HAMP

Synonyms

HAMP, PLTR, LEAP1, Hepcidin, Hepcidin Preproprotein, LEAP-1, Putative Liver Tumor Regressor, HEPC, Hepc20, Hepcidin Antimicrobial Peptide, HFE2B, Liver-Expressed Antimicrobial Peptide 1, Hepc25, Hepcidins

Description

Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes .Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa .

KO Status

RenMab: F0

Drug Information

Drugs in clinical trials: 3
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

LJPC-401

LJPC-401

Phase 2 Clinical

Inserm

Thalassemia, beta-Thalassemia, Iron Overload, Hemochromatosis, Anemia, Sickle Cell

FMX-8

FMX-8

Phase 2 Clinical

Ferrumax

Anemia

LJPC‑401 (synthetic human hepcidin)

LJPC‑401

Phase 2 Clinical

Inserm

Iron Overload, Hemochromatosis

ALN-AC3

ALN ANG, ALN F12, ALN-APC, ALN-HDV, ALN-HPN, ALN-PDL, ALN-TMP

Preclinical

Alnylam Pharmaceuticals

Anemia, Adenoviridae Infections, Hepatitis, Genetic Diseases, Inborn, Hepatitis D, Hepatitis B, Amyloidosis, Angioedemas, Hereditary, Hyperoxaluria, Primary

XEN-701

XEN-701

Pending

Isis Pharmaceuticals, Xenon Pharma

Anemia

PRS-080

PRS-080, PRS-080#022-DP

Pending

Pieris Pharmaceuticals

Anemia

M-012

M-012

Pending

University Of California

Iron Overload

LY-2787106

LY-2787106

Discontinued

Eli Lilly And Company

Anemia

Lexaptepid pegol

NOX-H94

Discontinued

Noxxon Pharma

Anemia, Inflammation, Kidney Failure, Chronic, Chronic Disease

References


Title

Authors

Source

Hepcidin revisited, disulfide connectivity, dynamics, and structure

Jordan J.B., Poppe L., Haniu M., Arvedson T., Syed R., Li V., Kohno H., Kim H., Schnier P.D., Harvey T.S., Miranda L.P., Cheetham J., Sasu B.J.,

J. Biol. Chem. 284:24155-24167(2009)

Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload

Biasiotto G., Belloli S., Ruggeri G., Zanella I., Gerardi G., Corrado M., Gobbi E., Albertini A., Arosio P.,

Clin. Chem. 49:1981-1988(2003)

Hepcidin: a urinary antimicrobial peptide synthesized in the liver

Park C.H., Valore E.V., Waring A.J., Ganz T.,

J. Biol. Chem. 276:7806-7810(2001)

LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity

Krause A., Neitz S., Maegert H.-J., Schulz A., Forssmann W.-G., Schulz-Knappe P., Adermann K.,

FEBS Lett. 480:147-150(2000)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment

Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,

Genome Res. 13:2265-2270(2003)

The DNA sequence and biology of human chromosome 19

Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Lucas S.M.,

Nature 428:529-535(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Chemical synthesis of beta-defensins and LEAP-1/hepcidin

Kluever E., Schulz A., Forssmann W.-G., Adermann K.,

J. Pept. Res. 59:241-248(2002)

Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis

Merryweather-Clarke A.T., Cadet E., Bomford A., Capron D., Viprakasit V., Miller A., McHugh P.J., Chapman R.W., Pointon J.J., Wimhurst V.L., Livesey K.J., Tanphaichitr V., Rochette J., Robson K.J.,

Hum. Mol. Genet. 12:2241-2247(2003)

Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R)

Roetto A., Daraio F., Porporato P., Caruso R., Cox T.M., Cazzola M., Gasparini P., Piperno A., Camaschella C.,

Blood 103:2407-2409(2004)