G-CSFR

Synonyms

CSF3R, Colony Stimulating Factor 3 Receptor, G-CSF Receptor, CD114 Antigen, G-CSF-R, GCSFR, Granulocyte Colony-Stimulating Factor Receptor, CD114, SCN7, Colony Stimulating Factor 3 Receptor (Granulocyte), Receptors, Granulocyte Colony-Stimulating Factor,

Description

The granulocyte colony-stimulating factor receptor (G-CSF-R), also known as CD114 (Cluster of Differentiation 114), is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF).The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2.

KO Status

F0

Drug Information

Launched drugs: 29
Drugs in clinical trials: 93
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Filgrastim biosimilar (Biosidus)

Approved

Biosidus

Neutropenia

Filgrastim biosimilar (Fresenius Kabi Oncology)

Approved

Fresenius Kabi

Neutropenia

Filgrastim biosimilar (RPG Life Sciences)

Approved

Rpg Life Sciences

Neutropenia

Pegfilgrastim biosimilar (USV)

NDA/BLA

Usv

Neutropenia

Filgrastim biosimilar (Accord Healthcare)

Approved

Accord Healthcare

Neutropenia

Pegylated recombinant human granulocyte colony stimulating factor (Chongqing Fujin Biological Medicine)

Chongqing Fujin Biological Medicine Co Ltd

Filgrastim biosimilar (Apexcela)

SBS-6002, Leuco-Plus-300

Approved

Apexcela

Neutropenia

Pegfilgrastim biosimilar (Sandoz)

LAEP-2006

Approved

Clariant Produkte (Schweiz) Ag

Neutropenia, Febrile Neutropenia

Filgrastim biosimilar (Claris Lifesciences)

Approved

Claris Lifesciences

Neutropenia

Filgrastim biosimilar (Nanogen)

Approved

Nanogen Biopharmaceutical Co

Neutropenia

Filgrastim biosimilar (CIGB/Heber Biotec)

Approved

Center For Genetic Engineering And Biotechnology, Heber Biotec

Neutropenia

Filgrastim biosimilar (Emcure Pharmaceuticals)

Approved

Emcure

Neutropenia

Pegfilgrastim biosimilar (Intas Biopharmaceuticals)

INTP-5

Approved

Apotex, Intas Biopharmaceuticals

Neutropenia

Filgrastim biosimilar (Dong-A)

DA-3030

Approved

Dong-A Pharmaceutical Co Ltd

Neutropenia, Diabetic Neuropathies, Breast Neoplasms

Filgrastim biosimilar (Xiamen Amoytop Biotech)

Approved

Xiamen Amoytop Biotech Co Ltd

Neutropenia

Filgrastim biosimilar (Amega Biotech)

Approved

Amega Biotech

Neutropenia

Pegfilgrastim-jmdb

MYL-1401H

Approved

Biocon

Chemotherapy-Induced Febrile Neutropenia, Neutropenia, Breast Neoplasms, Febrile Neutropenia

Filgrastim biosimilar(Shandong Xinshidai Biotech)

NDA/BLA

Lunan Pharmaceutical Group Corp

Immune System Diseases

Filgrastim biosimilar (Apotex/Intas)

Approved

Apotex, Intas Biopharmaceuticals

Neutropenia

Pegfilgrastim biosimilar (Cinfa Biotech)

B-12019

Approved

Cinfa Biotech

Neutropenia