IL15

Synonyms

IL-15, Interleukin-15, IL15, Interleukin 15, MGC9721

KO Status

RenMab: Antibody Discovery

Drug Information

Drugs in clinical trials: 9
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

AMG-714

AMG-714, PRV-015, HuMab-IL15

Phase 2 Clinical

Genmab

Arthritis, Rheumatoid, Celiac Disease, Psoriasis

OXS-3550

OXS-3550-TriKE, GTB-3550, OXS-3550, OXIS-3550, 161533-TriKE, 161533 TriKE

Phase 2 Clinical

University Of Minnesota, Oxis Biotech

Mastocytosis, Systemic, Myelodysplastic Syndromes, Leukemia, Mast-Cell, Leukemia, Myeloid, Acute

FT-538

FT-538

Phase 1 Clinical

Fate Therapeutics

Solid tumours, Leukemia, Myeloid, Acute

FT-596

FT-596

Phase 1 Clinical

Fate Therapeutics Inc

Lymphoma, B-Cell, Leukemia, Lymphocytic, Chronic, B-Cell

CALY-002

Phase 1 Clinical

Calypso Biotech Bv

Celiac Disease, Eosinophilic Esophagitis

Heterodimeric interleukin 15(Novartis Pharma)

NIZ-985

Phase 1 Clinical

Novartis Pharma Ag

Solid tumours, Lymphoma, Melanoma

XmAb24306

XmAb-24306, RG-6323, RO-7310729

Phase 1 Clinical

Xencor

Solid tumours

TA-MUC1 x IL15(Glycotope)

TAMUC1 x IL15

Preclinical

Glycotope

Neoplasms

ASKG-315

ASKG-315

Preclinical

Askgene Pharma

Neoplasms

FT-536

FT-536

Preclinical

Dana-Farber Cancer Institute, Fate Therapeutics Inc

Solid tumours

References


Title

Authors

Source

Engineering a high-affinity anti-IL-15 antibody: crystal structure reveals an alpha-helix in VH CDR3 as key component of paratope

Lowe D.C., Gerhardt S., Ward A., Hargreaves D., Anderson M., Ferraro F., Pauptit R.A., Pattison D.V., Buchanan C., Popovic B., Finch D.K., Wilkinson T., Sleeman M., Vaughan T.J., Mallinder P.R.,

J. Mol. Biol. 406:160-175(2011)

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

Grabstein K.H., Eisenman J., Shanebeck K., Rauch C., Srinivasan S., Fung V., Beers C., Richardson J., Schoenborn M.A., Ahdieh M., Johnson L., Alderson M.R., Watson J.D., Anderson D.M., Giri J.G.,

Science 264:965-968(1994)

Genomic sequence and chromosomal location of the human interleukin-15 gene (IL15)

Krause H., Jandrig B., Wernicke C., Bulfone-Paus S., Pohl T., Diamantstein T.,

Cytokine 8:667-674(1996)

Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines

Meazza R., Verdiani S., Biassoni R., Coppolecchia M., Gaggero A., Orengo A.M., Colombo M.P., Azzarone B., Ferrini S.,

Oncogene 12:2187-2192(1996)

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

Tagaya Y., Kurys G., Thies T.A., Losi J.M., Azimi N., Hanover J.A., Bamford R.N., Waldmann T.A.,

Proc. Natl. Acad. Sci. U.S.A. 94:14444-14449(1997)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain

Ratthe C., Girard D.,

J. Leukoc. Biol. 76:162-168(2004)