F8, Coagulation factor VIII, AHF, Coagulation Factor VIII, Procoagulant Component, Antihemophilic Factor, F8C, Coagulation Factor VIII A1 Domain, Coagulation Factor VIII C2 Domain, Coagulation Factor VIIIc, Factor VIII F8B, Factor VIIIF8B, Hemophilia A, DXS1253E, FVIII, HEMA, F8B, Factor VIII, Procoagulant component


Coagulation factor VIII (F8), along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.

KO Status

RenMab: F1 (+/-)

Drug Information

Launched drugs: 9
Drugs in clinical trials: 9
Latest Research Phase: Approved

Drug Name





Clinical Trials

Protein C activated (Kaketsuken/Teijin)


Kaketsuken, Teijin Pharma

Pulmonary Embolism, Purpura, Venous Thrombosis

Antihemophilic factor/von Willebrand factor (CSL Behring)


Csl Behring Llc

von Willebrand Diseases, Hemophilia A

Antihemophilic factor/von Willebrand factor complex (Human, Grifols Biologicals)


Grifols Sa

von Willebrand Diseases, Hemophilia A

Von Willebrand factor/coagulation factor VIII complex (human, Octapharma)



von Willebrand Diseases, Hemophilia A

Human protein C (Baxalta)



Purpura Fulminans, Protein C Deficiency

Von Willebrand factor (LFB)



Lfb Biotechnologies

von Willebrand Diseases

Von Willebrand factor (Recombinant)

BAX-111, rVWF, SHP-677



von Willebrand Diseases

Factor VIII/von Willebrand factor (Bio Products Laboratory)


Bio Products Laboratory Ltd

Hemophilia A

Valoctocogene roxaparvovec



Biomarin Pharmaceutical Inc

Hematologic Diseases, Blood Coagulation Disorders, Hemophilia A

Giroctocogene fitelparvovec

Phase 3 Clinical

Sangamo Therapeutics

Hemophilia A





Lithuanian haemophilia A and B registry comprising phenotypic and genotypic data

Ivaskevicius V., Jurgutis R., Rost S., Muller A., Schmitt C., Wulff K., Herrmann F.H., Muller C.R., Schwaab R., Oldenburg J.,

Br. J. Haematol. 112:1062-1070(2001)

Site and type of mutations in the factor VIII gene in patients and carriers of haemophilia A

Theophilus B.D.M., Enayat M.S., Williams M.D., Hill F.G.H.,

Haemophilia 7:381-391(2001)

Mild haemophilia A discovered in a previously multi-operated 73-year-old man: characterization of a new mutation

Bauduer F., Ducout L., Bendriss P., Falaises B., Lavergne J.-M.,

Haemophilia 7:419-421(2001)

Molecular pathology of haemophilia A in Turkish patients: identification of 36 independent mutations

Timur A.A., Guergey A., Aktuglu G., Kavakli K., Canatan D., Olek K., Caglayan S.H.,

Haemophilia 7:475-481(2001)

Seven novel and four recurrent point mutations in the factor VIII (F8C) gene

Bogdanova N., Lemcke B., Markoff A., Pollmann H., Dworniczak B., Eigel A., Horst J.,

Hum. Mutat. 18:546-546(2001)

Rapid hemophilia A molecular diagnosis by a simple DNA sequencing procedure: identification of 14 novel mutations

Vidal F., Farssac E., Altisent C., Puig L., Gallardo D.,

Thromb. Haemost. 85:580-583(2001)

Skewed X-chromosome inactivation in monochorionic diamniotic twin sisters results in severe and mild hemophilia A

Valleix S., Vinciguerra C., Lavergne J.-M., Leuer M., Delpech M., Negrier C.,

Blood 100:3034-3036(2002)

Factor VIII deficiency not induced by FVIII gene mutation in a female first cousin of two brothers with haemophilia A

Mazurier C., Parquet-Gernez A., Gaucher C., Lavergne J.-M., Goudemand J.,

Br. J. Haematol. 119:390-392(2002)

Three novel point mutations causing haemophilia A

Sukarova-Stefanovska E., Zisovski N., Muratovska O., Kostova S., Efremov G.D.,

Haemophilia 8:715-718(2002)

The identification and classification of 41 novel mutations in the factor VIII gene (F8C)

Cutler J.A., Mitchell M.J., Smith M.P., Savidge G.F.,

Hum. Mutat. 19:274-278(2002)