Nuclear Factor For High Endothelial Venules, DVS27-Related Protein, IL1F11, IL33, Interleukin-1 family member 11, IL-1F11, Interleukin 33, Nuclear Factor From High Endothelial Venules, C9orf26, NF-HEV, Chromosome 9 Open Reading Frame 26 (NF-HEV), Interleukin-1 Family, Member 11, NFEHEV, DVS27, IL-33, NFHEV, Interleukin-33, DKFZp586H0523

KO Status


Drug Information

Drugs in clinical trials: 4
Latest Research Phase: Phase 2 Clinical

Drug Name





Clinical Trials

Anti-IL-33 mAb (Regeneron Pharmaceuticals/Sanofi)

REGN-3500, SAR-440340

Phase 3 Clinical

Regeneron Pharmaceuticals Inc, Sanofi

Asthma, Pulmonary Disease, Chronic Obstructive, Dermatitis, Atopic



Phase 2 Clinical

Eli Lilly And Company

Dermatitis, Atopic



Phase 2 Clinical


Pulmonary Eosinophilia, Sinusitis, Asthma, Peanut Hypersensitivity, Dermatitis, Atopic, Hypersensitivity



Phase 2 Clinical

Mitsubishi Tanabe Pharma Corp

Rhinitis, Allergic, Seasonal, Pain, Autoimmune Diseases, Inflammation



Phase 1 Clinical

Pfizer Inc

Nose Diseases, Sinusitis, Dermatitis, Atopic





The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?

Moussion C., Ortega N., Girard J.P.,

PLoS ONE 3:E3331-E3331(2008)

Mature interleukin-33 is produced by calpain-mediated cleavage in vivo

Hayakawa M., Hayakawa H., Matsuyama Y., Tamemoto H., Okazaki H., Tominaga S.,

Biochem. Biophys. Res. Commun. 387:218-222(2009)

Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases

Luthi A.U., Cullen S.P., McNeela E.A., Duriez P.J., Afonina I.S., Sheridan C., Brumatti G., Taylor R.C., Kersse K., Vandenabeele P., Lavelle E.C., Martin S.J.,

Immunity 31:84-98(2009)

Interleukin-33 is biologically active independently of caspase-1 cleavage

Talabot-Ayer D., Lamacchia C., Gabay C., Palmer G.,

J. Biol. Chem. 284:19420-19426(2009)

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

Cayrol C., Girard J.P.,

Proc. Natl. Acad. Sci. U.S.A. 106:9021-9026(2009)

The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription

Ali S., Mohs A., Thomas M., Klare J., Ross R., Schmitz M.L., Martin M.U.,

J. Immunol. 187:1609-1616(2011)

Interleukin 33 as a mechanically responsive cytokine secreted by living cells

Kakkar R., Hei H., Dobner S., Lee R.T.,

J. Biol. Chem. 287:6941-6948(2012)

HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33

Osbourn M., Soares D.C., Vacca F., Cohen E.S., Scott I.C., Gregory W.F., Smyth D.J., Toivakka M., Kemter A.M., le Bihan T., Wear M., Hoving D., Filbey K.J., Hewitson J.P., Henderson H., Gonzalez-Ciscar A., Errington C., Vermeren S., McSorley H.J.,

Immunity 47:739-751(2017)

Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes

Lingel A., Weiss T.M., Niebuhr M., Pan B., Appleton B.A., Wiesmann C., Bazan J.F., Fairbrother W.J.,

Structure 17:1398-1410(2009)

Structural insights into the interaction of IL-33 with its receptors

Liu X., Hammel M., He Y., Tainer J.A., Jeng U.S., Zhang L., Wang S., Wang X.,

Proc. Natl. Acad. Sci. U.S.A. 110:14918-14923(2013)