GAS6

References

Title

Authors

Source

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and analysis of human chromosome 13

Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ross M.T.,

Nature 428:522-528(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

Varnum B.C., Young C., Elliott G., Garcia A., Bartley T.D., Fridell Y.W., Hunt R.W., Trail G., Clogston C., Toso R.J., Yanagihara D., Bennett L., Silber M., Merewether L.A., Tseng A., Escobar E., Liu E.T., Yamane H.K.,

Nature 373:623-626(1995)

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

Stitt T.N., Conn G., Gore M., Lai C., Bruno J., Radziejewski C., Mattsson K., Fisher J., Gies D.R., Jones P.F., Masiakowski P., Ryan T.E., Tobkes N.J., Chen D.H., DiStefano P.S., Long G.L., Basilico C., Goldfarb M.P., Yancopoulos G.D.,

Cell 80:661-670(1995)

Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6

Marcandalli P., Gostissa M., Varnum B., Goruppi S., Schneider C.,

FEBS Lett. 415:56-58(1997)

Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

Nagata K., Ohashi K., Nakano T., Arita H., Zong C., Hanafusa H., Mizuno K.,

J. Biol. Chem. 271:30022-30027(1996)

The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation

Goruppi S., Yamane H., Marcandalli P., Garcia A., Clogston C., Gostissa M., Varnum B., Schneider C.,

FEBS Lett. 415:59-63(1997)

A single kinase generates the majority of the secreted phosphoproteome

Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J., Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N., Pinna L.A., Pagliarini D.J., Dixon J.E.,

Cell 161:1619-1632(2015)

Acidification prevents endothelial cell apoptosis by Axl activation

D'Arcangelo D., Gaetano C., Capogrossi M.C.,

Circ. Res. 91:E4-12(2002)

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development

Park I.K., Giovenzana C., Hughes T.L., Yu J., Trotta R., Caligiuri M.A.,

Blood 113:2470-2477(2009)

The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry

Morizono K., Xie Y., Olafsen T., Lee B., Dasgupta A., Wu A.M., Chen I.S.,

Cell Host Microbe 9:286-298(2011)

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry

Meertens L., Carnec X., Lecoin M.P., Ramdasi R., Guivel-Benhassine F., Lew E., Lemke G., Schwartz O., Amara A.,

Cell Host Microbe 12:544-557(2012)

Tyro3 family-mediated cell entry of Ebola and Marburg viruses

Shimojima M., Takada A., Ebihara H., Neumann G., Fujioka K., Irimura T., Jones S., Feldmann H., Kawaoka Y.,

J. Virol. 80:10109-10116(2006)

Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl

Mark M.R., Chen J., Hammonds R.G., Sadick M., Godowski P.J.,

J. Biol. Chem. 271:9785-9789(1996)

Structural basis for Gas6-Axl signalling

Sasaki T., Knyazev P.G., Clout N.J., Cheburkin Y., Goehring W., Ullrich A., Timpl R., Hohenester E.,

EMBO J. 25:80-87(2006)

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade

Manfioletti G., Brancolini C., Avanzi G., Schneider C.,

Mol. Cell. Biol. 13:4976-4985(1993)

Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke

Munoz X., Sumoy L., Ramirez-Lorca R., Villar J., de Frutos P.G., Sala N.,

Hum. Mutat. 23:506-512(2004)

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.

Manfioletti G., Brancolini C., Avanzi G., Schneider C.,

Mol. Cell. Biol. 13:4976-4985(1993)

Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke.

Munoz X., Sumoy L., Ramirez-Lorca R., Villar J., de Frutos P.G., Sala N.,

Hum. Mutat. 23:506-512(2004)

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and analysis of human chromosome 13.

Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ross M.T.,

Nature 428:522-528(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6.

Varnum B.C., Young C., Elliott G., Garcia A., Bartley T.D., Fridell Y.W., Hunt R.W., Trail G., Clogston C., Toso R.J., Yanagihara D., Bennett L., Silber M., Merewether L.A., Tseng A., Escobar E., Liu E.T., Yamane H.K.,

Nature 373:623-626(1995)

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases.

Stitt T.N., Conn G., Gore M., Lai C., Bruno J., Radziejewski C., Mattsson K., Fisher J., Gies D.R., Jones P.F., Masiakowski P., Ryan T.E., Tobkes N.J., Chen D.H., DiStefano P.S., Long G.L., Basilico C., Goldfarb M.P., Yancopoulos G.D.,

Cell 80:661-670(1995)

Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6.

Marcandalli P., Gostissa M., Varnum B., Goruppi S., Schneider C.,

FEBS Lett. 415:56-58(1997)

Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases.

Nagata K., Ohashi K., Nakano T., Arita H., Zong C., Hanafusa H., Mizuno K.,

J. Biol. Chem. 271:30022-30027(1996)

The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation.

Goruppi S., Yamane H., Marcandalli P., Garcia A., Clogston C., Gostissa M., Varnum B., Schneider C.,

FEBS Lett. 415:59-63(1997)

Acidification prevents endothelial cell apoptosis by Axl activation.

D'Arcangelo D., Gaetano C., Capogrossi M.C.,

Circ. Res. 91:E4-12(2002)

The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.

Park I.K., Giovenzana C., Hughes T.L., Yu J., Trotta R., Caligiuri M.A.,

Blood 113:2470-2477(2009)

The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry.

Morizono K., Xie Y., Olafsen T., Lee B., Dasgupta A., Wu A.M., Chen I.S.,

Cell Host Microbe 9:286-298(2011)

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.

Meertens L., Carnec X., Lecoin M.P., Ramdasi R., Guivel-Benhassine F., Lew E., Lemke G., Schwartz O., Amara A.,

Cell Host Microbe 12:544-557(2012)

Tyro3 family-mediated cell entry of Ebola and Marburg viruses.

Shimojima M., Takada A., Ebihara H., Neumann G., Fujioka K., Irimura T., Jones S., Feldmann H., Kawaoka Y.,

J. Virol. 80:10109-10116(2006)

A single kinase generates the majority of the secreted phosphoproteome.

Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J., Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N., Pinna L.A., Pagliarini D.J., Dixon J.E.,

Cell 161:1619-1632(2015)

Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl.

Mark M.R., Chen J., Hammonds R.G., Sadick M., Godowski P.J.,

J. Biol. Chem. 271:9785-9789(1996)

Structural basis for Gas6-Axl signalling.

Sasaki T., Knyazev P.G., Clout N.J., Cheburkin Y., Goehring W., Ullrich A., Timpl R., Hohenester E.,

EMBO J. 25:80-87(2006)

Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid.

Furie B., Bouchard B.A., Furie B.C.,

Blood 93:1798-1808(1999)

The vitamin K-dependent carboxylase.

Berkner K.L.,

J Nutr 130:1877-1880(2000)

Three ways to make a vesicle.

Kirchhausen T.,

Nat Rev Mol Cell Biol 1:187-198(2000)

Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo.

Stenina O., Pudota B.N., McNally B.A., Hommema E.L., Berkner K.L.,

Biochemistry 40:10301-10309(2001)

Crystal structure of a C-terminal fragment of growth arrest-specific protein Gas6. Receptor tyrosine kinase activation by laminin G-like domains.

Sasaki T., Knyazev P.G., Cheburkin Y., Gohring W., Tisi D., Ullrich A., Timpl R., Hohenester E.,

J Biol Chem 277:44164-44170(2002)

Ligand recognition and homophilic interactions in Tyro3: structural insights into the Axl/Tyro3 receptor tyrosine kinase family.

Heiring C., Dahlbaeck B., Muller Y.A.,

J. Biol. Chem. 279:6952-6958(2004)

Signalling and functional diversity within the Axl subfamily of receptor tyrosine kinases.

Hafizi S., Dahlback B.,

Cytokine Growth Factor Rev. 17:295-304(2006)

Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily.

Hafizi S., Dahlback B.,

FEBS J 273:5231-5244(2006)

Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells.

Seitz H.M., Camenisch T.D., Lemke G., Earp H.S., Matsushima G.K.,

J Immunol 178:5635-5642(2007)

The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis.

Dyer M.D., Neff C., Dufford M., Rivera C.G., Shattuck D., Bassaganya-Riera J., Murali T.M., Sobral B.W.,

PLoS One 5:e12089-e12089(2010)

Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa.

Gogstad G.O., Hagen I., Korsmo R., Solum N.O.,

Biochim Biophys Acta 670:150-162(1981)

Synonyms

Description

KO Status

Drug Information

AVB-S6-500