IL10RA

Synonyms

IL-10RA, IL-10R1, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R subunit alpha, CDw210a, IL-10 receptor subunit alpha, CD210, HIL-10R, Interleukin 10 Receptor Subunit Alpha, Interleukin 10 Receptor, Alpha, Interleukin-10 Receptor Alpha Chain, CD210 Antigen, IL10R, CD210a

Description

Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well . In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively . These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy .

KO Status

RenMab: F1 (+/-)

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

anti-ILT3 CAR-T(Carbiogene)

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71, SI-F019

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)

IO-202

IO-202

Phase 1 Clinical

Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute

GSK3903371

GSK3903371

Clinical

Glaxosmithkline Plc

Neoplasms

NKp46 NKCE

NKp46-NKCE, NKp46 NKCE

Preclinical

Neoplasms

SAR-443579

SAR-443579, SAR443579, IPH6101, IPH-6101

Preclinical

Neoplasms

BI-1910

BI-1910

Preclinical

Bioinvent International

Solid tumours

IPR-1110

IPR 1110

Preclinical

Neoplasms

MNPR-101

huATN-658, ATN-291 F(ab’)2

Preclinical

Monopar Therapeutics Inc

Neoplasms

References


Title

Authors

Source

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Yoon S.I., Jones B.C., Logsdon N.J., Walter M.R.,

Structure 13:551-564(2005)

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor

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N. Engl. J. Med. 361:2033-2045(2009)

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Eur. J. Gastroenterol. Hepatol. 25:1235-1240(2013)

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Shim J.O., Seo J.K.,

J. Hum. Genet. 59:337-341(2014)

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Human chromosome 11 DNA sequence and analysis including novel gene identification

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Nature 440:497-500(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Signal peptide prediction based on analysis of experimentally verified cleavage sites

Zhang Z., Henzel W.J.,

Protein Sci. 13:2819-2824(2004)

Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors

Usacheva A., Kotenko S., Witte M.M., Colamonici O.R.,

J. Immunol. 169:1302-1308(2002)