MMP-9

Synonyms

EC:3.4.24.35, EC 3.4.24, CLG4B, MMP9, Matrix Metallopeptidase 9, Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase), GELB, Matrix Metalloproteinase-9, 92 KDa Type IV Collagenase, Macrophage Gelatinase, Type V Collagenase, Gelatinase B, EC 3.4.24.35, MANDP2, Matrix Metalloproteinase 9, 92 kDa gelatinase, MMP-9, Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase),

Description

Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. It plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.

KO Status

F0

Drug Information

Launched drugs: 3
Drug in clinical trials: 1
Latest Research Phase:Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Abametapir

HA-44, DFD-11, Ha44 Gel, BRN-0123183

Approved

Hatchtech

Lice Infestations

Andecaliximab

GS-5745

Phase 3 Clinical

Gilead

Cystic Fibrosis, Esophageal Neoplasms, Stomach Neoplasms, Arthritis, Rheumatoid, Pancreatic Neoplasms, Breast Neoplasms, Colitis, Ulcerative, Colorectal Neoplasms, Pulmonary Disease, Chronic Obstructive, Carcinoma, Non-Small-Cell Lung, Crohn Disease, Adenocarcinoma

AQU-005

AQU-005, NMAQU-005, NM-AQU-005

Phase 1 Clinical

Aquilus Pharmaceuticals

Neuralgia

CALY-001

CALY-001

Clinical

Calypso Biotech

Inflammatory Bowel Diseases, Crohn Disease

S-3304

S-3304

Pending

Shionogi & Co Ltd

Lung Neoplasms, Carcinoma, Non-Small-Cell Lung

Incyclinide

CMT-3, COL-3, NSC-683551

Discontinued

Galderma

Acne Vulgaris, Rosacea

SD-7300

Discontinued

Pfizer Pharmaceuticals Ltd (China)

Neoplasms

RBx-10017609

Discontinued

Sun Pharmaceutical

Pulmonary Disease, Chronic Obstructive

ABT-518

ABT 518

Discontinued

Abbvie Inc

Neoplasms

AZD-1236

AZD-1236

Discontinued

Astrazeneca Plc

Cystic Fibrosis, Pulmonary Disease, Chronic Obstructive

AE-941

AE-941, NSC-706456

Discontinued

Aeterna Zentaris

Kidney Neoplasms, Carcinoma, Renal Cell, Carcinoma, Non-Small-Cell Lung

RS-130830

CTS-1027, RS-130830, RO-1130830

Discontinued

F. Hoffmann-La Roche Ltd

Hepatitis C, Arthritis, Hepatitis C, Chronic

Rebimastat

D-2163, BMS-275291

Discontinued

Celltech

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung

CP-471358

CP-471358

Discontinued

Pfizer Pharmaceuticals Ltd (China)

Neoplasms

Tanomastat

BAY-12-9566

Discontinued

Bayer Ag

Ovarian Neoplasms, Pancreatic Neoplasms, Small Cell Lung Carcinoma, Carcinoma, Non-Small-Cell Lung

PG-116800

PG-116800, PG-530742, PGE-7113313

Discontinued

Procter & Gamble

Heart Failure, Myocardial Infarction, Cardiomegaly, Osteoarthritis, Knee, Osteoarthritis