IFNG

Synonyms

Immune interferon, Interferon gamma, IFNG, IFN-Gamma, IFG, IFI, Interferon-gamma

Description

Interferon gamma is a dimerized soluble cytokine that is the only member of the type II class of interferons.The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes.It was also shown to be produced in human lymphocytes,or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.

KO Status

F2 (-/-)

Drug Information

Launched drugs: 5
Drugs in clinical trials: 9
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Cadi-05

Cadi-05

Approved

National Institute Of Allergy And Infectious Diseases

Leprosy, Carcinoma, Non-Small-Cell Lung

Recombinant interferon gamma (Shanghai Chemo Wanbang Biopharma)

Approved

Shanghai Chemo Wanbang Biophama Co Ltd

Liver Cirrhosis, Arthritis, Rheumatoid

Emapalumab

NI-0501

Approved

Novimmune

Macrophage Activation Syndrome, Rare Diseases, Arthritis, Juvenile, Lymphohistiocytosis, Hemophagocytic

Interferon biosimilar (LG Life Sciences)

Approved

Lg Life Sciences Ltd

Leukemia

Thalidomide

K-17, NSC-66847, NSC-527179

Approved

Celgene Corp

HIV Infections, Spondylitis, Ankylosing, Myelodysplastic Syndromes, Multiple Myeloma, Erythema Nodosum, HIV Wasting Syndrome, Leprosy, Lepromatous, Carcinoma, Hepatocellular

Tadekinig alfa (AB2 Bio)

Phase 3 Clinical

Ab2 Bio

Macrophage Activation Syndrome, Immune System Diseases

OCH-NCNP1

OCH-NCNP1

Phase 2 Clinical

Keio University

Multiple Sclerosis, Crohn Disease

Interferon gamma (aerosol, IPF/ COPD), Stony Brook University School of Medicine

Phase 2 Clinical

Stony Brook University School Of Medicine, Nyu Langone Medical Center, Nostrum

Pulmonary Fibrosis, Pulmonary Disease, Chronic Obstructive

LP-0058

LP-0058, LEO-32731

Phase 2 Clinical

Leo Pharma Inc

Drug-Related Side Effects and Adverse Reactions, Psoriasis, Dermatitis, Atopic

Vidofludimus

4SC-101, SC-12267

Phase 2 Clinical

4sc Ag

Inflammatory Bowel Diseases, Arthritis, Rheumatoid, Colitis, Ulcerative, Crohn Disease

References


Title

Authors

Source

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation

Rinderknecht E., O'Conner B.H., Rodriguez H.,

J. Biol. Chem. 259:6790-6797(1984)

Structural characterization of human interferon gamma. Heterogeneity of the carboxyl terminus

Pan Y.C.E., Stern A.S., Familletti P.C., Khan F.R., Chizzonite R.,

Eur. J. Biochem. 166:145-149(1987)

Studies on the sugar chains of interferon-gamma from human peripheral-blood lymphocytes

Yamamoto S., Hase S., Yamauchi H., Tanimoto T., Ikenaka T.,

J. Biochem. 105:1034-1039(1989)

Three-dimensional structure of recombinant human interferon-gamma

Ealick S.E., Cook W.J., Vijay-Kumar S., Carson M., Nagabhushan T.L., Trotta P.P., Bugg C.E.,

Science 252:698-702(1991)

Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor

Walter M.R., Windsor W.T., Nagabhushan T.L., Lundell D.J., Lunn C.A., Zauodny P.J., Narula S.K.,

Nature 376:230-235(1995)

Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma

Landar A., Curry B., Parker M.H., DiGiacomo R., Indelicato S.R., Nagabhushan T.L., Rizzi G., Walter M.R.,

J. Mol. Biol. 299:169-179(2000)

Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex

Thiel D.J., le Du M.-H., Walter R.L., D'Arcy A., Chene C., Fountoulakis M., Garotta G., Winkler F.K., Ealick S.E.,

Structure 8:927-936(2000)

1H, 13C, and 15N NMR backbone assignments and secondary structure of human interferon-gamma

Grzesiek S., Doebeli H., Gentz R., Garotta G., Labhardt A.M., Bax A.,

Biochemistry 31:8180-8190(1992)

Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population

Dufour C., Capasso M., Svahn J., Marrone A., Haupt R., Bacigalupo A., Giordani L., Longoni D., Pillon M., Pistorio A., Di Michele P., Iori A.P., Pongiglione C., Lanciotti M., Iolascon A.,

Br. J. Haematol. 126:682-685(2004)