FLT3
Synonyms
EC 2.7.10, EC:2.7.10.1, Receptor-type tyrosine-protein kinase FLT3, FLT3, FLT-3, FLK2, STK-1, FL cytokine receptor, Fms Related Tyrosine Kinase 3, Stem Cell Tyrosine Kinase 1, CD135 Antigen, CD135, STK1, Growth Factor Receptor Tyrosine Kinase Type III, Fms-Related Tyrosine Kinase 3, Fetal Liver Kinase 2, Fetal Liver Kinase-2, EC 2.7.10.1, fms-Like Tyrosine Kinase 3, Fms Related Receptor Tyrosine Kinase 3, FLK-2,Description
Tyrosine-protein kinase receptor FLT3 is a protein that in humans is encoded by the FLT3 gene. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. CD135 is the receptor for the cytokine Flt3 ligand (FLT3L).Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
KO Status
F1 (+/-)
Drug Information
Launched drugs: 30
Drugs in clinical trials: 10
Latest Research Phase:Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Midostaurin
PKC-412, PKC-412A, CGP-41231, CGP-41251
Approved
Novartis Pharma Ag
Hematologic Neoplasms, Leukemia, Mastocytosis, Systemic, Leukemia, Mast-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Hepatic Insufficiency, Leukemia, Myeloid, Acute, Mastocytosis
NCT Number
NCT03379727
NCT04174612
NCT00651261
NCT03512197
NCT04027309
NCT03092674
NCT03280030
NCT01830361
NCT03207334
NCT03591510
NCT01846624
NCT01477606
NCT00233454
NCT02756962
NCT01883362
NCT03951961
NCT03686345
NCT02723435
NCT03836209
NCT01920204
NCT04097470
NCT02634827
NCT00782067
NCT00045942
NCT01093573
NCT01202877
NCT03760445
NCT00866281
NCT04385290
NCT04075747
NCT02078609
NCT01130662
NCT03900949
NCT01161550
NCT04496999
NCT01174888
NCT01429337
NCT00819546
NCT01282502
NCT00093600
NCT02624570
NCT03114228
Intervention Type
Drug
Drug
Other;Drug
Drug
Drug
Other;Biological;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Procedure;Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Procedure;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Acute Myeloid Leukemia
Acute Myeloid Leukemia With FLT3/ITD Mutation
Leukemia
Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia; Myelodysplastic Syndrome With Excess Blasts-2
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Myelodysplastic Syndrome With Excess Blasts-2
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
FLT3-mutated Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) With Multilineage Dysplasia Following Myelodysplastic Syndrome, in Adults; AML (Adult) With 11q23 (MLL) Abnormalities; AML (Adult) With Del (5q); AML (Adult) With Inv (16) (p13; q22); AML (Adult) With t (16;16) (p13; q22); AML (Adult) With t (8; 21) (q22; q22); Secondary AML (Adult); Untreated AML (Adult)
Acute Myeloid Leukemia
Systemic Mastocytosis, Aggressive (ASM); Leukemia, Mast Cell; Hematological Non-mast Cell Lineage Disease (AHNMD)
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia, Adult
Core Binding Factor Acute Myeloid Leukemia (CBF-AML)
Acute Myeloid Leukemia With Gene Mutations; Adult Acute Myeloid Leukemia in Remission
Acute Myeloid Leukemia
Indolent Systemic Mastocytosis
AML/MDS
Acute Myeloid Leukemia With FLT3/ITD Mutation; Acute Myeloid Leukemia With Gene Mutations; FLT3 Tyrosine Kinase Domain Point Mutation; Secondary Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Leukemia
Acute Myeloid Leukemia; Myelodysplastic Syndromes
Untreated Adult Acute Myeloid Leukemia
Leukemia
Leukemia, Myeloid, Acute
Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia
Acute Myeloid Leukemia
AML and High Risk MDS
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Leukemia, Myeloid, Acute
AML, Adult
Acute Myeloid Leukemia; Acute Myeloid Leukemia With Multilineage Dysplasia Following; Myelodysplastic Syndrome; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia
Hepatic Impairment
Acute Myeloid Leukemia; Myelodysplastic Syndrome
Adenocarcinoma of the Rectum
Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia (AML) With; FLT3 Mutation, Internal Tandem Duplication (ITD) or Tyrosine Kinase Domain (TKD)
FLT3-mutated Acute Myeloid Leukemia
Study Phase
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
N/A
N/A
Recruitment Status
Active, not recruiting
Recruiting
Active, not recruiting
Active, not recruiting
Recruiting
Active, not recruiting
Active, not recruiting
Completed
Withdrawn
Suspended
Terminated
Completed
Completed
Recruiting
Completed
Recruiting
Recruiting
Withdrawn
Recruiting
Unknown status
Recruiting
Terminated
Completed
Completed
Completed
Completed
Withdrawn
Terminated
Recruiting
Recruiting
Completed
Completed
Recruiting
Completed
Recruiting
Completed
Completed
Active, not recruiting
Completed
Completed
No longer available
No longer available
CTx-0294886
CTx-294886, AMP-886
Preclinical
Cancer Therapeutics, Amplia Therapeutics Ltd
Pulmonary Fibrosis
Sunitinib Malate
SU-11248, SU-010398, PHA-290940, PNU-290940, PHA-290940AD, PNU-290940AD, SU-011248-L-malate salt, GB-102
Approved
Pfizer Pharmaceuticals Ltd (China)
Kidney Neoplasms, Liver Neoplasms, Solid tumours, Carcinoma, Renal Cell, Carcinoma, Islet Cell, Stomach Neoplasms, Pancreatic neuroendocrine tumors (pNET), Pancreatic Neoplasms, Neoplasms by Histologic Type, Kidney Diseases, Neuroendocrine Tumors, Urologic Diseases, Prostatic Neoplasms, Diabetic macular oedema, Breast Neoplasms, Gastrointestinal Stromal Tumors, Colorectal Neoplasms, Urologic Neoplasms, Urogenital Neoplasms, Carcinoma, Hepatocellular, Carcinoma, Non-Small-Cell Lung, Macular Degeneration, Retinal Vein Occlusion
NCT Number
NCT02570789
NCT00793871
NCT02691793
NCT00706706
NCT01525550
NCT01402089
NCT00930345
NCT02555748
NCT03141177
NCT00326898
NCT03729245
NCT00732914
NCT01099423
NCT01582672
NCT02535351
NCT00393939
NCT00375674
NCT01064310
NCT00693992
NCT00373256
NCT01265901
NCT00083889
NCT01481870
NCT00676650
NCT03013946
NCT00428597
NCT00471328
NCT00699374
NCT00457392
NCT00075218
NCT00435409
NCT00397345
NCT00373113
NCT00372567
NCT04394975
NCT00457691
NCT00869011
NCT01164202
NCT03025893
NCT03909724
NCT00495625
NCT01482949
NCT00792025
NCT01731925
NCT00397488
NCT00556049
NCT00814021
NCT00979992
NCT00663559
NCT03541902
NCT00430261
NCT00626509
NCT00299741
NCT02645149
NCT00113516
NCT00265317
NCT00453310
NCT03066427
NCT00389974
NCT01168440
NCT02068586
NCT03170180
NCT01551459
NCT01089088
NCT00514228
NCT00392444
NCT00499473
NCT00267748
NCT01306045
NCT00843037
NCT00482911
NCT00953459
NCT00541008
NCT00378911
NCT01829217
NCT00616109
NCT02790580
NCT01118351
NCT01216657
NCT01664182
NCT02761057
NCT01020630
NCT00491738
NCT00891878
NCT01784978
NCT00077974
NCT04085341
NCT01118039
NCT00411151
NCT00372775
NCT01499121
NCT01616186
NCT00619268
NCT00606008
NCT03641326
NCT00853125
NCT00388037
NCT02465060
NCT01824615
NCT00381641
NCT00631618
NCT00246571
NCT00795171
NCT00967603
NCT01718327
NCT00078000
NCT00408252
NCT00089648
NCT01402817
NCT00338884
NCT03592199
NCT01850147
NCT00361309
NCT00434356
NCT00662025
NCT00397787
NCT00482755
NCT01082809
NCT00715442
NCT03463460
NCT01396408
NCT02060370
NCT02689167
NCT00578526
NCT02402062
NCT00979966
NCT02560012
NCT00092001
NCT00748358
NCT01254864
NCT00734851
NCT00923117
NCT02626754
NCT02713763
NCT00668811
NCT01391130
NCT00678119
NCT02693535
NCT01100177
NCT00400569
NCT00444314
NCT00695292
NCT00702884
NCT01620216
NCT00768144
NCT01215565
NCT00570882
NCT00270413
NCT01164228
NCT02960906
NCT01034878
NCT03109015
NCT00543049
NCT02925234
NCT01070186
NCT00137423
NCT00462982
NCT00077987
NCT00535379
NCT00550810
NCT01621568
NCT00434109
NCT04341181
NCT00434226
NCT00474994
NCT01517243
NCT00247676
NCT00698815
NCT00847015
NCT00668863
NCT01835158
NCT00519896
NCT00400114
NCT01019798
NCT00717587
NCT00824538
NCT02142036
NCT01210053
NCT00514137
NCT00982657
NCT00577382
NCT00513695
NCT00393796
NCT00903175
NCT01219751
NCT03379012
NCT01396148
NCT00886132
NCT00748163
NCT02623127
NCT00589784
NCT00387335
NCT00806663
NCT00787787
NCT00556205
NCT00056693
NCT00465179
NCT00730353
NCT00392496
NCT00859456
NCT00471276
NCT00673504
NCT00371553
NCT00617253
NCT01158222
NCT00796861
NCT01108445
NCT00425386
NCT00961571
NCT00609622
NCT00821327
NCT01216371
NCT01121562
NCT04633122
NCT00330564
NCT02072031
NCT00243503
NCT03297606
NCT00570908
NCT02432846
NCT00510640
NCT00480935
NCT00459875
NCT01371201
NCT00864721
NCT00859339
NCT03323710
NCT00912912
NCT02019576
NCT00254540
NCT00672594
NCT01042795
NCT00459979
NCT00526656
NCT00137449
NCT02400385
NCT02928575
NCT00910039
NCT00524316
NCT02398552
NCT01176799
NCT00226811
NCT00398112
NCT01309633
NCT00329043
NCT00709995
NCT00620347
NCT01215578
NCT03035630
NCT00054886
NCT00478426
NCT00794950
NCT01069770
NCT01803503
NCT01238055
NCT01024205
NCT00489944
NCT01391962
NCT01731158
NCT02315625
NCT00521092
NCT00936832
NCT00451048
NCT00599313
NCT00387426
NCT01462695
NCT00453895
NCT02071641
NCT00853372
NCT00463060
NCT00887575
NCT00890110
NCT02446795
NCT00879619
NCT00753727
NCT00304200
NCT00975806
NCT02919371
NCT00496223
NCT02483247
NCT02380625
NCT00417885
NCT00905021
NCT00818350
NCT00891475
NCT00361244
NCT01070706
NCT00616122
NCT00457743
NCT00137436
NCT00522249
NCT00453154
NCT00673816
NCT00783653
NCT00931450
NCT00113529
NCT00417677
NCT02401815
NCT03277924
NCT01462214
NCT00402415
NCT03275558
NCT02386111
NCT00981890
NCT01308034
NCT00790595
NCT01005472
NCT00861419
NCT01286896
NCT00357318
NCT00884676
NCT00599924
NCT00611728
NCT01548170
NCT00906360
NCT01381822
NCT00712504
NCT03900793
NCT01122888
NCT00694096
NCT00555256
NCT03249740
NCT00553696
NCT00543504
NCT01061411
NCT00777478
NCT00437372
NCT00462553
NCT00174434
NCT00720148
NCT00705874
NCT00372853
NCT00291577
NCT01258348
NCT02058901
NCT02779283
NCT01743300
NCT00524186
NCT03878524
NCT00631527
NCT00495872
NCT01472081
NCT00813423
NCT02616185
NCT00387920
NCT02074878
NCT00573404
NCT00511849
NCT00422344
NCT01441388
NCT02164240
NCT00729833
NCT00399152
NCT01498835
NCT00555672
NCT00581789
NCT00499135
NCT00421512
NCT00555620
NCT00747305
NCT03905889
NCT00372424
NCT00732992
NCT00904657
NCT00890747
NCT00788060
NCT00631410
NCT00528619
NCT00615446
NCT01122615
NCT00618124
NCT01243359
NCT00583063
NCT00864864
NCT00537056
NCT01700699
NCT01636908
NCT00979381
NCT00749320
NCT00980213
NCT00532064
NCT01740154
NCT04659343
NCT02282059
NCT02156310
NCT01190241
NCT01934452
NCT02187042
NCT02649725
NCT01711268
NCT02921724
NCT00836745
NCT02776644
NCT01339962
NCT01860118
NCT00978926
NCT03140176
NCT00979329
NCT03424876
NCT02264665
NCT00876382
NCT01033981
NCT00428220
NCT00700258
NCT04368546
NCT00716820
NCT01227213
NCT02841865
NCT00684645
NCT00873210
NCT01917214
NCT03097601
NCT02789137
NCT04033991
NCT04076787
NCT01758575
NCT00831857
NCT02944617
NCT00849186
NCT01502228
NCT00656669
NCT01370109
NCT01459757
NCT00943839
NCT01098903
NCT00531544
NCT02751827
NCT02184416
NCT01582204
NCT04669366
NCT00520533
NCT00716625
NCT02071719
NCT00798889
NCT00130897
NCT01073644
NCT04353765
NCT02208583
NCT01507740
NCT01947296
NCT00509704
NCT01054911
NCT00094029
NCT01026337
NCT02848768
NCT02208128
NCT02068170
NCT01441661
NCT00444795
NCT01246843
NCT00460798
NCT01381601
NCT03092128
NCT03185039
NCT01827254
NCT01381614
NCT02086695
NCT02551718
NCT02428335
NCT04115189
NCT02404584
NCT00443534
NCT04175262
NCT01014065
NCT02450123
NCT02688491
NCT00691730
NCT02747173
NCT03571438
NCT03519542
NCT02239952
Intervention Type
Drug
Drug
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Biological;Drug
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Drug
Procedure;Other;Biological;Drug
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Drug
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Biological
Other
Drug
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Drug
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Drug
Other
Behavioral
Device
Other
Other
Drug
Other
Drug
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Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other
Diagnostic Test
Drug
Drug
Other
Other;Drug;Dietary Supplement
Procedure;Drug
Procedure;Drug
Drug
Other
Other;Drug
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Other
Other
Drug
Drug
Biological;Drug
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Other
Drug
Other;Drug;Genetic
Drug
Biological;Genetic
Drug
Drug
Drug
Drug
Other
Drug;Combination Product
Drug
Drug
Indications
Clear-cell Metastatic Renal Cell Carcinoma
Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors
Refractory Solid Tumors
Carcinoma, Renal Cell
Well-differentiated Pancreatic Neuroendocrine Tumor
Non Small-cell Lung Cancer; Renal-cell Cancer; Gastrointestinal Stroma Tumor
Metastatic Renal Cell Carcinoma
Metastatic Renal Cell Cancer
Renal Cell Carcinoma
Clear Cell Renal Cell Carcinoma; Stage I Renal Cell Cancer AJCC v6 and v7; Stage II Renal Cell Cancer AJCC v7; Stage III Renal Cell Cancer AJCC v7
Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma
Renal Cell Carcinoma
Kidney Cancer
Advanced Renal Cell Carcinoma; Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma
Clear-cell Metastatic Renal Cell Carcinoma
Breast Neoplasms
Kidney Neoplasms
Carcinoma, Renal Cell
Stage IIIB Lung Non-Small Cell Cancer AJCC v7; Stage IV Non-Small Cell Lung Cancer AJCC v7
Breast Neoplasms
Metastatic Renal Cell Carcinoma
Carcinoma, Renal Cell
Metastatic Renal Cell Carcinoma
Prostatic Neoplasms
Renal Cell Carcinoma, Metastatic; Renal Cell Cancer, Recurrent
Carcinoma, Islet Cell; Carcinoma, Pancreas
Gastrointestinal Stromal Tumors
Carcinoma, Hepatocellular
Carcinoma, Non-Small Cell Lung
Gastrointestinal Stromal Tumor
Breast Neoplasms
Clear Cell Renal Carcinoma
Breast Neoplasms
Gastrointestinal Stromal Tumor
Primary Disease: Unresectable or Metastatic Renal Cell Carcinoma Focus of the Study:PFS Assessed by IRC Per RECIST 1.1
Metastatic Colorectal Cancer
Renal Cell Carcinoma
Liver Cancer
Glioblastoma Multiforme; Glioblastoma, Adult; Glioblastoma; Recurrent Brain Tumor; GBM
Colorectal Cancer; Metastasis
Liver Cancer
Renal Cell Carcinoma
Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter
Carcinoid Tumors
Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer
Renal Cell Carcinoma; Neoplasm Metastases
Kidney Cancer; Metastatic Cancer
Ovarian Clear Cell Adenocarcinoma; Recurrent Ovarian Carcinoma
Carcinoma Renal Cells
Malignant Neoplasms of Urinary Tract; Renal Cell Carcinoma; Chromophobe Renal Cell Carcinoma; Metastatic Renal Cell Carcinoma; Papillary Renal Cell Carcinoma; Renal Cell Carcinoma Associated With Xp11.2 Translocations/TFE3 Gene Fusions; Sarcomatoid Renal Cell Carcinoma; Stage IV Renal Cell Cancer AJCC v8; Unclassified Renal Cell Carcinoma
Lung Cancer; Adenocarcinoma
Kidney Cancer
Prostate Cancer
Melanoma
Non-small Cell Lung Cancer
Carcinoma, Non-Small-Cell Lung
Extragonadal Germ Cell Tumor; Ovarian Cancer; Teratoma; Testicular Germ Cell Tumor
Clear Cell Renal Carcinoma
Cervical Adenocarcinoma; Cervical Adenosquamous Cell Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Cancer; Stage IVB Cervical Cancer
Von Hippel-Lindau Disease
Ciliary Body and Choroid Melanoma, Medium/Large Size; Ciliary Body and Choroid Melanoma, Small Size; Iris Melanoma; Stage I Intraocular Melanoma; Stage IIA Intraocular Melanoma; Stage IIB Intraocular Melanoma; Stage IIIA Intraocular Melanoma; Stage IIIB Intraocular Melanoma; Stage IIIC Intraocular Melanoma
Stomach Neoplasms
Metastatic Uveal Melanoma
Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer
Liver Cancer
Advanced Malignant Mesothelioma; Recurrent Malignant Mesothelioma
Adult Anaplastic Astrocytoma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Oligodendroglioma; Adult Pineal Gland Astrocytoma
Carcinoma, Renal Cell
Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell Lung; Carcinoma, Thymic
Paraganglioma; Pheochromocytoma
Intraocular Melanoma; Malignant Conjunctival Neoplasm
Lung Cancer
Kidney Cancer
Recurrent Uterine Sarcoma; Uterine Leiomyosarcoma
Lung Cancer
Extensive-Stage Small Cell Lung Cancer
Breast Cancer
Recurrent Bladder Cancer; Transitional Cell Carcinoma of the Bladder
Chemo-refractory Melanoma
Advanced Renal Cell Carcinoma; Advanced Sarcomatoid Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7
Locally Advanced Papillary Renal Cell Carcinoma; Metastatic Papillary Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7; Type 1 Papillary Renal Cell Carcinoma; Type 2 Papillary Renal Cell Carcinoma; Unresectable Renal Cell Carcinoma
Adenocarcinoma
Renal Cell Carcinoma
Adenocarcinoma of the Gastroesophageal Junction; Esophageal Cancer
Metastatic Renal Cell Carcinoma
Carcinoma, Renal Cell
Diabetic Macular Edema; Retina Vein Occlusion
Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer
Gastric Adenocarcinoma; Barrett Esophagus
Non-Small Cell Lung Cancer
Clear Cell, Metastatic Renal Cell Carcinoma
Locally Metastatic Malignant Neoplasm
Metastatic Renal Cell Carcinoma
Anaplastic Astrocytoma; Glioblastoma
Gliosarcoma; Central Nervous System Sarcoma
Kidney Cancer
Recurrent Fallopian Tube Cancer; Recurrent Ovarian Epithelial Cancer; Recurrent Primary Peritoneal Cavity Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Primary Peritoneal Cavity Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Primary Peritoneal Cavity Cancer; Stage IIIC Fallopian Tube Cancer; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Primary Peritoneal Cavity Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Epithelial Cancer; Stage IV Primary Peritoneal Cavity Cancer
Advanced Malignant Solid Neoplasm; Bladder Carcinoma; Breast Carcinoma; Cervical Carcinoma; Colon Carcinoma; Colorectal Carcinoma; Endometrial Carcinoma; Esophageal Carcinoma; Gastric Carcinoma; Glioma; Head and Neck Carcinoma; Kidney Carcinoma; Liver and Intrahepatic Bile Duct Carcinoma; Lung Carcinoma; Lymphoma; Malignant Uterine Neoplasm; Melanoma; Ovarian Carcinoma; Pancreatic Carcinoma; Plasma Cell Myeloma; Prostate Carcinoma; Rectal Carcinoma; Recurrent Bladder Carcinoma; Recurrent Breast Carcinoma; Recurrent Cervical Carcinoma; Recurrent Colon Carcinoma; Recurrent Colorectal Carcinoma; Recurrent Esophageal Carcinoma; Recurrent Gastric Carcinoma; Recurrent Glioma; Recurrent Head and Neck Carcinoma; Recurrent Liver Carcinoma; Recurrent Lung Carcinoma; Recurrent Lymphoma; Recurrent Malignant Solid Neoplasm; Recurrent Melanoma; Recurrent Ovarian Carcinoma; Recurrent Pancreatic Carcinoma; Recurrent Plasma Cell Myeloma; Recurrent Prostate Carcinoma; Recurrent Rectal Carcinoma; Recurrent Skin Carcinoma; Recurrent Thyroid Gland Carcinoma; Recurrent Uterine Corpus Cancer; Refractory Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Plasma Cell Myeloma; Skin Carcinoma; Thyroid Gland Carcinoma; Uterine Corpus Cancer
Ovarian Cancer; Adverse Effects
Differentiated Thyroid Gland Carcinoma; Recurrent Thyroid Gland Carcinoma; Refractory Thyroid Gland Carcinoma; Stage III Thyroid Gland Follicular Carcinoma AJCC v7; Stage III Thyroid Gland Medullary Carcinoma AJCC v7; Stage IV Thyroid Gland Follicular Carcinoma AJCC v7; Stage IV Thyroid Gland Medullary Carcinoma AJCC v7; Stage IV Thyroid Gland Papillary Carcinoma AJCC v7; Stage IVA Thyroid Gland Follicular Carcinoma AJCC v7; Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVA Thyroid Gland Papillary Carcinoma AJCC v7; Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7; Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVB Thyroid Gland Papillary Carcinoma AJCC v7; Stage IVC Thyroid Gland Follicular Carcinoma AJCC v7; Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVC Thyroid Gland Papillary Carcinoma AJCC v7; Thyroid Gland Hurthle Cell Carcinoma; Unresectable Thyroid Gland Carcinoma
Metastatic Melanoma
Breast Neoplasms
Hormone Refractory Prostate Cancer
Pancreatic Cancer
Unresectable and Advanced Cholangiocarcinoma
Breast Neoplasms
Recurrent Disease; Squamous Cell Head and Neck Carcinoma; Palliative Treatment
Carcinoma, Renal Cell
Neurofibromatosis; NF1; Plexiform Neurofibromas
Carcinoma, Renal Cell
Clear Cell Renal Cell Carcinoma
Cancer; Lung Cancer
Hepatocellular Carcinoma; Liver Cancer
Metastatic Breast Cancer
Advanced/Metastatic Breast Cancer
Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer
Breast Cancer
Advanced Biliary Tract Adenocarcinoma
Renal Cell Carcinoma
Thymic Carcinoma
Advanced Rare Tumours
Genitourinary Cancer; Kidney Cancer
Kidney Neoplasms; Metastatic Renal Cell Cancer
Urothelial Cancer; Bladder Cancer; Adult
Neuroendocrine Tumors; Pancreatic Neoplasms
Non-clear Cell Renal Cell Cancer
Carcinoma, Renal Cell
Carcinoma, Non-Small-Cell Lung
Prostatic Neoplasms; Neoplasms, Hormone-Dependent; Tumor Markers, Biological; Survival Rate; Disease-Free Survival
Prostate Cancer
Prostate Cancer
Glioblastoma Multiforme; Malignant Gliomas; Anaplastic Gliomas
Renal Cell Carcinoma
Pancreatic Neuroendocrine Tumour Metastatic
Papillary Thyroid Cancer; Follicular Thyroid Cancer; Differentiated Thyroid Cancer
Metastatic Clear Cell Renal Cell Carcinoma
Renal Cell Carcinoma
Lymphoma, Non-Hodgkin; Multiple Myeloma; Advanced Solid Tumors
Glioblastoma
Liposarcoma; Leiomyosarcoma; Fibrosarcoma; Malignant Fibrous Histiocytoma
Metastatic Renal Cell Carcinoma
Small Cell Lung Cancer
Esophageal Cancer
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Adult Acute Lymphoblastic Leukemia
Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
Hepatocellular Carcinoma; Fibrolamellar Hepatocellular Carcinoma
Metastatic Renal Cell Carcinoma
Metastatic Breast Cancer
Kidney Cancer
Clear Cell Metastatic Renal Cell Carcinoma
Carcinoma, Renal Cell
Carcinoma, Renal Cell
Platinum Refractory Epithelial Ovarian Cancer; Primary Cancer of the Peritoneum; Cancer of the Fallopian Tube
Cancer; Tumors; Neoplasm; Neoplasia
Renal Cell Carcinoma
Carcinoma, Renal Cell Metastasis
Kidney Cancer; Melanoma (Skin); Metastatic Cancer
Colorectal Neoplasms
Glioblastoma Multiforme
Prostate Cancer; Hormone Refractory
Thymoma; Thymus Neoplasms
Neuroendocrine Tumor; Islet Cell Tumor
Cancer; Tumors; Neoplasms; Neoplasia
Non-Small Cell Lung Cancer
Adult Malignant Fibrous Histiocytoma of Bone; Desmoid Tumor; Endometrial Cancer; Ovarian Cancer; Sarcoma; Small Intestine Cancer
Metastatic Renal Cell Carcinoma
Liver Neoplasms; Unresectable Hepatocellular Carcinoma
Recurrent Non-Small Cell Lung Carcinoma; Stage IIIB Non-Small Cell Lung Cancer AJCC v7; Stage IV Non-Small Cell Lung Cancer AJCC v7
Bladder Cancer; Urinary Bladder
Unresectable or Metastatic Colorectal Cancer
Clear Cell Renal Cell Carcinoma; Metastatic Kidney Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7
Recurrent Thyroid Cancer; Stage IVA Follicular Thyroid Cancer; Stage IVA Papillary Thyroid Cancer; Stage IVB Follicular Thyroid Cancer; Stage IVB Papillary Thyroid Cancer; Stage IVC Follicular Thyroid Cancer; Stage IVC Papillary Thyroid Cancer; Thyroid Gland Medullary Carcinoma
Esophageal Cancer
Non Small Cell Lung Cancer
Kidney Cancer
Breast Cancer
Metastatic Cancer
Non-small Cell Lung Cancer
Refractory Multiple Myeloma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma
Solid Tumor
Mucosal Lentiginous Melanoma; Acral Lentiginous Malignant Melanoma
Inflammatory Breast Cancer; Male Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
Bladder Cancer
Renal Cell Carcinoma
Metastatic Renal Cell Carcinoma
Metastatic Renal Cell Carcinoma
Gastrointestinal Stromal Tumors
Adenoid Cystic Carcinoma; Salivary Gland Cancer
Lung Cancer
Thymic Carcinoma
CNS Cancer; Meningioma; Intracranial Hemangiopericytoma; Hemangioblastoma; Neurofibromatosis
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity
Metastatic Colorectal Cancer; Liver Metastases
Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer
Renal Cell Carcinoma
Neuroendocrine Tumors
Renal Cell Cancer; Kidney Cancer
Esophageal Cancer
Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma
Sarcoma, Soft Tissue
Breast Neoplasms
Pancreatic Cancer
Relapsed or Cisplatin-Refractory Germ Cell Cancer
Cancer; Renal Cell Carcinoma
Clear Cell Renal Cell Carcinoma; Stage IV Renal Cell Cancer
Ascites
Advanced Non-clear Cell Renal Cell Carcinoma
Kidney Cancer
Metastatic Colorectal Cancer
Colorectal Neoplasms
Urothelial Cancer
Renal Cell Carcinoma; Pulmonary Metastases
Pancreatic Neuroendocrine Tumors
Gastrointestinal Stromal Tumor(GIST)
Von Hippel-Lindau Syndrome; Renal Cell Carcinoma; Hemangioblastoma
Anlotinib; RCC
Breast Neoplasms
Lymphoma, Non-Hodgkin; Multiple Myeloma; Advanced Solid Tumors
Breast Cancer
Renal Cell Carcinoma, Metastatic
Cancer; Thyroid Carcinoma
Renal Cell Carcinoma
Kidney Cancer
Malignant Progressive Pheochromocytoma and Paraganglioma (PPGL)
Non Small Cell Lung Cancer
Transitional Cell Carcinoma of the Bladder
Renal Cell Carcinoma
Genitourinary Disease
Clear Cell Metastatic Renal Cell Carcinoma
Carcinoma, Renal Cell
Prostate Cancer; Prostatectomy
Urothelial Carcinoma; Bladder Cancer
Kidney Cancer
Bladder Cancer
Gastrointestinal Stromal Tumors
Melanoma
Glioblastoma Multiforme
Cognitive/Functional Effects; Metastatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Liver Cancer
Metastatic Renal Cell Carcinoma
Breast Cancer
Stomach Neoplasms
B-cell Chronic Lymphocytic Leukemia; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia
Nasopharyngeal Carcinoma
Prostate Cancer
Metastatic Renal Cell Carcinoma
Lung Cancer
Neuroendocrine Tumors; Pancreatic Neoplasms; Advanced Disease; Sunitinib
Clear-cell Renal Cell Carcinoma; RCC; Kidney Cancer; Clear-cell Kidney Carcinoma
Kidney Neoplasms
Endometrial Adenocarcinoma; Endometrial Endometrioid Adenocarcinoma; Endometrial Serous Adenocarcinoma; Recurrent Uterine Corpus Carcinoma; Stage IVA Uterine Corpus Cancer AJCC v7; Stage IVB Uterine Corpus Cancer AJCC v7; Uterine Carcinosarcoma; Uterine Corpus Carcinosarcoma
Urinary Tract Urothelial Carcinoma
Clear Cell Renal Cell Carcinoma; Metastasis
Solid Tumors; Breast Cancer; Non-small Cell Lung Cancer; Prostate Cancer; Gastric Cancer
Advanced Gastric Cancer
Kidney Cancer
Intraocular Melanoma
Sarcoma, Alveolar Soft Part
Metastatic Renal Cell Carcinoma
Neuroendocrine Tumors; Neuroendocrine Carcinoma; Neuroendocrine Neoplasms; Carcinoma, Neuroendocrine; Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas
AIDS-related Kaposi Sarcoma; Classic Kaposi Sarcoma
Colorectal Cancer; Metastatic Cancer
Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Myelodysplastic Syndromes; Secondary Myelodysplastic Syndromes
Metastatic Prostate Cancer
Accelerated Phase Chronic Myelogenous Leukemia; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blastic Phase Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Mast Cell Leukemia; Meningeal Chronic Myelogenous Leukemia; Primary Myelofibrosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage II Chronic Lymphocytic Leukemia; Stage III Chronic Lymphocytic Leukemia; Stage IV Chronic Lymphocytic Leukemia; T-cell Large Granular Lymphocyte Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Hairy Cell Leukemia
Childhood Cerebellar Anaplastic Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Cerebral Astrocytoma; Childhood Infratentorial Ependymoma; Childhood Mixed Glioma; Childhood Oligodendroglioma; Childhood Supratentorial Ependymoma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma
Adrenocortical Carcinoma
Metastatic Renal Cell Carcinoma
Advanced Renal Cell Carcinoma
Cancer
Breast Cancer
Renal Cell Cancer
Renal Cell Carcinoma; Kidney Cancer
Prostate Cancer; Adenocarcinoma of the Prostate; Recurrent Prostate Cancer; Stage I Prostate Cancer; Stage III Prostate Cancer; Stage IV Prostate Cancer
Soft Tissue Sarcoma
Metastatic Malignant Melanoma
Renal Cell Carcinoma
Renal Cell Carcinoma
Melanoma
Cancer
Ebola Virus Disease
Breast Neoplasms
Metastatic Breast Cancer
Urinary Bladder Neoplasms
Carcinoma, Renal Cell
Colorectal Carcinoma
Breast Cancer
Breast Cancer
Gastrointestinal Stromal Tumors
Prostatic Neoplasms
Carcinoma, Renal Cell
Extensive Stage Lung Small Cell Carcinoma; Recurrent Lung Small Cell Carcinoma
Von Hippel-Lindau Syndrome
Acute Myeloid Leukemia
Breast Cancer
Carcinoma, Renal Cell
Renal Cell Carcinoma
Gastrointestinal Stromal Tumors
Soft Tissue Sarcoma; Bone Sarcoma
Metastatic Renal Cell Cancer
Tumors
Recurrent Glioblastoma; Gliosarcoma; Anaplastic Gliomas
Carcinoma, Renal Cell; Kidney Diseases; Kidney Neoplasms; Urogenital Neoplasms; Urologic Diseases; Urologic Neoplasms; Neoplasms; Neoplasms by Histologic Type; Clear-cell Metastatic Renal Cell Carcinoma
Brain Metastases
Non GIST Sarcomas
Prostate Cancer
Metastatic Melanoma
Advanced Solid Tumors
Malignant Solid Tumour
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Adult Solid Tumor, Protocol Specific
Colorectal Neoplasms; Neoplasms
Glioblastoma
Cancer
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Stage III Salivary Gland Cancer; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Salivary Gland Cancer; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary
Advanced Renal Cell Carcinoma; Gastrointestinal Stromal Tumors; Pancreatic Neuroendocrine Tumors
Advanced Solid Tumors; Non Small Cell Lung Cancer
Osteosarcoma
Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Solid Neoplasm; Recurrent Adult Brain Neoplasm
Renal Cell Cancer
Non-Small Cell Lung Cancer
Neovascular Age-Related Macular Degeneration
Stomach Neoplasms
Advanced Cancer
Clear Cell Sarcoma of the Kidney; Recurrent Renal Cell Carcinoma; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer
Colorectal Cancer
Cancer; Head and Neck Cancer; Pelvic Cancer; Nervous System Neoplasms; Thoracic Neoplasms
Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Breast Neoplasms
Solid Tumors
Cancer
Carcinoma, Renal Cell
Breast Neoplasms
Metastatic Renal Cell Cancer
Solid Tumors
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia
Healthy
Esophageal Cancer; Gastric Cancer
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IIIA Hodgkin Lymphoma; Ann Arbor Stage IIIB Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Ann Arbor Stage IVA Hodgkin Lymphoma; Ann Arbor Stage IVB Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid Cell Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Prognostic Stage IV Breast Cancer AJCC v8; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage IIA Pancreatic Cancer AJCC v8; Stage IIB Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma
Prostate Cancer
Solid Tumors
Renal Cell Carcinoma; Clear-cell Metastatic Renal Cell Carcinoma
Adult Solid Neoplasm
Prostatic Neoplasms
Central Nervous System Metastases; Childhood Central Nervous System Choriocarcinoma; Childhood Central Nervous System Embryonal Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Central Nervous System Germinoma; Childhood Central Nervous System Mixed Germ Cell Tumor; Childhood Central Nervous System Teratoma; Childhood Central Nervous System Yolk Sac Tumor; Recurrent Childhood Central Nervous System Embryonal Tumor; Unspecified Childhood Solid Tumor, Protocol Specific
Breast Cancer
Gastrointestinal Stromal Tumor
Neoplasms
Renal Cell Carcinoma; Kidney Cancer
Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Hepatocellular
Gastrointestinal Stromal Tumor
Advanced Cancer; Advanced Solid Tumors
Renal Cancer; GIST
Soft Tissue Sarcoma
Stomach Neoplasms
Non Small Cell Lung Cancer
Adult Solid Neoplasm; Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer
Metastatic Renal Cell Carcinoma; Kidney Cancer
Stomach Neoplasms
Kidney Cancer
Renal Cell Carcinoma Metastatic
Breast Cancer
Neoplasm, Malignant
Blood Pressure
Accelerated Phase Chronic Myelogenous Leukemia; Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome; Acute Undifferentiated Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Grade III Lymphomatoid Granulomatosis; Adult Langerhans Cell Histiocytosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Aggressive NK-cell Leukemia; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Malignancies; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Neutrophilic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Clear Cell Renal Cell Carcinoma; Cutaneous B-cell Non-Hodgkin Lymphoma; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Extramedullary Plasmacytoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV Infection; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Isolated Plasmacytoma of Bone; Light Chain Deposition Disease; Mast Cell Leukemia; Myelodysplastic Syndrome With Isolated Del(5q); Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Myeloid/NK-cell Acute Leukemia; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Osteolytic Lesions of Multiple Myeloma; Peripheral T-cell Lymphoma; Plasma Cell Neoplasm; Polycythemia Vera; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Myelofibrosis; Primary Systemic Amyloidosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Renal Cell Cancer; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Stage IV Renal Cell Cancer; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia
Renal Cell Carcinoma
Colorectal Neoplasms
Neoplasms
Solid Tumors
Renal Cell Cancer; Kidney Cancer
Solid Tumors; Breast Cancer; Neoplasms
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage I Renal Cell Cancer; Stage II Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Solid Tumors
Glioblastoma; Brain Tumor
Kidney Neoplasms; Carcinoma, Renal Cell; Kidney (Renal Cell) Cancer
Differentiated Thyroid Cancer
Cancer; Advanced Solid Tumors
Renal Cell Carcinoma; GIST
Renal Cell Carcinoma
Neoplasms; Renal Cell Carcinoma
Malignant Neoplasm
Fatigue; Recurrent Renal Cell Cancer; Stage IV Renal Cell Cancer
Kidney Cancer; Renal Cell Carcinoma Metastatic; Drug Toxicity; Drug Side Effect; Drug Mechanism
Pancreatic Neuroendocrine Tumors
Renal Cancer
Advanced Solid Tumors; Inoperable; Metastasis
Complete Remission in Renal Cell Carcinoma
Metastatic/Advanced Renal Cell Carcinoma
Patient's Satisfaction
Renal Cell Carcinoma
Cancer; Oral Drug Administration
Renal Cell Carcinoma
Renal Cell Carcinoma
Renal Cell Carcinoma
Parkinson's Disease
Advanced Malignancy
Metastatic Renal Cell Carcinoma
Renal Cell Cancer; Colorectal Cancer; GIST
GIST
Pancreatic Neuroendocrine Tumor, Well Differentiated and Progressive
Renal Cell Carcinoma
Metastatic Renal Cell Carcinoma
Metastatic Breast Cancer; Advanced Breast Cancer; Metastatic Castration Resistant Prostate Cancer; Metastatic Renal Cell Cancer; Non-Small Cell Lung Cancer; Thyroid Cancer; Advanced/Metastatic Non-Small Cell Lung Cancer; Advanced Gastric Cancer; Gastrointestinal Stromal Tumor; Hepatocellular Carcinoma; Pancreatic Islet Cell Carcinoma; Pancreatic Neuroendocrine Tumor
Carcinoma, Renal Cell, Advanced; Lymphoma, Mantle-Cell; Gastrointestinal Stroma Tumors
Renal Cell Cancer Metastatic; Hypertension; Sodium Imbalance
Gastrointestinal Stromal Tumors
Hypertension; Renal Function; Insulin Sensitivity; Renal Cell Carcinoma
Pancreatic Neuroendocrine Tumors
Metastatic Renal Cell Carcinoma
Advanced or Metastatic Renal Cell Carcinoma; Renal Cancer
Metastatic Renal Cell Carcinoma
Metastatic Kidney Cancers
Metastatic Renal Cell Carcinoma
Carcinoma; Renal Cell
Metastatic Renal Cell Carcinoma
Advanced or Metastatic Solid Malignancy
Renal Cell Carcinoma
Diarrhea; Metastatic Renal Cell Carcinoma; Stage IV Renal Cell Cancer
Kidney Cancer
Renal Cell Carcinoma
Breast Cancer
Renal Cell Carcinoma 4
GIST
Kidney Cancer
Cancer
Metastatic Renal Cell Carcinoma
Cancer
Metastatic Renal Cell Carcinoma (mRCC)
Renal Cancer
Kidney Neoplasms
Renal Cell Carcinoma
Carcinoma, Renal Cell
Renal Cell Cancer
Solid Tumors
Carcinoma, Renal Cell
Metastatic Renal Cell Carcinoma
Locally Advanced or Metastatic Renal Cell Carcinoma
Hormone Refractory Prostate Cancer
Hepatocellular Cancer; Non-small Cell Lung Cancer; Renal Cell Cancer; Colorectal Cancer
Cancer
Renal Cell Cancer
Tumor
Gastrointestinal Neoplasm
Renal Cell Carcinoma; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer
Metastatic Clear Cell Renal Cell Carcinoma
Renal Cell Carcinoma
Delirium; QT-prolongation
Renal Cell Carcinoma
Gastrointestinal Stromal Tumors
Metastatic Renal Cell Cancer; GIST
Renal Cell Carcinoma
Carcinoma, Renal Cell
Gastrointestinal Stromal Tumors; Germline Mutation; Somatic Mutation; Plasma Concentration
Kidney Cancer
Metastatic Renal Cell Carcinoma
Carcinoma, Renal Cell
Cardiotoxicity
Recurrent Acute Leukemia of Ambiguous Lineage; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Acute Leukemia of Ambiguous Lineage
Renal Cell Cancer; Fatigue
Metastatic Renal Cell Carcinoma ( mRCC)
Kidney Neoplasms
Neoplasms
Metastatic Renal Cell Carcinoma (mRCC)
Renal Cell Carcinoma; Cardiotoxicity; Heart Failure; Hypertension
Refractory Solid Tumors
Renal Neoplasms; Targeted Molecular Therapy
Unspecified Adult Solid Tumor, Protocol Specific
Renal Cell Carcinoma
Kidney Cancer
Metastatic Renal Cell Carcinoma
Cancer; High-grade Glioma
Study Phase
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Early Phase 1
Early Phase 1
N/A
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Recruitment Status
Active, not recruiting
Completed
Recruiting
Completed
Completed
Completed
Terminated
Active, not recruiting
Active, not recruiting
Completed
Recruiting
Completed
Unknown status
Terminated
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Unknown status
Terminated
Recruiting
Terminated
Completed
Terminated
Completed
Completed
Completed
Completed
Terminated
Terminated
Recruiting
Completed
Unknown status
Completed
Recruiting
Recruiting
Terminated
Terminated
Completed
Unknown status
Completed
Completed
Completed
Completed
Completed
Recruiting
Completed
Unknown status
Completed
Not yet recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Recruiting
Recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Active, not recruiting
Active, not recruiting
Terminated
Terminated
Unknown status
Completed
Completed
Completed
Recruiting
Terminated
Terminated
Completed
Active, not recruiting
Completed
Terminated
Completed
Terminated
Completed
Completed
Unknown status
Completed
Completed
Completed
Withdrawn
Completed
Completed
Recruiting
Terminated
Completed
Recruiting
Completed
Active, not recruiting
Completed
Completed
Unknown status
Completed
Completed
Completed
Terminated
Completed
Terminated
Completed
Active, not recruiting
Unknown status
Completed
Terminated
Completed
Completed
Completed
Completed
Active, not recruiting
Recruiting
Active, not recruiting
Completed
Recruiting
Completed
Completed
Completed
Terminated
Completed
Completed
Active, not recruiting
Terminated
Terminated
Terminated
Completed
Completed
Terminated
Completed
Recruiting
Completed
Completed
Completed
Completed
Completed
Unknown status
Completed
Terminated
Completed
Completed
Active, not recruiting
Unknown status
Completed
Completed
Completed
Recruiting
Withdrawn
Completed
Completed
Completed
Unknown status
Unknown status
Active, not recruiting
Completed
Recruiting
Terminated
Completed
Active, not recruiting
Completed
Completed
Completed
Completed
Active, not recruiting
Completed
Completed
Unknown status
Unknown status
Terminated
Completed
Unknown status
Completed
Terminated
Completed
Completed
Terminated
Completed
Unknown status
Completed
Completed
Completed
Withdrawn
Completed
Completed
Completed
Completed
Terminated
Withdrawn
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Terminated
Terminated
Completed
Unknown status
Completed
Recruiting
Terminated
Unknown status
Completed
Recruiting
Terminated
Completed
Completed
Terminated
Completed
Recruiting
Completed
Terminated
Withdrawn
Terminated
Active, not recruiting
Completed
Completed
Terminated
Completed
Completed
Completed
Withdrawn
Unknown status
Terminated
Terminated
Unknown status
Unknown status
Completed
Completed
Completed
Active, not recruiting
Completed
Completed
Terminated
Withdrawn
Completed
Completed
Completed
Unknown status
Unknown status
Completed
Completed
Unknown status
Active, not recruiting
Completed
Terminated
Withdrawn
Withdrawn
Completed
Completed
Terminated
Completed
Completed
Terminated
Completed
Completed
Completed
Unknown status
Unknown status
Terminated
Unknown status
Terminated
Terminated
Recruiting
Terminated
Active, not recruiting
Unknown status
Terminated
Terminated
Unknown status
Completed
Terminated
Completed
Terminated
Completed
Completed
Terminated
Completed
Terminated
Completed
Unknown status
Completed
Terminated
Completed
Recruiting
Completed
Terminated
Withdrawn
Terminated
Active, not recruiting
Completed
Completed
Completed
Completed
Unknown status
Completed
Completed
Completed
Completed
Completed
Terminated
Unknown status
Completed
Recruiting
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Unknown status
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Recruiting
Completed
Completed
Active, not recruiting
Active, not recruiting
Active, not recruiting
Completed
Terminated
Terminated
Completed
Completed
Withdrawn
Active, not recruiting
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Unknown status
Active, not recruiting
Completed
Completed
Completed
Terminated
Terminated
Recruiting
Recruiting
Completed
Terminated
Recruiting
Completed
Unknown status
Unknown status
Active, not recruiting
Completed
Completed
Completed
Completed
Completed
Recruiting
Completed
Unknown status
Completed
Completed
Terminated
Completed
Recruiting
Active, not recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Active, not recruiting
Completed
Terminated
Completed
Recruiting
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Unknown status
Recruiting
Active, not recruiting
Not yet recruiting
Terminated
Completed
Terminated
Completed
Approved for marketing
Terminated
Recruiting
Unknown status
Terminated
Completed
Completed
Terminated
Approved for marketing
Completed
Completed
Unknown status
Completed
Completed
Completed
Completed
Completed
Completed
Unknown status
Recruiting
Completed
Completed
Completed
Active, not recruiting
Withdrawn
Active, not recruiting
Completed
Completed
Completed
Completed
Recruiting
Not yet recruiting
Unknown status
Terminated
Recruiting
Completed
Recruiting
Nintedanib Esylate
BIBF-1120
Approved
C.H. Boehringer Sohn Ag & Co. Kg
Ovarian Neoplasms, Solid tumours, Carcinoma, Renal Cell, Scleroderma, Systemic, Idiopathic Pulmonary Fibrosis, Lung Diseases, Interstitial, Pulmonary Fibrosis, Multiple Myeloma, Prostatic Neoplasms, Peritoneal Neoplasms, Colorectal Neoplasms, Hepatic Insufficiency, Genital Neoplasms, Female, Carcinoma, Hepatocellular, Carcinoma, Non-Small-Cell Lung
NCT Number
NCT02579603
NCT02598193
NCT03939520
NCT02606877
NCT02788474
NCT04619680
NCT03717012
NCT01335464
NCT01979952
NCT01335477
NCT03313180
NCT02802345
NCT02597933
NCT00806819
NCT04541680
NCT03820726
NCT01619085
NCT03283007
NCT02149108
NCT02999178
NCT00805194
NCT02231164
NCT01015118
NCT04093024
NCT01907100
NCT02009579
NCT01441297
NCT02568449
NCT02152059
NCT01362361
NCT04338802
NCT01583322
NCT02496585
NCT02780700
NCT01669798
NCT01004003
NCT02531737
NCT02856867
NCT02730416
NCT01251484
NCT03292250
NCT02299141
NCT02808247
NCT00904839
NCT01136174
NCT02182063
NCT02863055
NCT02558387
NCT01610869
NCT01380782
NCT00710762
NCT02389764
NCT02866370
NCT02452463
NCT03287947
NCT01024920
NCT02399215
NCT01948141
NCT03805477
NCT01225887
NCT01417156
NCT01170065
NCT04161014
NCT00987935
NCT00801294
NCT02234596
NCT02278978
NCT00514683
NCT00706628
NCT03954782
NCT01788982
NCT02182050
NCT02665143
NCT01658462
NCT03562416
NCT03062943
NCT03377023
NCT02902484
NCT02308553
NCT01484080
NCT01488344
NCT04046614
NCT02393755
NCT03361319
NCT01666600
NCT02300298
NCT01329549
NCT03363815
NCT00730821
NCT02667704
NCT01679613
NCT02619162
NCT02182219
NCT01346540
NCT01594125
NCT02668393
NCT03675581
NCT01485874
NCT01951846
NCT00998296
NCT01684111
NCT01022853
NCT00876460
NCT02182076
NCT02191865
NCT03422068
NCT02182193
NCT02182206
NCT01314105
NCT03513484
NCT02856425
NCT02225405
NCT02751385
NCT01770392
NCT01349296
NCT00715403
NCT02572752
NCT02182141
NCT00979576
NCT01683682
NCT02182232
NCT02182128
NCT02182258
NCT02835833
NCT02182102
NCT02182245
NCT02392455
NCT03710824
NCT02171156
NCT04325217
NCT04614441
NCT03281200
NCT03958071
NCT03047031
NCT02230982
NCT04525547
NCT02607722
NCT03843892
NCT04702893
NCT03017885
NCT03242759
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug;Behavioral
Drug
Other;Procedure;Biological;Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Other;Drug
Radiation;Drug
Drug
Drug
Drug;Dietary Supplement
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Progressive Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis; Interstitial Lung Disease; Respiratory Disease
Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis
Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis
Scleroderma, Systemic
Carcinoma, Non-Small-Cell Lung
SARS-Cov-2 Induced Pulmonary Fibrosis
Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis
Lung-transplant Recipients
Colorectal Neoplasms
Lung Diseases, Interstitial
Carcinoma, Non-Small-Cell Lung
Carcinoma, Non-Small-Cell Lung
Ovarian Neoplasms; Peritoneal Neoplasms
Lung Diseases, Interstitial
Mesothelioma
Uterine Cervical Neoplasms
Small Cell Lung Cancer; Small Cell Lung Cancer Recurrent
Recurrent Pleural Malignant Mesothelioma; Stage IV Pleural Mesothelioma
Small Cell Lung Cancer; Platinum-sensitive
Colorectal Cancer
COVID-19; Nintedanib; Safety; Effect of Drugs
Ovarian Cancer
Lung Cancer; Lung Metastases
Colorectal Neoplasms
Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer
Carcinoma, Hepatocellular
Lung Neoplasms
Esophagogastric Adenocarcinoma; Metastatic Disease; No Previous Chemotherapy for Metastatic Esophagogastric Cancer
Endometrial Cancer
Recurrent Glioblastoma
HNSCC; Head and Neck Neoplasms
Carcinoma, Non-Small-Cell Lung; Non-Small Cell Lung Cancer; Nonsmall Cell Lung Cancer
Sarcoma, Soft Tissue
Colorectal Neoplasms
Idiopathic Pulmonary Fibrosis
Prostatic Neoplasms
Malignant Pleural Mesothelioma
Recurrent or Metastatic Salivary Gland Cancer of the Head and Neck
Ovarian Cancer; Fallopian Tube Cancer
Glioblastoma; Gliosarcoma; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma
Ovarian Neoplasms
Breast Cancer
Ovarian Clear Cell Carcinoma; Endometrial Clear Cell Carcinoma
Lung Non-Squamous Non-Small Cell Carcinoma; Radiation-Induced Pneumonitis; Stage II Lung Non-Small Cell Cancer AJCC v7; Stage IIA Lung Non-Small Cell Carcinoma AJCC v7; Stage IIB Lung Non-Small Cell Carcinoma AJCC v7; Stage III Lung Non-Small Cell Cancer AJCC v7; Stage IIIA Lung Non-Small Cell Cancer AJCC v7; Stage IIIB Lung Non-Small Cell Cancer AJCC v7; Stage IV Lung Non-Small Cell Cancer AJCC v7
Appendix Cancer
Carcinoma, Renal Cell
Carcinoid Tumor; Metastatic Carcinoid Tumor; Neuroendocrine Neoplasm
Recurrent Non-small Cell Lung Cancer; Squamous Cell Lung Cancer; Stage III Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
Bronchiolitis Obliterans Syndrome (BOS); Bronchiolitis Obliterans (BO)
Endometrial Adenocarcinoma; Endometrial Clear Cell Adenocarcinoma; Endometrial Mucinous Adenocarcinoma; Endometrial Serous Adenocarcinoma; Endometrial Squamous Cell Carcinoma; Endometrial Transitional Cell Carcinoma; Endometrial Undifferentiated Carcinoma; Malignant Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm; Recurrent Uterine Corpus Carcinoma
Pulmonary Fibrosis
Pulmonary Fibrosis
Pneumoconiosis Coal; Asbestosis; Silicosis
Carcinoma, Hepatocellular
Colorectal Neoplasms
Esophagogastric Adenocarcinoma
Urothelial Carcinoma
Pulmonary Fibrosis
Prostatic Neoplasms
Hemorrhagic Hereditary Telangiectasia
Medullary Thyroid Cancer (MTC); Differentiated Thyroid Cancer (DTC)
Carcinoma, Non-Small-Cell Lung
Relapsed/Refractory Acute Myeloid Leukemia
Breast Cancer
Idiopathic Pulmonary Fibrosis; Lung Transplant; Complications
Lymphangioleiomyomatosis
Non Small Cell Lung Cancer; Lung Cancer, Nonsmall Cell; Non Small Cell Lung Cancer Metastatic
Cancer of Pancreas
Cutaneous Malignant Melanoma
Breast Cancer
Acute Myeloid Leukemia
Adenocarcinoma of the Lung
Colon Adenocarcinoma; Rectal Adenocarcinoma; Recurrent Colon Carcinoma; Recurrent Rectal Carcinoma; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer
NSCLC, Recurrent; Adenocarcinoma of Lung
Glioblastoma Multiforme
Carcinoma, Non-Small-Cell Lung
Ovarian Neoplasms
Heathy Volunteer
Neoplasms
Healthy
Healthy
Breast Cancer
Prostatic Neoplasms
Carcinoma, Non-Small-Cell Lung
Carcinoma, Hepatocellular
Carcinoma, Non-Small-Cell Lung
Scleroderma, Systemic
Ovarian Cancer
Malignant Solid Tumour
Neoplasms
Carcinoma, Non-Small-Cell Lung
Neoplasms
Carcinoma, Non-Small-Cell Lung
Healthy
Hepatic Insufficiency
Idiopathic Pulmonary Fibrosis
Healthy
Tumors
Ovarian Neoplasms; Peritoneal Neoplasms
Acute Myeloid Leukemia With t(9;11)(p22.3;q23.3); MLLT3-KMT2A; Fibroblast Growth Factor Basic Form Measurement; FLT3 Internal Tandem Duplication; Recurrent Adult Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
Patients With Any Advanced Solid Tumors
Stage IB Non-Small Cell Lung Carcinoma AJCC v7; Stage II Non-Small Cell Lung Cancer AJCC v7; Stage IIA Non-Small Cell Lung Carcinoma AJCC v7; Stage IIB Non-Small Cell Lung Carcinoma AJCC v7; Stage IIIA Non-Small Cell Lung Cancer AJCC v7
Carcinoma, Non-Small-Cell Lung
Healthy
Solid Tumors
Neoplasms
Healthy
Multiple Myeloma
Carcinoma, Non-Small-Cell Lung
Carcinoma, Non-Small-Cell Lung
Carcinoma, Non-Small-Cell Lung
Tumors
Healthy
Renal Cell Carcinoma; Colorectal Adenocarcinoma; Non-squamous Non-small Cell Lung Cancer; Platinum-refractory Ovarian Carcinoma; Cervical Carcinoma
Carcinoma, Non-Small-Cell Lung
Genital Neoplasms, Female
Carcinoma, Non-Small-Cell Lung
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Lung Diseases, Interstitial
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Lung Diseases, Interstitial
Lung Diseases, Interstitial
Non-small Cell Lung Cancer
Pulmonary Fibrosis
Study Phase
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Recruitment Status
Completed
Completed
Recruiting
Completed
Completed
Recruiting
Terminated
Completed
Completed
Completed
Active, not recruiting
Completed
Completed
Completed
Recruiting
Active, not recruiting
Active, not recruiting
Recruiting
Completed
Completed
Completed
Terminated
Completed
Recruiting
Terminated
Active, not recruiting
Completed
Active, not recruiting
Withdrawn
Completed
Not yet recruiting
Completed
Active, not recruiting
Terminated
Completed
Completed
Active, not recruiting
Withdrawn
Active, not recruiting
Completed
Recruiting
Active, not recruiting
Active, not recruiting
Completed
Completed
Completed
Recruiting
Unknown status
Completed
Completed
Completed
Terminated
Recruiting
Terminated
Terminated
Completed
Active, not recruiting
Completed
Recruiting
Completed
Completed
Completed
Not yet recruiting
Completed
Completed
Completed
Unknown status
Completed
Completed
Recruiting
Completed
Completed
Recruiting
Completed
Recruiting
Recruiting
Recruiting
Recruiting
Completed
Completed
Unknown status
Recruiting
Active, not recruiting
Withdrawn
Terminated
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Recruiting
Recruiting
Active, not recruiting
Terminated
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Recruiting
Recruiting
Approved for marketing
Recruiting
Not yet recruiting
Completed
Completed
Recruiting
No longer available
Not yet recruiting
Recruiting
Approved for marketing
Not yet recruiting
Recruiting
Completed
Ponatinib Hydrochloride
AP-24534, INCB-84344, AP24534 HCl, AP24534-HCL, AP24534 hydrochloride
Approved
Ariad
Leukemia, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Solid tumours, Hematologic Neoplasms, Blast Crisis, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Chronic-Phase, Philadelphia Chromosome, Gastrointestinal Stromal Tumors, Leukemia, Myeloid, Acute, Lymphoma, Leukemia, Biphenotypic, Acute
NCT Number
NCT03589326
NCT01650805
NCT02627677
NCT04530565
NCT01761747
NCT02272998
NCT04475731
NCT01874665
NCT01935336
NCT04188405
NCT04233346
NCT01813734
NCT02776605
NCT01746836
NCT02398825
NCT04688983
NCT03690115
NCT04554459
NCT02478164
NCT02265341
NCT03895671
NCT04591431
NCT04043676
NCT04070443
NCT01641107
NCT01424982
NCT01620216
NCT03807479
NCT02467270
NCT04160546
NCT03147612
NCT01570868
NCT03171389
NCT03838692
NCT01838642
NCT01207440
NCT03263572
NCT02767063
NCT02428543
NCT03934372
NCT04501614
NCT03704688
NCT01667133
NCT02829840
NCT03576547
NCT00660920
NCT03878524
NCT02779283
NCT02455024
NCT01549548
NCT01888562
NCT01592136
NCT02551718
NCT03331211
NCT03709017
NCT01957514
NCT02981784
NCT02448095
Intervention Type
Drug
Drug
Drug
Biological;Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Procedure;Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Other;Biological;Drug
Other;Drug
Drug
Drug
Drug
Biological;Drug
Drug
Drug
Drug
Drug
Drug
Biological;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug;Behavioral
Biological;Drug
Drug
Procedure;Other;Biological;Drug
Biological;Drug;Device
Drug
Drug
Drug
Other;Drug;Genetic
Drug
Drug
Other
Procedure;Drug
Drug
Indications
Lymphoblastic Leukemia, Acute, Adult; Acute Lymphoid Leukemia; Leukemia, Acute Lymphoblastic; Leukemia, Lymphoblastic; Ph1 Chromosome; Leukemia, Lymphoblastic, Acute, Philadelphia-Positive
Chronic Myeloid Leukemia
Chronic Phase Chronic Myeloid Leukemia
B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Non-Small Cell Lung Cancer, Head and Neck Cancer
Malignant Neoplasm
Philadelphia-Positive ALL; Acute Lymphoblastic Leukemia, in Relapse
GIST
Adenocarcinoma of the Lung; Extensive Stage Small Cell Lung Cancer; Limited Stage Small Cell Lung Cancer; Recurrent Non-small Cell Lung Cancer; Recurrent Small Cell Lung Cancer; Stage IIIA Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
Acute Myeloid Leukemia; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Acute Myeloid Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Chronic Myeloid Leukemia; Acute Lymphoblastic Leukemia
Non Small Cell Lung Cancer
ALL
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive, BCR-ABL1 Positive Chronic Myelogenous Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Chronic Myeloid Leukemia; Chronic Phase; Adults
Acute Lymphoblastic Leukemia, Adult
Leukemia, Myeloid, Acute
Acute Lymphoblastic Leukemia, Adult; Ph+ ALL; Newly Diagnosed
Glioblastoma
Malignant Hepatobiliary Neoplasm
CHRONIC MYELOGENOUS LEUKAEMIA IN ACCELERATED PHASE; CHRONIC MYELOGENOUS LEUKAEMIA IN MYELOID BLAST CRISIS
Breast Cancer; Gastrointestinal Cancer; Non Small Cell Lung Cancer; Other Cancer
Chronic Myeloid Leukemia
Philadelphia Chromosome Positive CML; BCR-ABL Positive Chronic Myelogenous Leukemia
Philadelphia Positive; BCR-ABL Positive; Acute Lymphoblastic Leukemia
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Lymphoblastic Leukemia; Adult Acute Lymphoblastic Leukemia in Complete Remission; B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive; Untreated Adult Acute Lymphoblastic Leukemia
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Adult Acute Lymphoblastic Leukemia
Leukemia, Myeloid, Chronic-Phase
Myeloid Leukemia, Chronic, Chronic Phase
Chronic Myeloid Leukemia, Chronic Phase
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia With BCR-ABL1; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive; Recurrent Acute Lymphoblastic Leukemia; Refractory Acute Lymphoblastic Leukemia
Leukemia
GIST, Malignant; KIT Exon 13 Mutation; KIT Gene Mutation
Medullary Thyroid Cancer
Thyroid Neoplasms
Chronic Myeloid Leukemia; Ph+ Acute Lymphoblastic Leukemia
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Acute Lymphoblastic Leukemia; BCR-ABL1 Fusion Protein Expression; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive; Recurrent Acute Lymphoblastic Leukemia; Refractory Acute Lymphoblastic Leukemia; t(9;22)
Leukemia, Myeloid, Chronic-Phase
Acute Myeloid Lukemia
Acute Myeloid Leukemia; Accelerated Phase Chronic Myeloid Leukemia; Blast Phase Chronic Myeloid Leukemia; Chronic Phase Chronic Myeloid Leukemia; Acute Lymphoblastic Leukemia; Acute Lymphocytic Leukemia; Leukemia; Lymphoma; Solid Tumors
Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL); Ph+ Mixed Phenotype Acute Leukemia (MPAL)
Non Small Cell Lung Cancer; KRAS Gene Mutation
Chronic Myeloid Leukemia (CML); Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)
Leukemia; FLT3-Mutated Acute Myeloid Leukemia; FLT3-Mutated High-Risk Myelodysplastic Syndrome
Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Philadelphia Chromosome Positive; Recurrent Acute Lymphoblastic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Acute Lymphoblastic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; t(9;22)
Chronic Myelogenous Leukemia; Hematologic Malignancies
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IIIA Hodgkin Lymphoma; Ann Arbor Stage IIIB Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Ann Arbor Stage IVA Hodgkin Lymphoma; Ann Arbor Stage IVB Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid Cell Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Prognostic Stage IV Breast Cancer AJCC v8; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage IIA Pancreatic Cancer AJCC v8; Stage IIB Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia
Myeloid Leukemia, Chronic-Phase, Accelerated-Phase, Blast-Phase, Ph+ALL
Philadelphia Chromosome Positive (Ph+) Leukemias; Chronic Myeloid Leukemia
Endometrial Neoplasms
Chronic Myeloid Leukemia (CML); Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)
Recurrent Acute Leukemia of Ambiguous Lineage; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Acute Leukemia of Ambiguous Lineage
Leukemia, Lymphoblastic, Acute
Chronic Myeloid Leukemia; Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia
Estrogen Receptor Negative; HER2/Neu Negative; Progesterone Receptor Negative; Stage IV Breast Cancer AJCC v6 and v7; Triple-Negative Breast Carcinoma
Leukemia
Chronic Myeloid Leukemia; Philadelphia Positive
Study Phase
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Recruitment Status
Recruiting
Terminated
Active, not recruiting
Recruiting
Terminated
Recruiting
Not yet recruiting
Completed
Active, not recruiting
Recruiting
Recruiting
Completed
Recruiting
Active, not recruiting
Recruiting
Not yet recruiting
Recruiting
Not yet recruiting
Completed
Completed
Recruiting
Recruiting
Recruiting
Recruiting
Active, not recruiting
Recruiting
Unknown status
Recruiting
Active, not recruiting
Recruiting
Recruiting
Terminated
Recruiting
Not yet recruiting
Terminated
Completed
Recruiting
Recruiting
Active, not recruiting
Recruiting
Not yet recruiting
Active, not recruiting
Completed
Withdrawn
Recruiting
Completed
Recruiting
Completed
Terminated
No longer available
Withdrawn
Approved for marketing
Active, not recruiting
Unknown status
Recruiting
Active, not recruiting
Completed
Recruiting
Pexidartinib
PLX-3397
Approved
Daiichi Sankyo Co Ltd
Giant Cell Tumor of Tendon Sheath, Solid tumours, Synovitis, Pigmented Villonodular, Hodgkin Disease, Arthritis, Rheumatoid, Glioblastoma, Giant Cell Tumors, Prostatic Neoplasms, Gastrointestinal Stromal Tumors, Leukemia, Myeloid, Acute
NCT Number
NCT04526704
NCT02371369
NCT04488822
NCT01349036
NCT02071940
NCT04703322
NCT01499043
NCT01217229
NCT02390752
NCT02401815
NCT01790503
NCT01349049
NCT02584647
NCT02452424
NCT01596751
NCT01826448
NCT02472275
NCT01042379
NCT02734433
NCT01090570
NCT02777710
NCT01525602
NCT03291288
NCT03138759
NCT03901313
NCT01004861
NCT03158103
NCT04223635
NCT02975700
NCT04635111
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Radiation;Drug
Drug
Drug
Biological;Drug
Drug
Drug
Other;Radiation;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Tenosynovial Giant Cell Tumor
Pigmented Villonodular Synovitis; Giant Cell Tumors of the Tendon Sheath; Tenosynovial Giant Cell Tumor
Tenosynovial Giant Cell Tumor
Recurrent Glioblastoma
Malignant Melanoma
Tenosynovial Giant Cell Tumor
Prostate Cancer
Hodgkin Lymphoma
Neurofibroma, Plexiform; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Prolymphocytic, Acute; Sarcoma
Gastrointestinal Stromal Tumors
Patients With Newly Diagnosed Glioblastoma
Acute Myeloid Leukemia
Sarcoma; Malignant Peripheral Nerve Sheath Tumors
Melanoma; Non-small Cell Lung Cancer; Squamous Cell Carcinoma of the Head and Neck; Gastrointestinal Stromal Tumor (GIST); Ovarian Cancer
Metastatic Breast Cancer
V600-mutated BRAF Unresectable Melanoma; V600-mutated BRAF Metastatic Melanoma; Stage III or Stage IV Metastatic Melanoma That Has Not Been Previously Treated With a Selective BRAF Inhibitor
Stage I Prostate Adenocarcinoma; Stage II Prostate Adenocarcinoma; Stage III Prostate Adenocarcinoma
Breast Neoplasms; Breast Cancer; Breast Tumors; Angiosarcoma
Advanced Solid Tumors
Rheumatoid Arthritis
Colorectal Cancer; Pancreatic Cancer; Metastatic Cancer; Advanced Cancer
Solid Tumors
Drug Interaction Potential
Pharmacokinetics in Healthy Volunteers
Healthy Volunteers
Solid Tumor
Gastrointestinal Stromal Tumor (GIST)
Moderate Hepatic Impairment
Melanoma
Hepatotoxicity; Tenosynovial Giant Cell Tumor
Study Phase
Phase 4
Phase 3
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Early Phase 1
N/A
N/A
Recruitment Status
Recruiting
Active, not recruiting
Recruiting
Terminated
Unknown status
Not yet recruiting
Terminated
Completed
Recruiting
Completed
Completed
Completed
Recruiting
Terminated
Completed
Terminated
Completed
Recruiting
Active, not recruiting
Withdrawn
Completed
Completed
Active, not recruiting
Completed
Completed
Active, not recruiting
Active, not recruiting
Completed
Active, not recruiting
Recruiting
Gilteritinib fumarate
ASP-2215 hemifumarate, ASP-2215, 66D-92MGC8M (UNII code)
Approved
Astellas
Hepatic Insufficiency, Leukemia, Myeloid, Acute
NCT Number
NCT02997202
NCT02421939
NCT02752035
NCT03182244
NCT04027309
NCT04293562
NCT02927262
NCT03836209
NCT04140487
NCT02014558
NCT03730012
NCT02495233
NCT04336982
NCT02310321
NCT02561455
NCT04240002
NCT04699877
NCT02456883
NCT02236013
NCT03625505
NCT02571816
NCT03964038
NCT02181660
NCT04691648
NCT03409081
NCT03315299
NCT03070093
Intervention Type
Drug
Drug
Drug
Drug
Drug
Procedure;Drug;Behavioral
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Acute Myeloid Leukemia
Leukemia, Acute Myeloid (AML)
Acute Myeloid Leukemia (AML); Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation
Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation
Acute Myeloid Leukemia; Myelodysplastic Syndrome With Excess Blasts-2
Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML); Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) / Internal Tandem Duplication (ITD) Mutation
Acute Myeloid Leukemia
Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome
Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML); Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation
Non-Small-Cell Lung Cancer
Leukemia, Myeloid, Acute
Acute Myeloid Leukemia; FLT3-mutated Acute Myeloid Leukemia
Advanced Solid Tumors; Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML); Acute Myeloid Leukemia With FMS-like Tyrosine Kinase 3 (FLT3) Mutation / Internal Tandem Duplication (ITD)
Renal Impaired; Gilteritinib; Normal Renal Function; Pharmacokinetics of ASP2215
Advanced Solid Tumors; Pharmacokinetics of 14C-labeled Gilteritinib
Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML)
Hepatic Impairment; Healthy
Healthy Volunteer
Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia With FMS-like Tyrosine Kinase (FLT3) Mutation
Acute Myeloid Leukemia (AML); FMS-like Tyrosine Kinase-3 (FLT3) Mutations
AML
Acute Myeloid Leukemia (AML); FMS-like Tyrosine Kinase-3 (FLT3) Mutations
Study Phase
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
N/A
N/A
N/A
N/A
Recruitment Status
Active, not recruiting
Active, not recruiting
Active, not recruiting
Recruiting
Recruiting
Recruiting
Active, not recruiting
Recruiting
Recruiting
Completed
Recruiting
Terminated
Recruiting
Recruiting
Completed
Recruiting
Not yet recruiting
Completed
Active, not recruiting
Recruiting
Completed
Completed
Completed
Not yet recruiting
No longer available
No longer available
Approved for marketing
Fedratinib
TG-101348, SAR-302503
Approved
Sanofi
Hematologic Neoplasms, Polycythemia Vera, Kidney Diseases, Primary Myelofibrosis, Hepatic Insufficiency, Thrombocythemia, Essential
NCT Number
NCT03952039
NCT01437787
NCT03755518
NCT01420770
NCT01420783
NCT01692366
NCT04282187
NCT01523171
NCT04446650
NCT00724334
NCT01763190
NCT03983239
NCT04231435
NCT01585623
NCT03983161
NCT00631462
NCT01762462
NCT01836705
NCT03723148
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Primary Myelofibrosis; Post-Polycythemia Vera; Myelofibrosis
Hematopoietic Neoplasm
Primary Myelofibrosis; Post-Polycythemia Vera; Myelofibrosis
Hematopoietic Neoplasm
Hematopoietic Neoplasm
Myelofibrosis
Acute Myeloid Leukemia; Essential Thrombocythemia; Myelodysplastic Syndrome; Myelodysplastic/Myeloproliferative Neoplasm; Myeloproliferative Neoplasm; Myeloproliferative Neoplasm, Unclassifiable; Polycythemia Vera; Primary Myelofibrosis; Secondary Myelofibrosis
Hematopoietic Neoplasm
Primary Myelofibrosis
Myelofibrosis
Renal Impairment
Healthy Volunteers
Healthy Volunteers
Solid Tumor
Healthy Volunteers; Hepatic Impairment
Myelofibrosis
Hepatic Impairment
Neoplasm Malignant
Myelofibrosis
Study Phase
Phase 3
Phase 3
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
N/A
Recruitment Status
Recruiting
Completed
Recruiting
Completed
Completed
Completed
Recruiting
Completed
Not yet recruiting
Completed
Completed
Completed
Completed
Completed
Recruiting
Completed
Completed
Completed
Available
Quizartinib
AC-220, ASP-2689, AC-010220
Approved
Ambit Biosciences
Leukemia, Myelodysplastic Syndromes, Myeloproliferative Disorders, Hepatic Insufficiency, Leukemia, Myeloid, Acute
NCT Number
NCT02668653
NCT02039726
NCT02272478
NCT03135054
NCT02984995
NCT04107727
NCT04047641
NCT03989713
NCT00989261
NCT04209725
NCT01565668
NCT04128748
NCT03793478
NCT03661307
NCT04687761
NCT04112589
NCT01892371
NCT03735875
NCT01236144
NCT04493138
NCT02675478
NCT03723681
NCT01411267
NCT01049893
NCT00462761
NCT04473664
NCT03552029
NCT01390337
NCT02834390
NCT01468467
NCT04459598
NCT04459585
NCT01576185
NCT03746912
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Indications
Acute Myeloid Leukemia; Leukemia
AML
Acute Myeloid Leukaemia; Myelodysplastic Syndrome
AML; FLT3-ITD Mutation
Leukemia, Myeloid, Acute
Acute Myeloid Leukemia
Acute Myeloid Leukemia; Blasts 20 Percent or More of Bone Marrow Nucleated Cells; High Risk Myelodysplastic Syndrome; Recurrent Acute Biphenotypic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent High Risk Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory High Risk Myelodysplastic Syndrome
AML According to WHO 2016 Classification (Except Acute Promyelocytic Leukemia), Refractory to Induction Therapy or Relapsed After First Line Treatment
Acute Myeloid Leukemia
Leukemia, Myeloid, Acute
Leukemia, Myeloid, Acute
Acute Myeloid Leukemia; Blasts More Than 10 Percent of Bone Marrow Nucleated Cells; High Risk Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome
Acute Myeloid Leukemia
Acute Myeloid Leukemia; Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia
Leukemia, Myeloid, Acute; De Novo; Age More 60yr
Acute Myeloid Leukemia
FLT3 Gene Mutation Negative; FLT3 Internal Tandem Duplication Positive; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Myelomonocytic Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Chronic Myelomonocytic Leukemia; Refractory Myelodysplastic Syndrome
Acute Myeloid Leukemia With FLT3/ITD Mutation; Recurrent Acute Myeloid Leukemia; Refractory Acute Leukemia
Acute Myeloid Leukaemia; High Risk Myelodysplastic Syndrome
Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Myeloproliferative Neoplasm; Recurrent Chronic Myelomonocytic Leukemia; Recurrent Myelodysplastic Syndrome; Recurrent Myeloproliferative Neoplasm
Relapsed AML; Refractory AML
Acute Myeloid Leukemia (AML)
Lymphoblastic Leukemia, Acute, Childhood; Myelogenous Leukemia, Acute, Childhood
Solid Tumors
Acute Myeloid Leukemia; Leukemia; Myelodysplastic Syndrome; AML; MDS
Hepatic Impairment; Moderate Impaired Hepatic Function
Acute Myeloid Leukemia
Leukemia, Myeloid, Acute
Acute Myeloid Leukemia
Leukemia, Myeloid, Acute
Healthy Subjects; Drug-drug Interaction; Pharmacokinetics; Quizartinib
Healthy Subjects; Drug-drug Interaction; Pharmacokinetics; Quizartinib
Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
Acute Myeloid Leukemia With Gene Mutations
Study Phase
Phase 3
Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Early Phase 1
Early Phase 1
N/A
N/A
Recruitment Status
Active, not recruiting
Active, not recruiting
Recruiting
Active, not recruiting
Completed
Recruiting
Recruiting
Not yet recruiting
Completed
Recruiting
Completed
Recruiting
Recruiting
Recruiting
Recruiting
Recruiting
Active, not recruiting
Recruiting
Completed
Recruiting
Completed
Recruiting
Completed
Completed
Completed
Recruiting
Recruiting
Completed
Completed
Completed
Active, not recruiting
Active, not recruiting
Completed
No longer available
Brigatinib
AP-26113
Approved
Ariad, Takeda Pharmaceutical Co Ltd
Carcinoma, Lung Neoplasms, Lymphoma, Large-Cell, Anaplastic, Carcinoma, Non-Small-Cell Lung
NCT Number
NCT02737501
NCT03596866
NCT02706626
NCT03535740
NCT04223596
NCT04318938
NCT03737994
NCT04634110
NCT03410108
NCT02094573
NCT03719898
NCT04074993
NCT04374305
NCT04591431
NCT03868423
NCT04260009
NCT01449461
NCT04005144
NCT04227028
NCT03420742
NCT03707938
NCT02784158
NCT04647110
NCT03546894
NCT03389399
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Biological;Drug
Drug
Procedure;Drug
Drug
Drug
Drug
Indications
Non-small Cell Lung Cancer; Lung Cancer; Advanced Malignancies; Carcinoma
ALK+ Advanced NSCLC
Non-Small Cell Lung Cancer
ALK-positive Advanced NSCLC
Lung Cancer; NSCLC; NSCLC Stage IIIB; NSCLC Stage IV
NSCLC
Lung Non-Squamous Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Brain Metastases; Lung Cancer
ALK-positive Advanced NSCLC
Carcinoma, Non-Small-Cell Lung
Anaplastic Large Cell Lymphoma, ALK-Positive
Non Small Cell Lung Cancer
Neurofibromatosis Type 2; Vestibular Schwannoma; Non-vestibular Schwannoma; Meningioma; Ependymoma
Breast Cancer; Gastrointestinal Cancer; Non Small Cell Lung Cancer; Other Cancer
Advanced Malignant Neoplasm; ALK Fusion Protein Expression; ALK Gene Amplification; ALK Gene Mutation; Locally Advanced Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Neoplasm in the Central Nervous System; Metastatic Malignant Solid Neoplasm; ROS1 Fusion Positive; ROS1 Gene Amplification; ROS1 Gene Mutation
Anaplastic Lymphoma Kinase Positive (ALK +) Anaplastic Large Cell Lymphoma; Inflammatory Myofibroblastic Tumors; Solid Tumors
Lymphoma, Large-Cell, Anaplastic; Carcinoma, Non-Small-Cell Lung
ALK Gene Rearrangement; Lung Non-Small Cell Carcinoma; Progressive Disease; ROS1 Gene Rearrangement; Stage IIIB Lung Cancer; Stage IIIC Lung Cancer; Stage IV Lung Cancer; Stage IVA Lung Cancer; Stage IVB Lung Cancer
Locally Advanced Lung Non-Small Cell Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Carcinoma, Advanced ALK+ or ROS1+Non-Small-Cell Lung, Neoplasm, Advanced ALK+ or ROS1+Solid Tumors
Advanced Lung Carcinoma; ALK Gene Rearrangement; Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8
Non-small Cell Lung Cancer; Lung Cancer; Advanced Malignancies; Carcinoma
ALK-positive NSCLC
Anaplastic Lymphoma Kinase-positive; Carcinoma Non-small-cell Lung
Non-Small Cell Lung Cancer
Study Phase
Phase 3
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Early Phase 1
N/A
N/A
N/A
N/A
Recruitment Status
Completed
Recruiting
Recruiting
Active, not recruiting
Recruiting
Recruiting
Recruiting
Not yet recruiting
Active, not recruiting
Completed
Recruiting
Recruiting
Recruiting
Recruiting
Recruiting
Withdrawn
Completed
Recruiting
Recruiting
Active, not recruiting
Recruiting
No longer available
Not yet recruiting
Recruiting
Recruiting
Sorafenib Tosylate
NSC-724772, BAY-43-0006, BAY-43-9006, BAY-54-9085
Approved
Onyx Pharmaceuticals Inc
Liver Neoplasms, Solid tumours, Kidney Neoplasms, Ovarian Neoplasms, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Carcinoma, Renal Cell, Carcinoma, Pancreatic Neoplasms, Kidney Diseases, Neoplasms, Liver Diseases, Hepatitis B, Breast Neoplasms, Hepatitis C, Thyroid Neoplasms, Lung Neoplasms, Carcinoma, Hepatocellular, Carcinoma, Non-Small-Cell Lung, Fasting, Neoplasm Metastasis, Melanoma
NCT Number
NCT00352859
NCT01203787
NCT02961998
NCT02504983
NCT03178656
NCT03518502
NCT01409499
NCT03212625
NCT01806740
NCT01098760
NCT01849588
NCT02733809
NCT00110019
NCT00863746
NCT01761266
NCT00606866
NCT01004978
NCT01214343
NCT01371981
NCT01075555
NCT01556490
NCT00984282
NCT02562755
NCT00901901
NCT00326898
NCT04143191
NCT01613846
NCT00692770
NCT02436902
NCT02774187
NCT02971696
NCT00105443
NCT01903694
NCT00558636
NCT04709380
NCT01245582
NCT01482442
NCT01730937
NCT00111020
NCT00492986
NCT01234337
NCT01829035
NCT00492752
NCT02867280
NCT00625378
NCT04163237
NCT01015833
NCT03755791
NCT01833299
NCT03017326
NCT00586105
NCT00478114
NCT00732914
NCT03236649
NCT01324076
NCT02460991
NCT00073307
NCT04387695
NCT01405573
NCT01135056
NCT00449033
NCT00300885
NCT01481870
NCT00541021
NCT02066181
NCT00474786
NCT03605706
NCT00111007
NCT00492258
NCT02856126
NCT00494299
NCT02220088
NCT01932385
NCT01906216
NCT02794337
NCT01747642
NCT02474290
NCT03533582
NCT04674345
NCT02711007
NCT00865709
NCT00281957
NCT00480389
NCT00126594
NCT00430235
NCT00661180
NCT00329641
NCT01253070
NCT00922584
NCT01158287
NCT00199160
NCT00801801
NCT01620216
NCT00492297
NCT01334710
NCT01357486
NCT00726986
NCT01915602
NCT03037437
NCT00622466
NCT02747537
NCT00411671
NCT00098540
NCT03164057
NCT00108953
NCT00595985
NCT00265798
NCT00112671
NCT00703365
NCT00794235
NCT00217620
NCT01687673
NCT00064350
NCT03812770
NCT00464919
NCT00096395
NCT01775501
NCT00525161
NCT02599090
NCT02517736
NCT00098618
NCT03582618
NCT00722072
NCT01851408
NCT00844688
NCT00253578
NCT00889343
NCT00906373
NCT00095966
NCT00618384
NCT03009461
NCT02559778
NCT00117637
NCT03722498
NCT00467025
NCT00454194
NCT01731158
NCT02638428
NCT03812783
NCT01480817
NCT03768375
NCT01141309
NCT02050919
NCT01047891
NCT00573755
NCT00044512
NCT01093222
NCT00589420
NCT00607438
NCT00096434
NCT01248247
NCT01100242
NCT00605566
NCT00387751
NCT00096512
NCT01934829
NCT02135874
NCT01025453
NCT01338857
NCT03578874
NCT02114658
NCT03622541
NCT04232722
NCT02143726
NCT01703455
NCT00373373
NCT01736878
NCT01265576
NCT02129322
NCT00600015
NCT01204177
NCT00406601
NCT01290926
NCT00619996
NCT00112905
NCT00492505
NCT00119249
NCT01159327
NCT00808145
NCT00096200
NCT03630120
NCT00110344
NCT00445588
NCT00126568
NCT03606590
NCT00101400
NCT00445042
NCT00522301
NCT02178358
NCT01900002
NCT00696696
NCT00837148
NCT01605734
NCT01444807
NCT00548899
NCT00794859
NCT00893373
NCT00278382
NCT00101413
NCT04710641
NCT00079612
NCT04051853
NCT01187212
NCT01342627
NCT02908165
NCT00238121
NCT00093457
NCT02330783
NCT00839111
NCT00557830
NCT02560012
NCT01946529
NCT00490685
NCT00694291
NCT01041482
NCT00544817
NCT00131937
NCT00101114
NCT02021929
NCT03971201
NCT00621686
NCT00466752
NCT01510756
NCT00496756
NCT00609401
NCT00110994
NCT00813293
NCT00872014
NCT00881751
NCT00954135
NCT00510289
NCT00791778
NCT00390325
NCT02672488
NCT01232296
NCT00494182
NCT01126645
NCT03439891
NCT04599777
NCT00182689
NCT02836847
NCT01664182
NCT00939627
NCT00657254
NCT01539018
NCT00654238
NCT00919009
NCT00090545
NCT00943449
NCT00253370
NCT00095693
NCT00632541
NCT00880542
NCT00887107
NCT01502410
NCT04000737
NCT00826540
NCT00586495
NCT00722969
NCT00673361
NCT01217034
NCT01624285
NCT00245102
NCT00801385
NCT00301847
NCT00126659
NCT02624700
NCT02196857
NCT00107432
NCT02084732
NCT00619541
NCT03170895
NCT00747799
NCT00532025
NCT00378703
NCT00855218
NCT00917462
NCT00758381
NCT00493636
NCT01170104
NCT00114244
NCT00456716
NCT02716766
NCT03275376
NCT00990860
NCT01817751
NCT00461851
NCT01189370
NCT02645149
NCT00661375
NCT00854620
NCT00874874
NCT01262482
NCT00752063
NCT02029001
NCT01259193
NCT00436215
NCT00483301
NCT00238212
NCT00576056
NCT00661830
NCT00754923
NCT00647426
NCT03565536
NCT01425216
NCT01762150
NCT00098254
NCT00618982
NCT01005199
NCT01616186
NCT00597493
NCT00786110
NCT01556815
NCT01507064
NCT00678288
NCT01714609
NCT02981498
NCT01222676
NCT01171651
NCT02425605
NCT00714948
NCT00844883
NCT00623402
NCT01715441
NCT03899428
NCT00848640
NCT00330421
NCT00875615
NCT00131911
NCT02122003
NCT00093626
NCT04518852
NCT00866320
NCT01272557
NCT01418729
NCT00772694
NCT00498836
NCT01804374
NCT02406508
NCT02187302
NCT00889057
NCT02311205
NCT00609804
NCT01471353
NCT00602576
NCT00941967
NCT01091207
NCT01320111
NCT01033240
NCT00919061
NCT00499525
NCT01182272
NCT01897610
NCT03251612
NCT00810394
NCT01871766
NCT01215266
NCT04326439
NCT00326495
NCT01840592
NCT00303966
NCT00837876
NCT00496301
NCT00949182
NCT01032850
NCT01771458
NCT00452387
NCT00390611
NCT01377025
NCT01703910
NCT01194869
NCT01263951
NCT00764972
NCT00768937
NCT02530476
NCT01029418
NCT01271504
NCT00547443
NCT00448149
NCT01226056
NCT00565370
NCT00672178
NCT00474929
NCT02642913
NCT00217399
NCT01264705
NCT02227914
NCT00414388
NCT01254890
NCT02279719
NCT00609934
NCT02024087
NCT00516828
NCT00924807
NCT01258608
NCT00892424
NCT00933816
NCT01335074
NCT00989469
NCT02400788
NCT00634751
NCT00126503
NCT00882869
NCT00392821
NCT00791544
NCT00335764
NCT04069949
NCT00121251
NCT00869570
NCT02728050
NCT00955721
NCT01445080
NCT00542971
NCT03247088
NCT00811759
NCT00825734
NCT00785226
NCT00541840
NCT00510250
NCT00864032
NCT00815295
NCT00867321
NCT03563170
NCT00417248
NCT00538005
NCT03211416
NCT00536575
NCT00389285
NCT00828074
NCT01754987
NCT00999843
NCT00329719
NCT01462214
NCT00712790
NCT00634634
NCT00473486
NCT00862082
NCT00526799
NCT01434602
NCT02560779
NCT00971126
NCT01306058
NCT01534260
NCT00956436
NCT00822848
NCT02354898
NCT00384969
NCT00303797
NCT00610246
NCT00093613
NCT00405210
NCT01801163
NCT02636426
NCT02288507
NCT00665990
NCT00572078
NCT00981162
NCT00375310
NCT01640665
NCT01069328
NCT01893099
NCT00418496
NCT02240433
NCT00466232
NCT01008566
NCT01518413
NCT01498952
NCT00789763
NCT02412475
NCT00933777
NCT03878524
NCT00734526
NCT02988440
NCT00780169
NCT01618253
NCT00788099
NCT02143401
NCT00767468
NCT01183663
NCT00119639
NCT02332031
NCT01634893
NCT00687674
NCT00533585
NCT01276210
NCT00811993
NCT00663741
NCT00398814
NCT00613145
NCT00259129
NCT01075113
NCT02270788
NCT00712855
NCT00495872
NCT01128998
NCT00884416
NCT00095459
NCT00844168
NCT01844947
NCT00943943
NCT00997022
NCT00244972
NCT00349206
NCT02599337
NCT00452218
NCT00635791
NCT01008917
NCT00217646
NCT01932177
NCT00908167
NCT00622479
NCT01724606
NCT00942682
NCT01005797
NCT02358395
NCT00589550
NCT00846131
NCT01531361
NCT00892658
NCT00255658
NCT00509613
NCT02989870
NCT03132454
NCT00562913
NCT01078961
NCT01159301
NCT00703638
NCT01666756
NCT00779311
NCT00424385
NCT01187199
NCT00118170
NCT00287495
NCT02423239
NCT01398501
NCT02292173
NCT00870532
NCT02323906
NCT02035527
NCT00449280
NCT00126620
NCT00573690
NCT01608139
NCT00543335
NCT00875745
NCT00954278
NCT01011010
NCT01131689
NCT01683149
NCT01441388
NCT01308723
NCT00121264
NCT02069145
NCT02406521
NCT01042041
NCT00873002
NCT00759928
NCT02538393
NCT01861314
NCT00565968
NCT01497444
NCT01897038
NCT00544609
NCT02101593
NCT01561833
NCT02779283
NCT01303341
NCT00478374
NCT00562523
NCT00727233
NCT00436579
NCT01450384
NCT02298348
NCT02349867
NCT01383343
NCT00828594
NCT00627835
NCT00976170
NCT00974896
NCT01197170
NCT00941863
NCT00131989
NCT00829231
NCT00861419
NCT01585870
NCT00543504
NCT01376453
NCT00606125
NCT00823290
NCT00984425
NCT00827177
NCT00639262
NCT01348503
NCT00134069
NCT01337492
NCT00405366
NCT03965546
NCT01411423
NCT01839630
NCT01507740
NCT01539681
NCT00895674
NCT01700699
NCT00532064
NCT01195649
NCT00979381
NCT01412671
NCT02015728
NCT01636908
NCT00792350
NCT03140332
NCT02448056
NCT02977754
NCT01449825
NCT04639284
NCT01947296
NCT00876382
NCT03338166
NCT02013089
NCT00979329
NCT02156297
NCT01578109
NCT03340636
NCT01157013
NCT02450149
NCT00602862
NCT02537158
NCT01191385
NCT01209299
NCT00771147
NCT01751763
NCT01933945
NCT01466504
NCT00964743
NCT02209441
NCT02551718
NCT00544167
NCT04353765
NCT01190241
NCT02847468
NCT01005875
NCT02785835
NCT02691780
NCT04659343
NCT03730675
NCT01124669
NCT00900536
NCT02751827
NCT01446224
NCT02973204
NCT03113604
NCT01982097
NCT02071719
NCT02072486
NCT01319942
NCT02834546
NCT04152356
NCT02259647
NCT01557127
NCT01141478
NCT02649725
NCT02150317
NCT01411579
NCT01508364
NCT01012011
NCT01246843
NCT00727532
NCT01353794
NCT00978926
NCT01381601
NCT01328223
NCT03644511
NCT03097848
NCT02303444
NCT04553458
NCT02789137
NCT01728948
NCT01621906
NCT01078311
NCT01339962
NCT02185560
NCT02187081
NCT01758575
NCT02786342
NCT01230697
NCT02748304
NCT00619242
NCT01576185
NCT02867891
NCT02529761
NCT01481805
NCT01411436
NCT02111889
NCT01908322
NCT01470495
NCT02616692
NCT01381614
NCT00812175
NCT02184416
Intervention Type
Drug
Drug
Drug
Procedure;Drug
Procedure;Drug
Procedure;Drug
Procedure;Drug
Drug
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Other;Drug
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Other;Drug
Drug
Other;Drug
Drug
Device
Drug
Biological;Drug
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Other;Drug
Procedure;Drug
Drug
Drug
Procedure;Other;Drug
Procedure;Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Radiation;Drug
Drug
Drug
Drug
Other
Drug
Drug
Drug
Drug
Other;Drug
Drug
Procedure
Drug
Drug
Drug
Drug
Drug
Other;Procedure;Drug
Drug;Device
Drug
Radiation;Drug
Other;Drug
Drug;Device
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Procedure;Drug
Procedure;Drug
Drug
Procedure;Drug
Other;Drug
Procedure;Drug
Procedure;Radiation;Drug
Drug;Dietary Supplement
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Other;Biological;Drug
Drug
Drug
Drug
Other;Procedure;Drug
Drug
Other;Drug
Drug
Drug
Other;Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Biological;Drug;Combination Product
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Radiation;Drug
Drug
Other;Biological;Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Biological;Drug
Drug
Drug
Procedure;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Procedure;Drug
Procedure;Drug
Procedure;Drug
Biological
Drug
Other;Procedure;Radiation;Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Other;Biological;Drug
Other;Drug
Drug
Biological;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Procedure;Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug;Device
Drug
Drug
Other;Drug
Drug
Other;Radiation;Drug
Drug
Drug
Procedure;Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
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Other;Drug
Drug
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Drug
Drug
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Drug
Drug
Drug
Drug
Procedure;Radiation;Drug
Drug
Drug
Drug
Radiation;Drug
Drug
Other;Biological;Drug
Drug
Procedure;Drug
Biological;Drug
Other;Procedure;Drug;Genetic
Drug
Drug
Drug
Drug
Procedure;Drug
Drug
Biological;Drug
Drug
Drug
Drug
Drug
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Procedure
Other;Biological;Drug
Drug
Drug
Procedure;Drug
Biological;Drug
Other;Procedure;Biological;Drug
Drug
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Procedure
Drug
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Other;Procedure;Radiation;Drug
Other;Drug
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Other;Drug
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Biological;Drug
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Drug
Procedure;Drug
Other;Drug
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Other;Drug;Genetic
Drug
Other;Procedure;Drug
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Other;Drug
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Other;Biological;Drug
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Procedure;Drug
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Other;Drug
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Procedure;Drug
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Drug
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Drug;Combination Product
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Other;Drug
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Procedure;Radiation;Drug
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Procedure;Other
Procedure;Drug
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Other;Procedure;Radiation;Drug
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Radiation;Drug
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Procedure;Drug
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Procedure;Other;Drug
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Other;Drug
Combination Product
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Procedure;Drug
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Other;Drug
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Other;Drug
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Procedure;Drug
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Radiation;Drug
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Radiation
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Radiation;Drug
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Radiation;Drug
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Other;Drug
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Biological;Drug;Device
Other;Drug
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Other;Procedure;Drug
Other;Procedure;Drug
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Other;Radiation;Drug
Biological;Drug
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Other;Drug
Drug
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Drug
Drug
Radiation;Drug
Drug
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Drug
Radiation;Drug
Drug
Drug
Drug
Drug
Biological;Combination Product
Drug
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Drug
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Procedure;Other
Drug
Biological
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Procedure;Drug
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Other
Other
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Other
Procedure;Drug
Other
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Other;Genetic
Drug
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Other;Drug;Genetic
Drug
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Other
Radiation;Drug
Drug
Drug
Procedure;Drug
Other;Genetic
Other;Genetic
Other
Drug
Procedure;Drug
Other
Drug
Other;Drug
Other
Biological
Drug
Drug
Drug
Radiation;Drug
Behavioral
Procedure
Drug
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Drug
Drug
Drug
Radiation
Drug
Procedure;Drug
Drug
Procedure;Drug;Dietary Supplement;Device;Combination Product
Drug
Device
Other
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Other;Drug
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Indications
Carcinoma, Renal Cell
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Portal Vein Tumor Thrombus
Hepatocellular Carcinoma; Metastasis
Hepatectomy; Hepatocellular Carcinoma; Sorafenib
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Cancer
Hepatocellular Carcinoma
Mucosal Melanoma; Recurrent Melanoma; Stage IIIA Skin Melanoma; Stage IIIB Skin Melanoma; Stage IIIC Skin Melanoma; Stage IV Skin Melanoma
Carcinoma; Non-Small-Cell Lung
Hepatocellular Carcinoma (HCC)
Metastatic Renal Cell Carcinoma
Hepatocellular Carcinoma; Unresectable Hepatocellular Carcinoma
Advanced Hepatocellular Carcinoma; Carcinoma; Carcinoma, Hepatocellular; Liver Neoplasms; Neoplasms
Acute Myeloid Leukemia; Leukemia Cutis; Myeloid Neoplasm; Myeloid Sarcoma
Liver Cancer
Unresectable Hepatocellular Carcinoma
Thyroid Neoplasms
Hepatocellular Carcinoma (HCC)
Carcinoma, Hepatocellular
Clear Cell Renal Cell Carcinoma; Stage I Renal Cell Cancer AJCC v6 and v7; Stage II Renal Cell Cancer AJCC v7; Stage III Renal Cell Cancer AJCC v7
Hepatocellular Carcinoma
Renal Cell Carcinoma
Carcinoma, Hepatocellular
Hepatocellular Carcinoma
Hepatocellular Carcinoma
HCC
Carcinoma, Hepatocellular
Child-Pugh A Hepatocellular Carcinoma
Carcinoma, Non-Small-Cell Lung
Radiotherapy; Toripalimab; Sorafenib; Advanced Liver Cancer
Hepatic Neoplasm Malignant
Liver Carcinoma
Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer
Carcinoma, Renal Cell
Carcinoma, Renal Cell
Breast Cancer
Advanced Adult Hepatocellular Carcinoma
Carcinoma, Hepatocellular
Hepatocellular Carcinoma; Recurrence
Neoplasms
Advanced Liver Cancer
Advanced Adult Hepatocellular Carcinoma; Recurrent Hepatocellular Carcinoma; Stage III Hepatocellular Carcinoma AJCC v7; Stage IIIA Hepatocellular Carcinoma AJCC v7; Stage IIIB Hepatocellular Carcinoma AJCC v7; Stage IIIC Hepatocellular Carcinoma AJCC v7; Stage IV Hepatocellular Carcinoma AJCC v7; Stage IVA Hepatocellular Carcinoma AJCC v7; Stage IVB Hepatocellular Carcinoma AJCC v7; Unresectable Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma; Face Cancer
Hepatoblastoma; Carcinoma, Hepatocellular
Carcinoma, Renal Cell
Renal Cell Carcinoma
Renal Cell Carcinoma
Hepatocellular Carcinoma (HCC)
Liver Cancer
Hepatocellular Carcinoma; Hepatoma; Liver Cell Carcinoma
Carcinoma, Renal Cell
Unresectable Hepatocellular Carcinoma; Portal Vein Thrombosis
Advanced Adult Hepatocellular Carcinoma
Hepatocellular Carcinoma
Carcinoma, Non-Small-Cell Lung
Carcinoma, Non-Small Cell Lung
Metastatic Renal Cell Carcinoma
Pancreatic Cancer
Desmoid-Type Fibromatosis
Renal Cell Carcinoma
Advanced Hepatocellular Carcinoma
Melanoma
Kidney Cancer
Hepatocellular Carcinoma
Carcinoma, Hepatocellular
Hepatocellular Carcinoma
Liver Cancer
Hepatocellular Carcinoma
Carcinoma, Hepatocellular
Quality of Life
Acute Myeloid Leukemia; Hematopoietic Stem Cell Transplantation
Childhood Hepatocellular Carcinoma; Childhood Malignant Liver Neoplasm; Fibrolamellar Carcinoma; Hepatoblastoma; Hepatocellular Malignant Neoplasm, Not Otherwise Specified
Acute Leukemia; Relapse; Hematopoietic Stem Cell Transplantation
Osteosarcoma; Metastasis
Metastatic Colorectal Cancer
Recurrent Melanoma; Stage IV Melanoma
Renal Cell Carcinoma; Metastatic Disease
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Stage IV Renal Cell Cancer
Adenocarcinoma of the Prostate
Chronic Myelogenous Leukemia
Ciliary Body and Choroid Melanoma, Medium/Large Size; Extraocular Extension Melanoma; Iris Melanoma; Metastatic Intraocular Melanoma; Recurrent Intraocular Melanoma
Acute Myeloid Leukemia With FLT3/ITD Mutation; Acute Myeloid Leukemia With Inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11; Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; Acute Promyelocytic Leukemia With PML-RARA; FLT3 Gene Mutation; Therapy-Related Acute Myeloid Leukemia
Non-Small Cell Lung Cancer
Esophageal Cancer; Gastric Cancer
Head and Neck Neoplasms
Non Squamous Cell Lung Cancer; Non Small Cell Lung Cancer
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndrome; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Refractory Adult Acute Lymphoblastic Leukemia
Melanoma
Liver Cancer
Hepatocellular Carcinoma; CHILD B
Lung Cancer
Carcinoma, Hepatocellular
Hepatocellular Cancer
Breast Cancer
Pediatric Solid Tumors
Lung Cancer
Recurrent Non-small Cell Lung Cancer; Stage IIIB Non-small Cell Lung Cancer; Stage IV Non-small Cell Lung Cancer
Acute Myeloid Leukemia; Myelodysplastic Syndromes
Carcinoma, Hepatocellular
Gastric Cancer
Gastrointestinal Stromal Tumor
Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Bladder Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Stage III Bladder Cancer; Stage IV Bladder Cancer; Transitional Cell Carcinoma of the Bladder
Carcinoma, Hepatocellular
Melanoma Stage III or IV; No Prior Chemotherapy
Sarcoma
Hepatocellular Carcinoma
Lung Cancer
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Recurrent Ovarian Epithelial Cancer; Recurrent Primary Peritoneal Cavity Cancer
Hepatocellular Cancer
Breast Cancer
Glioblastoma; Gliosarcoma
Uveal Melanoma
Clear Cell Renal Cell Carcinoma; Papillary Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer
Hepatocellular Carcinoma; Advanced Cancer
Breast Cancer
Melanoma; Recurrent Melanoma; Stage III Melanoma; Stage IV Melanoma
Hepatocellular Carcinoma
Refractory Multiple Myeloma
Colorectal Neoplasms
Hepatocellular Carcinoma
Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage II Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer
Hepatocellular Carcinoma
HepatoCellular Carcinoma; Portal Vein Thrombosis
Neuroblastoma
Carcinoma, Renal Cell
Hepatocellular Carcinoma
Advanced Renal Cell Carcinoma
Lung Cancer
Metastatic Renal Cell Carcinoma
Relapsed Pediatric Solid Tumor; Refractory Pediatric Solid Tumor; Relapsed Pediatric AML; Refractory Pediatric AML
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Cholangiocarcinoma of the Extrahepatic Bile Duct; Gallbladder Cancer
Thyroid Cancer
Pleomorphic Rhabdomyosarcoma; Stage IIB Adult Soft Tissue Sarcoma AJCC v7; Stage III Adult Soft Tissue Sarcoma AJCC v7; Stage IV Adult Soft Tissue Sarcoma AJCC v7
Ovarian Cancer
Breast Cancer
Carcinoma, Hepatocellular
Extrahepatic Bile Duct Adenocarcinoma; Gallbladder Adenocarcinoma; Gallbladder Adenocarcinoma With Squamous Metaplasia; Hilar Cholangiocarcinoma; Recurrent Extrahepatic Bile Duct Carcinoma; Recurrent Gallbladder Carcinoma; Undifferentiated Gallbladder Carcinoma; Unresectable Extrahepatic Bile Duct Carcinoma; Unresectable Gallbladder Carcinoma
Prostate Cancer
Breast Cancer
Male Breast Cancer; Recurrent Breast Cancer; Stage IV Breast Cancer
Lung Cancer
Metastatic Renal Cell Carcinoma
Neuroendocrine Tumors
Recurrent Melanoma; Stage III Skin Melanoma; Stage IV Skin Melanoma
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary
Hepatocellular Carcinoma
Acute Bilineal Leukemia; Acute Biphenotypic Leukemia; Acute Leukemia of Ambiguous Lineage; Acute Undifferentiated Leukemia; Mixed Phenotype Acute Leukemia; Mixed Phenotype Acute Leukemia, B/Myeloid, Not Otherwise Specified; Mixed Phenotype Acute Leukemia, T/Myeloid, Not Otherwise Specified; Recurrent Mixed Phenotype Acute Leukemia
Thyroid Cancer
neurofibromatosis1 (NF1); Recurrent or Progressive Optic Pathway Gliomas (OPG); Recurrent or Progressive Low-grade Glioma
Hepatocellular Carcinoma
Thyroid Carcinoma
FLT3-ITD Mutation; AML
HCC
Refractory Hurthle Cell Thyroid Cancer
Salivary Gland Cancer
Acute Myeloid Leukemia
Medullary Thyroid Carcinoma
HCC
Hepatocellular Carcinoma
Non-Small Cell Lung Cancer
Carcinoma, Hepatocellular
Sarcoma, Soft Tissue
Colorectal Cancer
Prostate Cancer
Adenocarcinoma of the Bladder; Distal Urethral Cancer; Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter; Proximal Urethral Cancer; Recurrent Bladder Cancer; Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter; Recurrent Urethral Cancer; Regional Transitional Cell Cancer of the Renal Pelvis and Ureter; Squamous Cell Carcinoma of the Bladder; Stage III Bladder Cancer; Stage IV Bladder Cancer; Transitional Cell Carcinoma of the Bladder; Urethral Cancer Associated With Invasive Bladder Cancer
Melanoma (Skin)
Stage III Melanoma; Stage IV Melanoma
Small Cell Lung Cancer
Hepatocellular Carcinoma
Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma
Thyroid Cancer; Thyroid Cancer, Medullary; Differentiated Thyroid Cancer; Papillary Thyroid Cancer; Follicular Thyroid Cancer; Poorly Differentiated Thyroid Gland Carcinoma
Carcinoma, Renal Cell
Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
Anaplastic Thyroid Cancer; Recurrent Thyroid Cancer
Hepatocellular Carcinoma
Breast Neoplasms; Breast Cancer
Carcinoma, Renal Cell
Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Hepatocellular Carcinoma
Advanced Adult Hepatocellular Carcinoma; BCLC Stage C Hepatocellular Carcinoma; Recurrent Adult Hepatocellular Carcinoma; Stage III Hepatocellular Carcinoma AJCC v7; Stage IIIA Hepatocellular Carcinoma AJCC v7; Stage IIIB Hepatocellular Carcinoma AJCC v7; Stage IIIC Hepatocellular Carcinoma AJCC v7; Stage IV Hepatocellular Carcinoma AJCC v7; Stage IVA Hepatocellular Carcinoma AJCC v7; Stage IVB Hepatocellular Carcinoma AJCC v7; Unresectable Hepatocellular Carcinoma
Pancreatic Cancer
Sarcoma; Synovial Sarcoma; Leiomyosarcoma; Malignant Peripheral Nerve Sheath Tumor
PHENYTOIN/SORAFENIB [VA Drug Interaction]; Carcinoma, Hepatocellular
Metastatic Renal Cell Carcinoma
Breast Cancer
Mesothelioma
Acute Myeloid Leukemia (AML)
Anaplastic Large Cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Mantle Cell Lymphoma
Cancer; Carcinoma, Non-Small Cell Lung
Hepatocellular Carcinoma; Hepatitis B; Hepatitis C
Carcinoma, Renal Cell
BCLC Stage C HCC; CP-B Liver Cirrhosis
Malignant Neoplasm of Stomach; Effects of Chemotherapy
Metastatic Renal Cell Carcinoma
Hepatocellular Carcinoma
Recurrent Uterine Sarcoma; Stage III Uterine Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma
Prostate Cancer
Metastatic Renal Cell Carcinoma
Colorectal Neoplasms
Renal Cell Carcinoma
Carcinoma, Renal Cell
Desmoplastic Small Round Cell Tumor; Ewing Sarcoma of Bone or Soft Tissue; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Carcinoma, Hepatocellular
Prostate Cancer
Renal Cell Carcinoma
Glioblastoma Multiforme
Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell Cancer
Hepatopulmonary Syndrome
Hepatocellular Cancer
Brain and Central Nervous System Tumors
Adenocarcinoma of the Prostate; Stage II Prostate Cancer; Stage III Prostate Cancer
Chronic Lymphocytic Leukemia
Kidney Cancer
Metastatic Disease; Renal Cell Carcinoma
Cancer; Melanoma
Hepatocellular Cancer
Advanced Hepatocellular Carcinoma; Inoperable Hepatocellular Carcinoma
Liver Cancer
Breast Cancer
Myelodysplastic Syndromes; Leukemia, Myelomonocytic, Chronic
Ovarian Neoplasms
Hereditary Thyroid Gland Medullary Carcinoma; Locally Advanced Thyroid Gland Medullary Carcinoma; Multiple Endocrine Neoplasia Type 2A; Multiple Endocrine Neoplasia Type 2B; Recurrent Thyroid Gland Medullary Carcinoma; Sporadic Thyroid Gland Medullary Carcinoma; Stage III Thyroid Gland Medullary Carcinoma AJCC v7; Stage IV Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVA Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVB Thyroid Gland Medullary Carcinoma AJCC v7; Stage IVC Thyroid Gland Medullary Carcinoma AJCC v7
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Metastatic Head and Neck Squamous Cell Carcinoma; Metastatic Squamous Cell Carcinoma of the Hypopharynx; Metastatic Squamous Cell Carcinoma of the Larynx; Metastatic Squamous Cell Carcinoma of the Oral Cavity; Metastatic Squamous Cell Carcinoma of the Oropharynx; Recurrent Head and Neck Squamous Cell Carcinoma; Recurrent Hypopharyngeal Squamous Cell Carcinoma; Recurrent Laryngeal Squamous Cell Carcinoma; Recurrent Oral Cavity Squamous Cell Carcinoma; Recurrent Oropharyngeal Squamous Cell Carcinoma
Hepatocellular Carcinoma
Stage III Hepatocellular Carcinoma AJCC v8; Stage IIIA Hepatocellular Carcinoma AJCC v8; Stage IIIB Hepatocellular Carcinoma AJCC v7; Stage IIIC Hepatocellular Carcinoma AJCC v7; Stage IV Hepatocellular Carcinoma AJCC v8; Stage IVA Hepatocellular Carcinoma AJCC v8; Stage IVB Hepatocellular Carcinoma AJCC v8
Hepatocellular Carcinoma Non-resectable
Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer
Cholangiocarcinoma of the Extrahepatic Bile Duct; Gallbladder Cancer
Advanced Renal Cell Carcinoma; Advanced Sarcomatoid Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary
Neoplasm; Metastasis
Advanced Hepatocellular Carcinoma
Metastatic Differentiated Thyroid Cancer; Metastatic Poorly Differentiated Thyroid Cancer; Metastatic Anaplastic Thyroid Cancer; Metastatic Medullary Thyroid Cancer
Carcinoma, Hepatocellular
Prostate Cancer
Hepatocellular Carcinoma
Adenocarcinoma of the Gastroesophageal Junction; Metastatic Gastric Cancer; Advanced Unresectable Gastric Cancer
Anaplastic Thyroid Cancer; Insular Thyroid Cancer; Recurrent Thyroid Cancer; Stage III Follicular Thyroid Cancer; Stage III Papillary Thyroid Cancer; Stage IV Follicular Thyroid Cancer; Stage IV Papillary Thyroid Cancer
Metastatic Breast Cancer
Sarcoma
Thyroid Cancer
Childhood Hepatocellular Carcinoma; Papillary Thyroid Cancer; Previously Treated Childhood Rhabdomyosarcoma; Recurrent Childhood Liver Cancer; Recurrent Childhood Rhabdomyosarcoma; Recurrent Thyroid Cancer; Recurrent Wilms Tumor and Other Childhood Kidney Tumors
Advanced Hepatocellular Carcinoma
Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer
Carcinoma, Renal Cell
Non-Small Cell Lung Cancer
Melanoma
Hepatocellular Carcinoma; Unresectable Hepatocellular Carcinoma; Carcinoma, Hepatocellular; Liver Neoplasm
Adult Primary Hepatocellular Carcinoma; Localized Resectable Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer
Adult Angiosarcoma; Adult Epithelioid Sarcoma; Adult Leiomyosarcoma; Adult Malignant Fibrous Histiocytoma; Adult Neurofibrosarcoma; Adult Synovial Sarcoma; Ovarian Sarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Uterine Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage III Uterine Sarcoma; Stage IV Adult Soft Tissue Sarcoma; Stage IV Uterine Sarcoma; Uterine Carcinosarcoma; Uterine Leiomyosarcoma
Lung Cancer
Kidney Cancer; Metastatic Cancer
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage IV Renal Cell Cancer
Breast Cancer; Metastatic Breast Cancer; Recurrent Breast Cancer
Leukemia
Epithelial Mesothelioma; Recurrent Malignant Mesothelioma; Sarcomatous Mesothelioma; Stage IA Malignant Mesothelioma; Stage IB Malignant Mesothelioma; Stage II Malignant Mesothelioma; Stage III Malignant Mesothelioma; Stage IV Malignant Mesothelioma
Thyroid Cancer
Hepatocellular Carcinoma
AML; FLT3-ITD Mutation
Nasopharyngeal Neoplasms
Carcinoma, Non-Small-Cell Lung
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Stage IV Renal Cell Cancer AJCC v7
Carcinoma, Hepatocellular
Esophageal Cancer; Gastroesophageal Junction Cancer
Locally Advanced Pancreatic Cancer
Breast Cancer
Hepatocellular Carcinoma
Stage IV Pancreatic Cancer
Lung Cancer
Carcinoma, Hepatocellular; Secondary
Overall Survival; Tumor Responses
Hepatocellular Carcinoma
Glioblastoma; Recurrent Adult Brain Neoplasm; Malignant Glioma; WHO Grade III Glioma
Bladder Cancer
Renal Cell Cancer
Melanoma
Carcinoma, Renal Cell
Carcinoma, Renal Cell; Kidney Disease; Kidney Cancer
Sarcoma
Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (Relapsed After a Cisplatin Based Treatment)
Advanced Hepatocellular Carcinoma; Metastatic Hepatocellular Carcinoma
Malignant Solid Neoplasms
Hepatocellular Carcinoma
Ovarian Neoplasm; Fallopian Tube Cancer; Primary Peritoneal Cancer
Malignant Melanoma
Adenocarcinoma of the Extrahepatic Bile Duct; Adenocarcinoma of the Gallbladder; Adenocarcinoma With Squamous Metaplasia of the Gallbladder; Cholangiocarcinoma of the Extrahepatic Bile Duct; Cholangiocarcinoma of the Gallbladder; Recurrent Extrahepatic Bile Duct Cancer; Recurrent Gallbladder Cancer; Squamous Cell Carcinoma of the Gallbladder; Unresectable Extrahepatic Bile Duct Cancer; Unresectable Gallbladder Cancer
Carcinoma, Hepatocellular
Adenocarcinoma
Lung Cancer
Non-Small Cell Lung Cancer
Thyroid Cancer, Anaplastic
Keloids
Renal Cell Carcinoma
Non-Small-Cell Lung Carcinoma
Carcinoma, Renal Cell
Liver Cancer
Locally Metastatic Malignant Neoplasm
Recurrent Glioblastoma Multiforme
Adrenocortical Carcinoma
PHENYTOIN/SORAFENIB [VA Drug Interaction]; Liver Neoplasms; Carcinoma, Hepatocellular; Digestive System Neoplasms; Neoplasms by Site; Liver Diseases; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; DOXORUBICIN/TRASTUZUMAB [VA Drug Interaction]; HBV
Hepatocellular Carcinoma
Carcinoma, Renal Cell
Clinically Significant Portal Hypertension
Hepatocellular Carcinoma
Bladder Cancer
Carcinoma, Hepatocellular
Hepatocellular Carcinoma
Bladder Cancer; URINARY BLADDER
Hepatocellular Carcinoma; Hepatoma
Melanoma
Metastatic Colorectal Cancer Patients With KRAS Mutated Tumors
Hepatocellular Carcinoma
Metastatic Renal Cell Carcinoma
Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Metastatic Osteosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Osteosarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma; Stage IV Adult Soft Tissue Sarcoma
Liver Cancer
Gastrinoma; Glucagonoma; Insulinoma; Metastatic Gastrointestinal Carcinoid Tumor; Neuroendocrine Tumor; Pancreatic Polypeptide Tumor; Recurrent Gastrointestinal Carcinoid Tumor; Recurrent Islet Cell Carcinoma; Somatostatinoma; WDHA Syndrome
Metastatic Renal Cell Carcinoma
Primary Peritoneal Carcinoma; Recurrent Ovarian Carcinoma
Hepatocellular Carcinoma; Liver Neoplasms; Digestive System Neoplasms; Sorafenib; Molecular Mechanisms of Pharmacological Action; Liver Diseases; Antineoplastic Agents; Protein Kinase Inhibitors
Kidney Cancer
Liver Carcinoma
Advanced Hepatocarcinoma
Testicular Cancer
Malignant Melanoma
Metastatic Osteosarcoma; Relapsed Osteosarcoma
Hepatocellular Carcinoma (HCC)
Metastatic Renal Cell Carcinoma
Osteosarcoma
Hepatocellular Carcinoma; Metastasis
Non-Small Cell Lung Cancer
Colorectal Cancer Metastatic
Melanoma (Skin)
Liver Cancer
Gastrointestinal Stromal Tumors
Metastatic Breast Cancer
Advanced Hepatocellular Carcinoma; Liver Cancer; Hepatic Cancer; Liver Neoplasms
Extrahepatic Bile Duct Cancer; Gallbladder Cancer
Breast Cancer
Liver Cancer
Advanced Hepatocellular Carcinoma
Colorectal Cancer Metastatic
Unspecified Adult Solid Tumor, Protocol Specific
Rhabdomyosarcoma
Bladder Cancer
Acute Myeloid Leukemia; AML, Childhood
Metastatic Colorectal Cancer
Hepatocellular Carcinoma
Refractory Chronic Lymphocytic Leukemia; Stage I Chronic Lymphocytic Leukemia; Stage II Chronic Lymphocytic Leukemia; Stage III Chronic Lymphocytic Leukemia; Stage IV Chronic Lymphocytic Leukemia
Pancreatic Cancer
Carcinoma, Renal Cell
Liver Cancer
Hepatocellular Carcinoma
Reccurent/Metastatic Solid Tumor Disease
Metastatic Prostate Cancer
Ovarian Cancer
Uveal Melanoma
Adenocarcinoma of Colon; Adenocarcinoma of Rectum; Metastatic Disease
Breast Cancer
Differentiated Thyroid Cancer
Metastatic Breast Cancer
Hepatocellular Carcinoma
Leukemia; Acute Myeloid Leukemia
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Lung Cancer
Carcinoma, Renal Cell
Advanced Solid Tumors
Advanced Gastric Cancer
Renal Cell Carcinoma
Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm
Hepatocellular Carcinoma
Recurrent Breast Cancer; Stage IV Breast Cancer
Hepatocellular Carcinoma; Liver Cancer
Advanced Hepatocellular Carcinoma
Prostate Cancer
Leukemia
Hepatocellular Carcinoma
Renal Cell Carcinoma
Advanced Adult Hepatocellular Carcinoma
Leukemia; Myelodysplastic Syndromes
Prostate Cancer
Carcinoma, Hepatocellular
Liver Metastasis; Cancer
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Metastatic Colorectal Cancer
Hepatocellular Carcinoma
Pancreatic Neoplasms; Bile Duct Neoplasms
Chromophobe Renal Cell Carcinoma; Clear Cell Renal Cell Carcinoma; Papillary Renal Cell Carcinoma; Recurrent Renal Cell Carcinoma; Sarcomatoid Renal Cell Carcinoma; Stage IV Renal Cell Cancer
Advanced Hepatocellular Carcinoma
Kidney Cancer
Liver Carcinoma
Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
Unresectable Hepatocellular Cancer; Portal Vein Tumor Thrombus
Recurrent Renal Cell Carcinoma; Stage III Renal Cell Cancer AJCC v7; Stage IV Renal Cell Cancer AJCC v7
Colorectal Cancer
Acute Biphenotypic Leukemia; Acute Myeloid Leukemia; de Novo Myelodysplastic Syndrome; Myelodysplastic Syndrome; Myeloproliferative Neoplasm
Cholangiocarcinoma; Biliary Tract Cancer; Gallbladder Cancer
Blastic Phase; Childhood Acute Promyelocytic Leukemia With PML-RARA; Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Childhood Solid Neoplasm; Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Juvenile Myelomonocytic Leukemia; Philadelphia Chromosome Negative, BCR-ABL1 Positive Chronic Myelogenous Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Disease
AML; Acute Myeloid Leukemia; Myelodysplastic Disorders
Allogeneic Hematopoietic Stem Cell Transplant Recipient; Donor; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia
Melanoma (Skin)
Metastatic Breast Cancer
Advanced Cancer
Soft Tissue Sarcoma
Cancer of the Cervix
Soft Tissue Sarcoma
Squamous Cell Cancer
Liver Cancer
Hepatocellular Carcinoma Non-resectable; Hepatocellular Carcinoma Recurrent
Non-Small Cell Lung Cancer
Melanoma (Skin)
Advanced Adult Hepatocellular Carcinoma; Child-Pugh Class A; Stage III Hepatocellular Carcinoma; Stage IIIA Hepatocellular Carcinoma; Stage IIIB Hepatocellular Carcinoma; Stage IIIC Hepatocellular Carcinoma; Stage IV Hepatocellular Carcinoma; Stage IVA Hepatocellular Carcinoma; Stage IVB Hepatocellular Carcinoma
Multiple Myeloma
Carcinoma, Renal Cell
Breast Cancer
Metastatic Hepatocellular Carcinoma; Advanced Liver Cancer
Hepatocellular Carcinoma
Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Neoplasm
Metastatic Renal Cell Cancer
Hepatocellular Carcinoma
Metastatic Breast Cancer
Carcinoma, Non-Small-Cell Lung
Hepatocellular Carcinoma
Ovarian Cancer
Brain Tumor; Glioblastoma; Anaplastic Glioma
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatoma; Liver Neoplasms; Adenoma, Liver Cell; Carcinoma, Hepatocellular; Liver Neoplasms, Experimental
Acute Myeloid Leukemia
Hepatocellular Carcinoma
Sarcoma
Advanced Solid Tumors; Hepatocellular Carcinoma
Renal Cell Carcinoma
Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Stage III Multiple Myeloma; Stage IV Chronic Lymphocytic Leukemia; Unspecified Adult Solid Tumor, Protocol Specific
Cancer
Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Giant Cell Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
Primary Disease; Prostate Cancer
Hepatocellular Carcinoma
Neoplasms
Hepatocellular Cancer
Refractory Solid Tumors; Leukemia
SOLID TUMORS
Acinar Cell Adenocarcinoma of the Pancreas; Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage IV Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Pancreatic Cancer; Adenocarcinoma of the Pancreas
Metastatic Breast Cancer; Gastrointestinal Tumors
Carcinoma, Non-Small-Cell Lung; Lung Cancer
Ocular Melanoma
Renal Cancer; Melanoma
Hepatocellular Carcinoma
Small Cell Carcinoma; Lung Cancer
Adult Hepatocellular Carcinoma; Advanced Adult Hepatocellular Carcinoma; Localized Non-Resectable Adult Liver Carcinoma; Recurrent Adult Liver Carcinoma
Rhabdomyosarcoma and Other Soft Tissue Sarcomas; Ewing's Sarcoma Family of Tumors; Osteosarcoma; Neuroblastoma; Brain Tumors
Unresectable or Metastatic Hepatocellular Carcinoma (HCC)
Pancreatic Cancer
Leukemia, Acute Myeloid
Unspecified Adult Solid Tumor, Protocol Specific; Non-Small Cell Lung Cancer
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IIIA Hodgkin Lymphoma; Ann Arbor Stage IIIB Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Ann Arbor Stage IVA Hodgkin Lymphoma; Ann Arbor Stage IVB Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid Cell Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Prognostic Stage IV Breast Cancer AJCC v8; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage IIA Pancreatic Cancer AJCC v8; Stage IIB Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8; Unresectable Pancreatic Adenocarcinoma
Glioblastoma; Gliosarcoma
Hepatocellular Carcinoma
Metastatic Colorectal Cancer
Hepatocellular Carcinoma; Hepatocellular Cancer; Hepatoma; Liver Cancer
Advanced Solid Tumors; Lymphomas
Cirrhosis; Hepatitis B Infection; Hepatitis C Infection; Metastatic Malignant Solid Neoplasm; Recurrent Hepatocellular Carcinoma; Recurrent Malignant Solid Neoplasm; Refractory Malignant Neoplasm; Stage IV Hepatocellular Carcinoma AJCC v7; Unresectable Solid Neoplasm
Liver Cancer
Advanced Cancers
Kidney Diseases
Drug Interactions
Refractory or Relapsed Solid Tumors
Multiple Myeloma and Plasma Cell Neoplasm
Lung Cancer
Tumors Metastatic to Brain
Neoplasms
Gastric Cancer
Renal Cancer; Tumors
Refractory Malignancy
Neoplasms
Liver Cancer
Acute Myeloid Leukemia
Hepatocellular Carcinoma
Solid Tumors
Advanced Solid Tumors
Glioblastoma; Gliosarcoma; Anaplastic Astrocytoma; Anaplastic Oligoastrocytoma; Anaplastic Oligodendroglioma
Neoplasms
Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Resectable Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer
Urothelial Carcinoma; Bladder Cancer; Renal Pelvis Cancer; Ureter Cancer; Urethra Cancer
Acute Myelogenous Leukemia; Leukemia
Hepatocellular Cancer
Advanced Malignant Neoplasm
Melanoma; Recurrent Melanoma; Stage III Melanoma; Stage IV Melanoma
Fasting
Pulmonary Arterial Hypertension
Malignant Solid Tumour; Renal Cell Carcinoma; Non Small Cell Lung Carcinoma
Hepatocellular Carcinoma
Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia; Adult Acute Monoblastic Leukemia; Adult Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With Maturation; Adult Acute Myeloid Leukemia With Minimal Differentiation; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p22;q23); MLLT3-MLL; Adult Acute Myeloid Leukemia Without Maturation; Adult Acute Myelomonocytic Leukemia; Adult Acute Promyelocytic Leukemia With t(15;17)(q22;q12); PML-RARA; Adult Erythroleukemia; Adult Pure Erythroid Leukemia; Alkylating Agent-Related Acute Myeloid Leukemia; Blastic Phase; de Novo Myelodysplastic Syndrome; Previously Treated Myelodysplastic Syndrome; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndrome
Metastatic or Locally Advanced Solid Tumors
Acute Myeloid Leukemia; Infantile Leukemia (Both AML and ALL); Myelodysplastic Syndrome; Myelodysplastic/Myeloproliferative Neoplasms; Biphenotypic Leukemia
Carcinoma, Renal Cell
Breast Cancer; Brain Metastases
Neuroendocrine Tumor; Carcinoid Tumor; Pancreatic Neuroendocrine Tumor
Renal Cancer; Non Small Cell Lung Cancer (NSCLC); Soft Tissue Sarcoma
Hepatocellular Carcinoma
Kidney Cancer
Hepatocellular Carcinoma
Advanced Malignant Neoplasm; BRAF Gene Mutation; Metastatic Malignant Neoplasm; Recurrent Malignant Neoplasm; Refractory Malignant Neoplasm
Hepatocellular Carcinoma
Unspecified Adult Solid Tumor, Protocol Specific
Advanced Solid Tumor; Refractory to Standard Therapies
HepatoCellular Carcinoma; Unresectable HepatoCellular Carcinoma; Liver Cancer
Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia
Cancer
Melanoma
Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Blastic Phase Chronic Myelogenous Leukemia; Recurrent Adult Acute Myeloid Leukemia; Unspecified Adult Solid Tumor, Protocol Specific
Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Lung Cancer; Mesothelioma; Pancreatic Cancer; Prostate Cancer; Sarcoma
Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Advanced Adult Hepatocellular Carcinoma; BCLC Stage B Adult Hepatocellular Carcinoma; BCLC Stage C Adult Hepatocellular Carcinoma
Metastatic Colorectal Cancer
Prostate Cancer
Advanced Cancer
Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Multiple Myeloma; Splenic Marginal Zone Lymphoma; Stage II Multiple Myeloma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia
Kaposi's Sarcoma; HHV-8; KSHV
Hepatocellular Carcinoma; Pancreatic Cancer
Acute Myeloid Leukemia
Hepatocellular Cancer; Liver Cancer
Non-Small Cell Lung Cancer
Carcinoma, Hepatocellular
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma; Recurrent Metastatic Squamous Neck Cancer With Occult Primary; Recurrent Salivary Gland Cancer; Recurrent Squamous Cell Carcinoma of the Hypopharynx; Recurrent Squamous Cell Carcinoma of the Larynx; Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity; Recurrent Squamous Cell Carcinoma of the Nasopharynx; Recurrent Squamous Cell Carcinoma of the Oropharynx; Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Recurrent Verrucous Carcinoma of the Larynx; Recurrent Verrucous Carcinoma of the Oral Cavity; Salivary Gland Squamous Cell Carcinoma; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IVA Salivary Gland Cancer; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Oral Cavity Squamous Cell Carcinoma; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVA Verrucous Carcinoma of the Oral Cavity; Stage IVB Salivary Gland Cancer; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVB Verrucous Carcinoma of the Larynx; Stage IVB Verrucous Carcinoma of the Oral Cavity; Stage IVC Salivary Gland Cancer; Stage IVC Squamous Cell Carcinoma of the Larynx; Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IVC Squamous Cell Carcinoma of the Oropharynx; Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity; Stage IVC Verrucous Carcinoma of the Larynx; Stage IVC Verrucous Carcinoma of the Oral Cavity; Tongue Cancer; Untreated Metastatic Squamous Neck Cancer With Occult Primary
Advanced Solid Tumor
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Adult Solid Tumor, Protocol Specific
Advanced Cancers
Lung Cancer
Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Myelodysplastic Syndromes
Carcinoma, Non Small Cell Lung
Liver Cancer
Hepatocellular Carcinoma
Solid Tumor
Carcinoma, Renal Cell; Glioblastoma; Carcinoma, Hepatocellular
Carcinoma, Hepatocellular
Unspecified Adult Solid Tumor, Protocol Specific
Hepatocellular Cancer; Liver Cancer
Metastatic Renal Cell Carcinoma
Hepatocellular Carcinoma; Liver Cancer; Localized Unresectable Liver Cancer
Liver Cancer
Refractory Solid Tumors
Biological Availability
Acute Myeloid Leukemia; Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia
Melanoma (Skin)
Kidney Cancer; Liver Cancer
Carcinoma, Hepatocellular
Bladder Cancer
Hepatocellular Carcinoma
T Cell Lymphoma
Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia
Advanced Malignant Solid Neoplasm; Recurrent Melanoma; Refractory Malignant Solid Neoplasm; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7
Hepatocellular Carcinoma
Neoplasms
Neurofibromatosis Type I; Plexiform Neurofibroma
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Adult Solid Tumor
Neuroblastoma
Pancreatic Adenocarcinoma; Stage IA Pancreatic Cancer; Stage IB Pancreatic Cancer; Stage IIA Pancreatic Cancer; Stage IIB Pancreatic Cancer; Stage III Pancreatic Cancer; Recurrent Pancreatic Carcinoma
Recurrent Colon Carcinoma; Recurrent Rectal Carcinoma; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer
Hepatocellular Carcinoma
Locally Advanced Squamous Cell Carcinomas of the Head and Neck (SCCHN)
Hepatocellular Carcinoma
Advanced Malignancy; Advanced Solid Tumors; Cancer; Solid Tumors; Tumors
Solid Tumors; Advanced Cancer
Carcinoma
Adult Acute Basophilic Leukemia; Adult Acute Eosinophilic Leukemia; Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia
Liver Disease
Advanced Solid Tumors
Neoplasms
Advanced Cancer
Rectal Cancer
Neoplasms
Hepatocellular Carcinoma
Solid Tumors
Advanced Solid Tumors
Brain Metastases; Primary Brain Tumors
Hepatocellular Carcinoma
Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage III Colon Cancer; Stage III Rectal Cancer; Stage IV Colon Cancer; Stage IV Rectal Cancer
Carcinoma, Hepatocellular
Kidney Cancer
Hepatocellular Carcinoma; Liver Cancer; Liver Neoplasms; Metastatic Liver Cancer
Carcinoma, Renal Cell
Carcinoma, Hepatocellular
Hepatocellular Cancer; Non-small Cell Lung Cancer; Renal Cell Cancer; Colorectal Cancer
Hepatocellular Carcinoma
Carcinoma, Renal Cell; Carcinoma, Renal Cell (Advanced)
Differentiated Thyroid Cancer
Malignant Neoplasm
Carcinoma, Renal Cell
Renal Cell Carcinoma; GIST
Carcinoma, Renal Cell
Recurrent Childhood Brain Tumor
Cancer; Advanced Solid Tumors
Carcinoma, Hepatocellular
Hepatocellular Carcinoma; Perfusion Scanner
Carcinoma, Hepatocellular; Marker, Biological
HCC
Carcinoma, Renal Cell
Hepatocellular Carcinoma
Cancer
Renal Cell Carcinoma
Hepatocellular Carcinoma
Gastrointestinal Cancers
Renal Cell Cancer; Colorectal Cancer; GIST
Acute Myeloid Leukemia; FLT3-ITD Mutation
Acute Myeloid Leukemia With FLT3/ITD Mutation
Advanced or Metastatic Hepatocellular Carcinoma
Hepatocellular Carcinoma
Refractory Solid Tumors
Clear Cell Renal Cell Carcinoma
Hepatocellular Carcinoma
Carcinoma, Hepatocellular
Melanoma (Skin)
Carcinoma, Renal Cell; Carcinoma, Renal Cell (Advanced)
Carcinoma, Hepatocellular
Carcinoma, Hepatocellular
Renal Cell Carcinoma; Hepatocellular Carcinoma; Colorectal Carcinoma
Neoplastic Meningitis
Gastric Cancer.
Recurrent Acute Leukemia of Ambiguous Lineage; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Acute Leukemia of Ambiguous Lineage
Breast Cancer
Locally Advanced or Metastatic Renal Cell Carcinoma
Advanced Solid Tumors; Inoperable; Metastasis
Carcinoma, Hepatocellular
Hepatocellular Carcinoma; Liver Cancer
Hepatocellular Carcinoma; HIV; Chronic Hepatitis C; Hepatitis B Virus; Liver Cirrhosis
Refractory Solid Tumors
Kidney Cancer; Renal Cell Carcinoma Metastatic; Drug Toxicity; Drug Side Effect; Drug Mechanism
Hepatocellular Carcinoma; Portal Vein Tumor Thrombosis
Lung Cancer
Kidney Cancer
Cancer
Carcinoma, Renal Cell
Carcinoma, Hepatocellular; Neuroendocrine Tumors
Hepatocyte Receptor; Hepatocellular Carcinoma
Carcinoma, Renal Cell
Renal Cell Cancer
Advanced Adult Hepatocellular Carcinoma; Localized Non-Resectable Adult Hepatocellular Carcinoma; Stage III Childhood Hepatocellular Carcinoma; Stage IIIA Hepatocellular Carcinoma; Stage IIIB Hepatocellular Carcinoma; Stage IIIC Hepatocellular Carcinoma; Stage IV Childhood Hepatocellular Carcinoma; Stage IVA Hepatocellular Carcinoma; Stage IVB Hepatocellular Carcinoma
Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC)
HepatoCellular Carcinoma
Hepatocellular Carcinoma
Carcinoma, Renal Cell
Carcinoma, Hepatocellular
Patient's Satisfaction
Advanced Hepatocellular Carcinoma
Liver Metastases; Hepatocarcinoma
Carcinoma, Renal Cell
Carcinoma, Hepatocellular; Carcinoma, Renal Cell
Metastatic Renal Cell Cancer; GIST
Hereditary Clear Cell Renal Cell Carcinoma; Kidney Cancer
Carcinoma, Renal Cell
Advanced Malignancy
Carcinoma, Renal Cell
Hepatocellular Carcinoma
Hepatocellular Carcinoma
HCC
Thyroid Neoplasms
Hepatocellular Carcinoma
Metastatic Renal Cell Carcinoma
Carcinoma, Renal Cell
Metastatic Breast Cancer to the Brain
Hepatocellular Cancer
Renal Cell Carcinoma
Thyroid Carcinoma
HCC
Advanced or Metastatic Solid Malignancy
Hepatocellular Carcinoma
Kidney Cancer; Liver Cancer
Hepatocellular Carcinoma
Esophageal Cancer
Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
Acute Myeloid Leukemia
Hepatocellular Carcinoma
Hepatocellular Carcinoma
Carcinoma, Hepatocellular
Disseminated Malignant Neoplasm
Carcinoma, Hepatocellular
HCC; Radiofrequency Ablation; Sorafenib
Hepatocellular Cancer
Carcinoma, Renal Cell
Carcinoma, Hepatocellular
Metastatic Renal Cell Carcinoma (mRCC)
Study Phase
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Early Phase 1
Early Phase 1
Early Phase 1
N/A
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Recruitment Status
Terminated
Completed
Completed
Active, not recruiting
Unknown status
Recruiting
Completed
Completed
Terminated
Completed
Terminated
Recruiting
Completed
Completed
Active, not recruiting
Completed
Active, not recruiting
Unknown status
Active, not recruiting
Completed
Active, not recruiting
Completed
Completed
Completed
Completed
Recruiting
Completed
Completed
Recruiting
Completed
Completed
Completed
Completed
Terminated
Not yet recruiting
Withdrawn
Completed
Recruiting
Completed
Completed
Completed
Completed
Completed
Terminated
Active, not recruiting
Recruiting
Active, not recruiting
Recruiting
Completed
Recruiting
Completed
Completed
Completed
Unknown status
Unknown status
Terminated
Completed
Recruiting
Terminated
Unknown status
Completed
Terminated
Unknown status
Unknown status
Active, not recruiting
Completed
Recruiting
Completed
Completed
Recruiting
Completed
Terminated
Completed
Recruiting
Recruiting
Unknown status
Completed
Recruiting
Recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Active, not recruiting
Completed
Completed
Completed
Terminated
Unknown status
Completed
Terminated
Completed
Terminated
Completed
Recruiting
Terminated
Withdrawn
Completed
Completed
Recruiting
Completed
Terminated
Active, not recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Recruiting
Completed
Completed
Completed
Terminated
Withdrawn
Completed
Terminated
Recruiting
Terminated
Withdrawn
Unknown status
Completed
Terminated
Completed
Completed
Terminated
Completed
Recruiting
Completed
Terminated
Completed
Completed
Completed
Recruiting
Recruiting
Terminated
Recruiting
Active, not recruiting
Active, not recruiting
Completed
Terminated
Completed
Completed
Completed
Terminated
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Recruiting
Completed
Terminated
Completed
Completed
Completed
Recruiting
Active, not recruiting
Completed
Completed
Withdrawn
Unknown status
Withdrawn
Completed
Completed
Completed
Completed
Completed
Terminated
Unknown status
Completed
Terminated
Withdrawn
Completed
Active, not recruiting
Terminated
Completed
Terminated
Active, not recruiting
Completed
Completed
Terminated
Active, not recruiting
Completed
Completed
Completed
Unknown status
Unknown status
Completed
Unknown status
Completed
Completed
Completed
Not yet recruiting
Completed
Terminated
Completed
Terminated
Withdrawn
Completed
Completed
Unknown status
Unknown status
Terminated
Terminated
Active, not recruiting
Completed
Withdrawn
Unknown status
Completed
Completed
Completed
Terminated
Not yet recruiting
Completed
Completed
Terminated
Terminated
Completed
Completed
Completed
Completed
Completed
Unknown status
Terminated
Completed
Active, not recruiting
Unknown status
Completed
Active, not recruiting
Completed
Active, not recruiting
Recruiting
Completed
Recruiting
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Terminated
Terminated
Terminated
Completed
Completed
Recruiting
Completed
Completed
Unknown status
Terminated
Unknown status
Active, not recruiting
Completed
Unknown status
Completed
Terminated
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Unknown status
Completed
Unknown status
Completed
Completed
Completed
Recruiting
Unknown status
Active, not recruiting
Completed
Completed
Not yet recruiting
Completed
Completed
Unknown status
Completed
Unknown status
Recruiting
Unknown status
Completed
Completed
Completed
Terminated
Completed
Terminated
Completed
Unknown status
Terminated
Completed
Completed
Completed
Completed
Withdrawn
Completed
Unknown status
Unknown status
Completed
Terminated
Completed
Completed
Unknown status
Completed
Completed
Terminated
Completed
Completed
Completed
Recruiting
Completed
Completed
Completed
Completed
Terminated
Completed
Recruiting
Completed
Unknown status
Completed
Unknown status
Completed
Completed
Withdrawn
Completed
Completed
Unknown status
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Active, not recruiting
Unknown status
Completed
Recruiting
Completed
Active, not recruiting
Terminated
Recruiting
Completed
Active, not recruiting
Terminated
Completed
Completed
Completed
Terminated
Unknown status
Terminated
Completed
Unknown status
Completed
Terminated
Active, not recruiting
Unknown status
Completed
Completed
Terminated
Completed
Withdrawn
Completed
Suspended
Completed
Terminated
Completed
Active, not recruiting
Completed
Completed
Withdrawn
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Withdrawn
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Not yet recruiting
Completed
Completed
Recruiting
Terminated
Completed
Completed
Recruiting
Unknown status
Completed
Completed
Unknown status
Completed
Completed
Completed
Completed
Withdrawn
Terminated
Unknown status
Recruiting
Completed
Completed
Completed
Completed
Unknown status
Completed
Completed
Completed
Active, not recruiting
Terminated
Terminated
Terminated
Active, not recruiting
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Withdrawn
Completed
Withdrawn
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Recruiting
Terminated
Completed
Completed
Withdrawn
Completed
Active, not recruiting
Terminated
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Unknown status
Completed
Terminated
Active, not recruiting
Completed
Completed
Completed
Terminated
Completed
Active, not recruiting
Active, not recruiting
Completed
Completed
Withdrawn
Recruiting
Completed
Completed
Terminated
Completed
Active, not recruiting
Terminated
Completed
Active, not recruiting
Completed
Terminated
Unknown status
Completed
Active, not recruiting
Completed
Terminated
Completed
Completed
Completed
Completed
Withdrawn
Terminated
Completed
Completed
Completed
Completed
Completed
Withdrawn
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Active, not recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Active, not recruiting
Completed
Completed
Completed
Terminated
Completed
Active, not recruiting
Active, not recruiting
Completed
Terminated
Withdrawn
Completed
Completed
Active, not recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Terminated
Completed
Terminated
Completed
Recruiting
Completed
Completed
Terminated
Completed
Completed
Unknown status
Terminated
Terminated
Completed
Completed
Unknown status
Active, not recruiting
Completed
Completed
Not yet recruiting
Completed
Completed
Recruiting
Completed
Completed
Unknown status
Unknown status
Completed
Recruiting
Active, not recruiting
Unknown status
Completed
Completed
Completed
Unknown status
Withdrawn
Completed
Completed
Completed
Completed
Terminated
Terminated
Available
Active, not recruiting
Completed
Recruiting
Terminated
Recruiting
Terminated
Recruiting
Withdrawn
Recruiting
Recruiting
Completed
Completed
Unknown status
Completed
Recruiting
Withdrawn
Completed
Terminated
Completed
Unknown status
Completed
Recruiting
Completed
Completed
Unknown status
Unknown status
Unknown status
Completed
Completed
Completed
Completed
Terminated
Withdrawn
Completed
Completed
Unknown status
Terminated
Unknown status
Completed
Completed
Completed
Completed
Active, not recruiting
Unknown status
Completed
Active, not recruiting
Unknown status
Terminated
Recruiting
Unknown status
Terminated
Terminated
Completed
Completed
Recruiting
Completed
Completed
Completed
Completed
Unknown status
Completed
Completed
Completed
Recruiting
HH-30134
Preclinical
Neoplasms
HY-008
HY-008
Preclinical
Heyuan Biotechnology (Tianjin) Co Ltd
Leukemia, Myeloid, Acute
Lestaurtinib
SP-924, CEP-701, KT-5555, SPM-924, A-154475.0
Phase 3 Clinical
Kyowa Hakko Kirin
Bone Marrow Neoplasms, Leukemia, Myeloid, Polycythemia Vera, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prostatic Neoplasms, Psoriasis, Leukemia, Myeloid, Acute, Thrombocythemia, Essential
NCT Number
NCT00557193
NCT00586651
NCT00079482
NCT00494585
NCT00030186
NCT00081601
NCT00242827
NCT00236119
NCT00469859
NCT00668421
NCT00084422
NCT01150669
Intervention Type
Other;Biological;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other
Indications
Acute Lymphoblastic Leukemia; Acute Undifferentiated Leukemia; Childhood T Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic Leukemia
Polycythemia Vera; Essential Thrombocytosis
Acute Myeloid Leukemia
Leukemia; Myelofibrosis
Leukemia, Myeloid
Prostate Cancer
Myeloma
Psoriasis
Leukemia
Myelofibrosis; Essential Thrombocythemia; Polycythemia Vera
Neuroblastoma
Childhood Acute Lymphoblastic Leukemia; Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies
Study Phase
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
N/A
Recruitment Status
Active, not recruiting
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Unknown status
Completed
Completed
Pacritinib
SB-1518, ONX-0803
Phase 3 Clinical
S*Bio, Concert
Lymphoma, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Polycythemia Vera, Hodgkin Disease, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myelomonocytic, Chronic, Coronavirus Infections, Lymphoma, Mantle-Cell, Primary Myelofibrosis, Lymphoma, Non-Hodgkin, Leukemia, Myeloid, Acute, Lymphoma, Thrombocythemia, Essential
NCT Number
NCT04404361
NCT03165734
NCT01773187
NCT02055781
NCT01263899
NCT01436084
NCT02532010
NCT02469415
NCT02410551
NCT02277093
NCT04635059
NCT02251821
NCT02584777
NCT03645824
NCT00719836
NCT02677948
NCT00745550
NCT04520269
NCT02891603
NCT02807207
NCT02823171
NCT02807077
NCT02803762
NCT03601819
NCT02342353
NCT02323607
NCT02807116
NCT02807051
NCT02765724
NCT00741871
NCT02808455
NCT02564536
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Procedure;Drug;Behavioral
Drug
Drug
Other;Procedure;Radiation;Drug
Biological
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
COVID
Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis
Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis
Primary Myelofibrosis; Post-polycythemia Vera Myelofibrosis; Post-essential Thrombocythemia Myelofibrosis
Hodgkin Lymphoma; Mantle Cell Lymphoma; Indolent Lymphoma
Leukemia
Acute Myeloid Leukemia (AML)
Leukemia
Myeloproliferative Diseases
Colorectal Cancer
Prostate Cancer
Primary Myelofibrosis; Secondary Myelofibrosis
Primary Myelofibrosis
Myelofibrosis
Acute Myelogenous Leukemia; Chronic Myelogenous Leukemia; Chronic Myelomonocytic Leukemia; Myelodysplastic Syndromes; Myelofibrosis
Chronic Lymphocytic Leukemia; Lymphoma, Small Lymphocytic
Myelofibrosis; Myeloproliferative Disorders; Polycythemia Vera; Essential Thrombocythemia
Breast Cancer
Graft Vs Host Disease; GVHD
Healthy Subjects
Healthy
Myelofibrosis
Healthy
Lymphoma, T-Cell, Cutaneous; Lymphoma, T-Cell, Peripheral; Chronic Lymphocytic Leukemia; Lymphoproliferative Disorders; Waldenstrom Macroglobulinemia; Lymphoplasmacytic Lymphoma; Mantle Cell Lymphoma
Non-Small Cell Lung Cancer; Nonsmall Cell Lung Cancer; Carcinoma, Non-Small-Cell Lung
Recurrent Adult Acute Myeloid Leukemia; Secondary Acute Myeloid Leukemia; Therapy-Related Acute Myeloid Leukemia; Untreated Adult Acute Myeloid Leukemia
Healthy Subjects
Drug Interaction Study
Myelofibrosis
Lymphoma, Malignant; Hodgkin's Lymphoma; B Cell Lymphoma
Healthy Subjects
Chronic Myelomonocytic Leukemia; Juvenile Myelomonocytic Leukemia; Atypical Chronic Myeloid Leukemia; Myeloproliferative Neoplasm; Myelodysplastic Syndromes; Myelofibrosis
Study Phase
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Recruitment Status
Recruiting
Recruiting
Terminated
Terminated
Completed
Terminated
Terminated
Terminated
Terminated
Terminated
Not yet recruiting
Recruiting
Withdrawn
Recruiting
Completed
Withdrawn
Completed
Recruiting
Recruiting
Completed
Completed
Completed
Completed
Recruiting
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Withdrawn
SKLB-1028
SKLB-1028
Phase 3 Clinical
Sichuan University, China Shijiazhuang Pharmaceutical Group/Cspc
Leukemia, Leukemia, Myeloid, Acute
NCT Number
NCT04015024
NCT02859948
Intervention Type
Drug
Drug
Indications
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Study Phase
Phase 2
Phase 1
Recruitment Status
Not yet recruiting
Unknown status
Crenolanib Besylate
ARO-002, CP-868596, ARO-002-26, IND-112201, CP-868596-26
Phase 3 Clinical
Pfizer Pharmaceuticals Ltd (China)
Recurrence, Esophageal Neoplasms, Glioblastoma, Neoplasms, Gastrointestinal Stromal Tumors, Leukemia, Myeloid, Acute, Glioma, Carcinoma, Non-Small-Cell Lung
NCT Number
NCT03258931
NCT02298166
NCT02847429
NCT03250338
NCT02283177
NCT01522469
NCT02400255
NCT02626364
NCT03324243
NCT00386555
NCT01229644
NCT01657682
NCT01243346
NCT02626338
NCT02400281
NCT02270788
NCT01393912
NCT00949624
NCT03193918
NCT03620318
Intervention Type
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Newly Diagnosed FLT3 Mutated AML
Acute Myeloid Leukemia
GIST With D842V Mutated PDGFRA Gene
Relapsed/Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations
Newly Diagnosed AML With FLT3 Activating Mutations
Relapsed or Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations
Acute Myeloid Leukemia
Recurrent/Refractory Glioblastoma
Relapsed/Refractory FLT3-mutated AML
Carcinoma, Non-Small-Cell Lung
Glioma
Acute Myeloid Leukemia With FLT3 Activating Mutations That Has Relapsed or Been Refractory After One or More Prior Therapies
D842-related Mutant GIST
Relapsed/Refractory Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia
Acute Myeloid Leukemia
Diffuse Intrinsic Pontine Glioma; Progressive or Refractory High-Grade Glioma
Advanced Solid Tumors
Esophagogastric Adenocarcinoma
FLT3-ITD Mutation; FLT3/TKD Mutation; PDGFR-Alpha D842V; PDGFRA Gene Amplification
Study Phase
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
N/A
Recruitment Status
Recruiting
Terminated
Recruiting
Recruiting
Completed
Completed
Active, not recruiting
Completed
Withdrawn
Withdrawn
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Available
SEL-24
SEL-24, MEN-1703, SEL-24-1, SEL-24-B489, SEL-24 program
Phase 2 Clinical
Selvita
Leukemia, Myeloid, Acute
NCT Number
NCT03008187
Intervention Type
Drug
Indications
Acute Myeloid Leukemia
Study Phase
Phase 1/Phase 2
Recruitment Status
Recruiting
HM-43239
Phase 2 Clinical
Hanmi Pharmaceutical Co Ltd
Leukemia, Myeloid, Acute
NCT Number
NCT03850574
Intervention Type
Drug
Indications
Acute Myeloid Leukemia
Study Phase
Phase 1/Phase 2
Recruitment Status
Recruiting
RIVAL-01
TBio-6517
Phase 2 Clinical
Turnstone Biologics
Triple Negative Breast Neoplasms, Colorectal Neoplasms
NCT Number
NCT04301011
Intervention Type
Biological
Indications
Solid Tumor; Triple Negative Breast Cancer; Microsatellite Stable Colorectal Cancer
Study Phase
Phase 1/Phase 2
Recruitment Status
Recruiting
Fms-like tyrosine kinase 3 ligand (Celldex Therapeutics)
CDX-301
Phase 2 Clinical
Amgen Inc
Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Hodgkin Disease, Myelodysplastic Syndromes, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute, Carcinoma, Non-Small-Cell Lung, Leukemia, Lymphocytic, Chronic, B-Cell
NCT Number
NCT02839265
NCT04536077
NCT00019396
NCT03804944
NCT02200380
NCT02129075
NCT03789097
NCT01976585
NCT04616248
NCT03835533
NCT01465139
Intervention Type
Radiation;Drug
Procedure;Drug
Drug
Radiation;Biological;Drug
Drug
Other;Biological
Radiation;Drug
Drug
Biological;Radiation;Drug
Radiation;Drug;Device
Drug
Indications
Non-small Cell Lung Cancer (NSCLC)
Pancreatic Cancer; Cancer of the Pancreas; Pancreas Cancer
Stage IV Melanoma; Stage IV Renal Cell Cancer; Recurrent Renal Cell Cancer; Recurrent Melanoma
Breast Cancer
For Donors; Related Donors Giving Peripheral Blood Stem Cells (PBSC) to a Sibling; For Recipients; Acute Myelogenous Leukemia (AML); Acute Lymphoblastic Leukemia (ALL); Myelodysplastic Syndrome (MDS); Chronic Myelogenous Leukemia (CML); Non-Hodgkins Lymphoma (NHL); Hodgkins Disease (HD); Chronic Lymphocytic Leukemia (CLL)
Cutaneous Melanoma; Mucosal Melanoma; Ocular Melanoma; Stage IIB Cutaneous Melanoma AJCC v6 and v7; Stage IIC Cutaneous Melanoma AJCC v6 and v7; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7
Non-Hodgkin's Lymphoma; Metastatic Breast Cancer; Head and Neck Squamous Cell Carcinoma
Low-Grade B-cell Lymphoma
Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Breast Carcinoma; Prognostic Stage IV Breast Cancer AJCC v8; Unresectable Breast Carcinoma
Metastatic Castration-resistant Prostate Cancer
Healthy
Study Phase
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Recruitment Status
Active, not recruiting
Not yet recruiting
Completed
Recruiting
Terminated
Active, not recruiting
Recruiting
Recruiting
Not yet recruiting
Recruiting
Completed
Sorafenib/MG-005
MGD-1509
Phase 2 Clinical
Metagone Biotech, Tri-Service General Hospital
Neoplasms
NCT Number
NCT03406364
Intervention Type
Drug
Indications
Solid Tumor
Study Phase
Phase 1/Phase 2
Recruitment Status
Completed
NMS-03592088
NMS-P088, NMS-03592088
Phase 2 Clinical
Nerviano Medical Sciences
Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute
NCT Number
NCT03922100
Intervention Type
Drug
Indications
Acute Myeloid Leukemia (AML); Chronic Myelomonocytic Leukemia (CMML)
Study Phase
Phase 1/Phase 2
Recruitment Status
Recruiting
E-6201
E-6201
Phase 2 Clinical
Eisai Co Ltd
Leukemia, Myelomonocytic, Chronic, Myeloproliferative Disorders, Myelodysplastic Syndromes, Psoriasis, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute, Brain metastases, Melanoma
NCT Number
NCT01268527
NCT00539929
NCT02418000
NCT00794781
NCT03332589
Intervention Type
Other;Drug
Drug
Drug
Drug
Drug
Indications
Psoriasis Vulgaris
Chronic Plaque Psoriasis
AML; MDS; CMML
Advanced Solid Tumors
Malignant Melanoma; Brain Metastases
Study Phase
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Recruitment Status
Completed
Completed
Terminated
Unknown status
Recruiting
Flysyn
4G8-SDIEM
Phase 2 Clinical
Synimmune
Leukemia, Myeloid, Acute
NCT Number
NCT02789254
Intervention Type
Biological
Indications
Acute Myeloid Leukemia
Study Phase
Phase 1/Phase 2
Recruitment Status
Active, not recruiting
Ningetinib Tosylate
CT-053, CT-053-PTSA
Phase 2 Clinical
Hec Pharm Co Ltd
Intestinal Neoplasms, Stomach Neoplasms, Carcinoma, Renal Cell, Leukemia, Myeloid, Acute, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular
NCT Number
NCT04601610
NCT03876925
NCT03758287
NCT04577703
NCT03125876
Intervention Type
Drug
Drug
Drug
Drug
Drug
Indications
Advanced HCC
Renal Cell Cancer Metastatic
Non-small Cell Lung Cancer
Advanced Solid Tumors
Acute Myeloid Leukemia (AML)
Study Phase
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Recruitment Status
Not yet recruiting
Recruiting
Recruiting
Completed
Recruiting
Mivavotinib
TAK-659
Phase 2 Clinical
Takeda Pharmaceutical Co Ltd
Solid tumours, Squamous Cell Carcinoma of Head and Neck, Lymphoma, Large B-Cell, Diffuse, Triple Negative Breast Neoplasms, Lymphoma, Follicular, Leukemia, Myeloid, Acute, Lymphoma, Lymphoma, Non-Hodgkin, Carcinoma, Non-Small-Cell Lung, Adenocarcinoma
NCT Number
NCT03123393
NCT04079738
NCT02323113
NCT03756818
NCT03772288
NCT02834247
NCT03742258
NCT03338881
NCT03359733
NCT03238651
NCT03357627
NCT02000934
NCT02954406
NCT02551055
Intervention Type
Drug
Drug
Drug
Other;Drug
Drug
Drug
Biological;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Diffuse Large B-cell Lymphoma
AML; AML, Adult
Acute Myelogenous Leukemia
Advanced Malignant Solid Neoplasm; KRAS Gene Mutation; Ovarian Carcinoma; Refractory Malignant Solid Neoplasm; Refractory Ovarian Carcinoma
Lymphoma, Non-Hodgkin
Triple-Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Head and Neck Carcinoma, Squamous Cell; Advanced Solid Tumors
Diffuse Large B-Cell Lymphoma; Diffuse Large B-Cell Lymphoma Activated B-Cell Type; Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type; Diffuse Large B-Cell Lymphoma, Not Otherwise Specified; High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 Rearrangements; High Grade B-Cell Lymphoma, Not Otherwise Specified; T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
Advanced Solid Neoplasms; Lymphoma Neoplasms
Lymphoma, Malignant; Advanced Solid Neoplasms
Lymphoma, Non-Hodgkin; Lymphoma, Follicular, Marginal Zone
Lymphoma, Non-Hodgkin; Lymphoma, Large B-cell, Diffuse; Lymphoma, Follicular
Advanced Solid Tumor and Lymphoma Malignancies
Lymphoma, Non-Hodgkin
Advanced and Metastatic Gastric or Gastroesophageal Adenocarcinoma
Study Phase
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Recruitment Status
Terminated
Recruiting
Completed
Recruiting
Withdrawn
Terminated
Recruiting
Withdrawn
Withdrawn
Completed
Active, not recruiting
Active, not recruiting
Completed
Terminated
FF-10101
FF-10101, FF-10101-01, FF-10101 succinate
Phase 2 Clinical
Fujifilm Corp
Leukemia, Myeloid, Acute
NCT Number
NCT03194685
Intervention Type
Drug
Indications
AML, Adult
Study Phase
Phase 1/Phase 2
Recruitment Status
Recruiting
CG-806
CG-806, CG-026806
Phase 2 Clinical
Crystalgenomics Inc, Aptose
Hematologic Neoplasms, Lymphoma, Non-Hodgkin, Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Chronic, B-Cell
NCT Number
NCT04477291
NCT03893682
Intervention Type
Drug
Drug
Indications
Acute Myeloid Leukemia
Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma; Non-Hodgkin's Lymphoma
Study Phase
Phase 1/Phase 2
Phase 1
Recruitment Status
Recruiting
Recruiting
Dovitinib
TKI-258, CHIR-258, GFKI-258, CHIR-258LC, NVP-TKI258
Phase 2 Clinical
Novartis Pharma Ag
Stomach Diseases, Linitis Plastica, Liver Neoplasms, Stomach Neoplasms, Carcinoma, Renal Cell, Carcinoma, Adenocarcinoma, Scirrhous, Neoplasms, Glioblastoma, Pancreatic Neoplasms, Multiple Myeloma, Adrenocortical Carcinoma, Carcinoma, Adenoid Cystic, Breast Neoplasms, Prostatic Neoplasms, Hepatic Insufficiency, Gastrointestinal Stromal Tumors, Colorectal Neoplasms, Endometrial Neoplasms, Leukemia, Myeloid, Acute, Thyroid Neoplasms, Neoplasms by Site, Carcinoma, Hepatocellular, Melanoma, Carcinoma, Non-Small-Cell Lung
NCT Number
NCT01223027
NCT02116803
NCT01379534
NCT01964144
NCT00831792
NCT01478373
NCT01831726
NCT01719549
NCT02108782
NCT01888965
NCT01514526
NCT01741116
NCT01528345
NCT01058434
NCT01440959
NCT01262027
NCT02065323
NCT00790426
NCT01266070
NCT01861197
NCT01232296
NCT01753713
NCT01635907
NCT01769547
NCT01417143
NCT01994590
NCT01732107
NCT00958971
NCT01791387
NCT01524692
NCT01678105
NCT01676714
NCT01576380
NCT00303251
NCT01921673
NCT01484041
NCT01700270
NCT01155713
NCT01515969
NCT00715182
NCT00243763
NCT01972750
NCT02720926
NCT01471548
NCT01714765
NCT01596647
NCT02048943
NCT00279773
NCT01030055
NCT01497392
NCT01421004
NCT02268435
NCT01496534
NCT01270906
NCT01548924
NCT00669097
NCT01443481
NCT01680796
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other;Drug
Drug
Drug
Other;Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Metastatic Renal Cell Carcinoma
Solid Tumors
Solid Tumors and Advanced Endometrial Cancer; Endometrial Cancer; Second-line Treatment; VEGF
Thyroid Cancer
Prostate Cancer
Gastrointestinal Stromal Tumors
Tumor Pathway Activations Inhibited by Dovitinib
Gastric Cancer
Gastrinoma; Glucagonoma; Insulinoma; Pancreatic Polypeptide Tumor; Recurrent Islet Cell Carcinoma; Somatostatinoma
Colorectal Cancer; Pancreas Cancer
Adrenocortical Carcinoma
Hormone Refractory Prostate Cancer
Metastatic Breast Cancer
Relapsed or Refractory Multiple Myeloma
Gastrointestinal Stromal Tumors
Breast Cancer
Prostate Cancer
Urothelial Cancer
Von Hippel-Lindau Syndrome
Squamous NSCLC
Hepatocellular Carcinoma
Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
Advanced Metastatic Paraganglioma; Advanced Metastatic Pheochromocytoma; Recurrent Paraganglioma; Recurrent Pheochromocytoma; Unresectable Paraganglioma; Unresectable Pheochromocytoma
Advanced Malignant Pleural Mesothelioma; MPM
Adenoid Cystic Carcinoma
Prostate Cancer
Bladder Cancer
Metastatic Breast Cancer
Clear Cell Renal Cell Carcinoma
Adenoid Cystic Carcinoma
Recurrent Adenoid Cystic Carcinoma of the Salivary Glands; Metastatic Adenoid Cystic Carcinoma of the Salivary Glands; Salivary Gland Cancers; ACC
Non-Small Cell Lung Cancer; Colorectal Cancer
Adenocarcinoma, Scirrhous; Linitis Plastica; Stomach Neoplasms; Stomach Diseases; Neoplasms by Site; Neoplasms
Melanoma
Gastric Cancer
Breast Cancer
Advanced Solid Tumors, Excluding Breast Cancer
Neoplasm; Cancer; Tumors
Non-small Cell Lung Cancer (NSCLC), Recurrent; Non-small Cell Lung Cancer (NSCLC), Stage IV
Advanced/ Metastatic Renal Cell Cancer
Multiple Myeloma
First or Second Recurrence of Glioblastoma
Colorectal Cancer; Gastric Cancer
Advanced Solid Tumors
Metastatic Clear Cell Renal Cancer
Advanced Solid Tumors, Excluding Breast Cancer
Duct Cell Adenocarcinoma of the Pancreas; Recurrent Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Acute Myeloid Leukemia
Neoplasms; Cancer; Tumors
Adenocarcinoma of the Pancreas; Stage III Pancreatic Cancer; Stage IV Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Advanced Solid Tumors; Excluding Breast Cancer
Gastrointestinal Stromal Tumors
Solid Tumors; Bladder Cancer
Neoplasms; Cancer; Tumors
Solid Tumors
Advanced Solid Malignancies
Solid Tumors; Hepatic Impairment
Multiple Myeloma
Study Phase
Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Recruitment Status
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Withdrawn
Terminated
Completed
Unknown status
Terminated
Completed
Completed
Completed
Withdrawn
Completed
Terminated
Unknown status
Completed
Completed
Completed
Terminated
Completed
Terminated
Terminated
Completed
Unknown status
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Terminated
Completed
Terminated
Unknown status
Terminated
Completed
Completed
Completed
Withdrawn
Terminated
Completed
Completed
Completed
Withdrawn
Terminated
Terminated
Terminated
Completed
Completed
Withdrawn
AMG-553
AMG-553
Phase 1 Clinical
Amgen Inc
Recurrence, Leukemia, Myeloid, Acute
NCT Number
NCT03904069
Intervention Type
Drug
Indications
Relapsed/Refractory Acute Myeloid Leukemia
Study Phase
Phase 1
Recruitment Status
Not yet recruiting
AMG-427 (Amgen)
AMG-427
Phase 1 Clinical
Amgen Inc
Recurrence
NCT Number
NCT03541369
Intervention Type
Drug
Indications
Relapsed/Refractory Acute Myeloid Leukemia (AML)
Study Phase
Phase 1
Recruitment Status
Recruiting
MRX-2843
MRX-2843, UNC-2025, UNC-2371
Phase 1 Clinical
Meryx, University Of North Carolina At Chapel Hill, University Of Colorado At Denver
Solid tumours, Pathologic Processes, Neoplastic Processes, Neoplasm Metastasis
NCT Number
NCT03510104
Intervention Type
Drug
Indications
Advanced Cancer; Metastatic Cancer; Neoplasms; Neoplasm Metastasis; Neoplastic Processes; Pathologic Processes
Study Phase
Phase 1
Recruitment Status
Recruiting
Hydroxychloroquine/Sorafenib
Phase 1 Clinical
Vg Life Sciences
Ovarian Neoplasms
NCT Number
NCT01634893
Intervention Type
Drug
Indications
Refractory or Relapsed Solid Tumors
Study Phase
Phase 1
Recruitment Status
Completed
QBH-196
QBH-196
Phase 1 Clinical
Shenyang Pharmaceutical University
Stomach Neoplasms
PLX-7486
PLX-7486, PLX7486-TsOH
Phase 1 Clinical
Daiichi Sankyo Co Ltd
Giant Cell Tumor of Tendon Sheath, Solid tumours, Pancreatic Neoplasms
NCT Number
NCT01804530
Intervention Type
Drug
Indications
Solid Tumor; Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations; Tenosynovial Giant Cell Tumor
Study Phase
Phase 1
Recruitment Status
Terminated
FN-1501
FN-1501
Phase 1 Clinical
China Pharmaceutical University
Neoplasms, Leukemia, Myeloid, Acute
NCT Number
NCT03690154
Intervention Type
Drug
Indications
Advanced Cancer; Solid Tumor
Study Phase
Phase 1
Recruitment Status
Recruiting
CA-4948
AU-4948, CA-4948
Phase 1 Clinical
Aurigene
Hematologic Neoplasms, Leukemia, Myeloid, Myelodysplastic Syndromes, Lymphoma, Non-Hodgkin, Leukemia, Myeloid, Acute
NCT Number
NCT04278768
NCT03328078
Intervention Type
Drug
Drug
Indications
Acute Myelogenous Leukemia; Myelodysplastic Syndrome
Relapsed Hematologic Malignancy; Refractory Hematologic Malignancy
Study Phase
Phase 1
Phase 1
Recruitment Status
Recruiting
Recruiting
Zotiraciclib
SB-1317, TG-02
Phase 1 Clinical
S*Bio
Myeloproliferative Disorders, Blast Crisis, Multiple Myeloma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Glioma, Leukemia, Myeloid, Acute, Leukemia, Lymphocytic, Chronic, B-Cell, Carcinoma, Hepatocellular
NCT Number
NCT02942264
NCT01699152
NCT03224104
NCT01204164
NCT03738111
Intervention Type
Drug
Drug
Radiation;Drug
Drug
Drug
Indications
Brain Tumor; Astrocytoma; Astroglioma; Glioblastoma; Gliosarcoma
Chronic Lymphocytic Leukemia; Small Lymphocytic Lymphoma
Astrocytoma, Grade III; Glioblastoma
AML; ALL; Blast Crisis; MDS; Multiple Myeloma
Hepatocellular Carcinoma
Study Phase
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Recruitment Status
Completed
Completed
Recruiting
Completed
Withdrawn
MAX-40279
Max-40279, MAX-40279-01, MAX-4, MAX-40279-001
Phase 1 Clinical
Guangzhou Maxinovel Pharmaceiticals Co Ltd
Leukemia, Myeloid, Acute
NCT Number
NCT03412292
NCT04183764
NCT04187495
Intervention Type
Drug
Drug
Drug
Indications
Acute Myelogenous Leukemia (AML)
Solid Tumor
AML
Study Phase
Phase 1
Phase 1
Phase 1
Recruitment Status
Recruiting
Recruiting
Recruiting
XY0206
XY-0206
Phase 1 Clinical
Shijiazhuang Yiling Pharmaceutical Co Ltd, Nanjing University Of Chinese Medicine
Solid tumours, Leukemia, Myeloid, Acute
NCT Number
NCT04471064
NCT03658070
Intervention Type
Drug
Drug
Indications
Acute Myeloid Leukemia
Advanced or Metastatic Solid Tumours
Study Phase
Phase 1
Phase 1
Recruitment Status
Recruiting
Recruiting
HYML-122
HYML-122, CHMFL-FLT3-122
Phase 1 Clinical
Hefei Academy Of Physical Sciences, Chinese Academy Of Sciences, Hefei Cosource Pharmaceuticals
Leukemia, Leukemia, Myeloid, Acute
SKI-G-801
G-801, SKI-G-801, G-749 Hydrochloride
Phase 1 Clinical
Oscotec
Leukemia, Myeloid, Acute
NCT Number
NCT03564288
Intervention Type
Drug
Indications
Acute Myeloid Leukemia
Study Phase
Phase 1
Recruitment Status
Recruiting
Clifutinib Besylate
Phase 1 Clinical
Guangdong Dongyangguang Pharmaceutical Co Ltd
Leukemia, Myeloid, Acute
L-21649
L-21649, L-000021649
Pending
Merck Sharp & Dohme Corp
Leukemia, Myeloid, Acute
Silvestrol
Pending
The Ohio State University, National Cancer Institute
Neoplasms
LOXO-102
LOXO-102, LOXO-103, LOXO-104
Pending
Array Biopharma, Eli Lilly And Company
Neoplasms
QLNC-3A6 Di-Maleate
Pending
Qilu Pharmaceutical Co Ltd, Qilu Antibiotics (Linyi) Pharmaceutical
Neoplasms
JNJ-28312141
JNJ-28312141
Discontinued
Johnson & Johnson
Arthritis, Rheumatoid
XL-999
XL-999, EXEL-0999
Discontinued
Symphony Evolution, Exelixis, Glaxosmithkline Plc
Ovarian Neoplasms, Carcinoma, Renal Cell, Multiple Myeloma, Colorectal Neoplasms, Leukemia, Myeloid, Acute, Carcinoma, Non-Small-Cell Lung
NCT Number
NCT00322673
NCT00277316
NCT00304590
NCT00277329
NCT00277303
NCT00277290
NCT00491699
NCT00104117
NCT00955084
NCT01945164
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Acute Myeloid Leukemia; AML
Renal Cell Carcinoma
Multiple Myeloma
Non-small Cell Lung Cancer
Colorectal Cancer
Ovarian Cancer
Non-Small-Cell Lung Cancer
Cancer
Advanced Malignancies
Advanced Malignancy
Study Phase
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1
Phase 1
Phase 1
N/A
Recruitment Status
Terminated
Terminated
Terminated
Terminated
Terminated
Terminated
Terminated
Completed
Completed
No longer available
AC-886
AC-886
Discontinued
Daiichi Sankyo Co Ltd
Leukemia, Myeloid, Acute
Tozasertib
VX-680, MK-0457
Discontinued
Vertex Pharmaceuticals Incorporated
Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myelodysplastic Syndromes, Leukemia, Prolymphocytic, B-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung
NCT Number
NCT00290550
NCT00405054
NCT00111683
NCT00099346
NCT02532868
NCT00500006
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Carcinoma, Non-Small-Cell Lung
Leukemia
Chronic Myelogenous Leukemia in Blast Crisis; Lymphocytic Leukemia, B Cell, Acute; Myelodysplastic Syndromes; Myelogenous Leukemia, Chronic
Colorectal Cancer; Advanced Solid Tumors
Cancer
Chronic Myelogenous Leukemia; Leukemia, Lymphoblastic, Acute, Philadelphia-Positive
Study Phase
Phase 2
Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Recruitment Status
Terminated
Terminated
Completed
Terminated
Terminated
Terminated
AM-5992
AM-5992
Discontinued
Amgen Inc
Leukemia, Myeloid, Acute
SU-014813
SU-14813, SU-014813
Discontinued
Pfizer Pharmaceuticals Ltd (China)
Breast Neoplasms
NCT Number
NCT00322517
NCT00982267
Intervention Type
Drug
Drug
Indications
Breast Neoplasms
Neoplasms; Solid Tumors
Study Phase
Phase 2
Phase 1
Recruitment Status
Completed
Completed
LY-2457546
LY-2457546
Discontinued
Eli Lilly And Company
Leukemia, Myeloid, Acute
SGI-1776
SG-0407, SGI-1776
Discontinued
Astex Pharmaceuticals
Recurrence, Prostatic Neoplasms, Lymphoma, Non-Hodgkin
NCT Number
NCT00848601
NCT01239108
Intervention Type
Drug
Drug
Indications
Prostate Cancer; Non-Hodgkins Lymphoma
Relapsed/Refractory Leukemias
Study Phase
Phase 1
Phase 1
Recruitment Status
Terminated
Withdrawn
SC-71710
4SC-203, SC-71710
Discontinued
4sc Ag, Proqinase
Leukemia, Myeloid, Acute
NCT Number
NCT01054937
Intervention Type
Drug
Indications
Acute Myeloid Leukemia
Study Phase
Phase 1
Recruitment Status
Completed
CT-1578
CT-1578, SB-1578, ONX-0805
Discontinued
S*Bio
Arthritis, Rheumatoid
NCT Number
NCT01235871
Intervention Type
Drug
Indications
Healthy Volunteer
Study Phase
Phase 1
Recruitment Status
Completed
Tandutinib
MLN-518, CT-53518, MLN-0518
Discontinued
Takeda Pharmaceutical Co Ltd
Carcinoma, Renal Cell, Myelodysplastic Syndromes, Glioblastoma, Leukemia, Myeloid, Acute
NCT Number
NCT00390468
NCT00408902
NCT00667394
NCT00379080
NCT00297921
NCT00904852
NCT00274248
NCT00064584
Intervention Type
Drug
Other;Drug
Procedure;Biological;Drug
Procedure;Other;Drug
Drug
Drug
Drug
Drug
Indications
Metastatic Cancer; Pain; Prostate Cancer
Clear Cell Renal Cell Carcinoma; Recurrent Renal Cell Cancer; Stage IV Renal Cell Cancer
Glioblastoma; Gliosarcoma; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Anaplastic Mixed Oligoastrocytoma
Adult Brain Tumor; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
Acute Myelogenous Leukemia
Glioblastoma Multiforme
Acute Myelogenous Leukemia
Acute Myelogenous Leukemia; Myelodysplastic Syndrome
Study Phase
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Recruitment Status
Completed
Completed
Completed
Completed
Withdrawn
Withdrawn
Completed
Completed
AT-9283
AT-9283
Discontinued
Otsuka
Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Myelodysplastic Syndromes, Multiple Myeloma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Primary Myelofibrosis, Leukemia, Myeloid, Acute
NCT Number
NCT01145989
NCT00522990
NCT00443976
NCT01431664
NCT00985868
Intervention Type
Drug
Drug
Drug
Other;Drug
Other;Drug
Indications
Multiple Myeloma
Acute Myeloid Leukemia; Acute Lymphoblastic Leukemia; Chronic Myeloid Leukemia; Myelodysplastic Syndromes; Myelofibrosis
Non-Hodgkins Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific
Leukemia
Unspecified Childhood Solid Tumor, Protocol Specific
Study Phase
Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Recruitment Status
Completed
Terminated
Completed
Completed
Completed
Amuvatinib
HPK-56, MP-470
Discontinued
Astex Pharmaceuticals
Small Cell Lung Carcinoma
NCT Number
NCT01357395
NCT00881166
NCT00894894
NCT00504205
Intervention Type
Drug
Drug
Drug
Other;Procedure;Drug
Indications
Small Cell Lung Carcinoma
Malignant Disease
Solid Tumors
Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific
Study Phase
Phase 2
Phase 1
Phase 1
N/A
Recruitment Status
Completed
Completed
Completed
Terminated
Imidacrine
XF-02, C-1311, XLS-002, NSC-645809
Discontinued
University Of Bradford
Breast Neoplasms, Colorectal Neoplasms
AKN-028
BVT-II, AKN-028, BVT-63628
Discontinued
Akinion
Leukemia, Myeloid, Acute
NCT Number
NCT01573247
Intervention Type
Drug
Indications
Acute Myeloid Leukemia
Study Phase
Phase 1/Phase 2
Recruitment Status
Terminated
AG-2034
AG-2034, AGL-2034
Discontinued
Yissum
Neoplasms
KW-2449
KW-2449
Discontinued
Kyowa Hakko Kirin
Hematologic Neoplasms, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Myelodysplastic Syndromes, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute
NCT Number
NCT00779480
NCT00346632
Intervention Type
Drug
Drug
Indications
Acute Myelogenous Leukemia (AML)
Acute Myelogenous Leukemia; Acute Lymphoblastic Leukemia; Myelodysplastic Syndromes; Chronic Myelogenous Leukemia
Study Phase
Phase 1
Phase 1
Recruitment Status
Terminated
Terminated
FLX-925
AMG-925, FLX-925
Discontinued
Amgen Inc
Leukemia, Myeloid, Acute
NCT Number
NCT02335814
Intervention Type
Drug
Indications
Acute Myeloid Leukemia
Study Phase
Phase 1
Recruitment Status
Terminated
IMC EB10
Discontinued
Eli Lilly And Company
Leukemia, Myeloid, Leukemia, Myeloid, Acute
NCT Number
NCT00887926
Intervention Type
Biological
Indications
Myeloid Leukemia
Study Phase
Phase 1
Recruitment Status
Terminated