ITGAL

Synonyms

Leukocyte adhesion glycoprotein LFA-1 alpha chain, ITGAL, LFA-1A, Integrin Subunit Alpha L, Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide, CD11A, Integrin Gene Promoter, Antigen CD11A (P180), LFA-1 Alpha, LFA-1, LFA1A, CD11a Antigen, CD11 antigen-like family member A, Integrin, Alpha L (Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide), Integrin alpha-L, Leukocyte function-associated molecule 1 alpha chain, Antigen CD11A (P180), Lymphocyte Function-Associated Antigen 1, Alpha Polypeptide

Description

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in human is encoded by ITGAL gene. It is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.

KO Status

RenMab: F1 (+/-)

Drug Information

Launched drugs: 2
Drugs in clinical trials: 2
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Odulimomab

Approved

Immunotech

Rejection of renal transplantation, Graft vs Host Disease

VVN-001

VVN001, VVN-001

Phase 2 Clinical

VivaVision Biotech Inc

Dry Eye Syndromes, Xerophthalmia

P-28-R

P-28- R

Phase 1 Clinical

Canimguide Therapeutics

Head and Neck Neoplasms

Leukocyte function antigen-1 (LFA-1) antagonist (Actinobac Biomed)

Pending

Actinobac Biomed, University Of Medicine & Dentistry Of New Jersey

HIV Infections, Hematologic Diseases, Autoimmune Diseases, Psoriasis

Anti-CD8 monoclonal antibody (CytoDyn)

Pending

Cytodyn

HIV Infections

Recombinant anti-CD11a humanized monoclonal antibody (Shanghai CP Guojian)

CMAB-001

Pending

Shanghai Cp Guojian Pharmaceutical Co Ltd

Psoriasis

Efalizumab

G176CR, HU-1124

Withdrawn

Genentech Inc

Arthritis, Rheumatoid, Psoriasis, Arthritis, Psoriatic

References


Title

Authors

Source

The sequence and analysis of duplication-rich human chromosome 16

Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Pennacchio L.A.,

Nature 432:988-994(2004)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene

Shelley C.S., Farokhzad O.C., Arnaout M.A.,

Proc. Natl. Acad. Sci. U.S.A. 90:5364-5368(1993)

Characterization of the CD11a (alpha L, LFA-1 alpha) integrin gene promoter

Nueda A., Lopez-Cabrera M., Vara A., Corbi A.L.,

J. Biol. Chem. 268:19305-19311(1993)

Description of the leukocyte function-associated antigen 1 (LFA-1 or CD11a) promoter

Cornwell R.D., Gollahon K.A., Hickstein D.D.,

Proc. Natl. Acad. Sci. U.S.A. 90:4221-4225(1993)

JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes

Ostermann G., Weber K.S., Zernecke A., Schroeder A., Weber C.,

Nat. Immunol. 3:151-158(2002)

LFA-1 contributes an early signal for NK cell cytotoxicity

Barber D.F., Faure M., Long E.O.,

J. Immunol. 173:3653-3659(2004)

The functional interaction of the beta 2 integrin lymphocyte function-associated antigen-1 with junctional adhesion molecule-A is mediated by the I domain

Fraemohs L., Koenen R.R., Ostermann G., Heinemann B., Weber C.,

J. Immunol. 173:6259-6264(2004)

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms

Fagerholm S.C., Hilden T.J., Nurmi S.M., Gahmberg C.G.,

J. Cell Biol. 171:705-715(2005)

SARS-CoV accessory protein 7a directly interacts with human LFA-1

Haenel K., Willbold D.,

Biol. Chem. 388:1325-1332(2007)