FGF23

Synonyms

HFTC2, Tumor-Derived Hypophosphatemia Inducing Factor, UNQ3027/PRO9828, Tumor-derived hypophosphatemia-inducing factor, HYPF, FGF23, Fibroblast Growth Factor 23, Phosphatonin, FGF-23, HPDR2, PHPTC, ADHR, FGFN

Description

Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. FGF23 is a member of the fibroblast growth factor (FGF) family which participates in phosphate and vitamin D metabolism and regulation.Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

KO Status

RenMab: F0

Drug Information

Launched drug: 1
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Burosumab

KRN-23, UX-023

Approved

Kyowa Hakko Kirin Co Ltd

Hypophosphatemia, Hypophosphatemia, Familial, Osteomalacia, Genetic Diseases, X-Linked, Nevus, Sebaceous of Jadassohn, Familial Hypophosphatemic Rickets

References


Title

Authors

Source

Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo

Shimada T., Muto T., Urakawa I., Yoneya T., Yamazaki Y., Okawa K., Takeuchi Y., Fujita T., Fukumoto S., Yamashita T.,

Endocrinology 143:3179-3182(2002)

FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting

Riminucci M., Collins M.T., Fedarko N.S., Cherman N., Corsi A., White K.E., Waguespack S., Gupta A., Hannon T., Econs M.J., Bianco P., Gehron Robey P.,

J. Clin. Invest. 112:683-692(2003)

FGF23 is processed by proprotein convertases but not by PHEX

Benet-Pages A., Lorenz-Depiereux B., Zischka H., White K.E., Econs M.J., Strom T.M.,

Bone 35:455-462(2004)

FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

Shimada T., Hasegawa H., Yamazaki Y., Muto T., Hino R., Takeuchi Y., Fujita T., Nakahara K., Fukumoto S., Yamashita T.,

J. Bone Miner. Res. 19:429-435(2004)

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.,

J. Biol. Chem. 281:15694-15700(2006)

Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation

Kato K., Jeanneau C., Tarp M.A., Benet-Pages A., Lorenz-Depiereux B., Bennett E.P., Mandel U., Strom T.M., Clausen H.,

J. Biol. Chem. 281:18370-18377(2006)

Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro

Wang H., Yoshiko Y., Yamamoto R., Minamizaki T., Kozai K., Tanne K., Aubin J.E., Maeda N.,

J. Bone Miner. Res. 23:939-948(2008)

Fibroblast growth factor signalling: from development to cancer

Turner N., Grose R.,

Nat. Rev. Cancer 10:116-129(2010)

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

Goetz R., Beenken A., Ibrahimi O.A., Kalinina J., Olsen S.K., Eliseenkova A.V., Xu C., Neubert T.A., Zhang F., Linhardt R.J., Yu X., White K.E., Inagaki T., Kliewer S.A., Yamamoto M., Kurosu H., Ogawa Y., Kuro-o M., Mohammadi M.,

Mol. Cell. Biol. 27:3417-3428(2007)

A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification

Chefetz I., Heller R., Galli-Tsinopoulou A., Richard G., Wollnik B., Indelman M., Koerber F., Topaz O., Bergman R., Sprecher E., Schoenau E.,

Hum. Genet. 118:261-266(2005)