IL17A

Synonyms

Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8), CTLA8, IL17A, Interleukin 17A, Cytotoxic T-Lymphocyte-Associated Antigen 8, Cytotoxic T-Lymphocyte-Associated Protein 8, CTLA-8, IL-17A, IL-17, IL17, Interleukin-17A

Description

Interleukin 17A is a protein that in humans is encoded by the IL17A gene. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. It is involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.

Drug Information

Launched drugs: 3
Drugs in clinical trials: 17
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Ixekizumab

LY-2439821

Approved

Eli Lilly And Company

Non-radiographic axial spondyloarthritis, Spondylarthritis, Arthritis, Rheumatoid, Spondylitis, Ankylosing, Psoriasis, Arthritis, Psoriatic, Plaque psoriasis

Secukinumab

AIN-457, KB-03303A, NVP-AIN-457

Approved

Novartis Pharma Ag

Non-radiographic axial spondyloarthritis, Multiple Sclerosis, Relapsing-Remitting, Diabetes Mellitus, Type 1, Non-alcoholic Fatty Liver Disease, Inflammatory Bowel Diseases, Giant Cell Arteritis, Spondylitis, Ankylosing, Spondylarthritis, Arthritis, Rheumatoid, Lupus Nephritis, Arthritis, Juvenile, Multiple Sclerosis, Graves Ophthalmopathy, Tendinopathy, Psoriasis, Arthritis, Psoriatic, Lichen Planus, Parapsoriasis, Asthma, Arthritis, Uveitis, Hidradenitis Suppurativa, Behcet Syndrome, Gastroenteritis, Plaque psoriasis, Crohn Disease

Virulizin

Approved

Aptose

Carcinoma, Renal Cell, Stomach Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Sarcoma, Kaposi, Melanoma, Uterine Cervical Neoplasms

Vunakizumab

SHR-1314

Phase 3 Clinical

Jiangsu Hengrui Medicine Co Ltd

Spondylarthritis, Autoimmune Diseases, Spondylitis, Ankylosing, Lupus Nephritis, Psoriasis, Arthritis, Psoriatic, Plaque psoriasis

GR-1501

GR-1501

Phase 3 Clinical

Zhixiang (Shanghai) Pharmaceutical Technology Co Ltd, Chongqing Zhixiang Jintai Biopharmaceutical Co Ltd

Spondylarthritis, Psoriasis, Plaque psoriasis

COVA-322

COVA-322

Phase 2 Clinical

Covagen

Psoriasis

Recombinant anti-IL-17A humanized monoclonal antibody (Shanghai Junshi Biosciences)

JS005

Phase 2 Clinical

Shanghai Junshi Biosciences Co Ltd

Spondylitis, Ankylosing, Arthritis, Rheumatoid, Spondylarthritis, Psoriasis, Plaque psoriasis

ABY-035

AFB-035, ABY-035, IMG-020, IMG020

Phase 2 Clinical

Affibody

Spondylitis, Ankylosing, Psoriasis, Arthritis, Psoriatic, Uveitis

ALX-0761

M-1095, ALX-0761, MSB-0010841

Phase 2 Clinical

Ablynx

Psoriasis

CJM-112

CJM-112

Phase 2 Clinical

Novartis Pharma Ag

Acne Vulgaris, Triple Negative Breast Neoplasms, Multiple Myeloma, Multiple Sclerosis, Psoriasis, Colorectal Neoplasms, Asthma, Hidradenitis Suppurativa, Carcinoma, Non-Small-Cell Lung, Adenocarcinoma

References


Title

Authors

Source

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S.,

J. Exp. Med. 183:2593-2603(1996)

Human IL-17: a novel cytokine derived from T cells

Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J.,

J. Immunol. 155:5483-5486(1995)

The DNA sequence and analysis of human chromosome 6

Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Beck S.,

Nature 425:805-811(2003)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Signal peptide prediction based on analysis of experimentally verified cleavage sites

Zhang Z., Henzel W.J.,

Protein Sci. 13:2819-2824(2004)

Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells

Wright J.F., Guo Y., Quazi A., Luxenberg D.P., Bennett F., Ross J.F., Qiu Y., Whitters M.J., Tomkinson K.N., Dunussi-Joannopoulos K., Carreno B.M., Collins M., Wolfman N.M.,

J. Biol. Chem. 282:13447-13455(2007)

Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F

Kuestner R.E., Taft D.W., Haran A., Brandt C.S., Brender T., Lum K., Harder B., Okada S., Ostrander C.D., Kreindler J.L., Aujla S.J., Reardon B., Moore M., Shea P., Schreckhise R., Bukowski T.R., Presnell S., Guerra-Lewis P., Levin S.D.,

J. Immunol. 179:5462-5473(2007)

The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex

Wright J.F., Bennett F., Li B., Brooks J., Luxenberg D.P., Whitters M.J., Tomkinson K.N., Fitz L.J., Wolfman N.M., Collins M., Dunussi-Joannopoulos K., Chatterjee-Kishore M., Carreno B.M.,

J. Immunol. 181:2799-2805(2008)

Structure of IL-17A in complex with a potent, fully human neutralizing antibody

Gerhardt S., Abbott W.M., Hargreaves D., Pauptit R.A., Davies R.A., Needham M.R., Langham C., Barker W., Aziz A., Snow M.J., Dawson S., Welsh F., Wilkinson T., Vaugan T., Beste G., Bishop S., Popovic B., Rees G., Russell C.,

J. Mol. Biol. 394:905-921(2009)