FSHR
Synonyms
FSHR, FSH Receptor, Follicle Stimulating Hormone Receptor, FSH-R, ODG1, FSHR1, Receptors, FSH, LGR1, FSHRO, Follitropin Receptor, Follicle-Stimulating Hormone Receptor
Description
FSHR (Follicle-stimulating hormone receptor) is a G protein-coupled receptor for follitropin. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
KO Status
F0
Drug Information
Launched drugs: 21
Drugs in clinical trials: 12
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Follitropin alfa/Lutropin alfa
Approved
Merck Serono
Infertility, Female
NCT Number
NCT04719000
NCT02785822
NCT03177538
Intervention Type
Drug
Drug
Drug
Indications
Infertility
Polycystic Ovary Syndrome
Infertility, Female
Study Phase
Phase 4
Phase 4
Phase 4
Recruitment Status
Recruiting
Terminated
Completed
Follitropin beta biosimilar (Reliance Life Sciences)
Approved
Reliance Life Sciences
Endocrine System Diseases, Infertility, Female
Menotropins (Bharat serums and vaccines)
r-hMG
Approved
Bharat Serums And Vaccines
Infertility
Recombinant human FSH (LG Life Sciences)
Approved
Lg Chemical Ltd
Infertility, Female
Chorionic gonadotrophin (Merck & Co)
Approved
Merck Sharp & Dohme Corp
Infertility, Female
NCT Number
NCT03920514
NCT03115320
NCT01815138
NCT03423537
NCT04071574
NCT03825445
Intervention Type
Drug
Other, Drug
Drug
Drug
Drug
Drug
Indications
Intrauterine Insemination
Infertility
Ovarian Hyperstimulation Syndrome
HCG; IVF; Pregnancy Rates; ART; Chorionic Gonadotropin
Female Infertility; Female Infertility Due to Ovulatory Disorder; Premature Ovarian Failure; Polycystic Ovary Syndrome; Female Infertility of Tubal Origin; Ectopic Pregnancy; Salpingitis; Female Infertility Due to Tubal Block; Female Infertility Due to Tubal Occlusion; Hydrosalpinx; Female Infertility - Cervical/Vaginal; Female Infertility Endocrine; Endometriosis; Fibroids; Congenital Uterine Anomaly; Infections Uterine; Female Infertility of Other Origin
Ovulation Induction
Study Phase
Phase 4
Phase 4
Phase 4
Phase 3
N/A
N/A
Recruitment Status
Not yet recruiting
Terminated
Completed
Terminated
Active, not recruiting
Completed
Follicle stimulating hormone (Organon)
Org-33408
Approved
Merck Sharp & Dohme Corp
Infertility, Female
Follitropin alfa biosimilar (Teva)
XM-17
Approved
Teva
Anovulation
NCT Number
NCT02592031
NCT02809989
Intervention Type
Drug
Drug
Indications
Bioequivalence
Pregnancy Rate; Oocytes
Study Phase
Phase 1
N/A
Recruitment Status
Completed
Completed
Menotropin biosimilar (Klarvoyant Biogenics)
Approved
Infogix
Infertility
Follicle stimulating hormone biosimilar (Bharat Serums & Vaccines)
Approved
Bharat Serums And Vaccines
Infertility
Follicle stimulating hormone biosimilar (InSight Biopharmaceuticals)
Approved
Insight Biopharmaceuticals
Infertility, Female
Follicle stimulating hormone biosimilar (Sedico)
Approved
Sedico
Infertility
Follitropin alfa
SJ-0021
Approved
Merck Serono
Anovulation, Infertility, Hypogonadism, Infertility, Female
NCT Number
NCT00249834
NCT02892942
NCT01081626
NCT01504139
NCT04321551
NCT02430740
NCT00439829
NCT02719093
NCT03118830
NCT00298025
NCT01760278
NCT03057574
NCT02821819
NCT00328926
NCT01345812
NCT02992808
NCT00820482
NCT01210144
NCT00575302
NCT03737253
NCT01871532
NCT00835744
NCT00829244
NCT02140515
NCT03400722
NCT00889512
NCT00334425
NCT01267604
NCT03181685
NCT01783301
NCT02437032
NCT01185782
NCT01081639
NCT01687712
NCT01497197
NCT00335894
NCT01121666
NCT01084265
NCT00230815
NCT01183143
NCT01507376
NCT01071200
NCT00948805
NCT02335879
NCT00378001
NCT00702845
NCT02099916
NCT02237781
NCT02237755
NCT01112358
NCT00064987
NCT01337531
NCT01735422
NCT01110707
NCT02179255
NCT01604044
NCT02459418
NCT03535103
NCT01477073
NCT03857230
NCT03356964
NCT03237117
NCT01109654
NCT02329483
NCT01080729
NCT02128360
NCT01196143
NCT03914651
NCT01421095
NCT02477566
NCT01662180
NCT01100333
NCT00006156
NCT01269125
NCT02322398
NCT00989781
NCT02607293
NCT01125462
NCT02418533
NCT01115725
NCT01075854
NCT01100346
NCT01223079
NCT03358732
NCT02244866
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other, Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug, Dietary Supplement
Drug
Drug
Drug
Drug
Drug
Drug
Biological, Drug
Drug
Drug
Drug
Device
Drug
Drug
Drug
Drug
Biological
Drug
Biological, Drug
Drug
Drug
Drug
Drug
Procedure, Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Biological
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Other, Drug
Procedure, Drug
Drug
Radiation, Drug
Drug
Other
Drug
Drug
Drug
Drug
Drug
Device
Drug
Indications
Infertility
Infertility
Ovulation Induction
Progesterone Levels; Infertility
Transgenderism; Healthy
Infertility
Infertility
Infertility, Male; Varicocele
Invitro Fertilization
Infertile Women Undergoing Assisted Reproductive Technology (ART)
Embryo/Fetus Death; Blastocyst Disintegration; Aneuploidy; Complication of Implant; Chemical Pregnancy
Female Infertility
Infertility
Hypogonadotropic Hypogonadism
Patients for In Vitro Fertilization(IVF)Treatment
Infertility, Female
Ovarian Stimulation Preceding Intrauterine Insemination
In Vitro Fertilization
Infertility
Female Infertility
Infertility; Monofollicular Development
Infertility
Infertility
Infertility
Infertility, Female; Ovarian Stimulation; In Vitro Fertilisation
Infertility; Hypothalamic Amenorrhea; Hyperprolactinemia
Infertility
Infertility
Infertility; In Vitro Fertilization
Infertility
Infertility
Infertility; Ovulation Induction
Infertility; Ovulation Induction
Infertility
Infertility; Fertility; Follicle Stimulating Hormone Deficiency
Infertility
Infertility
Hypogonadism
Infertility
Infertility; Ovulation Induction; In-Vitro Fertilization
In Vitro Fertilization
Reproductive Techniques, Assisted
Infertility
Anovulation
Infertility
Infertility
Efficacy of DHEA; Pregnancy Rate; Diminished Ovarian Reserve; Changes in AMH
Female Infertility
Female Infertility
Ovarian Stimulation
Hypogonadism; Kallmann Syndrome
Polycystic Ovary Syndrome
Infertility
Infertility; Ovulation Induction
Female Infertility Due to Diminished Ovarian Reserve
Female Infertility
Healthy Volunteers
Infertility, Female
Female Infertility
Area Under Curve; Pharmacokinetics; Absorption
Progesterone Resistance
Female Infertility
Infertility
Infertility; Ovarian Hyperstimulation Syndrome
Multifollicular Stimulation
Infertility
Infertility
Infertility
Cancer; Infertility
In Vitro Fertilization; Polycystic Ovary Syndrome
Subfertility
Infertility
Healthy; Premature Ovarian Failure
Endometriosis; Infertility
Infertility
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
Infertility
Infertility; Fertility
Infertility
Multifollicular Stimulation
Infertility
Outcome During r-hFSH Stimulation; Outcome During r-hFSH and r-hLH Stimulation
The Study Focusses on Improving the Implantation Rate in IVF
Infertility
Study Phase
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2/Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
Phase 1
Phase 1
Phase 1
Early Phase 1
Early Phase 1
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Recruitment Status
Completed
Unknown status
Completed
Completed
Not yet recruiting
Recruiting
Completed
Unknown status
Completed
Completed
Unknown status
Unknown status
Terminated
Terminated
Terminated
Unknown status
Completed
Terminated
Withdrawn
Recruiting
Terminated
Completed
Completed
Unknown status
Unknown status
Terminated
Unknown status
Unknown status
Terminated
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Unknown status
Completed
Completed
Completed
Unknown status
Unknown status
Unknown status
Completed
Terminated
Unknown status
Completed
Completed
Enrolling by invitation
Completed
Completed
Unknown status
Completed
Completed
Completed
Unknown status
Completed
Unknown status
Terminated
Unknown status
Completed
Recruiting
Recruiting
Unknown status
Unknown status
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Follicle stimulating hormone biosimilar (Intas Pharmaceuticals)
Approved
Intas Biopharmaceuticals
Infertility, Female, Hypogonadism
Follitropin biosimilar (BioGeneric Pharma)
Approved
Biogeneric
Infertility, Female
Follitropin beta
Org-32489, CP090073
Approved
Merck Sharp & Dohme Corp
Infertility, Infertility, Female, Hypogonadism
NCT Number
NCT03755973
NCT04695483
NCT00823472
NCT01267604
NCT02719093
NCT02213627
NCT00866008
NCT00225433
NCT02069808
NCT02430740
NCT00750100
NCT02466204
NCT00702845
NCT00702806
NCT01286051
NCT01662180
NCT04142190
NCT03300518
NCT02635607
NCT00920634
NCT01882166
NCT00920361
NCT00702195
Intervention Type
Procedure, Drug
Drug
Drug
Drug, Dietary Supplement
Drug
Drug
Drug
Drug
Procedure, Drug
Drug
Drug
Drug
Biological, Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Infertility, Female; Endometrial Diseases
Infertility
in Vitro Fertilization; Ovulation Induction
Infertility
Infertility, Male; Varicocele
Female Reproductive Problem; Infertility
In Vitro Fertilization
Infertility
Egg Donation
Infertility
Infertility
Infertility
Infertility
Infertility; In Vitro Fertilization
Compare Pregnancy Rates Between FSH Stimulation and FSH and; GnRH Antagonist
Subfertility
Infertility
Infertility
Infertility
Anovulation
Infertility, Female
Fertilization in Vitro
Pregnancy
Study Phase
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 3
Phase 2
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Recruitment Status
Recruiting
Not yet recruiting
Terminated
Unknown status
Unknown status
Unknown status
Terminated
Completed
Completed
Recruiting
Completed
Completed
Completed
Completed
Completed
Unknown status
Completed
Recruiting
Unknown status
Completed
Terminated
Completed
Completed
Follitropin alfa biosimilar (Dong-A)
GX-F11, DA-3801
Approved
Dong-A Pharmaceutical Co Ltd
Anovulation, Infertility
NCT Number
NCT01820728
Intervention Type
Drug
Indications
Infertility; Anovulation
Study Phase
Phase 3
Recruitment Status
Completed
Follitropin alfa biosimilar (Finox Biotech)
Approved
Finox Biotech
Anovulation
NCT Number
NCT02625519
NCT01121666
NCT01687712
NCT01141270
NCT02459418
NCT02942849
NCT02941341
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Indications
Reproductive Techniques, Assisted
Infertility
Infertility
Healthy
Healthy Volunteers
Infertility
Infertility
Study Phase
Phase 4
Phase 3
Phase 3
Phase 1
Phase 1
N/A
N/A
Recruitment Status
Unknown status
Completed
Completed
Completed
Completed
Completed
Completed
Follitropin alfa biosimilar (CinnaGen)
rec Hu-FSH
Approved
Cinnagen
Infertility
Follitropin delta
FE-999049
Approved
Ferring Bv
Anovulation, Infertility, Infertility, Female
NCT Number
NCT01956110
NCT03738618
NCT01956123
NCT03228680
NCT03296527
NCT04773353
NCT03740737
NCT03809429
NCT01426386
NCT04778358
NCT02309671
NCT03564509
NCT04150861
NCT03830723
NCT03393780
NCT03697031
NCT04503707
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Other, Drug
Drug
Drug
Drug
Drug
Other, Drug
Drug
Drug
Drug
Drug
Drug
Indications
Infertility
Infertility, Female
Infertility
Infertility
Controlled Ovarian Simulation
Infertility
Infertility
Infertility, Female
Infertility
IVF
Infertility
Controlled Ovarian Stimulation
Infertility
Infertility; Intrauterine Insemination; Reproduction
Controlled Ovarian Stimulation
Controlled Ovarian Stimulation
Controlled Ovarian Stimulation
Study Phase
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1
N/A
N/A
N/A
N/A
Recruitment Status
Completed
Active, not recruiting
Completed
Completed
Active, not recruiting
Not yet recruiting
Active, not recruiting
Recruiting
Completed
Not yet recruiting
Completed
Completed
Completed
Active, not recruiting
Completed
Terminated
Recruiting
Urofollitropin biosimilar (Klarvoyant Biogenics)
Approved
Klarvoyant
Infertility, Male, Infertility, Female
Follicle stimulating hormone biosimilar (GeneScience Pharmaceuticals)
Genesci-008
Approved
Changchun Genescience Pharmaceutical Co Ltd
Infertility, Female
Follitropin alfa biosimilar (Qilu Pharmaceutical)
QL-1012
Phase 3 Clinical
Qilu Pharmaceutical Co Ltd
Anovulation, Infertility, Female
Urofollitropin
u-hFSH
Phase 3 Clinical
Merck Serono
Infertility, Infertility, Female
NCT Number
NCT00854373
NCT02544191
Intervention Type
Other, Drug
Drug
Indications
Infertility
Azoospermia
Study Phase
Phase 4
Phase 2
Recruitment Status
Completed
Unknown status
Follitropin alfa biosimilar (Allergan/Itero Biopharmaceuticals)
Phase 3 Clinical
Itero
Infertility
Follitropin beta biosimilar (Alapharmab)
LM-001
Phase 3 Clinical
Suzhou Alphamab Co Ltd
Endocrine System Diseases, Infertility, Infertility, Female
Recombinant human follicle-stimulating hormone-CTP fusion protein (Centergene)
Phase 3 Clinical
Centergene Pharmaceuticals, Suzhou Kangju Biotechnology Co Ltd
Infertility, Female
Corifollitropin alfa
FSH-CTP, MK-8962, Org-36286, SCH-900962
Phase 3 Clinical
Merck Sharp & Dohme Corp
Infertility, Hypogonadism
NCT Number
NCT02254928
NCT02046655
NCT02402192
NCT02490150
NCT02466204
NCT01633580
NCT03208972
NCT02213627
NCT02606500
NCT03177538
NCT04446845
NCT03939390
NCT02215135
NCT02471677
NCT03755973
NCT03939403
NCT01599494
NCT01816321
NCT01144416
NCT00696800
NCT01709331
NCT00702845
NCT03019575
NCT00696878
NCT03197077
NCT01146418
NCT00702585
NCT00702351
NCT01732068
NCT00697255
NCT00702806
NCT00598208
NCT01319695
NCT02448459
NCT00647933
NCT04416607
NCT04142190
NCT04482751
NCT00702234
NCT00702624
NCT00702273
NCT00702338
NCT03816670
NCT00702988
NCT01408615
NCT00703014
NCT00702546
Intervention Type
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Procedure, Drug
Drug
Drug
Drug
Biological, Drug
Biological, Drug
Drug
Biological, Drug
Drug
Biological, Drug
Procedure, Drug
Biological
Drug
Drug
Drug
Biological, Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Drug
Biological, Drug
Biological, Drug
Biological, Drug
Biological, Drug
Drug
Drug
Drug
Biological, Drug
Biological, Drug
Indications
Infertility
Subfertility
Infertility
Oocyte Donation
Infertility
Infertility
Infertility
Female Reproductive Problem; Infertility
Obesity
Infertility, Female
Infertility
Improving Ovarian Stimulation; Suboptimal Responders
In Vitro Fertilization
Infertility
Infertility, Female; Endometrial Diseases
Ovarian Stimulation
Infertility
Infertility; Poor Ovarian Response
Infertility
In Vitro Fertilization
Hypogonadism; Hypogonadotropic Hypogonadism
Infertility
Hypogonadotropic Hypogonadism
In Vitro Fertilization
Infertility, Female; Polycystic Ovary Syndrome
Infertility
Infertility
In Vitro Fertilization
Infertility; Poor Ovarian Response
Ovulation Induction
Infertility; In Vitro Fertilization
Fertilization
Infertility
Infertility
Infertility, Female
Infertility
Infertility, Female
Pregnancy; Neonates
Pregnancy; Neonates
In Vitro Fertilization
Pregnancy; Neonates
Fertility Disorders
Pregnancy; Neonates
Infertility, Female
Pregnancy; Neonates
In Vitro Fertilization
Study Phase
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 4
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 3
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 2
Phase 1/Phase 2
Phase 1
Phase 1
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
N/A
Recruitment Status
Terminated
Completed
Unknown status
Completed
Completed
Completed
Completed
Unknown status
Completed
Completed
Recruiting
Recruiting
Unknown status
Unknown status
Recruiting
Recruiting
Withdrawn
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Recruiting
Completed
Completed
Completed
Completed
Terminated
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Recruiting
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Completed
Follitropin alfa biosimilar (iVFarma)
Phase 3 Clinical
Bridge Pharma, Ivfarma
Infertility, Female
NCT Number
NCT03857230
Intervention Type
Drug
Indications
Area Under Curve; Pharmacokinetics; Absorption
Study Phase
Phase 1
Recruitment Status
Completed
Recombinant Human Follitropin (Beijing Shuanglu Pharmaceutical)
Phase 3 Clinical
Beijing Sl Pharmaceutical Co Ltd
Anovulation, Ovarian Diseases, Infertility, Female
Follitropin alfa biosimilar (JCR Pharmaceuticals/Aska)
JR-041, AKP-501
Phase 2 Clinical
Jcr Pharmaceuticals
Infertility
Choriogonadotropin beta
FE-999302
Phase 2 Clinical
Ferring Bv
Infertility
NCT Number
NCT02310919
NCT03564509
Intervention Type
Drug
Other, Drug
Indications
Infertility
Controlled Ovarian Stimulation
Study Phase
Phase 3
Phase 2
Recruitment Status
Completed
Completed
KN-015
KN-015
Phase 1 Clinical
Suzhou Alphamab Co Ltd
Infertility, Female
NCT Number
NCT03192527
Intervention Type
Drug
Indications
Infertility, Female
Study Phase
Phase 1
Recruitment Status
Unknown status
Recombinant Human Follicle Stimulating Hormone Fc Fusion Protein(Unicohealth)
IND
Guangzhou Unicohealth Biological Technology Co Ltd
Infertility
Corifollitropin alfa（Schering-Plough）
IND
ADX-68692
Cpd-23, ADX-68692, ADX-71743, ADX-71943, ADX-92639
Preclinical
Addex Therapeutics
Pain, Depressive Disorder, Major, Urinary Bladder, Overactive, Endometriosis, Muscle Spasticity, Prostatic Neoplasms, Gastroesophageal Reflux, Alzheimer Disease, Urinary Incontinence
Follitropin alfa biosimilar (Suzhou AlphaMab)
KN-006
Pending
Suzhou Alphamab Co Ltd
Infertility
Follicle stimulating hormone biosimilar (Amega Biotech)
Pending
Amega Biotech
Infertility, Male, Infertility, Female
Follitropin alfa biosimilar (GEMA)
Pending
Gema Pharma
Infertility
NCT Number
NCT02454556
Intervention Type
Drug
Indications
Infertility
Study Phase
Phase 3
Recruitment Status
Completed
AS 900672-Enriched
Discontinued
Merck Serono
Infertility
NCT Number
NCT00553514
NCT00505752
Intervention Type
Drug
Drug
Indications
Ovulation Induction
Infertility
Study Phase
Phase 2
Phase 2
Recruitment Status
Terminated
Completed
References
Title
Authors
Source
Cloning and sequencing of human FSH receptor cDNA
Minegish T., Nakamura K., Takakura Y., Ibuki Y., Igarashi M.,
Biochem. Biophys. Res. Commun. 175:1125-1130(1991)
Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts
Tilly J.L., Aihara T., Nishimori K., Jia X.-C., Billig H., Kowalski K.I., Perlas E.A., Hsueh A.J.,
Endocrinology 131:799-806(1992)
The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells
Kelton C.A., Cheng S.V., Nugent N.P., Schweickhardt R.L., Rosenthal J.L., Overton S.A., Wands G.D., Kuzeja J.B., Luchette C.A., Chappel S.C.,
Mol. Cell. Endocrinol. 89:141-151(1992)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,
Nature 434:724-731(2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor
Gromoll J., Gudermann T., Nieschlag E.,
Biochem. Biophys. Res. Commun. 188:1077-1083(1992)
New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype
Touraine P., Beau I., Gougeon A., Meduri G., Desroches A., Pichard C., Detoeuf M., Paniel B., Prieur M., Zorn J.-R., Milgrom E., Kuttenn F., Misrahi M.,
Mol. Endocrinol. 13:1844-1854(1999)
Characterization of single-nucleotide polymorphisms in coding regions of human genes
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,
Nat. Genet. 22:231-238(1999)
Distribution and function of FSH receptor genetic variants in normal men
Asatiani K., Gromoll J., Eckardstein S.V., Zitzmann M., Nieschlag E., Simoni M.,
Andrologia 34:172-176(2002)
A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure
Doherty E., Pakarinen P., Tiitinen A., Kiilavuori A., Huhtaniemi I., Forrest S., Aittomaeki K.,
J. Clin. Endocrinol. Metab. 87:1151-1155(2002)
A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics
Allen L.A., Achermann J.C., Pakarinen P., Kotlar T.J., Huhtaniemi I.T., Jameson J.L., Cheetham T.D., Ball S.G.,
Hum. Reprod. 18:251-256(2003)
Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene
Gromoll J., Dankbar B., Gudermann T.,
Mol. Cell. Endocrinol. 102:93-102(1994)
Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10
Gromoll J., Ried T., Holtgreve-Grez H., Nieschlag E., Gudermann T.,
J. Mol. Endocrinol. 12:265-271(1994)
Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors
Costagliola S., Panneels V., Bonomi M., Koch J., Many M.C., Smits G., Vassart G.,
EMBO J. 21:504-513(2002)
Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men
Song G.J., Park Y.S., Lee Y.S., Lee C.C., Kang I.S.,
Fertil. Steril. 77:499-504(2002)
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex
Nechamen C.A., Thomas R.M., Dias J.A.,
Mol. Cell. Endocrinol. 260:93-99(2007)
Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions
Jiang X., Dreano M., Buckler D.R., Cheng S., Ythier A., Wu H., Hendrickson W.A., el Tayar N.,
Structure 3:1341-1353(1995)
Structure of human follicle-stimulating hormone in complex with its receptor
Fan Q.R., Hendrickson W.A.,
Nature 433:269-277(2005)
Evidence for follicle-stimulating hormone receptor as a functional trimer
Jiang X., Fischer D., Chen X., McKenna S.D., Liu H., Sriraman V., Yu H.N., Goutopoulos A., Arkinstall S., He X.,
J. Biol. Chem. 289:14273-14282(2014)
Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure
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Cell 82:959-968(1995)
A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors
Kotlar T.J., Young R.H., Albanese C., Crowley W.F. Jr., Scully R.E., Jameson J.L.,
J. Clin. Endocrinol. Metab. 82:1020-1026(1997)
An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man
Gromoll J., Simoni M., Nieschlag E.,
J. Clin. Endocrinol. Metab. 81:1367-1370(1996)
The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry
Jiang M., Aittomaeki K., Nilsson C., Pakarinen P., Iitia A., Torresani T., Simonsen H., Goh V., Pettersson K., de la Chapelle A., Huhtaniemi I.,
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A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor
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J. Clin. Invest. 102:1352-1359(1998)
Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies
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J. Clin. Endocrinol. Metab. 88:3491-3498(2003)
A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome
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N. Engl. J. Med. 349:753-759(2003)
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor
Smits G., Olatunbosun O., Delbaere A., Pierson R., Vassart G., Costagliola S.,
N. Engl. J. Med. 349:760-766(2003)
A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome
Montanelli L., Delbaere A., Di Carlo C., Nappi C., Smits G., Vassart G., Costagliola S.,
J. Clin. Endocrinol. Metab. 89:1255-1258(2004)
Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology
De Leener A., Montanelli L., Van Durme J., Chae H., Smits G., Vassart G., Costagliola S.,
J. Clin. Endocrinol. Metab. 91:555-562(2006)
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome
De Leener A., Caltabiano G., Erkan S., Idil M., Vassart G., Pardo L., Costagliola S.,
Hum. Mutat. 29:91-98(2008)
Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome
Uchida S., Uchida H., Maruyama T., Kajitani T., Oda H., Miyazaki K., Kagami M., Yoshimura Y.,
PLoS ONE 8:E75478-E75478(2013)
Functional characterization of two naturally occurring mutations (Val514Ala and Ala575Val) in follicle-stimulating hormone receptor
Desai S.S., Achrekar S.K., Sahasrabuddhe K.A., Meharji P.K., Desai S.K., Mangoli V.S., Mahale S.D.,
J. Clin. Endocrinol. Metab. 100:E638-E645(2015)
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The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells.
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor.
Gromoll J., Gudermann T., Nieschlag E.,
Biochem. Biophys. Res. Commun. 188:1077-1083(1992)
Characterization of the 5' flanking region of the human follicle-stimulating hormone receptor gene.
Gromoll J., Dankbar B., Gudermann T.,
Mol. Cell. Endocrinol. 102:93-102(1994)
Localization of the human FSH receptor to chromosome 2p21 using a genomic probe comprising exon 10.
Gromoll J., Ried T., Holtgreve-Grez H., Nieschlag E., Gudermann T.,
J. Mol. Endocrinol. 12:265-271(1994)
Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.
Costagliola S., Panneels V., Bonomi M., Koch J., Many M.C., Smits G., Vassart G.,
EMBO J. 21:504-513(2002)
Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men.
Song G.J., Park Y.S., Lee Y.S., Lee C.C., Kang I.S.,
Fertil. Steril. 77:499-504(2002)
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.
Nechamen C.A., Thomas R.M., Dias J.A.,
Mol. Cell. Endocrinol. 260:93-99(2007)
Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions.
Jiang X., Dreano M., Buckler D.R., Cheng S., Ythier A., Wu H., Hendrickson W.A., el Tayar N.,
Structure 3:1341-1353(1995)
Structure of human follicle-stimulating hormone in complex with its receptor.
Fan Q.R., Hendrickson W.A.,
Nature 433:269-277(2005)
Evidence for follicle-stimulating hormone receptor as a functional trimer.
Jiang X., Fischer D., Chen X., McKenna S.D., Liu H., Sriraman V., Yu H.N., Goutopoulos A., Arkinstall S., He X.,
J. Biol. Chem. 289:14273-14282(2014)
Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure.
Aittomaeki K., Lucena J.L.D., Pakarinen P., Sistonen P., Tapanainen J., Gromoll J., Kaskikari R., Sankila E.-M., Lehvaslaiho H., Engel A.R., Nieschlag E., Huhtaniemi I., de la Chapelle A.,
Cell 82:959-968(1995)
A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors.
Kotlar T.J., Young R.H., Albanese C., Crowley W.F. Jr., Scully R.E., Jameson J.L.,
J. Clin. Endocrinol. Metab. 82:1020-1026(1997)
An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.
Gromoll J., Simoni M., Nieschlag E.,
J. Clin. Endocrinol. Metab. 81:1367-1370(1996)
The frequency of an inactivating point mutation (566C-->T) of the human follicle-stimulating hormone receptor gene in four populations using allele-specific hybridization and time-resolved fluorometry.
Jiang M., Aittomaeki K., Nilsson C., Pakarinen P., Iitia A., Torresani T., Simonsen H., Goh V., Pettersson K., de la Chapelle A., Huhtaniemi I.,
J. Clin. Endocrinol. Metab. 83:4338-4343(1998)
A novel phenotype related to partial loss of function mutations of the follicle stimulating hormone receptor.
Beau I., Touraine P., Meduri G., Gougeon A., Desroches A., Matuchansky C., Milgrom E., Kuttenn F., Misrahi M.,
J. Clin. Invest. 102:1352-1359(1998)
New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype.
Touraine P., Beau I., Gougeon A., Meduri G., Desroches A., Pichard C., Detoeuf M., Paniel B., Prieur M., Zorn J.-R., Milgrom E., Kuttenn F., Misrahi M.,
Mol. Endocrinol. 13:1844-1854(1999)
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,
Nat. Genet. 22:231-238(1999)
Distribution and function of FSH receptor genetic variants in normal men.
Asatiani K., Gromoll J., Eckardstein S.V., Zitzmann M., Nieschlag E., Simoni M.,
Andrologia 34:172-176(2002)
A novel mutation in the FSH receptor inhibiting signal transduction and causing primary ovarian failure.
Doherty E., Pakarinen P., Tiitinen A., Kiilavuori A., Huhtaniemi I., Forrest S., Aittomaeki K.,
J. Clin. Endocrinol. Metab. 87:1151-1155(2002)
A novel loss of function mutation in exon 10 of the FSH receptor gene causing hypergonadotrophic hypogonadism: clinical and molecular characteristics.
Allen L.A., Achermann J.C., Pakarinen P., Kotlar T.J., Huhtaniemi I.T., Jameson J.L., Cheetham T.D., Ball S.G.,
Hum. Reprod. 18:251-256(2003)
Delayed puberty and primary amenorrhea associated with a novel mutation of the human follicle-stimulating hormone receptor: clinical, histological, and molecular studies.
Meduri G., Touraine P., Beau I., Lahuna O., Desroches A., Vacher-Lavenu M.C., Kuttenn F., Misrahi M.,
J. Clin. Endocrinol. Metab. 88:3491-3498(2003)
A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome.
Vasseur C., Rodien P., Beau I., Desroches A., Gerard C., de Poncheville L., Chaplot S., Savagner F., Croue A., Mathieu E., Lahlou N., Descamps P., Misrahi M.,
N. Engl. J. Med. 349:753-759(2003)
Ovarian hyperstimulation syndrome due to a mutation in the follicle-stimulating hormone receptor.
Smits G., Olatunbosun O., Delbaere A., Pierson R., Vassart G., Costagliola S.,
N. Engl. J. Med. 349:760-766(2003)
A mutation in the follicle-stimulating hormone receptor as a cause of familial spontaneous ovarian hyperstimulation syndrome.
Montanelli L., Delbaere A., Di Carlo C., Nappi C., Smits G., Vassart G., Costagliola S.,
J. Clin. Endocrinol. Metab. 89:1255-1258(2004)
Presence and absence of follicle-stimulating hormone receptor mutations provide some insights into spontaneous ovarian hyperstimulation syndrome physiopathology.
De Leener A., Montanelli L., Van Durme J., Chae H., Smits G., Vassart G., Costagliola S.,
J. Clin. Endocrinol. Metab. 91:555-562(2006)
Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.
De Leener A., Caltabiano G., Erkan S., Idil M., Vassart G., Pardo L., Costagliola S.,
Hum. Mutat. 29:91-98(2008)
Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.
Uchida S., Uchida H., Maruyama T., Kajitani T., Oda H., Miyazaki K., Kagami M., Yoshimura Y.,
PLoS ONE 8:E75478-E75478(2013)
Functional characterization of two naturally occurring mutations (Val514Ala and Ala575Val) in follicle-stimulating hormone receptor.
Desai S.S., Achrekar S.K., Sahasrabuddhe K.A., Meharji P.K., Desai S.K., Mangoli V.S., Mahale S.D.,
J. Clin. Endocrinol. Metab. 100:E638-E645(2015)
Absence of mutations in the coding regions of follicle-stimulating hormone receptor gene in Singapore Chinese women with premature ovarian failure and polycystic ovary syndrome.
Tong Y., Liao W.X., Roy A.C., Ng S.C.,
Horm Metab Res 33:221-226(2001)
Mechanisms of gonadotropin desensitization.
Amsterdam A., Hanoch T., Dantes A., Tajima K., Strauss J.F., Seger R.,
Mol Cell Endocrinol 187:69-74(2002)
FSH-regulated gene expression profiles in ovarian tumours and normal ovaries.
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Mol Hum Reprod 8:426-433(2002)
Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
Feldman D.S., Zamah A.M., Pierce K.L., Miller W.E., Kelly F., Rapacciuolo A., Rockman H.A., Koch W.J., Luttrell L.M.,
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Mol Cell Endocrinol 189:157-168(2002)
Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor.
Vaskivuo T.E., Aittomaki K., Anttonen M., Ruokonen A., Herva R., Osawa Y., Heikinheimo M., Huhtaniemi I., Tapanainen J.S.,
Fertil Steril 78:108-113(2002)
Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants.
Wenzel-Seifert K., Liu H.Y., Seifert R.,
Biochem Pharmacol 64:9-20(2002)
Chimeras of the rat and human FSH receptors (FSHRs) identify residues that permit or suppress transmembrane 6 mutation-induced constitutive activation of the FSHR via rearrangements of hydrophobic interactions between helices 6 and 7.
Tao Y.X., Mizrachi D., Segaloff D.L.,
Mol Endocrinol 16:1881-1892(2002)
Genetic and functional analyses of polymorphisms in the human FSH receptor gene.
Sudo S., Kudo M., Wada S., Sato O., Hsueh A.J., Fujimoto S.,
Mol Hum Reprod 8:893-899(2002)
Follicle-stimulating hormone interacts with exoloop 3 of the receptor.
Sohn J., Ryu K., Sievert G., Jeoung M., Ji I., Ji T.H.,
J Biol Chem 277:50165-50175(2002)
Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction.
Simoni M., Nieschlag E., Gromoll J.,
Hum Reprod Update 8:413-421(2002)
An activated human follicle-stimulating hormone (FSH) receptor stimulates FSH-like activity in gonadotropin-deficient transgenic mice.
Haywood M., Tymchenko N., Spaliviero J., Koch A., Jimenez M., Gromoll J., Simoni M., Nordhoff V., Handelsman D.J., Allan C.M.,
Mol Endocrinol 16:2582-2591(2002)
The association of arrestin-3 with the follitropin receptor depends on receptor activation and phosphorylation.
Krishnamurthy H., Galet C., Ascoli M.,
Mol. Cell. Endocrinol. 204:127-140(2003)
Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein.
Zhang J.Y., Nawoschik S., Kowal D., Smith D., Spangler T., Ochalski R., Schechter L., Dunlop J.,
Eur J Pharmacol 472:33-38(2003)
Opposite contribution of two ligand-selective determinants in the N-terminal hormone-binding exodomain of human gonadotropin receptors.
Vischer H.F., Granneman J.C., Bogerd J.,
Mol Endocrinol 17:1972-1981(2003)
Postendocytotic trafficking of the follicle-stimulating hormone (FSH)-FSH receptor complex.
Krishnamurthy H., Kishi H., Shi M., Galet C., Bhaskaran R.S., Hirakawa T., Ascoli M.,
Mol Endocrinol 17:2162-2176(2003)
Regulation of follitropin receptor cell surface residency by the ubiquitin-proteasome pathway.
Cohen B.D., Bariteau J.T., Magenis L.M., Dias J.A.,
Endocrinology 144:4393-4402(2003)
Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.
de Castro F., Ruiz R., Montoro L., Perez-Hernandez D., Sanchez-Casas Padilla E., Real L.M., Ruiz A.,
Fertil Steril 80:571-576(2003)
Follicle-stimulating hormone receptor polymorphisms in women with normogonadotropic anovulatory infertility.
Laven J.S., Mulders A.G., Suryandari D.A., Gromoll J., Nieschlag E., Fauser B.C., Simoni M.,
Fertil Steril 80:986-992(2003)
Targeted expression of human FSH receptor Asp567Gly mutant mRNA in testis of transgenic mice: role of human FSH receptor promoter.
Nordhoff V., Gromoll J., Foppiani L., Luetjens C.M., Schlatt S., Kostova E., Huhtaniemi I., Nieschlag E., Simoni M.,
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Trans-activation of mutant follicle-stimulating hormone receptors selectively generates only one of two hormone signals.
Ji I., Lee C., Jeoung M., Koo Y., Sievert G.A., Ji T.H.,
Mol Endocrinol 18:968-978(2004)
New insights into the pathophysiology of ovarian hyperstimulation syndrome. What makes the difference between spontaneous and iatrogenic syndrome?
Delbaere A., Smits G., Olatunbosun O., Pierson R., Vassart G., Costagliola S.,
Hum Reprod 19:486-489(2004)
Age at natural menopause is not linked with the follicle-stimulating hormone receptor region: a sib-pair study.
Kok H.S., van Asselt K.M., Peeters P.H., van der Schouw Y.T., Grobbee D.E., Pearson P.L., Wijmenga C.,
Fertil Steril 81:611-616(2004)
Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor.
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Mol Endocrinol 18:2061-2073(2004)
Human follitropin receptor (FSHR) interacts with the adapter protein 14-3-3tau.
Cohen B.D., Nechamen C.A., Dias J.A.,
Mol Cell Endocrinol 220:1-7(2004)
Screening of FSH receptor gene in Argentine women with premature ovarian failure (POF).
Sundblad V., Chiauzzi V.A., Escobar M.E., Dain L., Charreau E.H.,
Mol Cell Endocrinol 222:53-59(2004)
Prediction of severity of symptoms in iatrogenic ovarian hyperstimulation syndrome by follicle-stimulating hormone receptor Ser680Asn polymorphism.
Daelemans C., Smits G., de Maertelaer V., Costagliola S., Englert Y., Vassart G., Delbaere A.,
J Clin Endocrinol Metab 89:6310-6315(2004)
Human follicle-stimulating hormone receptor (FSH-R) promoter/enhancer activity is inhibited by transcriptional factors, from the upstream stimulating factors family, via E-box and newly identified initiator element (Inr) in FSH-R non-expressing cells.
Putowski L.T., Schillings W.J., Lee C.M., Reddy E.P., Jakowicki J.A.,
Gynecol Endocrinol 19:9-17(2004)
Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron.
Hermann B.P., Heckert L.L.,
Mol Endocrinol 19:2112-2131(2005)
A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle.
Greb R.R., Grieshaber K., Gromoll J., Sonntag B., Nieschlag E., Kiesel L., Simoni M.,
J Clin Endocrinol Metab 90:4866-4872(2005)
Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity.
Urizar E., Montanelli L., Loy T., Bonomi M., Swillens S., Gales C., Bouvier M., Smits G., Vassart G., Costagliola S.,
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Association of human follitropin (FSH) receptor with splicing variant of human lutropin/choriogonadotropin receptor negatively controls the expression of human FSH receptor.
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Mol Endocrinol 19:2099-2111(2005)
Delineation of regions in the extracellular domain of follicle-stimulating hormone receptor involved in hormone binding and signal transduction.
Kene P.S., Dighe R.R., Mahale S.D.,
Am J Reprod Immunol 54:38-48(2005)
Absence of follicle-stimulating hormone receptor activating mutations in women with iatrogenic ovarian hyperstimulation syndrome.
d'Alva C.B., Serafini P., Motta E., Kohek M.B., Latronico A.C., Mendonca B.B.,
Fertil Steril 83:1695-1699(2005)
Follicle-stimulating hormone receptor gene haplotype distribution in normozoospermic and azoospermic men.
Ahda Y., Gromoll J., Wunsch A., Asatiani K., Zitzmann M., Nieschlag E., Simoni M.,
J Androl 26:494-499(2005)
Significance of a common single nucleotide polymorphism in exon 10 of the follicle-stimulating hormone (FSH) receptor gene for the ovarian response to FSH: a pharmacogenetic approach to controlled ovarian hyperstimulation.
Behre H.M., Greb R.R., Mempel A., Sonntag B., Kiesel L., Kaltwasser P., Seliger E., Ropke F., Gromoll J., Nieschlag E., Simoni M.,
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Follicle-stimulating hormone receptor polymorphisms in a population of infertile women.
Falconer H., Andersson E., Aanesen A., Fried G.,
Acta Obstet Gynecol Scand 84:806-811(2005)
Single-nucleotide polymorphisms in the promoter region influence the expression of the human follicle-stimulating hormone receptor.
Wunsch A., Ahda Y., Banaz-Yasar F., Sonntag B., Nieschlag E., Simoni M., Gromoll J.,
Fertil Steril 84:446-453(2005)
Role of nerve growth factor and FSH receptor in epithelial ovarian cancer.
Bose C.K.,
Reprod Biomed Online 11:194-197(2005)
Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology.
Galan J.J., Buch B., Cruz N., Segura A., Moron F.J., Bassas L., Martinez-Pineiro L., Real L.M., Ruiz A.,
Fertil Steril 84:910-918(2005)
Screening of FSH receptor gene mutation (C566T) in azoospermic men in Japan.
Ishikawa T., Fujisawa M., Tapanainen J.,
Arch Androl 52:15-19(2006)
Maintenance of spermatogenesis by the activated human (Asp567Gly) FSH receptor during testicular regression due to hormonal withdrawal.
Allan C.M., Garcia A., Spaliviero J., Jimenez M., Handelsman D.J.,
Biol Reprod 74:938-944(2006)
Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility.
Yang C.Q., Chan K.Y., Ngan H.Y., Khoo U.S., Chiu P.M., Chan Q.K., Xue W.C., Cheung A.N.,
Carcinogenesis 27:1502-1506(2006)
FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs.
Loutradis D., Patsoula E., Minas V., Koussidis G.A., Antsaklis A., Michalas S., Makrigiannakis A.,
J Assist Reprod Genet 23:177-184(2006)
[Follicular stimulating hormone receptor gene C566T mutation in premature ovarian failure].
Chen X.N., Chen G.A., Li M.Z.,
Zhonghua Fu Chan Ke Za Zhi 41:315-318(2006)
Mutation of the follicle-stimulating hormone receptor gene 5'-untranslated region associated with female hypertension.
Nakayama T., Kuroi N., Sano M., Tabara Y., Katsuya T., Ogihara T., Makita Y., Hata A., Yamada M., Takahashi N., Hirawa N., Umemura S., Miki T., Soma M.,
Hypertension 48:512-518(2006)
Follicle-stimulating hormone receptor gene polymorphism and ovarian responses to controlled ovarian hyperstimulation for IVF-ET.
Jun J.K., Yoon J.S., Ku S.Y., Choi Y.M., Hwang K.R., Park S.Y., Lee G.H., Lee W.D., Kim S.H., Kim J.G., Moon S.Y.,
J Hum Genet 51:665-670(2006)
A phosphorylation cluster of five serine and threonine residues in the C-terminus of the follicle-stimulating hormone receptor is important for desensitization but not for beta-arrestin-mediated ERK activation.
Kara E., Crepieux P., Gauthier C., Martinat N., Piketty V., Guillou F., Reiter E.,
Mol Endocrinol 20:3014-3026(2006)
Role of the intracellular domains of the human FSH receptor in G(alphaS) protein coupling and receptor expression.
Ulloa-Aguirre A., Uribe A., Zarinan T., Bustos-Jaimes I., Perez-Solis M.A., Dias J.A.,
Mol Cell Endocrinol 260-262:153-162(2007)
Assembly and structural characterization of an authentic complex between human follicle stimulating hormone and a hormone-binding ectodomain of its receptor.
Fan Q.R., Hendrickson W.A.,
Mol Cell Endocrinol 260-262:73-82(2007)
Follitropin receptors contain cryptic ligand binding sites.
Lin W., Bernard M.P., Cao D., Myers R.V., Kerrigan J.E., Moyle W.R.,
Mol Cell Endocrinol 260-262:83-92(2007)
The effect of splice variant of the human luteinizing hormone (LH) receptor on the expression of gonadotropin receptor.
Minegishi T., Nakamura K., Yamashita S., Omori Y.,
Mol Cell Endocrinol 260-262:117-125(2007)
FSH receptor genotype is associated with pregnancy but not with ovarian response in IVF.
Klinkert E.R., te Velde E.R., Weima S., van Zandvoort P.M., Hanssen R.G., Nilsson P.R., de Jong F.H., Looman C.W., Broekmans F.J.,
Reprod Biomed Online 13:687-695(2006)
FSH receptor gene polymorphisms in fertile and infertile Italian men.
Pengo M., Ferlin A., Arredi B., Ganz F., Selice R., Garolla A., Foresta C.,
Reprod Biomed Online 13:795-800(2006)
Genetic analysis of the follicle stimulating hormone receptor gene in women with polycystic ovary syndrome.
Orio F. Jr., Ferrarini E., Cascella T., Dimida A., Palomba S., Gianetti E., Colao A., Agretti P., Vitti P., Lombardi G., Pinchera A., Tonacchera M.,
J Endocrinol Invest 29:975-982(2006)
Follice-stimulating hormone receptor forms oligomers and shows evidence of carboxyl-terminal proteolytic processing.
Thomas R.M., Nechamen C.A., Mazurkiewicz J.E., Muda M., Palmer S., Dias J.A.,
Endocrinology 148:1987-1995(2007)
[The expression of gene encoding folitropin receptor in granulosa cells in women smoking cigarettes and nonsmokers participating in vitro fertilization programme].
Josiak M., Jedrzejczak P., Depa-Martynow M., Pawelczyk L.,
Przegl Lek 63:834-837(2006)
Poor ovarian response to gonadotropin stimulation is associated with low expression of follicle-stimulating hormone receptor in granulosa cells.
Cai J., Lou H.Y., Dong M.Y., Lu X.E., Zhu Y.M., Gao H.J., Huang H.F.,
Fertil Steril 87:1350-1356(2007)
Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism.
Ryan G.L., Feng X., d'Alva C.B., Zhang M., Van Voorhis B.J., Pinto E.M., Kubias A.E., Antonini S.R., Latronico A.C., Segaloff D.L.,
J Clin Endocrinol Metab 92:2312-2317(2007)
Effects of antisense oligodeoxynucleotide to follicle-stimulating hormone receptor on the cell proliferation and apoptosis in cells derived from human ovarian mucinous cystadenocarcinoma in Vitro.
Li S., Ma D., Zhu C.,
J Huazhong Univ Sci Technolog Med Sci 27:95-100(2007)
Polymorphism of the FSH receptor and ovarian response to FSH.
Wunsch A., Sonntag B., Simoni M.,
Ann Endocrinol (Paris) 68:160-166(2007)
Ras homolog enriched in striatum inhibits the functional activity of wild type thyrotropin, follicle-stimulating hormone, luteinizing hormone receptors and activating thyrotropin receptor mutations by altering their expression in COS-7 cells.
Agretti P., De Marco G., Pinchera A., Vitti P., Bernal J., Tonacchera M.,
J Endocrinol Invest 30:279-284(2007)
Early alterations in ovarian surface epithelial cells and induction of ovarian epithelial tumors triggered by loss of FSH receptor.
Chen X., Aravindakshan J., Yang Y., Sairam M.R.,
Neoplasia 9:521-531(2007)
Intrinsic differences in the response of the human lutropin receptor versus the human follitropin receptor to activating mutations.
Zhang M., Tao Y.X., Ryan G.L., Feng X., Fanelli F., Segaloff D.L.,
J Biol Chem 282:25527-25539(2007)
Estrogen receptor alpha gene polymorphisms are associated with idiopathic premature ovarian failure.
Bretherick K.L., Hanna C.W., Currie L.M., Fluker M.R., Hammond G.L., Robinson W.P.,
Fertil Steril 89:318-324(2008)
Absence of mutation in the follicle-stimulating hormone receptor gene in severe primary hypothyroidism associated with gonadal hyperstimulation.
Suarez E.A., d'Alva C.B., Campbell A., Miller-Horn J., Dever M., Faerber E., Medonca B.B., Latronico A.C., De Luca F.,
J Pediatr Endocrinol Metab 20:923-931(2007)
Gene polymorphisms and male infertility--a meta-analysis and literature review.
Tuttelmann F., Rajpert-De Meyts E., Nieschlag E., Simoni M.,
Reprod Biomed Online 15:643-658(2007)
Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome.
Binder H., Dittrich R., Hager I., Muller A., Oeser S., Beckmann M.W., Hamori M., Fasching P.A., Strick R.,
Reproduction 135:107-116(2008)
Functional and structural roles of conserved cysteine residues in the carboxyl-terminal domain of the follicle-stimulating hormone receptor in human embryonic kidney 293 cells.
Uribe A., Zarinan T., Perez-Solis M.A., Gutierrez-Sagal R., Jardon-Valadez E., Pineiro A., Dias J.A., Ulloa-Aguirre A.,
Biol Reprod 78:869-882(2008)
Comparative structural analysis of the binding domain of follicle stimulating hormone receptor.
Fan Q.R., Hendrickson W.A.,
Proteins 72:393-401(2008)
Follicle-stimulating hormone receptor polymorphism (Thr307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women.
Achrekar S.K., Modi D.N., Desai S.K., Mangoli V.S., Mangoli R.V., Mahale S.D.,
Fertil Steril 91:432-439(2009)
Analysis of single nucleotide polymorphisms of FSH receptor gene suggests association with testicular cancer susceptibility.
Ferlin A., Pengo M., Selice R., Salmaso L., Garolla A., Foresta C.,
Endocr Relat Cancer 15:429-437(2008)
Dissociation of heterotrimeric g proteins in cells.
Lambert N.A.,
Sci Signal 1:re5-re5(2008)
Screening of follicle-stimulating hormone receptor gene in women with premature ovarian failure in southern Brazil and associations with phenotype.
Vilodre L.C., Kohek M.B., Spritzer P.M.,
J Endocrinol Invest 31:552-557(2008)
Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
Simoni M., Tempfer C.B., Destenaves B., Fauser B.C.,
Hum Reprod Update 14:459-484(2008)
Predictors for partial suppression of spermatogenesis of hormonal male contraception.
Li J.W., Gu Y.Q.,
Asian J Androl 10:723-730(2008)
Anti-Mullerian hormone, its receptor, FSH receptor, and androgen receptor genes are overexpressed by granulosa cells from stimulated follicles in women with polycystic ovary syndrome.
Catteau-Jonard S., Jamin S.P., Leclerc A., Gonzales J., Dewailly D., di Clemente N.,
J Clin Endocrinol Metab 93:4456-4461(2008)
Follicle-stimulating hormone receptor DNA sequencing: investigation into possible glycoprotein receptor mutation in Van Wyk-Grumbach syndrome.
Sanjeevaiah A.R., Vassart G., Srikanta S.S.,
Endocr Pract 14:648-648(2008)
Mutations and polymorphisms of the FSH receptor (FSHR) gene: clinical implications in female fecundity and molecular biology of FSHR protein and gene.
Lussiana C., Guani B., Mari C., Restagno G., Massobrio M., Revelli A.,
Obstet Gynecol Surv 63:785-795(2008)
Critical involvement of the hinge region of the follicle-stimulating hormone receptor in the activation of the receptor.
Agrawal G., Dighe R.R.,
J Biol Chem 284:2636-2647(2009)
A distribution of two SNPs in exon 10 of the FSHR gene among the women with a diminished ovarian reserve in Ukraine.
Livshyts G., Podlesnaja S., Kravchenko S., Sudoma I., Livshits L.,
J Assist Reprod Genet 26:29-34(2009)
Follicle-stimulating hormone receptor polymorphism and seminal anti-Mullerian hormone in fertile and infertile men.
Zalata A.A., Hassan A.H., Nada H.A., Bragais F.M., Agarwal A., Mostafa T.,
Andrologia 40:392-397(2008)
Multilocus analyses reveal involvement of the ESR1, ESR2, and FSHR genes in migraine.
Oterino A., Toriello M., Cayon A., Castillo J., Colas R., Alonson-Arranz A., Ruiz-Alegria C., Quintela E., Monton F., Ruiz-Lavilla N., Gonzalez F., Pascual J.,
Headache 48:1438-1450(2008)
The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.
Heubner M., Riemann K., Otterbach F., Kimmig R., Kasimir-Bauer S., Siffert W., Wimberger P.,
Gynecol Oncol 112:486-489(2009)
A novel mutation in exon8 of the follicle-stimulating hormone receptor in a woman with primary amenorrhea.
Nakamura Y., Maekawa R., Yamagata Y., Tamura I., Sugino N.,
Gynecol Endocrinol 24:708-712(2008)
Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer.
Zhang Z., Jia L., Feng Y., Zheng W.,
Cancer Lett 278:56-64(2009)
Absence of 566C>T mutation in exon 7 of the FSHR gene in Indian women with premature ovarian failure.
Prakash G.J., Kanth V.V., Shelling A.N., Rozati R., Sujatha M.,
Int J Gynaecol Obstet 105:265-266(2009)
FSH receptor, KL1/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis.
Gonzalez-Fernandez R., Pena O., Hernandez J., Martin-Vasallo P., Palumbo A., Avila J.,
Fertil Steril 94:99-104(2010)
Poor ovarian response to gonadotrophin stimulation is associated with FSH receptor polymorphism.
Achrekar S.K., Modi D.N., Desai S.K., Mangoli V.S., Mangoli R.V., Mahale S.D.,
Reprod Biomed Online 18:509-515(2009)
Clomiphene citrate resistance in relation to follicle-stimulating hormone receptor Ser680Ser-polymorphism in polycystic ovary syndrome.
Overbeek A., Kuijper E.A., Hendriks M.L., Blankenstein M.A., Ketel I.J., Twisk J.W., Hompes P.G., Homburg R., Lambalk C.B.,
Hum Reprod 24:2007-2013(2009)
Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome.
Valkenburg O., Uitterlinden A.G., Piersma D., Hofman A., Themmen A.P., de Jong F.H., Fauser B.C., Laven J.S.,
Hum Reprod 24:2014-2022(2009)
Androgen, progesterone, and FSH receptor polymorphisms in ovarian cancer risk and outcome.
Ludwig A.H., Murawska M., Panek G., Timorek A., Kupryjanczyk J.,
Endocr Relat Cancer 16:1005-1016(2009)
No activating mutations of FSH receptor in four children with ovarian juvenile granulosa cell tumors and the association of these tumors with central precocious puberty.
Bas F., Pescovitz O.H., Steinmetz R.,
J Pediatr Adolesc Gynecol 22:173-179(2009)
Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Mullerian hormone in human granulosa cells.
Shi J., Yoshino O., Osuga Y., Koga K., Hirota Y., Hirata T., Yano T., Nishii O., Taketani Y.,
Fertil Steril 92:1794-1798(2009)
Single nucleotide polymorphism analysis of the follicle-stimulating hormone (FSH) receptor in Japanese with male infertility: identification of codon combination with heterozygous variations of the two discrete FSH receptor gene.
Shimoda C., Koh E., Yamamoto K., Matsui F., Sugimoto K., Sin H.S., Maeda Y., Kanaya J., Yoshida A., Namiki M.,
Endocr J 56:859-865(2009)
Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3).
Ahn J., Schumacher F.R., Berndt S.I., Pfeiffer R., Albanes D., Andriole G.L., Ardanaz E., Boeing H., Bueno-de-Mesquita B., Chanock S.J., Clavel-Chapelon F., Diver W.R., Feigelson H.S., Gaziano J.M., Giovannucci E., Haiman C.A., Henderson B.E., Hoover R.N., Hayes R.B.,
Hum Mol Genet 18:3749-3757(2009)
Accessibility of the extracellular loops of follicle stimulating hormone receptor and their role in hormone-receptor interaction.
Dupakuntla M., Mahale S.D.,
Mol Cell Endocrinol 315:131-137(2010)
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
BRIGHT Consortium, Talmud P.J., Drenos F., Shah S., Shah T., Palmen J., Verzilli C., Gaunt T.R., Pallas J., Lovering R., Li K., Casas J.P., Sofat R., Kumari M., Rodriguez S., Johnson T., Newhouse S.J., Dominiczak A., Samani N.J., Kjeldsen S.,
Am J Hum Genet 85:628-642(2009)
Multigenic combination of estrogen-related genes is associated with age at natural menopause in a Spanish population.
Mendoza N., Sanchez-Borrego R., Galiano D., Salamanca A., Mozas J., Quereda F., Vazquez F., Martinez-Astorquiza T., Moron F.,
Menopause Int 15:150-156(2009)
Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population and meta-analysis.
Lend A.K., Belousova A., Haller-Kikkatalo K., Punab M., Poolamets O., Peters M., Salumets A.,
Syst Biol Reprod Med 56:84-90(2010)
Single-nucleotide polymorphisms in the FSH receptor gene and ovarian performance: future role in IVF.
Mohiyiddeen L., Nardo L.G.,
Hum Fertil (Camb) 13:72-78(2010)
Frequency distribution of polymorphisms in the FSH receptor gene in infertility patients of different ethnicity.
Kuijper E.A., Blankenstein M.A., Luttikhof L.J., Roek S.J., Overbeek A., Hompes P.G., Twisk J.W., Lambalk C.B.,
Reprod Biomed Online 20:588-593(2010)
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorrhea.
Achrekar S.K., Modi D.N., Meherji P.K., Patel Z.M., Mahale S.D.,
J Assist Reprod Genet 27:317-326(2010)
FSHR gene polymorphisms influence bone mineral density and bone turnover in postmenopausal women.
Rendina D., Gianfrancesco F., De Filippo G., Merlotti D., Esposito T., Mingione A., Nuti R., Strazzullo P., Mossetti G., Gennari L.,
Eur J Endocrinol 163:165-172(2010)
Ovarian hyperstimulation syndrome (OHSS) due to mutations in the follicle-stimulating hormone receptor.
Rodien P., Beau I., Vasseur C.,
Ann Endocrinol (Paris) 71:206-209(2010)
Follicle stimulating hormone receptor mutations and reproductive disorders.
Tao Y.X., Segaloff D.L.,
Prog Mol Biol Transl Sci 89:115-131(2009)
Two FSHR variants, haplotypes and meta-analysis in Chinese women with premature ovarian failure and polycystic ovary syndrome.
Du J., Zhang W., Guo L., Zhang Z., Shi H., Wang J., Zhang H., Gao L., Feng G., He L.,
Mol Genet Metab 100:292-295(2010)
FSHR single nucleotide polymorphism frequencies in proven fathers and infertile men in Southeast Turkey.
Balkan M., Gedik A., Akkoc H., Izci Ay O., Erdal M.E., Isi H., Budak T.,
J Biomed Biotechnol 2010:640318-640318(2010)
The immunoexpression of FSH-R in the ductuli efferentes and the epididymis of men and rat: effect of FSH on the morphology and steroidogenic activity of rat epididymal epithelial cells in vitro.
Swider-Al-Amawi M., Kolasa A., Sikorski A., Marchlewicz M., Baranowska-Bosiacka I., Wiszniewska B.,
J Biomed Biotechnol 2010:506762-506762(2010)
Genetic variations of follicle stimulating hormone receptor are associated with polycystic ovary syndrome.
Gu B.H., Park J.M., Baek K.H.,
Int J Mol Med 26:107-112(2010)
Emerging roles for the FSH receptor adapter protein APPL1 and overlap of a putative 14-3-3tau interaction domain with a canonical G-protein interaction site.
Dias J.A., Mahale S.D., Nechamen C.A., Davydenko O., Thomas R.M., Ulloa-Aguirre A.,
Mol Cell Endocrinol 329:17-25(2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey S.D., Xie C., Do R., Montpetit A., Diaz R., Mohan V., Keavney B., Yusuf S., Gerstein H.C., Engert J.C., Anand S.,
Diabetes Care 33:2250-2253(2010)
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
Canzian F., Cox D.G., Setiawan V.W., Stram D.O., Ziegler R.G., Dossus L., Beckmann L., Blanche H., Barricarte A., Berg C.D., Bingham S., Buring J., Buys S.S., Calle E.E., Chanock S.J., Clavel-Chapelon F., DeLancey J.O., Diver W.R., Feigelson H.S.,
Hum Mol Genet 19:3873-3884(2010)
[Study of follicle-stimulating hormone receptor and tyrosine hydroxylase polymorphisms and pre-eclampsia in Chinese Han population].
Chen Y., Tong X.H., Sun C.J., Zhang W.Y.,
Zhonghua Yi Xue Za Zhi 90:1213-1215(2010)
Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage.
Hanna C.W., Bretherick K.L., Liu C.C., Stephenson M.D., Robinson W.P.,
Hum Reprod 25:2664-2671(2010)
A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C., Kraft P., Chasman D.I., Buring J.E., Chen C., Hankinson S.E., Pare G., Chanock S., Ridker P.M., Hunter D.J.,
Hum Genet 128:515-527(2010)
Preferential beta-arrestin signalling at low receptor density revealed by functional characterization of the human FSH receptor A189 V mutation.
Tranchant T., Durand G., Gauthier C., Crepieux P., Ulloa-Aguirre A., Royere D., Reiter E.,
Mol Cell Endocrinol 331:109-118(2011)
A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis.
Wang H.S., Cheng B.H., Wu H.M., Yen C.F., Liu C.T., Chao A., Wang T.H.,
Fertil Steril 95:455-457(2011)
In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA.
Nielsen M.E., Rasmussen I.A., Kristensen S.G., Christensen S.T., Mollgard K., Wreford Andersen E., Byskov A.G., Yding Andersen C.,
Mol Hum Reprod 17:63-70(2011)
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
Kerns S.L., Ostrer H., Stock R., Li W., Moore J., Pearlman A., Campbell C., Shao Y., Stone N., Kusnetz L., Rosenstein B.S.,
Int J Radiat Oncol Biol Phys 78:1292-1300(2010)
There is no complete linkage between the polymorphisms N680S and T307A of the follicular stimulating hormone receptor gene in fertile women.
Rodini G.P., Genro V.K., Matte U., Pereira F.S., Bilibio J.P., Greggianin C., Souza C.A., Cunha-Filho J.S.,
J Assist Reprod Genet 28:221-224(2011)
Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones.
Safarinejad M.R., Shafiei N., Safarinejad S.,
BJU Int 108:E117-25(2011)
The relationship between fertility and lifespan in humans.
Kuningas M., Altmae S., Uitterlinden A.G., Hofman A., van Duijn C.M., Tiemeier H.,
Age (Dordr) 33:615-622(2011)
Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure.
Kim S., Pyun J.A., Cha D.H., Ko J.J., Kwack K.,
Fertil Steril 95:2585-2588(2011)
Decreased degradation of internalized follicle-stimulating hormone caused by mutation of aspartic acid 6.30(550) in a protein kinase-CK2 consensus sequence in the third intracellular loop of human follicle-stimulating hormone receptor.
Kluetzman K.S., Thomas R.M., Nechamen C.A., Dias J.A.,
Biol Reprod 84:1154-1163(2011)
The adapter protein APPL1 links FSH receptor to inositol 1,4,5-trisphosphate production and is implicated in intracellular Ca(2+) mobilization.
Thomas R.M., Nechamen C.A., Mazurkiewicz J.E., Ulloa-Aguirre A., Dias J.A.,
Endocrinology 152:1691-1701(2011)
FSH receptor gene polymorphisms in fertile and infertile Han-Chinese males.
Li Y., Gu A., Yang H., Ding X., Ji G., Lu C., Xia Y., Song L., Wang X.,
Clin Chim Acta 412:1048-1052(2011)
Patients with endometriosis and patients with poor ovarian reserve have abnormal follicle-stimulating hormone receptor signaling pathways.
Gonzalez-Fernandez R., Pena O., Hernandez J., Martin-Vasallo P., Palumbo A., Avila J.,
Fertil Steril 95:2373-2378(2011)
An evolutionary genomic approach to identify genes involved in human birth timing.
Plunkett J., Doniger S., Orabona G., Morgan T., Haataja R., Hallman M., Puttonen H., Menon R., Kuczynski E., Norwitz E., Snegovskikh V., Palotie A., Peltonen L., Fellman V., DeFranco E.A., Chaudhari B.P., McGregor T.L., McElroy J.J., Muglia L.,
PLoS Genet 7:e1001365-e1001365(2011)
Influence of follicle-stimulating hormone receptor (FSHR) Ser680Asn polymorphism on ovarian function and in-vitro fertilization outcome: a meta-analysis.
Yao Y., Ma C.H., Tang H.L., Hu Y.F.,
Mol Genet Metab 103:388-393(2011)
ESR1, ESR2 and FSH receptor gene polymorphisms in combination: a useful genetic tool for the prediction of poor responders.
Anagnostou E., Mavrogianni D., Theofanakis C., Drakakis P., Bletsa R., Demirol A., Gurgan T., Antsaklis A., Loutradis D.,
Curr Pharm Biotechnol 13:426-434(2012)
Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cells.
Nordhoff V., Sonntag B., von Tils D., Gotte M., Schuring A.N., Gromoll J., Redmann K., Casarini L., Simoni M.,
Reprod Biomed Online 23:196-203(2011)
Follicle-stimulating hormone receptor polymorphism (G-29A) is associated with altered level of receptor expression in Granulosa cells.
Desai S.S., Achrekar S.K., Pathak B.R., Desai S.K., Mangoli V.S., Mangoli R.V., Mahale S.D.,
J Clin Endocrinol Metab 96:2805-2812(2011)
FSH-receptor Ala307Thr polymorphism is associated to polycystic ovary syndrome and to a higher responsiveness to exogenous FSH in Italian women.
Dolfin E., Guani B., Lussiana C., Mari C., Restagno G., Revelli A.,
J Assist Reprod Genet 28:925-930(2011)
Analysis of pituitary gonadotropin concentration in blood serum and immunolocalization and immunoexpression of follicle stimulating hormone and luteinising hormone receptors in ovaries of postmenopausal women.
Brodowska A., Laszczynska M., Brodowski J., Masiuk M., Starczewski A.,
Histol Histopathol 27:241-248(2012)
Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers.
Mohiyiddeen L., Newman W.G., McBurney H., Mulugeta B., Roberts S.A., Nardo L.G.,
Fertil Steril 97:677-681(2012)
Assessment of FSHR variants and antimullerian hormone in infertility patients with a reduced ovarian response to gonadotropin stimulation.
Binder H., Strick R., Zaherdoust O., Dittrich R., Hamori M., Beckmann M.W., Oppelt P.G.,
Fertil Steril 97:1169-75.e1(2012)
Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: a meta-analysis.
Wu W., Cai H., Sun H., Lu J., Zhao D., Qin Y., Han X., Niu X., Lu C., Xia Y., Wang S., De Moor B., Marchal K., Wang X.,
Gene 505:388-392(2012)
Variants in follicle-stimulating hormone receptor gene in infertile Brazilian men and the correlation to FSH serum levels and sperm count.
Ghirelli-Filho M., Peluso C., Christofolini D.M., Gava M.M., Glina S., Barbosa C.P., Bianco B.,
Reprod Sci 19:733-739(2012)
PCOS and peripheral AMH levels in relation to FSH receptor gene single nucleotide polymorphisms.
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The ovarian response to standard gonadotrophin stimulation depends on FSHR, SHBG and CYP19 gene synergism.
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A common Asn680Ser polymorphism in the follicle-stimulating hormone receptor gene is not associated with ovarian response to gonadotropin stimulation in patients undergoing in vitro fertilization.
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Immunohistochemical detection of FSH receptors in pituitary adenomas and adrenal tumors.
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Folia Histochem Cytobiol 50:325-330(2012)
Sertoli cell-specific expression of metastasis-associated protein 2 (MTA2) is required for transcriptional regulation of the follicle-stimulating hormone receptor (FSHR) gene during spermatogenesis.
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Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry.
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Association of rs6166 polymorphism with FSH receptor transcript variants and steroid production in human granulosa cell cultures.
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Study in 1790 Baltic men: FSHR Asn680Ser polymorphism affects total testes volume.
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FSH receptor gene variants are rarely associated with premature ovarian failure.
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The combination of genetic variants of the FSHB and FSHR genes affects serum FSH in women of reproductive age.
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Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women.
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Spontaneous ovarian hyperstimulation syndrome: case report, pathophysiological classification and diagnostic algorithm.
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Eur J Obstet Gynecol Reprod Biol 169:143-148(2013)
The impact of genetics profile (gene polymorphisms) in obese non-PCOS women entering an IVF/ICSI program.
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Curr Drug Targets 14:850-855(2013)
Research resource: small RNA-seq of human granulosa cells reveals miRNAs in FSHR and aromatase genes.
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Mol Endocrinol 27:1128-1141(2013)
Heterodimerization between the lutropin and follitropin receptors is associated with an attenuation of hormone-dependent signaling.
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Endocrinology 154:3925-3930(2013)
FSHB-211 and FSHR 2039 are associated with serum levels of follicle-stimulating hormone and antimullerian hormone in healthy girls: a longitudinal cohort study.
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Fertil Steril 100:1089-1095(2013)
Alterations of the FSH and LH receptor genes and evaluation of sperm ultrastructure in men with idiopathic hypergonadotropic hypogonadism.
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J Assist Reprod Genet 30:1101-1108(2013)
The G-protein coupled estrogen receptor (GPER/GPR30) is a gonadotropin receptor dependent positive prognosticator in ovarian carcinoma patients.
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PLoS One 8:e71791-e71791(2013)
Identification of two novel, alternatively spliced mRNA transcripts of the human follicle-stimulating hormone receptor.
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Mutations and polymorphisms in FSH receptor: functional implications in human reproduction.
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Association of follicle-stimulating hormone receptor polymorphisms with ovarian response in Chinese women: a prospective clinical study.
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PLoS One 8:e78138-e78138(2013)
Fine-mapping an association of FSHR with preterm birth in a Finnish population.
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PLoS One 8:e78032-e78032(2013)
Association between FSHR polymorphisms and polycystic ovary syndrome among Chinese women in north China.
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The Asn680Ser polymorphism of the follicle stimulating hormone receptor gene and ovarian cancer risk: a meta-analysis.
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Follicle-stimulating hormone receptor (FSHR) alternative skipping of exon 2 or 3 affects ovarian response to FSH.
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Mol Hum Reprod 20:630-643(2014)
Activation of a GPCR leads to eIF4G phosphorylation at the 5' cap and to IRES-dependent translation.
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J Mol Endocrinol 52:373-382(2014)
Reproductive physiology in young men is cumulatively affected by FSH-action modulating genetic variants: FSHR -29G/A and c.2039 A/G, FSHB -211G/T.
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PLoS One 9:e94244-e94244(2014)
FSH receptor (FSHR) expression in human extragonadal reproductive tissues and the developing placenta, and the impact of its deletion on pregnancy in mice.
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Biol Reprod 91:74-74(2014)
Follicle stimulating hormone receptor in mesenchymal stem cells integrates effects of glycoprotein reproductive hormones.
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Ann N Y Acad Sci 1335:100-109(2015)
The Ser680Asn polymorphism in the follicle-stimulating hormone receptor gene is associated with the ovarian response in controlled ovarian hyperstimulation.
Huang X., Li L., Hong L., Zhou W., Shi H., Zhang H., Zhang Z., Sun X., Du J.,
Clin Endocrinol (Oxf) 82:577-583(2015)
Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis.
Chen D.J., Ding R., Cao J.Y., Zhai J.X., Zhang J.X., Ye D.Q.,
Eur J Obstet Gynecol Reprod Biol 182:27-32(2014)
Pubertal onset in girls is strongly influenced by genetic variation affecting FSH action.
Hagen C.P., Sorensen K., Aksglaede L., Mouritsen A., Mieritz M.G., Tinggaard J., Wohlfart-Veje C., Petersen J.H., Main K.M., Rajpert-De Meyts E., Almstrup K., Juul A.,
Sci Rep 4:6412-6412(2014)
Follicle-stimulating hormone induced epithelial-mesenchymal transition of epithelial ovarian cancer cells through follicle-stimulating hormone receptor PI3K/Akt-Snail signaling pathway.
Yang Y., Zhang J., Zhu Y., Zhang Z., Sun H., Feng Y.,
Int J Gynecol Cancer 24:1564-1574(2014)
Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor.
Schaarschmidt J., Huth S., Meier R., Paschke R., Jaeschke H.,
PLoS One 9:e111570-e111570(2014)
Asn680ser polymorphism of the follicle-stimulating hormone receptor gene (FSHR) is not associated with recurrent pregnancy loss (RPL).
Koc A., Kaya O.O.,
Genet Couns 25:337-339(2014)
Effect of the FSH receptor single nucleotide polymorphisms (FSHR 307/680) on the follicular fluid hormone profile and the granulosa cell gene expression in human small antral follicles.
Borgbo T., Jeppesen J.V., Lindgren I., Lundberg Giwercman Y., Hansen L.L., Yding Andersen C.,
Mol Hum Reprod 21:255-261(2015)
Gene variation and premature ovarian failure: a meta-analysis.
Pu D., Xing Y., Gao Y., Gu L., Wu J.,
Eur J Obstet Gynecol Reprod Biol 182:226-237(2014)
Follicle-stimulating hormone receptor gene polymorphisms in women with endometriosis.
Kerimoglu O.S., Yılmaz S.A., Pekin A., Nergiz S., Incesu F., Dogan N.U., Acar H., Celik C.,
Arch Gynecol Obstet 291:1411-1416(2015)
Evaluating influence of the genotypes in the follicle-stimulating hormone receptor (FSHR) Ser680Asn (rs6166) polymorphism on poor and hyper-responders to ovarian stimulation: a meta-analysis.
Pabalan N., Trevisan C.M., Peluso C., Jarjanazi H., Christofolini D.M., Barbosa C.P., Bianco B.,
J Ovarian Res 7:285-285(2014)
Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.
Mitsuhashi M., Mitsuhashi T., Payan D.G.,
J Biol Chem 264:18356-18362(1989)
Leutinizing hormone/choriogonadotropin receptor and follicle stimulating hormone receptor gene variants in polycystic ovary syndrome.
Almawi W.Y., Hubail B., Arekat D.Z., Al-Farsi S.M., Al-Kindi S.K., Arekat M.R., Mahmood N., Madan S.,
J Assist Reprod Genet 32:607-614(2015)
Endothelial follicle-stimulating hormone receptor expression in invasive breast cancer and vascular remodeling at tumor periphery.
Planeix F., Siraj M.A., Bidard F.C., Robin B., Pichon C., Sastre-Garau X., Antoine M., Ghinea N.,
J Exp Clin Cancer Res 34:12-12(2015)
Follicle-stimulating hormone receptor polymorphism affects the outcome of ovulation induction in normogonadotropic (World Health Organization class 2) anovulatory subfertility.
Valkenburg O., van Santbrink E.J., Konig T.E., Themmen A.P., Uitterlinden A.G., Fauser B.C., Lambalk C.B., Laven J.S.,
Fertil Steril 103:1081-1088.e3(2015)
FSH receptor-specific residues L501 and I505 in extracellular loop 2 are essential for its function.
Banerjee A.A., Dupakuntla M., Pathak B.R., Mahale S.D.,
J Mol Endocrinol 54:193-204(2015)
Association between two polymorphisms of follicle stimulating hormone receptor gene and susceptibility to polycystic ovary syndrome: a meta-analysis.
Qiu L., Liu J., Hei Q.M.,
Chin Med Sci J 30:44-50(2015)
Novel Inactivating Mutation of the FSH Receptor in Two Siblings of Indian Origin With Premature Ovarian Failure.
Katari S., Wood-Trageser M.A., Jiang H., Kalynchuk E., Muzumdar R., Yatsenko S.A., Rajkovic A.,
J Clin Endocrinol Metab 100:2154-2157(2015)
LH (Trp8Arg/Ile15Thr), LHR (insLQ) and FSHR (Asn680Ser) polymorphisms genotypic prevalence in women with endometriosis and infertility.
Schmitz C.R., Souza C.A., Genro V.K., Matte U., Conto E.d., Cunha-Filho J.S.,
J Assist Reprod Genet 32:991-997(2015)
FSHR gene Thr307Ala and Asn680Ser polymorphisms in infertile men: an association study in North China and meta-analysis.
Wu X.Q., Xu S.M., Wang Y.Q., Li Q., Wang Z.Q., Zhang C.L., Shen Y.,
Genet Mol Res 14:5592-5601(2015)
Are FSHR polymorphisms risk factors to premature ovarian insufficiency?
Cordts E.B., Santos M.C., Bianco B., Barbosa C.P., Christofolini D.M.,
Gynecol Endocrinol 31:663-666(2015)
Impact of follicle-stimulating hormone receptor variants in female infertility.
Ilgaz N.S., Aydos O.S., Karadag A., Taspinar M., Eryilmaz O.G., Sunguroglu A.,
J Assist Reprod Genet 32:1659-1668(2015)
Follicle-Stimulating Hormone Receptor Expression in Endometriotic Lesions and the Associated Vasculature: An Immunohistochemical Study.
Robin B., Planeix F., Sastre-Garau X., Pichon C., Olesen T.K., Gogusev J., Ghinea N.,
Reprod Sci 23:885-891(2016)
Combined assessment of polymorphisms in the LHCGR and FSHR genes predict chance of pregnancy after in vitro fertilization.
Lindgren I., Baath M., Uvebrant K., Dejmek A., Kjaer L., Henic E., Bungum M., Bungum L., Cilio C., Leijonhufvud I., Skouby S., Andersen C.Y., Giwercman Y.L.,
Hum Reprod 31:672-683(2016)
Genetic variations altering FSH action affect circulating hormone levels as well as follicle growth in healthy peripubertal girls.
Busch A.S., Hagen C.P., Almstrup K., Main K.M., Juul A.,
Hum Reprod 31:897-904(2016)
A novel follicle-stimulating hormone receptor mutation causing primary ovarian failure: a fertility application of whole exome sequencing.
Bramble M.S., Goldstein E.H., Lipson A., Ngun T., Eskin A., Gosschalk J.E., Roach L., Vashist N., Barseghyan H., Lee E., Arboleda V.A., Vaiman D., Yuksel Z., Fellous M., Vilain E.,
Hum Reprod 31:905-914(2016)
Clinical efficacy of recombinant versus highly purified follicle-stimulating hormone according to follicle-stimulating hormone receptor genotype.
Lledo B., Dapena P., Ortiz J.A., Morales R., Llacer J., Bernabeu R.,
Pharmacogenet Genomics 26:288-293(2016)
Contribution of polymorphisms in ESR1, ESR2, FSHR, CYP19A1, SHBG, and NRIP1 genes to migraine susceptibility in Turkish population.
CoSkun S., Yucel Y., Cim A., Cengiz B., Oztuzcu S., Varol S., Ozdemir H.H., Uzar E.,
J Genet 95:131-140(2016)
Functional Expression of FSH Receptor in Endometriotic Lesions.
Ponikwicka-Tyszko D., Chrusciel M., Stelmaszewska J., Bernaczyk P., Sztachelska M., Sidorkiewicz I., Doroszko M., Tomaszewski J., Tapanainen J.S., Huhtaniemi I., Wolczynski S., Rahman N.A.,
J Clin Endocrinol Metab 101:2905-2914(2016)
Genetic Variations in FSH Action Affect Sex Hormone Levels and Breast Tissue Size in Infant Girls: A Pilot Study.
Henriksen L.S., Hagen C.P., Assens M., Busch A.S., Skakkebaek N.E., Almstrup K., Main K.M.,
J Clin Endocrinol Metab 101:3191-3198(2016)
Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study.
Simoni M., Santi D., Negri L., Hoffmann I., Muratori M., Baldi E., Cambi M., Marcou M., Greither T., Baraldi E., Tagliavini S., Carra D., Lombardo F., Gandini L., Pallotti F., Krausz C., Rastrelli G., Ferlin A., Behre H.M.,
Hum Reprod 31:1960-1969(2016)
Follicle-Stimulating Hormone Receptor Is Expressed by Most Ovarian Cancer Subtypes and Is a Safe and Effective Immunotherapeutic Target.
Perales-Puchalt A., Svoronos N., Rutkowski M.R., Allegrezza M.J., Tesone A.J., Payne K.K., Wickramasinghe J., Nguyen J.M., O'Brien S.W., Gumireddy K., Huang Q., Cadungog M.G., Connolly D.C., Tchou J., Curiel T.J., Conejo-Garcia J.R.,
Clin Cancer Res 23:441-453(2017)
Association of a promoter polymorphism in FSHR with ovarian reserve and response to ovarian stimulation in women undergoing assisted reproductive treatment.
Tohlob D., Abo Hashem E., Ghareeb N., Ghanem M., Elfarahaty R., Byers H., Pemberton P., Roberts S.A., Newman W.G., Mohiyiddeen L.,
Reprod Biomed Online 33:391-397(2016)
beta-arrestins regulate gonadotropin receptor-mediated cell proliferation and apoptosis by controlling different FSHR or LHCGR intracellular signaling in the hGL5 cell line.
Casarini L., Reiter E., Simoni M.,
Mol Cell Endocrinol 437:11-21(2016)
The carriers of the A/G-G/G allelic combination of the c.2039 A>G and c.-29 G>A FSH receptor polymorphisms retrieve the highest number of oocytes in IVF/ICSI cycles.
Allegra A., Marino A., Raimondo S., Maiorana A., Gullo S., Scaglione P., Volpes A., Alessandro R.,
J Assist Reprod Genet 34:263-273(2017)
Revisiting the expression and function of follicle-stimulation hormone receptor in human umbilical vein endothelial cells.
Stelmaszewska J., Chrusciel M., Doroszko M., Akerfelt M., Ponikwicka-Tyszko D., Nees M., Frentsch M., Li X., Kero J., Huhtaniemi I., Wolczynski S., Rahman N.A.,
Sci Rep 6:37095-37095(2016)
Functional characterization of two naturally occurring mutations V221G and T449N in the follicle stimulating hormone receptor.
Banerjee A.A., Achrekar S.K., Joseph S., Pathak B.R., Mahale S.D.,
Mol Cell Endocrinol 440:69-79(2017)
Relationship Between Genotype Variants Follicle-stimulating Hormone Receptor Gene Polymorphisms (FSHR) and Morphology of Oocytes Prior to ICSI Procedures.
Gashi Z., Elezaj S., Zeqiraj A., Grabanica D., Shabani I., Gruda B., Gashi F.,
Med Arch 70:364-368(2016)
Infertility and ovarian follicle reserve depletion are associated with dysregulation of the FSH and LH receptor density in human antral follicles.
Regan S.L., Knight P.G., Yovich J.L., Stanger J.D., Leung Y., Arfuso F., Dharmarajan A., Almahbobi G.,
Mol Cell Endocrinol 446:40-51(2017)
Association of follicle-stimulating hormone receptor single nucleotide polymorphisms with fertility in Greek men.
Tsitlakidis D., Katopodi T., Goulis D.G., Papadimas I., Kritis A.,
J Endocrinol Invest 40:721-726(2017)
The follicle-stimulating hormone receptor Asn680Ser polymorphism is associated with preterm birth in Hispanic women.
Dominguez-Lopez P., Diaz-Cueto L., Arechavaleta-Velasco M., Caldino-Soto F., Ulloa-Aguirre A., Arechavaleta-Velasco F.,
J Matern Fetal Neonatal Med 31:580-585(2018)
Brain-derived neurotrophic factor promotes human granulosa-like tumor cell steroidogenesis and proliferation by activating the FSH receptor-mediated signaling pathway.
Xie M., Li M., Zhou J., Ding X., Shao Y., Jing J., Liu Y., Yao B.,
Sci Rep 7:180-180(2017)
Genetic Variation of Follicle-Stimulating Hormone Action Is Associated With Age at Testicular Growth in Boys.
Busch A.S., Hagen C.P., Main K.M., Pereira A., Corvalan C., Almstrup K., Mericq V., Juul A.,
J Clin Endocrinol Metab 102:1740-1749(2017)
Reduced expression of follicle stimulating hormone receptor mRNA and protein in pregnancies complicated by pre‑eclampsia.
Li M., Jia Y., Ling Y., Chen Y., Zhang L., Luo D., Lai L., Guo M., Zhang D., Ren M., Xu H., Kuang H.,
Mol Med Rep 16:367-372(2017)
FSH receptor gene p. Thr307Ala and p. Asn680Ser polymorphisms are associated with the risk of polycystic ovary syndrome.
Kim J.J., Choi Y.M., Hong M.A., Chae S.J., Hwang K., Yoon S.H., Ku S.Y., Suh C.S., Kim S.H.,
J Assist Reprod Genet 34:1087-1093(2017)
A Novel Homozygous Missense FSHR Variant Associated with Hypergonadotropic Hypogonadism in Two Siblings from a Brazilian Family.
Franca M.M., Lerario A.M., Funari M.F.A., Nishi M.Y., Narcizo A.M., de Mello M.P., Guerra-Junior G., Maciel-Guerra A.T., Mendonca B.B.,
Sex Dev 11:137-142(2017)
The -29G/A FSH receptor gene polymorphism is associated with higher FSH and LH levels in normozoospermic men.
Tamburino L., La Vignera S., Tomaselli V., Condorelli R.A., Cannarella R., Mongioi L.M., Calogero A.E.,
J Assist Reprod Genet 34:1289-1294(2017)
The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis.
Wu Q., Zhang J., Zhu P., Jiang W., Liu S., Ni M., Zhang M., Li W., Zhou Q., Cui Y., Xia X.,
BMC Med Genet 18:81-81(2017)
A genome-wide association study identified a novel genetic loci STON1-GTF2A1L/LHCGR/FSHR for bilaterality of neovascular age-related macular degeneration.
Kawashima-Kumagai K., Yamashiro K., Yoshikawa M., Miyake M., Ming G.C.C., Fan Q., Koh J.Y., Saito M., Sugahara-Kuroda M., Oishi M., Akagi-Kurashige Y., Nakata I., Nakanishi H., Gotoh N., Oishi A., Tamura H., Ooto S., Tsujikawa A., Yoshimura N.,
Sci Rep 7:7173-7173(2017)
The role of gene polymorphisms and AMH level in prediction of poor ovarian response in Egyptian women undergoing IVF procedure.
Motawi T.M.K., Rizk S.M., Maurice N.W., Maged A.M., Raslan A.N., Sawaf A.H.,
J Assist Reprod Genet 34:1659-1666(2017)
Role of FSHR rs6165 and ESR2 rs4986938 polymorphisms in ovarian stimulation of Iranian women who underwent assisted reproduction treatment.
Kaviani M., Ghaderian S.M.H., Arefi S., Hashemi M., Afjeh S.S.A.,
Hum Antibodies 26:121-126(2017)
The effect of ovarian reserve and receptor signalling on granulosa cell apoptosis during human follicle development.
Regan S.L.P., Knight P.G., Yovich J.L., Stanger J.D., Leung Y., Arfuso F., Almahbobi G., Dharmarajan A.,
Mol Cell Endocrinol 470:219-227(2018)
Expression of FSHR in chondrocytes and the effect of FSH on chondrocytes.
Kong D., Guan Q., Li G., Xin W., Qi X., Guo Y., Zhao J., Xu J., Sun S., Gao L.,
Biochem Biophys Res Commun 495:587-593(2018)
A novel homozygous mutation in the FSHR gene is causative for primary ovarian insufficiency.
Liu H., Xu X., Han T., Yan L., Cheng L., Qin Y., Liu W., Zhao S., Chen Z.J.,
Fertil Steril 108:1050-1055.e2(2017)
Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer?
Bang A.K., Busch A.S., Almstrup K., Gromoll J., Kliesch S., Rajpert-De Meyts E., Skakkebaek N.E., Juul A., Tuttelmann F., Jorgensen N.,
Andrology 6:176-183(2018)
Polymorphism FSHR (-29G/A) as a genetic agent together with ESRI (XbaIG/A) in women with poor response to controlled ovarian hyperstimulation.
Zamaniara T., Taheripanah R., Ghaderian S.M.H., Zamaniara E., Aghabozorgi S.S.A.,
Hum Antibodies 26:143-147(2017)
Role of RAB5A in FSHR-mediated signal transduction in human granulosa cells.
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The Impact of FSHR Gene Polymorphisms Ala307Thr and Asn680Ser in the Endometriosis Development.
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Expression of follicle stimulating hormone receptors in intra-tumoral vasculature and in tumoral cells - the involvement in tumour progression and the perspectives of application in cancer diagnosis and therapy.
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The impact of FSH receptor polymorphism on time-to-pregnancy: a cross-sectional single-centre study.
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FSH Receptor Signaling: Complexity of Interactions and Signal Diversity.
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Extracellular loop 3 substitutions K589N and A590S in FSH receptor increase FSH-induced receptor internalization and along with S588T substitution exhibit impaired ERK1/2 phosphorylation.
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Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization.
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The N680S variant in the follicle-stimulating hormone receptor gene identifies hyperresponders to controlled ovarian stimulation.
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Combined study on the single nucleotide polymorphisms in the follicle-stimulating hormone receptor (Ser680Asn) and anti-Mullerian hormone receptor type II (-482A>G) as genetic markers in assisted reproduction.
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Novel FSHR mutations in Han Chinese women with sporadic premature ovarian insufficiency.
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Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells.
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Tyrosine nitrations impaired intracellular trafficking of FSHR to the cell surface and FSH-induced Akt-FoxO3a signaling in human granulosa cells.
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Correlation of the Aryl Hydrocarbon Receptor with FSHR in Ovarian Cancer Patients.
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Isolation and characterization of the human Gs alpha gene.
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The relationship between FSH receptor polymorphism status and IVF cycle outcome: a retrospective observational study.
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Sequence variants in FSHR and CYP19A1 genes and the ovarian response to controlled ovarian stimulation.
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Fertil Steril 112:749-757.e2(2019)
Effects of FSHR polymorphisms on premature ovarian insufficiency in human beings: a meta-analysis.
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Reprod Biol Endocrinol 17:80-80(2019)
The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study.
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Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor.
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