G-CSFR

Synonyms

CSF3R, Colony Stimulating Factor 3 Receptor, G-CSF Receptor, CD114 Antigen, G-CSF-R, GCSFR, Granulocyte Colony-Stimulating Factor Receptor, CD114, SCN7, Colony Stimulating Factor 3 Receptor (Granulocyte), Receptors, Granulocyte Colony-Stimulating Factor

Description

The granulocyte colony-stimulating factor receptor (G-CSF-R), also known as CD114 (Cluster of Differentiation 114), is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.

KO Status

F0

Drug Information

Launched drugs: 93
Drugs in clinical trials: 29
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Filgrastim biosimilar (Biosidus)

Approved

Biosidus

Neutropenia

Filgrastim biosimilar (Chandra Bhagat Pharma)

Approved

Chandra Bhagat Pharma(Cbc)

Neoplasms

Filgrastim biosimilar (Lupin)

Approved

Rubin Ltd

Neutropenia

Filgrastim biosimilar (Reliance Life Sciences)

Approved

Reliance Life Sciences

Neutropenia

Filgrastim biosimilar(Pooyesh Darou Pharmaceuticals)

G-CSF

Approved

Pooyesh Darou

Neutropenia, Myelodysplastic Syndromes, Leukemia, Myeloid, Acute, Lymphoma

Filgrastim biosimilar (Neiss Labs)

Approved

Neiss Labs

Neutropenia

Pegfilgrastim biosimilar (Amega Biotech)

Approved

Amega Biotech

Neutropenia

Lenograstim biosimilar (Biosidus)

Approved

Biosidus

Neutropenia

Pegfilgrastim biosimilar (Harvest Moon Pharmaceuticals/PanPharmaceuticals)

Approved

Harvest Moon

Neutropenia

Empegfilgrastim

BCD-017

Approved

Biocad

Neutropenia

References


Title

Authors

Source

Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains

Larsen A., Davis T., Curtis B.M., Gimpel S., Sims J.E., Cosman D., Park L., Sorensen E., March C.J., Smith C.A.,

J. Exp. Med. 172:1559-1570(1990)

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor

Fukunaga R., Seto Y., Mizushima S., Nagata S.,

Proc. Natl. Acad. Sci. U.S.A. 87:8702-8706(1990)

Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor

Seto Y., Fukunaga R., Nagata S.,

J. Immunol. 148:259-266(1992)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region

Haniu M., Horan T., Arakawa T., Le J., Katta V., Rohde M.F.,

Arch. Biochem. Biophys. 324:344-356(1995)

Functional domains of the granulocyte colony-stimulating factor receptor

Fukunaga R., Ishizaka-Ikeda E., Pan C.-X., Seto Y., Nagata S.,

EMBO J. 10:2855-2865(1991)

Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia

Dong F., Hoefsloot L.H., Schelen A.M., Broeders C.A., Meijer Y., Veerman A.J., Touw I.P., Lowenberg B.,

Proc. Natl. Acad. Sci. U.S.A. 91:4480-4484(1994)

Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders

Touw I.P., van de Geijn G.J.,

Front. Biosci. 12:800-815(2007)

Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia

Zeidler C., Germeshausen M., Klein C., Welte K.,

Br. J. Haematol. 144:459-467(2009)

Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand

Yamasaki K., Naito S., Anaguchi H., Ohkubo T., Ota Y.,

Nat. Struct. Biol. 4:498-504(1997)