IL11

Synonyms

Oprelvekin, IL-11, Interleukin 11, Adipogenesis inhibitory factor, AGIF

Description

Interleukin 11 (IL-11) is a protein that in humans is encoded by the IL11 gene. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production . Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation . Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'.

KO Status

RenMab: Immunization

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71, SI-F019

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)

GSK-6097608

GSK-6097608

Phase 1 Clinical

Glaxosmithkline Plc

Neoplasms

IO-202

IO-202

Phase 1 Clinical

Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute

XKH-001(Xinkanghe Biomedical)

XKH-001

Phase 1 Clinical

Beijing Xinkanghe Biomedical Technology Co Ltd

Inflammation

anti-ILT3 CAR-T(Carbiogene)

Phase 1 Clinical

Leukemia, Myeloid, Acute

GSK3903371

GSK3903371

Clinical

Glaxosmithkline Plc

Neoplasms

LBL-019

LBL-019

IND

Nanjing Leads Biolabs Co Ltd

Neoplasms

SIM1811-03

SIM1811-03, SIM0235

IND

Jiangsu Xiansheng Pharmaceutical Co Ltd

Solid tumours, Lymphoma, T-Cell, Cutaneous

ISB-880

ISB-880

Preclinical

Ichnos Sciences Sa

Autoimmune Diseases of the Nervous System

References


Title

Authors

Source

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11

Kawashima I., Ohsumi J., Mita-Honjo K., Shimoda-Takano K., Ishikawa H., Sakakibara S., Miyadai K., Takiguchi Y.,

FEBS Lett. 283:199-202(1991)

Genomic sequence and chromosomal location of human interleukin-11 gene (IL11)

McKinley D., Wu Q., Yang-Feng T., Yang Y.C.,

Genomics 13:814-819(1992)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and biology of human chromosome 19

Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Lucas S.M.,

Nature 428:529-535(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Characterization of a potent human interleukin-11 agonist

Harmegnies D., Wang X.M., Vandenbussche P., Leon A., Vusio P., Groetzinger J., Jacques Y., Goormaghtigh E., Devreese B., Content J.,

Biochem. J. 375:23-32(2003)

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

Lamertz L., Rummel F., Polz R., Baran P., Hansen S., Waetzig G.H., Moll J.M., Floss D.M., Scheller J.,

Sci. Signal. 11:0-0(2018)

The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6

Putoczki T.L., Dobson R.C., Griffin M.D.W.,

Acta Crystallogr. D 70:2277-2285(2014)

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine

Paul S.R., Bennett F., Calvetti J.A., Kelleher K., Wood C.R., O'Hara R.M. Jr., Leary A.C., Sibley B.S., Clark S.C., Williams D.A., Yang Y.-C.,

Proc. Natl. Acad. Sci. U.S.A. 87:7512-7516(1990)