GM-CSF

Synonyms

Molgramostim, Granulocyte-Macrophage Colony Stimulating Factor, Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF, Molgramostin, CSF2, Colony Stimulating Factor 2, Sargramostim, GMCSF, CSF, Granulocyte Macrophage-Colony Stimulating Factor, Colony Stimulating Factor 2 (Granulocyte-Macrophage)

Description

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

KO Status

F0

Drug Information

Drugs in clinical trials: 7
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

TJ-003234

TJM-2, TJ-003234, TJ-003234RAR101

Phase 3 Clinical

I-Mab Biopharma Co Ltd

Coronavirus Disease 2019 (COVID-19), Arthritis, Rheumatoid

Lenzilumab

KB-003

Phase 3 Clinical

Kalobios

Lymphoma, B-Cell, Coronavirus Disease 2019 (COVID-19), Leukemia, Myelomonocytic, Chronic, Arthritis, Rheumatoid

Otilimab

MOR-103, MOR-04357, GSK-3196165, GSK-165

Phase 3 Clinical

University Of Melbourne

Arthritis, Rheumatoid, Multiple Sclerosis, Severe Acute Respiratory Syndrome, Osteoarthritis

PBI-1402

PBI-1402

Phase 2 Clinical

Prometic Life Sciences

Anemia

Namilumab

MT-203, AMG-203, IZN-101

Phase 2 Clinical

Takeda Pharmaceutical Co Ltd, Amgen Inc

Arthritis, Rheumatoid, Spondylitis, Ankylosing, Psoriasis

PD-360324

PD-360324, PD-0360324

Phase 2 Clinical

Pfizer Pharmaceuticals Ltd (China)

Neoplasms, Lupus Erythematosus, Cutaneous, Sarcoidosis, Pulmonary

Gimsilumab

MORAb-022, KIN-1901

Phase 2 Clinical

Morphotek

Arthritis, Rheumatoid, Coronavirus Disease 2019 (COVID-19), Nasopharyngeal Neoplasms, Rheumatic Diseases, Inflammation

Interleukin-1 alpha (Dainippon)

Discontinued

F. Hoffmann-La Roche Ltd, Sumitomo Dainippon

Neoplasms

Plasmid cDNA vaccine (Colby Pharmaceutical)

Discontinued

Colby

Prostatic Neoplasms

Pancreatic cancer immunotherapy (Cell Genesys)

Discontinued

Cell Genesys

Pancreatic Neoplasms

References


Title

Authors

Source

Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor

Walter M.R., Cook W.J., Ealick S.E., Nagabhushan T.L., Trotta P.P., Bugg C.E.,

J. Mol. Biol. 224:1075-1085(1992)

The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation

Hansen G., Hercus T.R., McClure B.J., Stomski F.C., Dottore M., Powell J., Ramshaw H., Woodcock J.M., Xu Y., Guthridge M., McKinstry W.J., Lopez A.F., Parker M.W.,

Cell 134:496-507(2008)

Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins

Wong G.G., Witek J.S., Temple P.A., Wilkens K.M., Leary A.C., Luxenberg D.P., Jones S.S., Brown E.L., Kay R.M., Orr E.C., Shoemaker C., Golde D.W., Kaufman R.J., Hewick R.M., Wang E.A., Clark S.C.,

Science 228:810-815(1985)

Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes

Miyatake S., Otsuka T., Yokota T., Lee F., Arai K.,

EMBO J. 4:2561-2568(1985)

The DNA sequence and comparative analysis of human chromosome 5

Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Rubin E.M.,

Nature 431:268-274(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells

Kaushansky K., Lopez J.A., Brown C.B.,

Biochemistry 31:1881-1886(1992)

Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor

Diederichs K., Boone T., Karplus P.A.,

Science 254:1779-1782(1991)

Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells

Lee F., Yokota T., Otsuka T., Gemmell L., Larson N., Luh J., Arai K., Rennick D.,

Proc. Natl. Acad. Sci. U.S.A. 82:4360-4364(1985)

Genomic cloning, characterization, and multilineage growth-promoting activity of human granulocyte-macrophage colony-stimulating factor

Kaushansky K., O'Hara P.J., Berkner K., Segal G.M., Hagen F.S., Adamson J.W.,

Proc. Natl. Acad. Sci. U.S.A. 83:3101-3105(1986)