B-cell stimulatory factor 2, Interferon beta-2, IL6, IFNB2, IL-6, Interleukin-6, Interleukin 6, Hybridoma Growth Factor, IFN-Beta-2, BSF-2, CDF, B-Cell Differentiation Factor, Interferon, Beta 2, Interleukin BSF-2, BSF2, HGF, HSF, CTL Differentiation Factor, Interleukin 6 (Interferon, Beta 2),


Interleukin-6 is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (Probable). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4 T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4 T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability . Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF . Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance . 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand. Also acts as a myokine (Probable). Plays a protective role during liver injury, being required for maintenance of tissue regeneration. Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection . Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration.

KO Status

F1 (+/-)

Drug Information

Launched drugs: 18
Drugs in clinical trials: 5
Latest Research Phase:Approved

Drug Name





Clinical Trials

Luminol sodium



Selvim, Metrio

Immune System Diseases, Psoriasis


K-17, NSC-66847, NSC-527179



HIV Infections, Spondylitis, Ankylosing, Myelodysplastic Syndromes, Multiple Myeloma, HIV Wasting Syndrome, Erythema Nodosum, Leprosy, Lepromatous, Carcinoma, Hepatocellular




Ned Biosystems

Coronavirus Disease 2019 (COVID-19)

Mycobacterium cell wall-DNA Complex (ProMetic Life Sciences)



Prometic Life Sciences

Neoplasm Recurrence, Local, Urinary Bladder Neoplasms, Carcinoma in Situ


cCLB-8, CNTO-328


Eusa Pharma, Janssen Global Services Llc

Head and Neck Neoplasms, Ovarian Neoplasms, Respiratory Tract Infections, Carcinoma, Renal Cell, Pneumonia, Smoldering Multiple Myeloma, Pancreatic Neoplasms, Myelodysplastic Syndromes, Multiple Myeloma, Monoclonal Gammopathy of Undetermined Significance, Lung Diseases, Respiratory Distress Syndrome, Adult, Multicentric Castleman's Disease (MCD), Prostatic Neoplasms, Neoplasms, Plasma Cell, Colorectal Neoplasms, Castleman Disease, Lung Neoplasms, Lymphoma, Non-Hodgkin


IMiD-3, CC-5013, CDC-501, CDC-5013, ENMD-0997, IMID-5013


Celgene Corp

Lymphoma, B-Cell, Marginal Zone, Recurrence, Hematologic Diseases, Leukemia, Myeloid, Lymphoma, B-Cell, HIV Infections, Lymphoma, T-Cell, Peripheral, Anemia, Paraproteinemias, Blood Protein Disorders, Myelodysplastic Syndromes, Leukemia-Lymphoma, Adult T-Cell, Lymphoma, Large B-Cell, Diffuse, Smoldering Multiple Myeloma, Multiple Myeloma, Lymphoma, Follicular, Lymphoma, Mantle-Cell, Radiculopathy, Prostatic Neoplasms, Reflex Sympathetic Dystrophy, Lymphoma, Non-Hodgkin, Lymphoma, T-Cell, Waldenstrom Macroglobulinemia, Thrombocytopenia, Leukemia, Myeloid, Acute, Neoplasm Metastasis, Melanoma, Leukemia, Lymphocytic, Chronic, B-Cell, Carcinoma, Non-Small-Cell Lung, Crohn Disease, Complex Regional Pain Syndromes


CDC-394, CC-4047, IMiD-1, IMID-4047


Celgene Corp

Medulloblastoma, Lymphoma, B-Cell, Bone Marrow Neoplasms, Hodgkin Disease, Scleroderma, Systemic, Lymphoma, Large B-Cell, Diffuse, Multiple Myeloma, Central Nervous System Neoplasms, Lung Diseases, Interstitial, Prostatic Neoplasms, Sarcoma, Lymphoma, Follicular, Primary Myelofibrosis, Lymphoma, Non-Hodgkin, Carcinoma, Small Cell, Neoplasm Metastasis, Sarcoma, Kaposi, Anemia, Sickle Cell, Leukemia, Lymphocytic, Chronic, B-Cell


BA-003, CNTO-136


Glaxosmithkline Plc, Janssen Global Services Llc

Giant Cell Arteritis, Depressive Disorder, Major, Lupus Erythematosus, Cutaneous, Arthritis, Rheumatoid, Coronavirus Disease 2019 (COVID-19), Lupus Nephritis, Polymyalgia Rheumatica, Lupus Erythematosus, Systemic, Asthma



Phase 3 Clinical

Promore Pharma

Tissue Adhesions, Post-surgical adhesions


CDP-6038, Anti-IL6-UCB

Phase 3 Clinical


Arthritis, Rheumatoid, Coronavirus Disease 2019 (COVID-19), Arthritis, Crohn Disease


ALD-518, ALD518-003, BMS-645429, BMS-945429

Phase 3 Clinical

Alder Biopharmaceuticals

Anemia, Fatigue, Graft vs Host Disease, Arthritis, Rheumatoid, Rejection of organ transplantation, Arthritis, Psoriatic, Cachexia, Inflammation, Crohn Disease, Carcinoma, Non-Small-Cell Lung, Stomatitis


CD24-Fc-IgG, CD24-Fc, HAS-CD24

Phase 3 Clinical


HIV Infections, Leukemia, Graft vs Host Disease, Coronavirus Disease 2019 (COVID-19), Myelodysplastic Syndromes, Dyslipidemias, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute, Melanoma


GB-224, RYI-008, ARGX-109

Phase 2 Clinical


Arthritis, Rheumatoid

Anti-interleukin-6 receptor monoclonal antibody (Biocad)

Phase 2 Clinical


Autoimmune Diseases


PF-4236921, PF-04236921

Phase 2 Clinical

Pfizer Pharmaceuticals Ltd (China)

Arthritis, Rheumatoid, Lupus Erythematosus, Systemic, Crohn Disease


DMT-200, DMT-210, DMT-220, SIG-990

Phase 2 Clinical

Signum Dermalogix

Rosacea, Dermatitis, Atopic



Phase 2 Clinical


Anemia, Inflammation, Renal Insufficiency, Chronic

Cis-urocanic acid

Cis-UCA, UCA-001, UCA-002

Phase 2 Clinical

Herantis Pharma

Dry Eye Syndromes, Urinary Bladder Neoplasms, Xerophthalmia, Dermatitis, Atopic


GX-P4, HL-2351, rhIL-1Ra-hyFc

Phase 2 Clinical


Arthritis, Rheumatoid, Cryopyrin-Associated Periodic Syndromes


WBP-216, MEDI-5117

Phase 1 Clinical

Wuxi Apptec Co Ltd, Medimmune

Arthritis, Rheumatoid