IL13

Synonyms

Interleukin-13, IL13, Interleukin 13, IL-13, Bronchial Hyperresponsiveness-1 (Bronchial Asthma), Allergic Rhinitis, P600, NC30, MGC116789, MGC116788, BHR1, MGC116786, ALRH

KO Status

RenMab: F2 (-/-)

Drug Information

Drugs in clinical trials: 5
Latest Research Phase: Phase 3 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Tralokinumab

BAK-502G9, CAT-354

Approved

Medimmune Llc

Idiopathic Pulmonary Fibrosis, Colitis, Ulcerative, Asthma, Dermatitis, Atopic

Lebrikizumab

RG-3637, TNX-650, Anti-IL-13, MILR-1444A, PRO-301444, RO-4909832, RO-5490255, DRM-06, R-3637

Phase 3 Clinical

Genentech Inc

Hodgkin Disease, Idiopathic Pulmonary Fibrosis, Dermatitis, Skin Diseases, Asthma, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic, Eczema, Skin Diseases, Genetic

Cendakimab

ABT-308, RPC-4046

Phase 2 Clinical

Abbott Laoratories

Eosinophilic Esophagitis, Asthma

Dectrekumab/VAK-694

QBX-258

Phase 2 Clinical

Novartis Pharma Ag

Lymphedema, Asthma

Romilkimab

SUB-33159, SAR-156597

Phase 2 Clinical

Sanofi

Idiopathic Pulmonary Fibrosis, Scleroderma, Systemic

FWB-1313

FWB-1313

Preclinical

Shenzhen Forward Pharmaceuticals Co Ltd

Asthma, Dermatitis, Atopic

CNTO-5825

CNTO-5825

Pending

Janssen Global Services Llc

Asthma

AMG-317

AMG-317

Pending

Amgen Inc

Asthma

RO-7040547

RG-7990, BIT-7201A, RO-7040547

Pending

Genentech Inc

Asthma

RG-1671

R-1671, RG-1671

Pending

F. Hoffmann-La Roche Ltd

Asthma

References


Title

Authors

Source

Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses

Minty A.J., Chalon P., Derocq J.-M., Dumont X., Guillemot J.-C., Kaghad M., Labit C., Leplatois P., Liauzun P., Miloux B., Minty C., Casellas P., Loison G., Lupker J., Shire D., Ferrara P., Caput D.,

Nature 362:248-250(1993)

Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function

McKenzie A.N., Culpepper J.A., Waal Malefyt R., Briere F., Punnonen J., Aversa G., Sato A., Dang W., Cocks B.G., Menon S., de Vries J.E., Banchereau J., Zurawski G.R.,

Proc. Natl. Acad. Sci. U.S.A. 90:3735-3739(1993)

Tandem arrangement of human genes for interleukin-4 and interleukin-13: resemblance in their organization

Smirnov D.V., Smirnova M.G., Korobko V.G., Frolova E.I.,

Gene 155:277-281(1995)

Coexpression of the interleukin-13 and interleukin-4 genes correlates with their physical linkage in the cytokine gene cluster on human chromosome 5q23-31

Dolganov G., Bort S., Lovett M., Burr J., Schubert L., Short D., McGurn M., Gibson C., Lewis D.B.,

Blood 87:3316-3326(1996)

The DNA sequence and comparative analysis of human chromosome 5

Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Rubin E.M.,

Nature 431:268-274(2004)

Genetic variants of IL-13 signalling and human asthma and atopy

Heinzmann A., Mao X.-Q., Akaiwa M., Kreomer R.T., Gao P.-S., Ohshima K., Umeshita R., Abe Y., Braun S., Yamashita T., Roberts M.H., Sugimoto R., Arima K., Arinobu Y., Yu B., Kruse S., Enomoto T., Dake Y., Deichmann K.A.,

Hum. Mol. Genet. 9:549-559(2000)

Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population

Howard T.D., Whittaker P.A., Zaiman A.L., Koppelman G.H., Xu J., Hanley M.T., Meyers D.A., Postma D.S., Bleecker E.R.,

Am. J. Respir. Cell Mol. Biol. 25:377-384(2001)

A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis

Wang M., Xing Z.-M., Lu C., Ma Y.-X., Yu D.-L., Yan Z., Wang S.-W., Yu L.-S.,

Hum. Genet. 113:387-390(2003)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes

Morgan J.G., Dolganov G.M., Robbins S.E., Hinton L.M., Lovett M.,

Nucleic Acids Res. 20:5173-5179(1992)