IL6R

Synonyms

IL6RA, IL6RQ, IL6Q, Interleukin-6 Receptor alpha Subunit, sIL6R, gp80, IL-6R subunit alpha, Membrane glycoprotein 80, IL6R, Interleukin 6 Receptor, IL-6 Receptor Subunit Alpha, CD126 Antigen, IL-6R 1, IL-6RA, Interleukin-6 Receptor Subunit Alpha, IL-6R-Alpha, IL-6R-1, CD126

KO Status

F0

Drug Information

Launched drugs: 3
Drugs in clinical trials: 12
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Sarilumab

REGN-88, SAR-153191

Approved

Sanofi, Regeneron Pharmaceuticals Inc

Arthritis, Rheumatoid, Spondylitis, Ankylosing, Coronavirus Disease 2019 (COVID-19), Arthritis, Juvenile, Coronavirus Infections

Satralizumab

RG-6168, SA-237

Approved

Chugai Pharmaceutical Co Ltd

Neuromyelitis Optica

Tocilizumab

MRA, rhPM-1, RG-1569, HPM-1, MRA-SC, R-1569, RO-48775533

Approved

Chugai Pharmaceutical Co Ltd

Liver Neoplasms, Lymphoma, B-Cell, Cytokine Release Syndrome, Biliary Tract Neoplasms, Solid tumours, Giant Cell Arteritis, Polyarticular Juvenile Idiopathic Arthritis, Arthritis, Rheumatoid, Scleroderma, Systemic, Spondylitis, Ankylosing, Lymphoma, Large B-Cell, Diffuse, Carcinoma, Transitional Cell, Coronavirus Disease 2019 (COVID-19), Arthritis, Juvenile, Urinary Bladder Neoplasms, systemic sclerosis-associated interstitial lung disease, Takayasu Arteritis, Multicentric Castleman's Disease (MCD), Lymphoma, Follicular, Colorectal Neoplasms, Lymphoma, Non-Hodgkin, Leukemia, Myeloid, Acute, Lymphoma, Carcinoma, Hepatocellular

Tocilizumab biosimilar (Bio-Thera Solutions)

BAT-1806

Phase 3 Clinical

Bio-Thera Solutions Ltd

Arthritis, Rheumatoid

Recombinant humanized anti-IL-6R antibody (Hisun Pharma)

Phase 3 Clinical

Zhejiang Hisun Pharmaceutical Co Ltd

Arthritis, Rheumatoid, Arthritis

Recombinant humanized anti-IL-6R antibody (Livzon Group)

Phase 3 Clinical

Livzon Pharmaceutical Group Inc

Arthritis, Rheumatoid

Tocilizumab biosimilar (Fresenius kabi)

MSB-11456

Phase 3 Clinical

Merck Serono

Arthritis, Rheumatoid, Autoimmune Diseases

CMAB806

CMAB-806

Phase 3 Clinical

Taizhou Maibo Taike Biotechnology Co Ltd

Arthritis, Rheumatoid, Arthritis

Levilimab

BCD-089

Phase 3 Clinical

Biocad

Arthritis, Rheumatoid, Coronavirus Disease 2019 (COVID-19)

Tocilizumab biosimilar (AryoGen Pharmed)

Phase 3 Clinical

Aryogen Biopharma

Arthritis, Rheumatoid

References


Title

Authors

Source

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B., Taniguchi T., Hirano T., Kishimoto T.,

Science 241:825-828(1988)

Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells

Schooltink H., Stoyan T., Lenz D., Schmitz H., Hirano T., Kishimoto T., Heinrich P.C., Rose-John S.,

Biochem. J. 277:659-664(1991)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

The DNA sequence and biological annotation of human chromosome 1

Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., Bentley D.R.,

Nature 441:315-321(2006)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

Horiuchi S., Koyanagi Y., Zhou Y., Miyamoto H., Tanaka Y., Waki M., Matsumoto A., Yamamoto M., Yamamoto N.,

Eur. J. Immunol. 24:1945-1948(1994)

Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor

Cole A.R., Hall N.E., Treutlein H.R., Eddes J.S., Reid G.E., Moritz R.L., Simpson R.J.,

J. Biol. Chem. 274:7207-7215(1999)

Soluble cytokine receptors are present in normal human urine

Novick D., Engelmann H., Wallach D., Rubinstein M.,

J. Exp. Med. 170:1409-1414(1989)

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130

Yawata H., Yasukawa K., Natsuka S., Murakami M., Yamasaki K., Hibi M., Taga T., Kishimoto T.,

EMBO J. 12:1705-1712(1993)

The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells

Martens A.S., Bode J.G., Heinrich P.C., Graeve L.,

J. Cell Sci. 113:3593-3602(2000)