LINGO-1

Synonyms

UNQ201, FLJ14594, MRT64, Leucine-rich repeat and immunoglobulin domain-containing protein 1, LINGO1, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 6A, UNQ201/PRO227, Leucine Rich Repeat And Ig Domain Containing 1, Leucine-Rich Repeat Neuronal Protein 1, Leucine Rich Repeat Neuronal 6A, LRRN6A, LERN1

KO Status

F0

Drug Information

Drug in clinical trials: 1
Latest Research Phase: Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Opicinumab

BIIB-033, Anti-LINGO-1, Anti-LINGO-1 antibody

Phase 2 Clinical

Biogen Inc

Multiple Sclerosis, Relapsing-Remitting, Optic Neuritis, Multiple Sclerosis, Neurodegenerative Diseases

References


Title

Authors

Source

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

The full-ORF clone resource of the German cDNA consortium

Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.,

BMC Genomics 8:399-399(2007)

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Mi S., Lee X., Shao Z., Thill G., Ji B., Relton J., Levesque M., Allaire N., Perrin S., Sands B., Crowell T., Cate R.L., McCoy J.M., Pepinsky R.B.,

Nat. Neurosci. 7:221-228(2004)

LINGO-1 negatively regulates myelination by oligodendrocytes

Mi S., Miller R.H., Lee X., Scott M.L., Shulag-Morskaya S., Shao Z., Chang J., Thill G., Levesque M., Zhang M., Hession C., Sah D., Trapp B., He Z., Jung V., McCoy J.M., Pepinsky R.B.,

Nat. Neurosci. 8:745-751(2005)

A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors

Park J.B., Yiu G., Kaneko S., Wang J., Chang J., He X.L., Garcia K.C., He Z.,

Neuron 45:345-351(2005)

LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex

Carim-Todd L., Escarceller M., Estivill X., Sumoy L.,

Eur. J. Neurosci. 18:3167-3182(2003)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment

Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Gray A.M.,

Genome Res. 13:2265-2270(2003)

Complete sequencing and characterization of 21,243 full-length human cDNAs

Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Sugano S.,

Nat. Genet. 36:40-45(2004)

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models

Inoue H., Lin L., Lee X., Shao Z., Mendes S., Snodgrass-Belt P., Sweigard H., Engber T., Pepinsky B., Yang L., Beal M.F., Mi S., Isacson O.,

Proc. Natl. Acad. Sci. U.S.A. 104:14430-14435(2007)

Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth

Budel S., Padukkavidana T., Liu B.P., Feng Z., Hu F., Johnson S., Lauren J., Park J.H., McGee A.W., Liao J., Stillman A., Kim J.E., Yang B.Z., Sodi S., Gelernter J., Zhao H., Hisama F., Arnsten A.F., Strittmatter S.M.,

J. Neurosci. 28:13161-13172(2008)