IL11RA

Synonyms

Interleukin-11 Receptor Alpha Chain, Interleukin 11 Receptor Subunit Alpha, Interleukin 11 Receptor, Alpha, IL-11R-Alpha, IL-11 Receptor Subunit Alpha, Interleukin-11 Receptor Subunit Alpha, IL11RA, IL-11RA, IL-11R Subunit Alpha, CRSDA, Interleukin-11 Receptor alpha Subunit, sIL-11RA, sIL-11R, sIL11RA

KO Status

F0

Drug Information

Launched drugs: 9
Drug in clinical trials: 1
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Recombinant human interleukin 11 (BioGeneric Pharma)

Approved

Biogeneic Pharma

Thrombocytopenia

Oprelvekin biosimilar (Hangzhou Jiuyuan Gene Engineering)

Approved

Hangzhou Jiuyuan Gene Engineering Co Ltd

Thrombocytopenia

Recombinant human interleukin-11 (Kerun Biopharmaceutical)

Approved

Chongqing Kerun Biologic Pharmaceutical Development Co Ltd

Thrombocytopenia

Recombinant human interleukin-11 (Diao group)

Approved

Chengdu Di'Ao Jiuhong Pharmaceutical Factory

Thrombocytopenia

Recombinant human interleukin-11 (Shanghai CP Guojian)

Approved

Shanghai Cp Guojian Pharmaceutical Co Ltd

Thrombocytopenia

Recombinant human interleukin-11 (Qilu Pharmaceutical)

Approved

Qilu Pharmaceutical Co Ltd

Thrombocytopenia

Recombinant human interleukin-11 (Beijing ShuangLu Pharmaceutical)

Approved

Beijing Sl Pharmaceutical Co Ltd

Thrombocytopenia

Recombinant human interleukin-11 (Xiamen Amoytop Biotech)

rHuIL-11

Approved

Xiamen Amoytop Biotech Co Ltd

Thrombocytopenia

Δ1-9, alanine 10, asparagine 134, recombinant human interleukin-11

Phase 3 Clinical

Fuzhou Quanye Economic Technology Co Ltd

Thrombocytopenia

Recombinant human interleukin-11 (Shanghai Zhangjiang)

Pending

Shanghai Zhangjiang Biotechnology Co Ltd

Thrombocytopenia

References


Title

Authors

Source

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Increased expression of the interleukin-11 receptor and evidence of STAT3 activation in prostate carcinoma

Campbell C.L., Jiang Z., Savarese D.M., Savarese T.M.,

Am. J. Pathol. 158:25-32(2001)

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling

Lokau J., Nitz R., Agthe M., Monhasery N., Aparicio-Siegmund S., Schumacher N., Wolf J., Moeller-Hackbarth K., Waetzig G.H., Groetzinger J., Mueller-Newen G., Rose-John S., Scheller J., Garbers C.,

Cell Rep. 14:1761-1773(2016)

Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses

Lamertz L., Rummel F., Polz R., Baran P., Hansen S., Waetzig G.H., Moll J.M., Floss D.M., Scheller J.,

Sci. Signal. 11:0-0(2018)

Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth

Nieminen P., Morgan N.V., Fenwick A.L., Parmanen S., Veistinen L., Mikkola M.L., van der Spek P.J., Giraud A., Judd L., Arte S., Brueton L.A., Wall S.A., Mathijssen I.M., Maher E.R., Wilkie A.O., Kreiborg S., Thesleff I.,

Am. J. Hum. Genet. 89:67-81(2011)

Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11

Cherel M., Sorel M., Lebeau B., Dubois S., Moreau J.-F., Bataille R., Minvielle S., Jacques Y.,

Blood 86:2534-2540(1995)

Molecular cloning and characterization of the human interleukin-11 receptor alpha-chain gene, IL11RA, located on chromosome 9p13

Van Leuven F., Stas L., Hilliker C., Miyake Y., Bilinski P., Gossler A.,

Genomics 31:65-70(1996)

DNA sequence and analysis of human chromosome 9

Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L., Dunham I.,

Nature 429:369-374(2004)