IL13RA2

Synonyms

IL-13RA2, IL-13R-alpha-2, Interleukin-13-binding protein, IL13RA2, Interleukin 13 Receptor Subunit Alpha 2, Interleukin 13 Receptor, Alpha 2, IL-13 Receptor Subunit Alpha-2, Cancer/Testis Antigen 19, IL-13R Subunit Alpha-2, Interleukin-13 Receptor Subunit Alpha-2, Interleukin 13 Binding Protein, CD213a2 Antigen, CD213A2, IL-13R, IL13BP, IL13R, CT19, Interleukin 13 Receptor Alpha 2 Chain, Interleukin-13 Receptor alpha2 Subunit,

Description

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene. IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.

KO Status

F0

Drug Information

Launched drugs: 2
Drugs in clinical trials: 0
Latest Research Phase:Phase 1 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

ICT-140

ICT-140

Preclinical

Immunocellular Therapeutics

Ovarian Neoplasms

IL13Ralpha2 CAR-T cell therapy (Jonsson Comprehensive Cancer Center)

Phase 1 Clinical

Uclas Jonsson Comprehensive Cancer Center

Melanoma

MB-101 (Mustang Bio)

MB-101

Phase 1 Clinical

City Of Hope National Medical Center, Mustang Bio

Glioblastoma

IL-13-Zetakine

SB-313, SB-313-xTZ, IL-13-Zetakine

Discontinued

City Of Hope National Medical Center

Glioblastoma