FSHR
Synonyms
FSH-R, ODG1, LGR1, FSHR1, Receptors, FSH, FSHRO, Follitropin Receptor, Follicle-Stimulating Hormone Receptor, FSHR, FSH Receptor, Follicle Stimulating Hormone Receptor
Description
FSHR (Follicle-stimulating hormone receptor) is a G protein-coupled receptor for follitropin. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
KO Status
RenMab: F2 (-/-)
Drug Information
Launched drugs: 23
Drugs in clinical trials: 14
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Follicle stimulating hormone biosimilar (GeneScience Pharmaceuticals)
Genesci-008
Approved
Changchun Genescience Pharmaceutical Co Ltd
Infertility, Female
Follitropin beta
Org-32489, CP090073
Approved
Merck Sharp & Dohme Corp
Infertility, Infertility, Female, Hypogonadism
Corifollitropin alfa
FSH-CTP, MK-8962, Org-36286, SCH-900962
Approved
Merck Sharp & Dohme Corp
Anovulation, Infertility, Hypogonadism
Menotropin biosimilar (Klarvoyant Biogenics)
Approved
Infogix
Infertility
Chorionic gonadotrophin (Merck & Co)
Approved
Merck Sharp & Dohme Corp
Infertility, Female
Follitropin alfa/Lutropin alfa
Approved
Merck Serono
Infertility, Female
Urofollitropin
u-hFSH
Approved
Merck Serono
Infertility, Infertility, Female
Follicle stimulating hormone biosimilar (Sedico)
Approved
Sedico
Infertility
Follicle stimulating hormone biosimilar (Bharat Serums & Vaccines)
Approved
Bharat Serums And Vaccines
Infertility
Follitropin alfa biosimilar (Dong-A)
GX-F11, DA-3801
Approved
Dong-A Pharmaceutical Co Ltd
Anovulation, Infertility
References
Title
Authors
Source
Cloning and sequencing of human FSH receptor cDNA
Minegish T., Nakamura K., Takakura Y., Ibuki Y., Igarashi M.,
Biochem. Biophys. Res. Commun. 175:1125-1130(1991)
Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts
Tilly J.L., Aihara T., Nishimori K., Jia X.-C., Billig H., Kowalski K.I., Perlas E.A., Hsueh A.J.,
Endocrinology 131:799-806(1992)
The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells
Kelton C.A., Cheng S.V., Nugent N.P., Schweickhardt R.L., Rosenthal J.L., Overton S.A., Wands G.D., Kuzeja J.B., Luchette C.A., Chappel S.C.,
Mol. Cell. Endocrinol. 89:141-151(1992)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,
Nature 434:724-731(2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor
Gromoll J., Gudermann T., Nieschlag E.,
Biochem. Biophys. Res. Commun. 188:1077-1083(1992)
New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype
Touraine P., Beau I., Gougeon A., Meduri G., Desroches A., Pichard C., Detoeuf M., Paniel B., Prieur M., Zorn J.-R., Milgrom E., Kuttenn F., Misrahi M.,
Mol. Endocrinol. 13:1844-1854(1999)
Characterization of single-nucleotide polymorphisms in coding regions of human genes
Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,
Nat. Genet. 22:231-238(1999)
Distribution and function of FSH receptor genetic variants in normal men
Asatiani K., Gromoll J., Eckardstein S.V., Zitzmann M., Nieschlag E., Simoni M.,
Andrologia 34:172-176(2002)