FSHR

Synonyms

FSHR, FSH Receptor, Follicle Stimulating Hormone Receptor, FSH-R, ODG1, FSHR1, Receptors, FSH, LGR1, FSHRO, Follitropin Receptor, Follicle-Stimulating Hormone Receptor

Description

FSHR (Follicle-stimulating hormone receptor) is a G protein-coupled receptor for follitropin. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.

KO Status

F0

Drug Information

Launched drugs: 21
Drugs in clinical trials: 12
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Follitropin alfa/Lutropin alfa

Approved

Merck Serono

Infertility, Female

Follitropin beta biosimilar (Reliance Life Sciences)

Approved

Reliance Life Sciences

Endocrine System Diseases, Infertility, Female

Menotropins (Bharat serums and vaccines)

r-hMG

Approved

Bharat Serums And Vaccines

Infertility

Recombinant human FSH (LG Life Sciences)

Approved

Lg Chemical Ltd

Infertility, Female

Chorionic gonadotrophin (Merck & Co)

Approved

Merck Sharp & Dohme Corp

Infertility, Female

Follicle stimulating hormone (Organon)

Org-33408

Approved

Merck Sharp & Dohme Corp

Infertility, Female

Follitropin alfa biosimilar (Teva)

XM-17

Approved

Teva

Anovulation

Menotropin biosimilar (Klarvoyant Biogenics)

Approved

Infogix

Infertility

Follicle stimulating hormone biosimilar (Bharat Serums & Vaccines)

Approved

Bharat Serums And Vaccines

Infertility

Follicle stimulating hormone biosimilar (InSight Biopharmaceuticals)

Approved

Insight Biopharmaceuticals

Infertility, Female

References


Title

Authors

Source

Cloning and sequencing of human FSH receptor cDNA

Minegish T., Nakamura K., Takakura Y., Ibuki Y., Igarashi M.,

Biochem. Biophys. Res. Commun. 175:1125-1130(1991)

Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts

Tilly J.L., Aihara T., Nishimori K., Jia X.-C., Billig H., Kowalski K.I., Perlas E.A., Hsueh A.J.,

Endocrinology 131:799-806(1992)

The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells

Kelton C.A., Cheng S.V., Nugent N.P., Schweickhardt R.L., Rosenthal J.L., Overton S.A., Wands G.D., Kuzeja J.B., Luchette C.A., Chappel S.C.,

Mol. Cell. Endocrinol. 89:141-151(1992)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Molecular cloning of a truncated isoform of the human follicle stimulating hormone receptor

Gromoll J., Gudermann T., Nieschlag E.,

Biochem. Biophys. Res. Commun. 188:1077-1083(1992)

New natural inactivating mutations of the follicle-stimulating hormone receptor: correlations between receptor function and phenotype

Touraine P., Beau I., Gougeon A., Meduri G., Desroches A., Pichard C., Detoeuf M., Paniel B., Prieur M., Zorn J.-R., Milgrom E., Kuttenn F., Misrahi M.,

Mol. Endocrinol. 13:1844-1854(1999)

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,

Nat. Genet. 22:231-238(1999)

Distribution and function of FSH receptor genetic variants in normal men

Asatiani K., Gromoll J., Eckardstein S.V., Zitzmann M., Nieschlag E., Simoni M.,

Andrologia 34:172-176(2002)