IL23A

Synonyms

Interleukin-23 Subunit p19, IL-23-A, IL-23 subunit alpha, IL-23A, IL23P19, IL-23, SGRF, Interleukin-Six, G-CSF Related Factor, Interleukin 23 Subunit Alpha, Interleukin 23, Alpha Subunit P19, Interleukin 23 P19 Subunit, P19, JKA3 Induced Upon T-Cell Activation, Interleukin-23 subunit alpha, IL23A

KO Status

RenMab: Antibody Discovery

Drug Information

Launched drugs: 2
Drugs in clinical trials: 4
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Guselkumab

CNTO-1959

Approved

Janssen Global Services Llc

Adenomatous Polyposis Coli, Giant Cell Arteritis, Scleroderma, Systemic, Lupus Nephritis, Psoriasis, Celiac Disease, Colitis, Ulcerative, Arthritis, Psoriatic, Hidradenitis Suppurativa, Crohn Disease

Tildrakizumab

SUNPG-1623-III, SUNPG-1623-IV, SUNPG 1623-II, SUNPG-1623, SUNPG-1622-I, SUNPG-1623-I, MK-3222, SCH-900222, SUNPG-1622

Approved

Merck Sharp & Dohme Corp

Spondylitis, Ankylosing, Psoriasis, Arthritis, Psoriatic, Plaque psoriasis

Mirikizumab

Anti-IL-23-MAb (Lilly), LY-3074828

Phase 3 Clinical

Eli Lilly And Company

Inflammatory Bowel Diseases, Psoriasis, Colitis, Ulcerative, Crohn Disease

IBI-112(Innovent Biologics)

IBI-112

Phase 2 Clinical

Innovent Biologics(Suzhou) Co Ltd

Psoriasis, Colitis, Ulcerative, Plaque psoriasis, Crohn Disease

NBL-012

NBL-012, NBL012

Phase 1 Clinical

CSPC Pharmaceutical Group Ltd

Autoimmune Diseases, Psoriasis, Hidradenitis Suppurativa

QX-004N

QX-004N

Phase 1 Clinical

Jiangsu Quanxin Biomedical Co Ltd

Psoriasis

References


Title

Authors

Source

Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression

Fedele G., Stefanelli P., Spensieri F., Fazio C., Mastrantonio P., Ausiello C.M.,

Infect. Immun. 73:1590-1597(2005)

Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns

Vanden Eijnden S., Goriely S., De Wit D., Goldman M., Willems F.,

Eur. J. Immunol. 36:21-26(2006)

In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin

Piskin G., Sylva-Steenland R.M.R., Bos J.D., Teunissen M.B.M.,

J. Immunol. 176:1908-1915(2006)

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

Vaknin-Dembinsky A., Balashov K., Weiner H.L.,

J. Immunol. 176:7768-7774(2006)

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T., Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J., Kastelein R.A.,

Immunity 13:715-725(2000)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment

Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,

Genome Res. 13:2265-2270(2003)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M., Moore K.W.,

J. Immunol. 168:5699-5708(2002)

Regulation of virus-induced IL-12 and IL-23 expression in human macrophages

Pirhonen J., Matikainen S., Julkunen I.,

J. Immunol. 169:5673-5678(2002)

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

Smits H.H., van Beelen A.J., Hessle C., Westland R., de Jong E., Soeteman E., Wold A., Wierenga E.A., Kapsenberg M.L.,

Eur. J. Immunol. 34:1371-1380(2004)