IL1B

Synonyms

Interleukin 1beta, IL1beta, Catabolin, IL-1 beta, IL1B, Interleukin 1 Beta, IL1F2, Pro-Interleukin-1-Beta, Preinterleukin 1 Beta, Interleukin-1 Beta, IL1-BETA, IL-1, Interleukin-1beta, IL-1B,

KO Status

F2 (-/-)

Drug Information

Launched drugs: 4
Drugs in clinical trials: 7
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Rilonacept

KPL-914, RGN-303

Approved

Regeneron Pharmaceuticals Inc

Anemia, Muckle-Wells Syndrome (MWS), Arthritis, Juvenile, Genetic Diseases, Inborn, Hyperlipoproteinemia Type I, Pericarditis, Cryopyrin-Associated Periodic Syndromes, Gout, Renal Insufficiency, Chronic

Canakinumab

ACZ-885

Approved

Novartis Pharma Ag

Diabetes Mellitus, Type 1, Familial Mediterranean Fever, Prediabetic State, Cytokine Release Syndrome, Still's Disease, Adult-Onset, Atherosclerosis, Mevalonate Kinase Deficiency, Diabetes Mellitus, Type 2, Triple Negative Breast Neoplasms, Hereditary Autoinflammatory Diseases, Coronavirus Disease 2019 (COVID-19), Muckle-Wells Syndrome (MWS), Arthritis, Rheumatoid, Dry Eye Syndromes, Arthritis, Juvenile, Mucocutaneous Lymph Node Syndrome, Hyperimmunoglobulin D syndrome, Tumor necrosis factor receptor associated periodic syndrome, Polymyalgia Rheumatica, Cryopyrin-Associated Periodic Syndromes, Arthritis, Gouty, Sarcoidosis, Pulmonary, Colorectal Neoplasms, Gout, Pulmonary Disease, Chronic Obstructive, Aortic Aneurysm, Abdominal, Melanoma, Peripheral Arterial Disease, Anemia, Sickle Cell, Carcinoma, Non-Small-Cell Lung, Diabetes Mellitus, Behcet Syndrome, Macular Degeneration, Adenocarcinoma

Diacerein

AC-201, AC-203, Art-50, SF-277, CCP-020, KW-4800, AC-201CR

Approved

Diabetes Mellitus, Type 2, Epidermolysis Bullosa Simplex, Epidermolysis Bullosa, Epidermolysis Bullosa, Junctional, Osteoarthritis, Knee, Diabetes Complications, Pemphigoid, Bullous, Arthritis, Osteoarthritis, Osteoarthritis, Hip, Diabetes Mellitus, Epidermolysis Bullosa Dystrophica

Thalidomide

K-17, NSC-66847, NSC-527179

Approved

Celgene Corp

HIV Infections, Spondylitis, Ankylosing, Myelodysplastic Syndromes, Multiple Myeloma, Erythema Nodosum, HIV Wasting Syndrome, Leprosy, Lepromatous, Carcinoma, Hepatocellular

PG-201

PG-201

Approved

Viromed

Osteoarthritis, Knee, Osteoarthritis

RPH-104

RPH-104

Phase 3 Clinical

Trpharm

Schnitzler Syndrome, ST Elevation Myocardial Infarction, Coronavirus Disease 2019 (COVID-19), Gout

CD24-Fc

HAS-CD24, CD24-Fc-IgG, MK-7110, MK7110, CD24-Fc

Phase 3 Clinical

Oncoimmune

HIV Infections, Leukemia, Coronavirus Disease 2019 (COVID-19), Graft vs Host Disease, Myelodysplastic Syndromes, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Dyslipidemias, Leukemia, Myeloid, Acute, Melanoma

HMPL-004 (Hutchison Medipharma)

HMPL-004

Phase 3 Clinical

Hutchison Medipharma Ltd

Lupus Erythematosus, Systemic, Colitis, Ulcerative, Crohn Disease

Ajulemic acid

CT-3, HU-239, IP-751, DMH-11C, JBT-101, CPL-7075, DMH-THC-11-OIC

Phase 3 Clinical

Corbus Pharma

Cystic Fibrosis, Dermatomyositis, Scleroderma, Systemic, Lupus Erythematosus, Systemic, Scleroderma, Diffuse

Gevokizumab

AB-7, S-78989, VPM-087, XOMA-052, XMA-005.2

Phase 3 Clinical

Xoma

Acne Vulgaris, Diabetes Mellitus, Type 1, Pyoderma Gangrenosum, Diabetes Mellitus, Type 2, Carcinoma, Renal Cell, Esophageal Neoplasms, Arthritis, Rheumatoid, Colorectal Neoplasms, Uveitis, Osteoarthritis, Behcet Syndrome, Labyrinth Diseases, Panuveitis

PXL-01

PXL-01

Phase 3 Clinical

Promore Pharma

Tissue Adhesions, Post-surgical adhesions

FL-101

FL-101

Phase 2 Clinical

Flame Biosciences Inc

Carcinoma, Non-Small-Cell Lung

金纳单抗

Phase 1 Clinical

Changchun Genescience Pharmaceutical Co Ltd

Arthritis, Juvenile, Gout

AK-114

AK-114, AK114

Preclinical

Zhongshan Akeso Biopharma Co Ltd

Inflammation

APX-002 (Apexigen/Jiangsu T-mab BioPharma)

TK-002, APX-002

Preclinical

Epitomics, Jiangsu T-Mab Biopharma, Apexigen

Inflammation

IL-1 Affibody

Preclinical

Affibody, Sobi

Autoimmune Diseases, Inflammation

Anti-IL1B antibody

613

Preclinical

Shenyang Sunshine Pharmaceutical Co Ltd

Aceclofenac/Diacerein/Glucosamine

Pending

Jenburkt Pharmaceuticals

Osteoarthritis

Interleukin-1 receptor (Immunex)

Pending

Amgen Inc

HIV Infections, Leukemia, Myeloid, Diabetes Mellitus, Type 1, Graft vs Host Disease, Rejection of organ transplantation, Hypersensitivity

Y-25510

Y-25510

Pending

Mitsubishi Tanabe Pharma

Leukopenia, Thrombocytopenia