GLP2R

Synonyms

Glucagon-like peptide 2 receptor, Glucagon Like Peptide 2 Receptor, GLP-2 Receptor, GLP-2-R, GLP-2R, Glucagon-Like Peptide-2 Receptor, Epididymis Secretory Sperm Binding Protein, GLP2R

Description

GLP2R (Glucagon-like peptide 2 receptor) is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 6
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Teduglutide

SHP-633, ALX-0600, [Gly2]GLP-2

Approved

Shire Development Llc

Kidney Diseases, Short Bowel Syndrome, Hepatic Insufficiency, Crohn Disease, Malabsorption Syndromes

Glepaglutide

ZP-1848

Phase 3 Clinical

Zealand Pharma

Inflammatory Bowel Diseases, Kidney Diseases, Short Bowel Syndrome

Apraglutide

FE-203799

Phase 3 Clinical

Ferring Bv

Hodgkin Disease, Short Bowel Syndrome, Lymphoma, Non-Hodgkin, Renal Insufficiency, Chronic

HM-15912

HM-15910, HM-15912

Phase 2 Clinical

Hanmi Pharmaceutical Co Ltd

Short Bowel Syndrome

Elsiglutide

ZP-1846

Phase 2 Clinical

Zealand Pharma A/S

Diarrhea

ZP-7570

ZP-7570

Phase 1 Clinical

Zealand Pharma A/S

Short Bowel Syndrome

SHP-681

SHP-681, TAK-681

Phase 1 Clinical

Shire

Short Bowel Syndrome

ZP-GG-72

ZP-GG-72

Preclinical

C.H. Boehringer Sohn Ag & Co. Kg, Zealand Pharma

Obesity, Diabetes Mellitus

SAN-134

SAN-134

Pending

Nordic Bioscience

Osteoporosis

References


Title

Authors

Source

Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2

Munroe D.G., Gupta A.K., Kooshesh F., Vyas T.B., Rizkalla G., Wang H., Demchyshyn L., Yang Z.-H., Kamboj R.K., Chen H., McCallum K., Sumner-Smith M., Drucker D.J., Crivici A.,

Proc. Natl. Acad. Sci. U.S.A. 96:1569-1573(1999)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.

Munroe D.G., Gupta A.K., Kooshesh F., Vyas T.B., Rizkalla G., Wang H., Demchyshyn L., Yang Z.-H., Kamboj R.K., Chen H., McCallum K., Sumner-Smith M., Drucker D.J., Crivici A.,

Proc. Natl. Acad. Sci. U.S.A. 96:1569-1573(1999)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Glucagon-like peptide 2.

Drucker D.J.,

Trends Endocrinol. Metab. 10:153-156(1999)

Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.

Feldman D.S., Zamah A.M., Pierce K.L., Miller W.E., Kelly F., Rapacciuolo A., Rockman H.A., Koch W.J., Luttrell L.M.,

J Biol Chem 277:28631-28640(2002)

Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants.

Wenzel-Seifert K., Liu H.Y., Seifert R.,

Biochem Pharmacol 64:9-20(2002)

Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein.

Zhang J.Y., Nawoschik S., Kowal D., Smith D., Spangler T., Ochalski R., Schechter L., Dunlop J.,

Eur J Pharmacol 472:33-38(2003)

The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.

Koehler J.A., Yusta B., Drucker D.J.,

Mol Endocrinol 19:459-473(2005)

GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors.

Orskov C., Hartmann B., Poulsen S.S., Thulesen J., Hare K.J., Holst J.J.,

Regul Pept 124:105-112(2005)