglyceridemia, Non-alcoholic Fatty Liver Disease
BOS-580
Phase 2 Clinical
Novartis Pharma Ag
Non-alcoholic Fatty Liver Disease
Recombinant human FGF21 Fc fusion protein(Anyuan Pharmaceutical)
IND
Anyuan Pharmaceutical Technology (Shanghai) Co Ltd
References
Title
Authors
Source
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
Nishimura T., Nakatake Y., Konishi M., Itoh N.,
Biochim. Biophys. Acta 1492:203-206(2000)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,
Genome Res. 13:2265-2270(2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites
Zhang Z., Henzel W.J.,
Protein Sci. 13:2819-2824(2004)
FGF-21 as a novel metabolic regulator
Kharitonenkov A., Shiyanova T.L., Koester A., Ford A.M., Micanovic R., Galbreath E.J., Sandusky G.E., Hammond L.J., Moyers J.S., Owens R.A., Gromada J., Brozinick J.T., Hawkins E.D., Wroblewski V.J., Li D.-S., Mehrbod F., Jaskunas S.R., Shanafelt A.B.,
J. Clin. Invest. 115:1627-1635(2005)
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
Kurosu H., Choi M., Ogawa Y., Dickson A.S., Goetz R., Eliseenkova A.V., Mohammadi M., Rosenblatt K.P., Kliewer S.A., Kuro-o M.,
J. Biol. Chem. 282:26687-26695(2007)
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors
Wu X., Lemon B., Li X., Gupte J., Weiszmann J., Stevens J., Hawkins N., Shen W., Lindberg R., Chen J.-L., Tian H., Li Y.,
J. Biol. Chem. 283:33304-33309(2008)
Different roles of N- and C- termini in the functional activity of FGF21
Micanovic R., Raches D.W., Dunbar J.D., Driver D.A., Bina H.A., Dickinson C.D., Kharitonenkov A.,
J. Cell. Physiol. 219:227-234(2009)
Fibroblast growth factor signalling: from development to cancer
Turner N., Grose R.,
Nat. Rev. Cancer 10:116-129(2010)