IFNAR1

Synonyms

IFNBR, IFN-Alpha-REC, Beta-Type Antiviral Protein, IFNAR, Cytokine Receptor Class-II Member 1, Interferon Receptor 1, IFNAR1, Interferon Alpha/Beta Receptor 1, Interferon Alpha And Beta Receptor Subunit 1, Type I Interferon Receptor 1, Interferon (Alpha, Beta And Omega) Receptor 1, Alpha-Type Antiviral Protein, IFN-Alpha/Beta Receptor 1, AVP, Interferon-Beta Receptor 1, IFRC, IFN-R-1, CRF2-1, Cytokine Receptor Family 2 Member 1, Interferon-Alpha/Beta Receptor Alpha Chain

Description

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. It usually acts as a heterodimer together with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade and triggers the tyrosine phosphorylation of many proteins, including JAK, TYK2, STAT proteins, and IFNRα- and β-subunits. It can form an active IFNB1 receptor by itself and activate a signal cascade that does not involve activation of the JAK-STAT pathway.

KO Status

RenMab: F0

Drug Information

Launched drugs: 5
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Recombinant human interferon α2b biosimilar (Zhejiang Hansheng)

Approved

Zhejiang Hansheng Pharmaceutical Co Ltd Of Beisheng Pharma

Virus Diseases, Neoplasms

Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering)

Approved

Harbin Pharmaceutical Group Holding Co Ltd

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Hairy Cell, Varicella Zoster Virus Infection, Multiple Myeloma, Hepatitis, Viral, Human, Lymphoma, Non-Hodgkin, Condylomata Acuminata

Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical)

Approved

Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd

Leukemia, Hairy Cell, Hepatitis, Multiple Myeloma, Leukemia, Myeloid, Chronic-Phase, Lymphoma, Non-Hodgkin, Condylomata Acuminata, Herpes Zoster

Interferon beta (Toray/Daiichi Sankyo)

DL-8234

Approved

Toray Industries Inc

Medulloblastoma, Glioblastoma, Hepatitis B, Hepatitis C, Astrocytoma, Melanoma

Anifrolumab

MEDI-546, MDX-1333

Approved

Medimmune Llc, Medarex

Scleroderma, Systemic, Lupus Nephritis, Lupus Erythematosus, Systemic

Interferon-α (Flamel Technologies)

Discontinued

Avadel Pharmaceuticals

Hepatitis C

References


Title

Authors

Source

Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis

Kumar K.G., Barriere H., Carbone C.J., Liu J., Swaminathan G., Xu P., Li Y., Baker D.P., Peng J., Lukacs G.L., Fuchs S.Y.,

J. Cell Biol. 179:935-950(2007)

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach

Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.,

Anal. Chem. 81:4493-4501(2009)

Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA

Uze G., Lutfalla G., Gresser I.,

Cell 60:225-234(1990)

The structure of the human interferon alpha/beta receptor gene

Lutfalla G., Gardiner K., Proudhon D., Vielh E., Uze G.,

J. Biol. Chem. 267:2802-2809(1992)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha

Claudinon J., Gonnord P., Beslard E., Marchetti M., Mitchell K., Boularan C., Johannes L., Eid P., Lamaze C.,

J. Biol. Chem. 284:24328-24340(2009)

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins

Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.,

Nat. Biotechnol. 27:378-386(2009)

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions

Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.,

Sci. Signal. 2:RA46-RA46(2009)

A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses

Zheng H., Gupta V., Patterson-Fortin J., Bhattacharya S., Katlinski K., Wu J., Varghese B., Carbone C.J., Aressy B., Fuchs S.Y., Greenberg R.A.,

Cell Rep. 5:180-193(2013)

Toward a comprehensive characterization of a human cancer cell phosphoproteome

Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.,

J. Proteome Res. 12:260-271(2013)