ITGB7

Synonyms

Gut homing receptor beta subunit, Integrin Beta 7 Subunit, Integrin, Beta 7, Integrin Subunit Beta 7

Description

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7.It is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. It also interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced ​​CS-1 region of fibronectin. Interactions involves the tripeptide LDT in MADCAM1, and LDV in fibronectin. It binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide LDI in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

KO Status

RenMab: F2 (-/-)

Drug Information

Drug Name

Code

Phase

Company

Indications

Clinical Trials

anti-ILT3 CAR-T(Carbiogene)

Nidanilimab

CAN-04

Phase 2 Clinical

Lund University Foundation

Squamous Cell Carcinoma of Head and Neck, Pancreatic Neoplasms, Triple Negative Breast Neoplasms, Carcinoma, Transitional Cell, Breast Neoplasms, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal, Carcinoma, Non-Small-Cell Lung, Melanoma

HLX-71

HLX-71, SI-F019

Phase 1 Clinical

Hengenix Biotech Inc

Coronavirus Disease 2019 (COVID-19)

IO-202

IO-202

Phase 1 Clinical

Leukemia, Myelomonocytic, Chronic, Leukemia, Myeloid, Acute

GSK3903371

GSK3903371

Clinical

Glaxosmithkline Plc

Neoplasms

NKp46 NKCE

NKp46-NKCE, NKp46 NKCE

Preclinical

Neoplasms

SAR-443579

SAR-443579, SAR443579, IPH6101, IPH-6101

Preclinical

Neoplasms

BI-1910

BI-1910

Preclinical

Bioinvent International

Solid tumours

IPR-1110

IPR 1110

Preclinical

Neoplasms

MNPR-101

huATN-658, ATN-291 F(ab’)2

Preclinical

Monopar Therapeutics Inc

Neoplasms

References


Title

Authors

Source

A family of beta 7 integrins on human mucosal lymphocytes

Parker C.M., Cepek K.L., Russell G.J., Shaw S.K., Posnett D.N., Schwarting R., Brenner M.B.,

Proc. Natl. Acad. Sci. U.S.A. 89:1924-1928(1992)

HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit

Micklem K.J., Dong Y., Willis A., Pulford K.A., Visser L., Duerkop H., Poppema S., Stein H., Mason D.Y.,

Am. J. Pathol. 139:1297-1301(1991)

Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains

Yuan Q., Jiang W.-M., Krissansen G.W., Watson J.D.,

Int. Immunol. 2:1097-1108(1990)

Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains

Yuan Q., Jiang W.-M., Krissansen G.W., Watson J.D.,

Int. Immunol. 3:1373-1374(1991)

Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes

Erle D.J., Rueegg C., Sheppard D., Pytela R.,

J. Biol. Chem. 266:11009-11016(1991)

The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1

Jiang W.-M., Jenkins D., Yuan Q., Leung E., Choo K.H., Watson J.D., Krissansen G.W.,

Int. Immunol. 4:1031-1040(1992)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The role of alpha and beta chains in ligand recognition by beta 7 integrins

Higgins J.M.G., Cernadas M., Tan K., Irie A., Wang J.-H., Takada Y., Brenner M.B.,

J. Biol. Chem. 275:25652-25664(2000)

Integrins: bidirectional, allosteric signaling machines

Hynes R.O.,

Cell 110:673-687(2002)

HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells

Arthos J., Cicala C., Martinelli E., Macleod K., Van Ryk D., Wei D., Xiao Z., Veenstra T.D., Conrad T.P., Lempicki R.A., McLaughlin S., Pascuccio M., Gopaul R., McNally J., Cruz C.C., Censoplano N., Chung E., Reitano K.N., Fauci A.S.,

Nat. Immunol. 9:301-309(2008)