IL3RA
Synonyms
Interleukin-3 Receptor Subunit Alpha, Interleukin-3 Receptor alpha Subunit, IL3RY, IL3RX, IL-3R Subunit Alpha, CD123 Antigen, IL-3RA, IL-3 Receptor Alpha SP2 Isoform, Interleukin 3 Receptor Subunit Alpha, IL3RAY, IL3R, IL-3 Receptor Subunit Alpha, HIL-3Ra, Interleukin 3 Receptor, Alpha (Low Affinity), CD123, IL3RA, IL-3R-Alpha,Description
Interleukin 3 receptor alpha (low affinity) (IL3RA) is also known as CD123 (Cluster of Differentiation 123). This protein associates with a beta subunit common to the receptors for IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) to form a high-affinity receptor for IL-3. IL3RA is playing an important role in the development of leukemia and in the proliferation, differentiation and apoptosis of the leukemic cells.
KO Status
F0
Drug Information
Launched drugs: 19
Drug in clinical trials: 1
Latest Research Phase:Approved
Drug Name
Code
Phase
Company
Indications
Clinical Trials
Tagraxofusp-erzs
DTIL-3, SL-401, DT388 IL3
Approved
Texas A&M University Development Foundation
Blastic Plasmacytoid Dendritic Cell Neoplasm
HY-007
HY-007
Preclinical
Heyuan Biotechnology (Tianjin) Co Ltd
Leukemia, Myeloid, Acute
APVO-437
APVO-437
Preclinical
Aptevo
Precursor Cell Lymphoblastic Leukemia-Lymphoma
CD123/CLL1 CAR-T Cell Therapy (Fujian Medical University)
Phase 3 Clinical
Fujian Medical University
Leukemia, Myeloid, Acute
Talacotuzumab
CSL-362, JNJ-473, CSL-362-AML, JNJ-56022473, IL-13 MAb-CSL
Phase 3 Clinical
Csl
Myelodysplastic Syndromes, Lupus Erythematosus, Systemic, Leukemia, Myeloid, Acute
CD123 CAR-T cell therapy
Phase 2 Clinical
Chongqing Precision Biotechnology Co Ltd
Leukemia, Myeloid, Leukemia, Leukemia, Myeloid, Acute
Flotetuzumab
MGD-006, S-80880
Phase 2 Clinical
Macrogenics
Myelodysplastic Syndromes, Leukemia, Myeloid, Acute
Anti-CD123 chimeric antigen receptor T cell therapy (Chongqing Precision Biotech)
Phase 2 Clinical
Chongqing Precision Biotechnology Co Ltd
Leukemia, Myeloid, Acute
IMGN-632
IMGN-632
Phase 2 Clinical
Immunogen
Myeloproliferative Disorders, Blastic Plasmacytoid Dendritic Cell Neoplasm, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute
Anti-CD123 CAR T-cell therapy (Southwest Hospital)
Phase 2 Clinical
Southwest Hospital Chongqing
Leukemia, Myeloid
MB-102 (Mustang Bio)
MB-102
Phase 2 Clinical
Mustang Bio, City Of Hope National Medical Center
Blastic Plasmacytoid Dendritic Cell Neoplasm, Leukemia, Myeloid, Acute
JNJ-63709178
JNJ-9178, CNTO-9958, JNJ-63709178
Phase 1 Clinical
Janssen Global Services Llc, Genmab
Leukemia, Myeloid, Acute
Vibecotamab
XmAb-14045
Phase 1 Clinical
Xencor
Hematologic Neoplasms, Blastic Plasmacytoid Dendritic Cell Neoplasm, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute
Anti-CD123 CAR T-cell therapy (University of Pennsylvania/Novartis)
Phase 1 Clinical
Novartis Pharma Ag, University Of Pennsylvania
Leukemia, Myeloid, Acute
Anti-CD123 CAR T-cell therapy (Nanjing Legend Biotech)
Phase 1 Clinical
Nanjing Legend Biotechnology Co Ltd
Leukemia, Myeloid, Acute
KHK-2823
KHK-2823
Phase 1 Clinical
Kyowa Hakko Kirin
Myelodysplastic Syndromes, Leukemia, Myeloid, Acute
APVO436
APVO-436
Phase 1 Clinical
Aptevo
Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myeloid, Acute
UniCAR-T-CD-123
UniCAR-T-CD123
Phase 1 Clinical
Gemoab Monoclonals Gmbh
Blastic Plasmacytoid Dendritic Cell Neoplasm, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute
CD123 CAR-T cells (Hebei Senlang Biotechnology)
Phase 1 Clinical
Hebei Senlang Biological Technology Co Ltd
Leukemia, Myeloid, Acute
CSL-360
IL-3Rα, CSL-360
Phase 1 Clinical
Csl Ltd
Leukemia, Myeloid, Acute