IL9

Synonyms

IL9, Interleukin-9, T-cell growth factor P40, Interleukin 9, Homolog Of Mouse T Cell And Mast Cell Growth Factor 40, P40 T-Cell And Mast Cell Growth Factor, Cytokine P40, P40 Cytokine, IL-9, HP40, P40

Description

Interluekin-9 (IL-9) is produced predominantly by helper T cells such as Th2 and Th9 cells. It normally functions through the activation of a JAK/STAT pathway and plays a critical role in immunity and the pathogenesis of cancer. In cancer, it yields different responses depending on the cancer cell line involved.

KO Status

F2 (-/-)

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Enokizumab

MEDI-528, 7F3com-2H2

Discontinued

Ludwig Institute For Cancer Research, Genaera

Asthma

References


Title

Authors

Source

Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40

Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K., Clark S.C.,

Blood 74:1880-1884(1989)

Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40

Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.,

Cytokine 2:9-12(1990)

Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene

Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.,

J. Immunol. 144:4235-4241(1990)

Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells

Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., Yang Y.C.,

Blood 77:1436-1441(1991)

The DNA sequence and comparative analysis of human chromosome 5

Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S., Rubin E.M.,

Nature 431:268-274(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40.

Yang Y.C., Ricciardi S., Ciarletta A., Calvetti J.A., Kelleher K., Clark S.C.,

Blood 74:1880-1884(1989)

Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40.

Renauld J.-C., Goethals A., Houssiau F., van Roost E., van Snick J.,

Cytokine 2:9-12(1990)

Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.

Renauld J.-C., Goethals A., Houssiau F., Merz H., van Roost E., van Snick J.,

J. Immunol. 144:4235-4241(1990)

Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells.

Kelleher K., Bean K., Clark S.C., Leung W.Y., Yang-Feng T.L., Chen J.W., Lin P.F., Luo W., Yang Y.C.,

Blood 77:1436-1441(1991)