FSHR

Synonyms

FSH-R, ODG1, LGR1, FSHR1, Receptors, FSH, FSHRO, Follitropin Receptor, Follicle-Stimulating Hormone Receptor, FSHR, FSH Receptor, Follicle Stimulating Hormone Receptor

Description

FSHR (Follicle-stimulating hormone receptor) is a G protein-coupled receptor for follitropin. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.

KO Status

RenMab: F2 (-/-)

Drug Information

Launched drugs: 23
Drugs in clinical trials: 14
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Follicle stimulating hormone biosimilar (GeneScience Pharmaceuticals)

Genesci-008

Approved

Changchun Genescience Pharmaceutical Co Ltd

Infertility, Female

Follitropin beta

Org-32489, CP090073

Approved

Merck Sharp & Dohme Corp

Infertility, Infertility, Female, Hypogonadism

Corifollitropin alfa

FSH-CTP, MK-8962, Org-36286, SCH-900962

Approved

Merck Sharp & Dohme Corp

Anovulation, Infertility, Hypogonadism

Menotropin biosimilar (Klarvoyant Biogenics)

Approved

Infogix

Infertility

Chorionic gonadotrophin (Merck & Co)

Approved

Merck Sharp & Dohme Corp

Infertility, Female

Follitropin alfa/Lutropin alfa

Approved

Merck Serono

Infertility, Female

Urofollitropin

u-hFSH

Approved

Merck Serono

Infertility, Infertility, Female

Follicle stimulating hormone biosimilar (Sedico)

Approved

Sedico

Infertility

Follicle stimulating hormone biosimilar (Bharat Serums & Vaccines)

Approved

Bharat Serums And Vaccines

Infertility

Follitropin alfa biosimilar (Dong-A)

GX-F11, DA-3801

Approved

Dong-A Pharmaceutical Co Ltd

Anovulation, Infertility

References


Title

Authors

Source

Cloning and sequencing of human FSH receptor cDNA

Minegish T., Nakamura K., Takakura Y., Ibuki Y., Igarashi M.,

Biochem. Biophys. Res. Commun. 175:1125-1130(1991)

Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts

Tilly J.L., Aihara T., Nishimori K., Jia X.-C., Billig H., Kowalski K.I., Perlas E.A., Hsueh A.J.,

Endocrinology 131:799-806(1992)

The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells

Kelton C.A., Cheng S.V., Nugent N.P., Schweickhardt R.L., Rosenthal J.L., Overton S.A., Wands G.D., Kuzeja J.B., Luchette C.A., Chappel S.C.,

Mol. Cell. Endocrinol. 89:141-151(1992)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor

Gromoll J., Gudermann T., Nieschlag E.,

Biochem. Biophys. Res. Commun. 188:1077-1083(1992)

New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype

Touraine P., Beau I., Gougeon A., Meduri G., Desroches A., Pichard C., Detoeuf M., Paniel B., Prieur M., Zorn J.-R., Milgrom E., Kuttenn F., Misrahi M.,

Mol. Endocrinol. 13:1844-1854(1999)

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,

Nat. Genet. 22:231-238(1999)

Distribution and function of FSH receptor genetic variants in normal men

Asatiani K., Gromoll J., Eckardstein S.V., Zitzmann M., Nieschlag E., Simoni M.,

Andrologia 34:172-176(2002)