IFNG

Synonyms

Immune interferon, Interferon gamma, IFNG, IFN-Gamma, IFG, IFI, Interferon-gamma,

Description

Interferon gamma is a dimerized soluble cytokine that is the only member of the type II class of interferons.The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes.It was also shown to be produced in human lymphocytes,or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.

KO Status

F1 (+/-)

Drug Information

Launched drugs: 9
Drugs in clinical trials: 5
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Interferon biosimilar (LG Life Sciences)

Approved

Lg Life Sciences

Leukemia

Emapalumab

NI-0501

Approved

Novimmune

Macrophage Activation Syndrome, Arthritis, Juvenile, Lymphohistiocytosis, Hemophagocytic

Recombinant interferon gamma (Shanghai Chemo Wanbang Biopharma)

Approved

Shanghai Chemo Wanbang Biophama Co Ltd

Arthritis, Rheumatoid, Liver Cirrhosis

Thalidomide

K-17, NSC-66847, NSC-527179

Approved

Celgene

HIV Infections, Spondylitis, Ankylosing, Myelodysplastic Syndromes, Multiple Myeloma, HIV Wasting Syndrome, Erythema Nodosum, Leprosy, Lepromatous, Carcinoma, Hepatocellular

Cadi-05

Cadi-05

Approved

National Institute Of Allergy And Infectious Diseases

Leprosy, Carcinoma, Non-Small-Cell Lung

Tadekinig alfa (AB2 Bio)

Phase 3 Clinical

Ab2 Bio

Immune System Diseases

Vidofludimus

4SC-101, SC-12267

Phase 2 Clinical

4sc Ag

Inflammatory Bowel Diseases, Arthritis, Rheumatoid, Colitis, Ulcerative, Crohn Disease

LP-0058

LP-0058, LEO-32731

Phase 2 Clinical

Leo Pharma Inc

Psoriasis, Dermatitis, Atopic

Interferon gamma (aerosol, IPF/ COPD), Stony Brook University School of Medicine

Phase 2 Clinical

Stony Brook University School Of Medicine, Nyu Langone Medical Center, Nostrum

Pulmonary Fibrosis, Pulmonary Disease, Chronic Obstructive

PP-001

PP-001

Phase 2 Clinical

4sc Ag

Keratoconjunctivitis, Uveitis

PDS-0101

PDS-0101B, PDS-0101C, PDS-0101, PDS-0101A, PDS-101

Phase 2 Clinical

Pds Biotechnology Corporation, Merck Serono

Head and Neck Neoplasms, Papillomavirus Infections, Anal intraepithelial neoplasia, Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasms

OCH-NCNP1

OCH-NCNP1

Phase 2 Clinical

Keio University

Multiple Sclerosis, Crohn Disease

Recombinant human interferon gamma adenovirus injection

Phase 1 Clinical

Guangzhou Dabo Biological Products Co Ltd

Liver Neoplasms, Nasopharyngeal Neoplasms

VPM-4001

VPM-4001, VPM-4-001

Pending

Memorial Sloan Kettering Cancer Center

Prostatic Neoplasms

Recombinant interferon gamma (Xiamen Amoytop Biotech/BioGeneric Pharma)

Pending

Xiamen Amoytop Biotech Co Ltd, Biogeneric

Delmitide

RDP-58, RDP-1258, Allotrap-1258

Pending

Genzyme Corp

Colitis, Ulcerative, Crohn Disease

QR-449

QR-440, QR-443, QR-449

Pending

Prophase Labs

Pain, Metabolic Diseases, Cachexia

Anti-interferon-gamma polyclonal antibody (Advanced Biotherapy)

Discontinued

Advanced Biotherapy

Herpes Simplex, Alopecia, Diabetes Mellitus, Type 1, Keratoplasty rejection, Arthritis, Rheumatoid, Multiple Sclerosis, Epidermolysis Bullosa, Psoriasis, Lupus Erythematosus, Systemic, Uveitis, Vitiligo, Pemphigus

Fontolizumab

Discontinued

Pdl Biopharma

Gastrointestinal Diseases, Arthritis, Rheumatoid, Autoimmune Diseases, Colitis, Psoriasis, Crohn Disease, Intestinal Diseases

AMG-811

AMG-811

Discontinued

Amgen Inc

Lupus Erythematosus, Discoid, Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Systemic, Psoriasis