Leukocyte adhesion glycoprotein LFA-1 alpha chain, ITGAL, LFA-1A, Integrin Subunit Alpha L, Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide, CD11A, Integrin Gene Promoter, Antigen CD11A (P180), LFA-1 Alpha, LFA-1, LFA1A, CD11a Antigen, CD11 antigen-like family member A, Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide), Integrin alpha-L, Leukocyte function-associated molecule 1 alpha chain, Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide


Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in human is encoded by ITGAL gene. It is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

KO Status

RenMab: F1 (+/-)

Drug Information

Launched drugs: 2
Drugs in clinical trials: 2
Latest Research Phase: Approved

Drug Name





Clinical Trials




Rejection of renal transplantation, Graft vs Host Disease


VVN001, VVN-001

Phase 2 Clinical

VivaVision Biotech Inc

Dry Eye Syndromes, Xerophthalmia


P-28- R

Phase 1 Clinical

Canimguide Therapeutics

Head and Neck Neoplasms

Leukocyte function antigen-1 (LFA-1) antagonist (Actinobac Biomed)


Actinobac Biomed, University Of Medicine & Dentistry Of New Jersey

HIV Infections, Hematologic Diseases, Autoimmune Diseases, Psoriasis

Anti-CD8 monoclonal antibody (CytoDyn)



HIV Infections

Recombinant anti-CD11a humanized monoclonal antibody (Shanghai CP Guojian)



Shanghai Cp Guojian Pharmaceutical Co Ltd



G176CR, HU-1124


Genentech Inc

Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic





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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

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Genome Res. 14:2121-2127(2004)

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Proc. Natl. Acad. Sci. U.S.A. 90:5364-5368(1993)

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JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes

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Nat. Immunol. 3:151-158(2002)

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J. Immunol. 173:3653-3659(2004)

The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain

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J. Immunol. 173:6259-6264(2004)

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J. Cell Biol. 171:705-715(2005)

SARS-CoV accessory protein 7a directly interacts with human LFA-1

Haenel K., Willbold D.,

Biol. Chem. 388:1325-1332(2007)