IFNAR1

Synonyms

CRF2-1, IFN-R-1, Cytokine Receptor Family 2 Member 1, Interferon-Alpha/Beta Receptor Alpha Chain, Cytokine Receptor Class-II Member 1, Interferon Receptor 1, IFNAR1, Interferon Alpha/Beta Receptor 1, IFN-Alpha-REC, Beta-Type Antiviral Protein, IFNAR, IFNBR, Interferon (Alpha, Beta And Omega) Receptor 1, Type I Interferon Receptor 1, Interferon Alpha And Beta Receptor Subunit 1, IFN-Alpha/Beta Receptor 1, AVP, Interferon-Beta Receptor 1, IFRC, Alpha-Type Antiviral Protein,

Description

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene. It usually acts as a heterodimer together with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade and triggers the tyrosine phosphorylation of many proteins, including JAK, TYK2, STAT proteins, and IFNRα- and β-subunits. It can form an active IFNB1 receptor by itself and activate a signal cascade that does not involve activation of the JAK-STAT pathway.

KO Status

F0

Drug Information

Launched drug: 1
Drugs in clinical trials: 3
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Recombinant human interferon alfa-2b (Harbin Pharmaceutical Group Bioengineering)

Approved

Harbin Pharmaceutical Group

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Hairy Cell, Varicella Zoster Virus Infection, Multiple Myeloma, Hepatitis, Viral, Human, Lymphoma, Non-Hodgkin, Condylomata Acuminata

Recombinant human interferon α2b biosimilar (Harbin High-Tech White Swan Pharmaceutical)

Approved

Harbin High-Tech Group Baitian'Er Pharmaceutical Co Ltd

Leukemia, Hairy Cell, Hepatitis, Multiple Myeloma, Leukemia, Myeloid, Chronic-Phase, Lymphoma, Non-Hodgkin, Condylomata Acuminata, Herpes Zoster

Recombinant human interferon α2b biosimilar (Zhejiang Hansheng)

Approved

Zhejiang Beisheng Pharmaceutical Hansheng Pharmaceutical Co Ltd

Virus Diseases, Neoplasms

Interferon beta (Toray/Daiichi Sankyo)

DL-8234

Approved

Toray

Medulloblastoma, Glioblastoma, Hepatitis B, Hepatitis C, Astrocytoma, Melanoma

Anifrolumab

MDX-1333, MEDI-546

Phase 3 Clinical

Medimmune Llc

Lupus Nephritis, Lupus Erythematosus, Systemic, Scleroderma, Localized

Interferon-α (Flamel Technologies)

Discontinued

Avadel Pharmaceuticals

Hepatitis C