IL3RA
Synonyms
Interleukin-3 Receptor Subunit Alpha, Interleukin-3 Receptor alpha Subunit, IL3RY, IL3RX, IL-3R Subunit Alpha, CD123 Antigen, IL-3RA, IL-3 Receptor Alpha SP2 Isoform, Interleukin 3 Receptor Subunit Alpha, IL3RAY, IL3R, IL-3 Receptor Subunit Alpha, HIL-3Ra, Interleukin 3 Receptor, Alpha (Low Affinity), CD123, IL3RA, IL-3R-Alpha
Description
Interleukin 3 receptor alpha (low affinity) (IL3RA) is also known as CD123 (Cluster of Differentiation 123). This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. IL3RA is playing an important role in the development of leukemia and in the proliferation, differentiation and apoptosis of the leukemic cells.
KO Status
RenMab: F2 (-/-)
Drug Information
Launched drug: 1
Drugs in clinical trials: 19
Latest Research Phase: Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Tagraxofusp-erzs
SL-401, DTIL-3, DT388 IL3
Approved
Texas A&M University Development Foundation
Blastic Plasmacytoid Dendritic Cell Neoplasm, Lymphoma
CD123/CLL1 CAR-T Cell Therapy (Fujian Medical University)
Phase 3 Clinical
Fujian Medical University
Leukemia, Myeloid, Acute
Talacotuzumab
CSL-362, JNJ-473, CSL-362-AML, JNJ-56022473, IL-13 MAb-CSL
Phase 3 Clinical
Csl Ltd
Myelodysplastic Syndromes, Lupus Erythematosus, Systemic, Leukemia, Myeloid, Acute
Anti-CD123 chimeric antigen receptor T cell therapy (Chongqing Precision Biotech)
Phase 2 Clinical
Chongqing Precision Biotechnology Co Ltd
Leukemia, Myeloid, Acute
MB-102 (Mustang Bio)
MB-102
Phase 2 Clinical
Mustang Bio, City Of Hope National Medical Center
Blastic Plasmacytoid Dendritic Cell Neoplasm, Leukemia, Myeloid, Acute
IMGN-632
IMGN-632
Phase 2 Clinical
Immunogen
Myeloproliferative Disorders, Blastic Plasmacytoid Dendritic Cell Neoplasm, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute
Anti-CD123 CAR T-cell therapy (Southwest Hospital)
Phase 2 Clinical
Southwest Hospital Chongqing
Leukemia, Myeloid
CD123 CAR-T cell therapy
Phase 2 Clinical
Chongqing Precision Biotechnology Co Ltd
Leukemia, Myeloid, Leukemia, Leukemia, Myeloid, Acute
Flotetuzumab
MGD-006, S-80880
Phase 2 Clinical
Macrogenics
Myelodysplastic Syndromes, Leukemia, Myeloid, Acute
UniCAR02-T
UniCAR02-T
Phase 1 Clinical
Cellex Patient Treatment Gmbh
Kidney Neoplasms, Carcinoma, Renal Cell, Breast Neoplasms, Prostatic Neoplasms, Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung
References
Title
Authors
Source
Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors
Kitamura T., Sato N., Arai K., Miyajima A.,
Cell 66:1165-1174(1991)
Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor
Kosugi H., Nakagawa Y., Hotta T., Saito H., Miyajima A., Arai K., Yokota T.,
Biochem. Biophys. Res. Commun. 208:360-367(1995)
A new isoform of IL-3 receptor alpha with novel differentiation activity and high affinity binding mode
Chen J., Olsen J., Ford S., Mirza S., Walker A., Murphy J.M., Young I.G.,
J. Biol. Chem. 284:5763-5773(2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,
Nat. Genet. 36:40-45(2004)
The DNA sequence of the human X chromosome
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., Bentley D.R.,
Nature 434:325-337(2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)
The MGC Project Team,
Genome Res. 14:2121-2127(2004)