IL1-BETA, IL-1, Interleukin-1beta, IL-1B, IL-1β, IL-1 β, IL1beta, Interleukin 1beta, Catabolin, IL-1 beta, IL1B, Interleukin 1 Beta, IL1F2, Pro-Interleukin-1-Beta, Preinterleukin 1 Beta, Interleukin-1 Beta

KO Status

RenMab: Immunization

Drug Information

Launched drugs: 5
Drugs in clinical trials: 10
Latest Research Phase: Approved

Drug Name





Clinical Trials


KPL-914, RGN-303


Regeneron Pharmaceuticals Inc

Anemia, Muckle-Wells Syndrome (MWS), Genetic Diseases, Inborn, Arthritis, Juvenile, Hyperlipoproteinemia Type I, Pericarditis, Cryopyrin-Associated Periodic Syndromes, Gout, Renal Insufficiency, Chronic





Osteoarthritis, Knee, Osteoarthritis


AC-201, AC-203, Art-50, SF-277, CCP-020, KW-4800, AC-201CR


Diabetes Mellitus, Type 2, Epidermolysis Bullosa Simplex, Epidermolysis Bullosa, Epidermolysis Bullosa, Junctional, Osteoarthritis, Knee, Diabetes Complications, Pemphigoid, Bullous, Osteoarthritis, Arthritis, Osteoarthritis, Hip, Diabetes Mellitus, Epidermolysis Bullosa Dystrophica


NSC-66847, NSC-527179, K-17, VP-02


Celgene Corp

HIV Infections, Spondylitis, Ankylosing, Myelodysplastic Syndromes, Idiopathic Pulmonary Fibrosis, Multiple Myeloma, HIV Wasting Syndrome, Erythema Nodosum, Leprosy, Lepromatous, Carcinoma, Hepatocellular




Novartis Pharma Ag

Diabetes Mellitus, Type 1, Familial Mediterranean Fever, Prediabetic State, Cytokine Release Syndrome, Still's Disease, Adult-Onset, Atherosclerosis, Mevalonate Kinase Deficiency, Diabetes Mellitus, Type 2, Triple Negative Breast Neoplasms, Hereditary Autoinflammatory Diseases, Coronavirus Disease 2019 (COVID-19), Myelodysplastic Syndromes, Muckle-Wells Syndrome (MWS), Arthritis, Rheumatoid, Dry Eye Syndromes, Arthritis, Juvenile, Mucocutaneous Lymph Node Syndrome, Hyperimmunoglobulin D syndrome, Tumor necrosis factor receptor associated periodic syndrome, Cryopyrin-Associated Periodic Syndromes, Arthritis, Gouty, Colorectal Neoplasms, Osteoarthritis, Knee, Alzheimer Disease, Cognitive Dysfunction, Sarcoidosis, Pulmonary, Gout, Pulmonary Disease, Chronic Obstructive, Carcinoma, Non-Small-Cell Lung, Aortic Aneurysm, Abdominal, Melanoma, Peripheral Arterial Disease, Anemia, Sickle Cell, Diabetes Mellitus, Adenocarcinoma, Behcet Syndrome, Macular Degeneration



Phase 3 Clinical

Promore Pharma

Tissue Adhesions, Post-surgical adhesions, Cicatrix



Phase 3 Clinical


Familial Mediterranean Fever, Schnitzler Syndrome, ST Elevation Myocardial Infarction, Coronavirus Disease 2019 (COVID-19), Pericarditis, Gout

HMPL-004 (Hutchison Medipharma)


Phase 3 Clinical

Hutchison Medipharma Ltd

Lupus Erythematosus, Systemic, Colitis, Ulcerative, Crohn Disease

Ajulemic acid

CT-3, HU-239, IP-751, DMH-11C, JBT-101, CPL-7075, DMH-THC-11-OIC

Phase 3 Clinical

Corbus Pharma

Cystic Fibrosis, Dermatomyositis, Scleroderma, Systemic, Lupus Erythematosus, Systemic, Scleroderma, Diffuse


XMA-005.2, AB-7, XOMA-052, S-78989, VPM-087

Phase 3 Clinical


Diabetes Mellitus, Type 1, Acne Vulgaris, Pyoderma Gangrenosum, Diabetes Mellitus, Type 2, Carcinoma, Renal Cell, Stomach Neoplasms, Esophageal Neoplasms, Arthritis, Rheumatoid, Colorectal Neoplasms, Uveitis, Osteoarthritis, Labyrinth Diseases, Panuveitis, Behcet Syndrome





Generation and annotation of the DNA sequences of human chromosomes 2 and 4

Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Wilson R.K.,

Nature 434:724-731(2005)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

Mizutani H., Schechter N., Lazarus G., Black R.A., Kupper T.S.,

J. Exp. Med. 174:821-825(1991)

Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1

Van Damme J., De Ley M., Opdenakker G., Billiau A., De Somer P., Van Beeumen J.,

Nature 314:266-268(1985)

Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow

Zsebo K.M., Wypych J., Yuschenkoff V.N., Lu H., Hunt P., Dukes P.P., Langley K.E.,

Blood 71:962-968(1988)

The role of arginine residues in interleukin 1 receptor binding

Nanduri V.B., Hulmes J.D., Pan Y.C., Kilian P.L., Stern A.S.,

Biochim. Biophys. Acta 1118:25-35(1991)

IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells

Tominaga K., Yoshimoto T., Torigoe K., Kurimoto M., Matsui K., Hada T., Okamura H., Nakanishi K.,

Int. Immunol. 12:151-160(2000)

Rapid secretion of interleukin-1beta by microvesicle shedding

MacKenzie A., Wilson H.L., Kiss-Toth E., Dower S.K., North R.A., Surprenant A.,

Immunity 15:825-835(2001)

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis

Nakahara H., Song J., Sugimoto M., Hagihara K., Kishimoto T., Yoshizaki K., Nishimoto N.,

Arthritis Rheum. 48:1521-1529(2003)

cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line

Nishida T., Nishino N., Takano M., Kawai K., Bando K., Masui Y., Nakai S., Hirai Y.,

Biochem. Biophys. Res. Commun. 143:345-352(1987)