IL10RA

Synonyms

IL-10RA, CD210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R subunit alpha, CDw210a, IL-10 receptor subunit alpha, CD210, HIL-10R, Interleukin 10 Receptor Subunit Alpha, Interleukin 10 Receptor, Alpha, Interleukin-10 Receptor Alpha Chain, CD210 Antigen, IL10R, IL-10R1

Description

Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well . In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively . These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy .

KO Status

RenMab: Immunization

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71, SI-F019

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)

GSK-6097608

GSK-6097608

Phase 1 Clinical

Glaxosmithkline Plc

Neoplasms

IO-202

IO-202

Phase 1 Clinical

Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute

XKH-001(Xinkanghe Biomedical)

XKH-001

Phase 1 Clinical

Beijing Xinkanghe Biomedical Technology Co Ltd

Inflammation

anti-ILT3 CAR-T(Carbiogene)

Phase 1 Clinical

Leukemia, Myeloid, Acute

GSK3903371

GSK3903371

Clinical

Glaxosmithkline Plc

Neoplasms

LBL-019

LBL-019

IND

Nanjing Leads Biolabs Co Ltd

Neoplasms

SIM1811-03

SIM1811-03, SIM0235

IND

Jiangsu Xiansheng Pharmaceutical Co Ltd

Solid tumours, Lymphoma, T-Cell, Cutaneous

ISB-880

ISB-880

Preclinical

Ichnos Sciences Sa

Autoimmune Diseases of the Nervous System

References


Title

Authors

Source

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Shim J.O., Seo J.K.,

J. Hum. Genet. 59:337-341(2014)

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Genome Res. 14:2121-2127(2004)

Signal peptide prediction based on analysis of experimentally verified cleavage sites

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Protein Sci. 13:2819-2824(2004)

Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors

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J. Immunol. 169:1302-1308(2002)