HRH3

Synonyms

GPCR97, HRH3, Histamine Receptor H3, G-protein coupled receptor 97, H3R, Histamine H3 receptor, HH3R, G Protein-Coupled Receptor 97, Receptors, Histamine H3

Description

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.

KO Status

RenMab: Immunization

RenLite: F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 6
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Pitolisant Hydrochloride

BF-2.649, BF-2649

Approved

Bioprojet

Diabetes Mellitus, Type 1, Sleepiness, Hypoglycemia, Myotonic Dystrophy, Prader-Willi Syndrome, Narcolepsy

GSK-239512

GSK-239512, GSK-239512A

Phase 2 Clinical

Glaxosmithkline Plc

Multiple Sclerosis, Relapsing-Remitting, Schizophrenia, Multiple Sclerosis, Alzheimer Disease, Cognitive Dysfunction, Dementia

Bavisant

BEN-2001, JNJ-1074, JNJ-31001074

Phase 2 Clinical

Johnson & Johnson

Sleepiness, Attention Deficit Disorder with Hyperactivity, Alcoholism, Parkinson Disease, Narcolepsy

SUVN-G3031

SUVN-G3031

Phase 2 Clinical

Suven Life Sciences

Parkinson Disease, Cognition Disorders, Narcolepsy

AZD-1979

AZD-1979

Phase 1 Clinical

Astrazeneca Plc

Obesity

Irdabisant

CEP-26401

Phase 1 Clinical

Teva

Cognitive Dysfunction, Cognition Disorders

[11C]TASP-0410457

[11C]TASP-457, [11C]TASP-0410457

Phase 1 Clinical

National Institute Of Radiological Sciences, Taisho Pharmaceutical Holdings Co Ltd

Diagnostic agents

Votucalis(Akari Therapeutics)

Preclinical

Akari Therapeutics

Pruritus, Neuralgia, Dermatitis, Atopic

SLS-010

SLS-010

Preclinical

Ligand Pharmaceuticals Inc

Narcolepsy

AZD-5213

AZD-5213

Pending

Astrazeneca Plc

Diabetic Neuropathies, Tourette Syndrome, Alzheimer Disease, Cognitive Dysfunction