IL17A
Synonyms
Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8), CTLA8, IL17A, Interleukin 17A, Cytotoxic T-Lymphocyte-Associated Antigen 8, Cytotoxic T-Lymphocyte-Associated Protein 8, CTLA-8, IL-17A, IL-17, IL17, Interleukin-17A
Description
Interleukin 17A is a protein that in humans is encoded by the IL17A gene. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. It is involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
Drug Information
Launched drugs: 3
Drugs in clinical trials: 17
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Ixekizumab
LY-2439821
Approved
Eli Lilly And Company
Non-radiographic axial spondyloarthritis, Spondylarthritis, Arthritis, Rheumatoid, Spondylitis, Ankylosing, Psoriasis, Arthritis, Psoriatic, Plaque psoriasis
Secukinumab
AIN-457, KB-03303A, NVP-AIN-457
Approved
Novartis Pharma Ag
Non-radiographic axial spondyloarthritis, Multiple Sclerosis, Relapsing-Remitting, Diabetes Mellitus, Type 1, Non-alcoholic Fatty Liver Disease, Inflammatory Bowel Diseases, Giant Cell Arteritis, Spondylitis, Ankylosing, Spondylarthritis, Arthritis, Rheumatoid, Lupus Nephritis, Arthritis, Juvenile, Multiple Sclerosis, Graves Ophthalmopathy, Tendinopathy, Psoriasis, Arthritis, Psoriatic, Lichen Planus, Parapsoriasis, Asthma, Arthritis, Uveitis, Hidradenitis Suppurativa, Behcet Syndrome, Gastroenteritis, Plaque psoriasis, Crohn Disease
Virulizin
Approved
Aptose
Carcinoma, Renal Cell, Stomach Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Sarcoma, Kaposi, Melanoma, Uterine Cervical Neoplasms
Vunakizumab
SHR-1314
Phase 3 Clinical
Jiangsu Hengrui Medicine Co Ltd
Spondylarthritis, Autoimmune Diseases, Spondylitis, Ankylosing, Lupus Nephritis, Psoriasis, Arthritis, Psoriatic, Plaque psoriasis
GR-1501
GR-1501
Phase 3 Clinical
Zhixiang (Shanghai) Pharmaceutical Technology Co Ltd, Chongqing Zhixiang Jintai Biopharmaceutical Co Ltd
Spondylarthritis, Psoriasis, Plaque psoriasis
COVA-322
COVA-322
Phase 2 Clinical
Covagen
Psoriasis
Recombinant anti-IL-17A humanized monoclonal antibody (Shanghai Junshi Biosciences)
JS005
Phase 2 Clinical
Shanghai Junshi Biosciences Co Ltd
Spondylitis, Ankylosing, Arthritis, Rheumatoid, Spondylarthritis, Psoriasis, Plaque psoriasis
ABY-035
AFB-035, ABY-035, IMG-020, IMG020
Phase 2 Clinical
Affibody
Spondylitis, Ankylosing, Psoriasis, Arthritis, Psoriatic, Uveitis
ALX-0761
M-1095, ALX-0761, MSB-0010841
Phase 2 Clinical
Ablynx
Psoriasis
CJM-112
CJM-112
Phase 2 Clinical
Novartis Pharma Ag
Acne Vulgaris, Triple Negative Breast Neoplasms, Multiple Myeloma, Multiple Sclerosis, Psoriasis, Colorectal Neoplasms, Asthma, Hidradenitis Suppurativa, Carcinoma, Non-Small-Cell Lung, Adenocarcinoma
References
Title
Authors
Source
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S.,
J. Exp. Med. 183:2593-2603(1996)
Human IL-17: a novel cytokine derived from T cells
Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J.,
J. Immunol. 155:5483-5486(1995)
The DNA sequence and analysis of human chromosome 6
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Beck S.,
Nature 425:805-811(2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)
Signal peptide prediction based on analysis of experimentally verified cleavage sites
Zhang Z., Henzel W.J.,
Protein Sci. 13:2819-2824(2004)
Identification of an interleukin 17F/17A heterodimer in activated human CD4+ T cells
Wright J.F., Guo Y., Quazi A., Luxenberg D.P., Bennett F., Ross J.F., Qiu Y., Whitters M.J., Tomkinson K.N., Dunussi-Joannopoulos K., Carreno B.M., Collins M., Wolfman N.M.,
J. Biol. Chem. 282:13447-13455(2007)
Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F
Kuestner R.E., Taft D.W., Haran A., Brandt C.S., Brender T., Lum K., Harder B., Okada S., Ostrander C.D., Kreindler J.L., Aujla S.J., Reardon B., Moore M., Shea P., Schreckhise R., Bukowski T.R., Presnell S., Guerra-Lewis P., Levin S.D.,
J. Immunol. 179:5462-5473(2007)
The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex
Wright J.F., Bennett F., Li B., Brooks J., Luxenberg D.P., Whitters M.J., Tomkinson K.N., Fitz L.J., Wolfman N.M., Collins M., Dunussi-Joannopoulos K., Chatterjee-Kishore M., Carreno B.M.,
J. Immunol. 181:2799-2805(2008)
Structure of IL-17A in complex with a potent, fully human neutralizing antibody
Gerhardt S., Abbott W.M., Hargreaves D., Pauptit R.A., Davies R.A., Needham M.R., Langham C., Barker W., Aziz A., Snow M.J., Dawson S., Welsh F., Wilkinson T., Vaugan T., Beste G., Bishop S., Popovic B., Rees G., Russell C.,
J. Mol. Biol. 394:905-921(2009)