Leucine Rich Repeat Containing 32, D11S833E, Garpin, Leucine-Rich Repeat-Containing Protein 32, LRRC32, Transforming Growth Factor Beta Activator LRRC32, GARP, Glycoprotein A Repetitions Predominant


Transforming growth factor beta activator LRRC32 is a key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).

KO Status

RenMab: Exclusive Partnership

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 1 Clinical

Drug Name





Clinical Trials


MGH-8, ABBV151, AGRX-115, ARGX-115

Phase 1 Clinical


Solid tumours




Shanghai Henlius Biologics Co Ltd

Solid tumours





The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins

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Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg

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Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32)

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GARP regulates the bioavailability and activation of TGFbeta

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Mol. Biol. Cell 23:1129-1139(2012)

Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor beta1 (TGF-beta1) Production in Human Regulatory T Cells

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J. Biol. Chem. 290:20105-20116(2015)