IL18RA

Synonyms

IL-1Rrp, IL-18R-1, CD218a, IL-18Ralpha, IL1 receptor-related protein, IL-18R1, CDw218a, IL-18R-alpha, Interleukin-18 receptor alpha, CD218 antigen-like family member A, IL1R-rp

Description

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene. IL18R1 is also known as CDw218a. This receptor is in the IL18 receptor complex and is responsible for the binding of the pro-inflammatory cytokine IL18, but does not bind IL1A or IL1B. This receptor is involved in IL18-mediated T helper 1 (Th1) cell IFNG synthesis. This receptor is independent of SLC12A3 or forms a complex with SLC12A3 and contributes to IL18-induced cytokine production.

KO Status

RenMab: Immunization

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71, SI-F019

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)

GSK-6097608

GSK-6097608

Phase 1 Clinical

Glaxosmithkline Plc

Neoplasms

IO-202

IO-202

Phase 1 Clinical

Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute

XKH-001(Xinkanghe Biomedical)

XKH-001

Phase 1 Clinical

Beijing Xinkanghe Biomedical Technology Co Ltd

Inflammation

anti-ILT3 CAR-T(Carbiogene)

Phase 1 Clinical

Leukemia, Myeloid, Acute

GSK3903371

GSK3903371

Clinical

Glaxosmithkline Plc

Neoplasms

LBL-019

LBL-019

IND

Nanjing Leads Biolabs Co Ltd

Neoplasms

SIM1811-03

SIM1811-03, SIM0235

IND

Jiangsu Xiansheng Pharmaceutical Co Ltd

Solid tumours, Lymphoma, T-Cell, Cutaneous

ISB-880

ISB-880

Preclinical

Ichnos Sciences Sa

Autoimmune Diseases of the Nervous System

References


Title

Authors

Source

Structural basis for the specific recognition of IL-18 by its alpha receptor

Wei H., Wang D., Qian Y., Liu X., Fan S., Yin H.S., Wang X.,

FEBS Lett. 588:3838-3843(2014)

The structural basis for receptor recognition of human interleukin-18

Tsutsumi N., Kimura T., Arita K., Ariyoshi M., Ohnishi H., Yamamoto T., Zuo X., Maenaka K., Park E.Y., Kondo N., Shirakawa M., Tochio H., Kato Z.,

Nat. Commun. 5:5340-5340(2014)

IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP

Parnet P., Garka K.E., Bonnert T.P., Dower S.K., Sims J.E.,

J. Biol. Chem. 271:3967-3970(1996)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Purification and characterization of the human interleukin-18 receptor

Torigoe K., Ushio S., Okura T., Kobayashi S., Taniai M., Kunikata T., Murakami T., Sanou O., Kojima H., Fujii M., Ohta T., Ikeda M., Ikegami H., Kurimoto M.,

J. Biol. Chem. 272:25737-25742(1997)

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

Tominaga K., Yoshimoto T., Torigoe K., Kurimoto M., Matsui K., Hada T., Okamura H., Nakanishi K.,

Int. Immunol. 12:151-160(2000)

IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells

Sareneva T., Julkunen I., Matikainen S.,

J. Immunol. 165:1933-1938(2000)

IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18

Debets R., Timans J.C., Churakowa T., Zurawski S., de Waal Malefyt R., Moore K.W., Abrams J.S., O'Garra A., Bazan J.F., Kastelein R.A.,

J. Immunol. 165:4950-4956(2000)