IL1B

Synonyms

IL1-BETA, IL-1, Interleukin-1beta, IL-1B, IL-1β, IL-1 β, IL1beta, Interleukin 1beta, Catabolin, IL-1 beta, IL1B, Interleukin 1 Beta, IL1F2, Pro-Interleukin-1-Beta, Preinterleukin 1 Beta, Interleukin-1 Beta

KO Status

RenMab: Immunization

Drug Information

Launched drugs: 5
Drugs in clinical trials: 10
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rilonacept

KPL-914, RGN-303

Approved

Regeneron Pharmaceuticals Inc

Anemia, Muckle-Wells Syndrome (MWS), Genetic Diseases, Inborn, Arthritis, Juvenile, Hyperlipoproteinemia Type I, Pericarditis, Cryopyrin-Associated Periodic Syndromes, Gout, Renal Insufficiency, Chronic

PG-201

PG-201

Approved

Viromed

Osteoarthritis, Knee, Osteoarthritis

Diacerein

AC-201, AC-203, Art-50, SF-277, CCP-020, KW-4800, AC-201CR

Approved

Diabetes Mellitus, Type 2, Epidermolysis Bullosa Simplex, Epidermolysis Bullosa, Epidermolysis Bullosa, Junctional, Osteoarthritis, Knee, Diabetes Complications, Pemphigoid, Bullous, Osteoarthritis, Arthritis, Osteoarthritis, Hip, Diabetes Mellitus, Epidermolysis Bullosa Dystrophica

Thalidomide

NSC-66847, NSC-527179, K-17, VP-02

Approved

Celgene Corp

HIV Infections, Spondylitis, Ankylosing, Myelodysplastic Syndromes, Idiopathic Pulmonary Fibrosis, Multiple Myeloma, HIV Wasting Syndrome, Erythema Nodosum, Leprosy, Lepromatous, Carcinoma, Hepatocellular

Canakinumab

ACZ-885

Approved

Novartis Pharma Ag

Diabetes Mellitus, Type 1, Familial Mediterranean Fever, Prediabetic State, Cytokine Release Syndrome, Still's Disease, Adult-Onset, Atherosclerosis, Mevalonate Kinase Deficiency, Diabetes Mellitus, Type 2, Triple Negative Breast Neoplasms, Hereditary Autoinflammatory Diseases, Coronavirus Disease 2019 (COVID-19), Myelodysplastic Syndromes, Muckle-Wells Syndrome (MWS), Arthritis, Rheumatoid, Dry Eye Syndromes, Arthritis, Juvenile, Mucocutaneous Lymph Node Syndrome, Hyperimmunoglobulin D syndrome, Tumor necrosis factor receptor associated periodic syndrome, Cryopyrin-Associated Periodic Syndromes, Arthritis, Gouty, Colorectal Neoplasms, Osteoarthritis, Knee, Alzheimer Disease, Cognitive Dysfunction, Sarcoidosis, Pulmonary, Gout, Pulmonary Disease, Chronic Obstructive, Carcinoma, Non-Small-Cell Lung, Aortic Aneurysm, Abdominal, Melanoma, Peripheral Arterial Disease, Anemia, Sickle Cell, Diabetes Mellitus, Adenocarcinoma, Behcet Syndrome, Macular Degeneration

Ensereptide

PXL-01

Phase 3 Clinical

Promore Pharma

Tissue Adhesions, Post-surgical adhesions, Cicatrix

RPH-104

RPH-104

Phase 3 Clinical

Trpharm

Familial Mediterranean Fever, Schnitzler Syndrome, ST Elevation Myocardial Infarction, Coronavirus Disease 2019 (COVID-19), Pericarditis, Gout

HMPL-004 (Hutchison Medipharma)

HMPL-004

Phase 3 Clinical

Hutchison Medipharma Ltd

Lupus Erythematosus, Systemic, Colitis, Ulcerative, Crohn Disease

Ajulemic acid

CT-3, HU-239, IP-751, DMH-11C, JBT-101, CPL-7075, DMH-THC-11-OIC

Phase 3 Clinical

Corbus Pharma

Cystic Fibrosis, Dermatomyositis, Scleroderma, Systemic, Lupus Erythematosus, Systemic, Scleroderma, Diffuse

Gevokizumab(Xoma)

XMA-005.2, AB-7, XOMA-052, S-78989, VPM-087

Phase 3 Clinical

Xoma

Diabetes Mellitus, Type 1, Acne Vulgaris, Pyoderma Gangrenosum, Diabetes Mellitus, Type 2, Carcinoma, Renal Cell, Stomach Neoplasms, Esophageal Neoplasms, Arthritis, Rheumatoid, Colorectal Neoplasms, Uveitis, Osteoarthritis, Labyrinth Diseases, Panuveitis, Behcet Syndrome

References


Title

Authors

Source

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

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Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1

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Nature 314:266-268(1985)

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IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

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Rapid secretion of interleukin-1beta by microvesicle shedding

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Immunity 15:825-835(2001)

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis

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Arthritis Rheum. 48:1521-1529(2003)

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

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