IL11

Synonyms

Oprelvekin, IL-11, AGIF, Adipogenesis inhibitory factor, Interleukin 11

Description

Interleukin 11 (IL-11) is a protein that in humans is encoded by the IL11 gene. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production . Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation . Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.

KO Status

RenMab: F2 (-/-)

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

anti-ILT3 CAR-T(Carbiogene)

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71, SI-F019

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)

IO-202

IO-202

Phase 1 Clinical

Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute

GSK3903371

GSK3903371

Clinical

Glaxosmithkline Plc

Neoplasms

NKp46 NKCE

NKp46-NKCE, NKp46 NKCE

Preclinical

Neoplasms

SAR-443579

SAR-443579, SAR443579, IPH6101, IPH-6101

Preclinical

Neoplasms

BI-1910

BI-1910

Preclinical

Bioinvent International

Solid tumours

IPR-1110

IPR 1110

Preclinical

Neoplasms

MNPR-101

huATN-658, ATN-291 F(ab’)2

Preclinical

Monopar Therapeutics Inc

Neoplasms

References


Title

Authors

Source

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11

Kawashima I., Ohsumi J., Mita-Honjo K., Shimoda-Takano K., Ishikawa H., Sakakibara S., Miyadai K., Takiguchi Y.,

FEBS Lett. 283:199-202(1991)

Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)

McKinley D., Wu Q., Yang-Feng T., Yang Y.C.,

Genomics 13:814-819(1992)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and biology of human chromosome 19

Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Lucas S.M.,

Nature 428:529-535(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Characterization of a potent human interleukin-11 agonist

Harmegnies D., Wang X.M., Vandenbussche P., Leon A., Vusio P., Groetzinger J., Jacques Y., Goormaghtigh E., Devreese B., Content J.,

Biochem. J. 375:23-32(2003)

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

Lamertz L., Rummel F., Polz R., Baran P., Hansen S., Waetzig G.H., Moll J.M., Floss D.M., Scheller J.,

Sci. Signal. 11:0-0(2018)

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

Putoczki T.L., Dobson R.C., Griffin M.D.W.,

Acta Crystallogr. D 70:2277-2285(2014)

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine

Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M. Jr., Leary A.C., Sibley B.S., Clark S.C., Williams D.A., Yang Y.-C.,

Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990)