GM-CSF, Molgramostin, CSF2, Colony Stimulating Factor 2, Sargramostim, GMCSF, CSF, Granulocyte Macrophage-Colony Stimulating Factor, Granulocyte-Macrophage Colony Stimulating Factor, Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Colony Stimulating Factor 2 (Granulocyte-Macrophage), Molgramostim

KO Status

RenMab: F0

Drug Information

Drugs in clinical trials: 9
Latest Research Phase: NDA/BLA

Drug Name





Clinical Trials





Lymphoma, B-Cell, Leukemia, Myelomonocytic, Chronic, Arthritis, Rheumatoid, Coronavirus Disease 2019 (COVID-19)


MOR-103, MOR-04357, GSK-3196165, GSK-165

Phase 3 Clinical

University Of Melbourne

Arthritis, Rheumatoid, Multiple Sclerosis, Severe Acute Respiratory Syndrome, Glycogen Storage Disease Type II, Osteoarthritis


TJM-2, TJ-003234, TJ-003234RAR101

Phase 3 Clinical

I-Mab Biopharma Co Ltd

Coronavirus Disease 2019 (COVID-19), Arthritis, Rheumatoid

Pexastimogene devacirepvec

TG-6006, JX-594

Phase 3 Clinical

Sillajen, Regeneron Pharmaceuticals Inc, National Cancer Institute, Samsung Medical Center & Samsung Electronics Devices Llc

Liver Neoplasms, Rhabdomyosarcoma, Carcinoma, Renal Cell, Squamous Cell Carcinoma of Head and Neck, Wilms Tumor, Neuroblastoma, Sarcoma, Ewing, Colorectal Neoplasms, Lung Neoplasms, Lymphoma, Carcinoma, Hepatocellular, Melanoma


MT-203, AMG-203, IZN-101

Phase 2 Clinical

Takeda Pharmaceutical Co Ltd, Amgen Inc

Arthritis, Rheumatoid, Spondylitis, Ankylosing, Psoriasis



Phase 2 Clinical


Solid tumours, Carcinoma, Merkel Cell, Triple Negative Breast Neoplasms, Neoplasms, Sarcoma, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Melanoma



Phase 2 Clinical

Prometic Life Sciences



PD-360324, PD-0360324

Phase 2 Clinical

Pfizer Pharmaceuticals Ltd (China)

Neoplasms, Lupus Erythematosus, Cutaneous, Sarcoidosis, Pulmonary


MORAb-022, KIN-1901

Phase 2 Clinical


Arthritis, Rheumatoid, Coronavirus Disease 2019 (COVID-19), Nasopharyngeal Neoplasms, Rheumatic Diseases, Inflammation

Interleukin-1 alpha (Dainippon)


F. Hoffmann-La Roche Ltd, Sumitomo Dainippon






Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor

Walter M.R., Cook W.J., Ealick S.E., Nagabhushan T.L., Trotta P.P., Bugg C.E.,

J. Mol. Biol. 224:1075-1085(1992)

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

Hansen G., Hercus T.R., McClure B.J., Stomski F.C., Dottore M., Powell J., Ramshaw H., Woodcock J.M., Xu Y., Guthridge M., McKinstry W.J., Lopez A.F., Parker M.W.,

Cell 134:496-507(2008)

Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins

Wong G.G., Witek J.S., Temple P.A., Wilkens K.M., Leary A.C., Luxenberg D.P., Jones S.S., Brown E.L., Kay R.M., Orr E.C., Shoemaker C., Golde D.W., Kaufman R.J., Hewick R.M., Wang E.A., Clark S.C.,

Science 228:810-815(1985)

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes

Miyatake S., Otsuka T., Yokota T., Lee F., Arai K.,

EMBO J. 4:2561-2568(1985)

The DNA sequence and comparative analysis of human chromosome 5

Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Rubin E.M.,

Nature 431:268-274(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells

Kaushansky K., Lopez J.A., Brown C.B.,

Biochemistry 31:1881-1886(1992)

Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor

Diederichs K., Boone T., Karplus P.A.,

Science 254:1779-1782(1991)

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells

Lee F., Yokota T., Otsuka T., Gemmell L., Larson N., Luh J., Arai K., Rennick D.,

Proc. Natl. Acad. Sci. U.S.A. 82:4360-4364(1985)

Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor

Kaushansky K., O'Hara P.J., Berkner K., Segal G.M., Hagen F.S., Adamson J.W.,

Proc. Natl. Acad. Sci. U.S.A. 83:3101-3105(1986)