FXI

Synonyms

FXI, F11, PTA, Coagulation Factor XI, Plasma Thromboplastin Antecedent, EC 3.4.21.27, Factor XI, Coagualtion Factor XI, EC 3.4.21, EC:3.4.21.27

Description

Coagulation factor XI (F11) triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

KO Status

F0

Drug Information

Launched drugs: 2
Drugs in clinical trials: 12
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Factor XI concentrate (factor XI deficiency), CSL Behring

Approved

Csl Behring Llc

Factor XI Deficiency

Human coagulation Factor XI (LFB)

Approved

Lfb Biotechnologies

Factor XI Deficiency

BMS-962212

BMS-962212, BMS-96221202, BMS-962212-02

Phase 2 Clinical

Bristol-Myers Squibb Company

Thrombosis

BMS-986177

JNJ-3093, BMS-986177, JNJ-70033093

Phase 2 Clinical

Bristol-Myers Squibb Company

Kidney Diseases, Stroke, Thromboembolism, Ischemic Attack, Transient, Thrombosis

BAY-2433334

BAY-2433334

Phase 2 Clinical

Bayer Ag

Myocardial Infarction, Stroke, Thromboembolism, Atrial Fibrillation

Osocimab

BAY-1213790, BAY1213790

Phase 2 Clinical

Bayer Ag

Thromboembolism

BAY-1213790

BAY-1213790

Phase 2 Clinical

Bayer Ag

Thromboembolism, Thrombosis

IONIS-FXIRX

FXI-ASO, ISIS-FXIRX, BAY-2306001, IONIS-FXIRX, ISIS-404071, ISIS-416858

Phase 2 Clinical

Ionis

Venous Thromboembolism, Thrombosis

Xisomab 3G3 (Oregon Health & Science University)

AB-022, AB-023

Phase 2 Clinical

Oregon Health & Science University

Thrombosis

IONIS-FXI-LRX

ION-957943, IONIS-FXI-LRx

Phase 1 Clinical

Ionis Pharmaceuticals Inc

Thrombosis

References


Title

Authors

Source

Severe factor XI deficiency in an Arab family associated with a novel mutation in exon 11

Wistinghausen B., Reischer A., Oddoux C., Ostrer H., Nardi M., Karpatkin M.,

Br. J. Haematol. 99:575-577(1997)

Identification of mutations and polymorphisms in the factor XI genes of an African American family by dideoxyfingerprinting

Martincic D., Zimmerman S.A., Ware R.E., Sun M.-F., Whitlock J.A., Gailani D.,

Blood 92:3309-3317(1998)

Identification of a novel mutation in a non-Jewish factor XI deficient kindred

Alhaq A., Mitchell M., Sethi M., Rahman S., Flynn G., Boulton P., Caeno G., Smith M., Savidge G.,

Br. J. Haematol. 104:44-49(1999)

Heterozygous factor XI deficiency associated with three novel mutations

Mitchell M., Cutler J., Thompson S., Moore G., Jenkins Ap Rees E., Smith M., Savidge G., Alhaq A.,

Br. J. Haematol. 107:763-765(1999)

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Cargill M., Altshuler D., Ireland J., Sklar P., Ardlie K., Patil N., Shaw N., Lane C.R., Lim E.P., Kalyanaraman N., Nemesh J., Ziaugra L., Friedland L., Rolfe A., Warrington J., Lipshutz R., Daley G.Q., Lander E.S.,

Nat. Genet. 22:231-238(1999)

Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene

Zivelin A., Bauduer F., Ducout L., Peretz H., Rosenberg N., Yatuv R., Seligsohn U.,

Blood 99:2448-2454(2002)

Dominant factor XI deficiency caused by mutations in the factor XI catalytic domain

Kravtsov D.V., Wu W., Meijers J.C.M., Sun M.-F., Blinder M.A., Dang T.P., Wang H., Gailani D.,

Blood 104:128-134(2004)

Severe factor XI deficiency caused by compound heterozygosity

Dai L., Mitchell M., Carson P., Creagh D., Cutler J., Savidge G., Alhaq A.,

Br. J. Haematol. 125:817-818(2004)

Genetic analysis in FXI deficiency: six novel mutations and the use of a polymerase chain reaction-based test to define a whole gene deletion

Hill M., McLeod F., Franks H., Gordon B., Dolan G.,

Br. J. Haematol. 129:825-829(2005)

Identification of five novel mutations in the factor XI gene (F11) of patients with factor XI deficiency

Quelin F., Mathonnet F., Potentini-Esnault C., Trigui N., Peynet J., Bastenaire B., Guillon L., Bigel M.L., Sauger A., Mazurier C., de Mazancourt P.,

Blood Coagul. Fibrinolysis 17:69-73(2006)