IFNAR1
Synonyms
IFNBR, IFN-Alpha-REC, Beta-Type Antiviral Protein, IFNAR, Cytokine Receptor Class-II Member 1, Interferon Receptor 1, IFNAR1, Interferon Alpha/Beta Receptor 1, Interferon Alpha And Beta Receptor Subunit 1, Type I Interferon Receptor 1, Interferon (Alpha, Beta And Omega) Receptor 1, Alpha-Type Antiviral Protein, IFN-Alpha/Beta Receptor 1, AVP, Interferon-Beta Receptor 1, IFRC, IFN-R-1, CRF2-1, Cytokine Receptor Family 2 Member 1, Interferon-Alpha/Beta Receptor Alpha Chain
Description
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. It usually acts as a heterodimer together with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade and triggers the tyrosine phosphorylation of many proteins, including JAK, TYK2, STAT proteins, and IFNRα- and β-subunits. It can form an active IFNB1 receptor by itself and activate a signal cascade that does not involve activation of the JAK-STAT pathway.
KO Status
RenMab: F0
Drug Information
Launched drugs: 5
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Recombinant human interferon α2b biosimilar (Zhejiang Hansheng)
Approved
Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma
Virus Diseases, Neoplasms
Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering)
Approved
Harbin Pharmaceutical Group Holding Co Ltd
Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Hairy Cell, Varicella Zoster Virus Infection, Multiple Myeloma, Hepatitis, Viral, Human, Lymphoma, Non-Hodgkin, Condylomata Acuminata
Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical)
Approved
Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd
Leukemia, Hairy Cell, Hepatitis, Multiple Myeloma, Leukemia, Myeloid, Chronic-Phase, Lymphoma, Non-Hodgkin, Condylomata Acuminata, Herpes Zoster
Interferon beta (Toray/Daiichi Sankyo)
DL-8234
Approved
Toray Industries Inc
Medulloblastoma, Glioblastoma, Hepatitis B, Hepatitis C, Astrocytoma, Melanoma
Anifrolumab
MEDI-546, MDX-1333
Approved
Medimmune Llc, Medarex
Scleroderma, Systemic, Lupus Nephritis, Lupus Erythematosus, Systemic
Interferon-α (Flamel Technologies)
Discontinued
Avadel Pharmaceuticals
Hepatitis C
References
Title
Authors
Source
Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis
Kumar K.G., Barriere H., Carbone C.J., Liu J., Swaminathan G., Xu P., Li Y., Baker D.P., Peng J., Lukacs G.L., Fuchs S.Y.,
J. Cell Biol. 179:935-950(2007)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.,
Anal. Chem. 81:4493-4501(2009)
Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA
Uze G., Lutfalla G., Gresser I.,
Cell 60:225-234(1990)
The structure of the human interferon alpha/beta receptor gene
Lutfalla G., Gardiner K., Proudhon D., Vielh E., Uze G.,
J. Biol. Chem. 267:2802-2809(1992)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)
Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha
Claudinon J., Gonnord P., Beslard E., Marchetti M., Mitchell K., Boularan C., Johannes L., Eid P., Lamaze C.,
J. Biol. Chem. 284:24328-24340(2009)
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.,
Nat. Biotechnol. 27:378-386(2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.,
Sci. Signal. 2:RA46-RA46(2009)
A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses
Zheng H., Gupta V., Patterson-Fortin J., Bhattacharya S., Katlinski K., Wu J., Varghese B., Carbone C.J., Aressy B., Fuchs S.Y., Greenberg R.A.,
Cell Rep. 5:180-193(2013)
Toward a comprehensive characterization of a human cancer cell phosphoproteome
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.,
J. Proteome Res. 12:260-271(2013)