GAS6

Synonyms

GAS6, AXLLG, Growth Arrest Specific 6, AXL Receptor Tyrosine Kinase Ligand, AXL Stimulatory Factor, Growth Arrest-Specific Protein 6, GAS-6, AXSF, FLJ34709, DKFZp666G247

Description

Growth arrest-specific protein 6 (GAS6) is a vitamin K-dependent protein that plays an important role in the pathogenesis of autoimmune diseases. Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry.

KO Status

F1 (+/-)

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

AVB-S6-500

Aravive S-6, AVB-S6-500, Ruga-S6, 3D-229, 3D229, AVB-500

Phase 3 Clinical

Aravive Biologics

Ovarian Neoplasms, Glomerulonephritis, IGA, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Carcinoma, Ovarian Epithelial, Peritoneal Neoplasms, Fallopian Tube Neoplasms

References


Title

Authors

Source

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and analysis of human chromosome 13

Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., Ross M.T.,

Nature 428:522-528(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6

Varnum B.C., Young C., Elliott G., Garcia A., Bartley T.D., Fridell Y.W., Hunt R.W., Trail G., Clogston C., Toso R.J., Yanagihara D., Bennett L., Silber M., Merewether L.A., Tseng A., Escobar E., Liu E.T., Yamane H.K.,

Nature 373:623-626(1995)

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

Stitt T.N., Conn G., Gore M., Lai C., Bruno J., Radziejewski C., Mattsson K., Fisher J., Gies D.R., Jones P.F., Masiakowski P., Ryan T.E., Tobkes N.J., Chen D.H., DiStefano P.S., Long G.L., Basilico C., Goldfarb M.P., Yancopoulos G.D.,

Cell 80:661-670(1995)

Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6

Marcandalli P., Gostissa M., Varnum B., Goruppi S., Schneider C.,

FEBS Lett. 415:56-58(1997)

Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

Nagata K., Ohashi K., Nakano T., Arita H., Zong C., Hanafusa H., Mizuno K.,

J. Biol. Chem. 271:30022-30027(1996)

The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation

Goruppi S., Yamane H., Marcandalli P., Garcia A., Clogston C., Gostissa M., Varnum B., Schneider C.,

FEBS Lett. 415:59-63(1997)

A single kinase generates the majority of the secreted phosphoproteome

Tagliabracci V.S., Wiley S.E., Guo X., Kinch L.N., Durrant E., Wen J., Xiao J., Cui J., Nguyen K.B., Engel J.L., Coon J.J., Grishin N., Pinna L.A., Pagliarini D.J., Dixon J.E.,

Cell 161:1619-1632(2015)

Acidification prevents endothelial cell apoptosis by Axl activation

D'Arcangelo D., Gaetano C., Capogrossi M.C.,

Circ. Res. 91:E4-12(2002)