Oncostatin-M, OSM, Oncostatin M, MGC20461

KO Status

RenMab: F1 (+/-)

Drug Information

Drugs in clinical trials: 2
Latest Research Phase: Phase 2 Clinical

Drug Name





Clinical Trials

KPL-716 (Biogen)


Phase 2 Clinical

Biogen Inc

Pruritus, Chronic Urticaria, Psoriasis, Prurigo, Neurodermatitis, Lichen Planus



Phase 2 Clinical

Glaxosmithkline Plc

Scleroderma, Systemic, Crohn Disease




Glaxosmithkline Plc

Arthritis, Rheumatoid





The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells

Zarling J.M., Shoyab M., Marquardt H., Hanson M.B., Lioubin M.N., Todaro G.J.,

Proc. Natl. Acad. Sci. U.S.A. 83:9739-9743(1986)

Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M

Nair B.C., DeVico A.L., Nakamura S., Copeland T.D., Chen Y., Patel A., O'Neil T., Oroszlan S., Gallo R.C., Sarngadharan M.G.,

Science 255:1430-1432(1992)

Cleavage of a hydrophilic C-terminal domain increases growth-inhibitory activity of oncostatin M

Linsley P.S., Kallestad J., Ochs V., Neubauer M.,

Mol. Cell. Biol. 10:1882-1890(1990)

Disulfide bond assignment and identification of regions required for functional activity of oncostatin M

Kallestad J.C., Shoyab M., Linsley P.S.,

J. Biol. Chem. 266:8940-8945(1991)

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6

Rose T.M., Bruce A.G.,

Proc. Natl. Acad. Sci. U.S.A. 88:8641-8645(1991)

Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells

Miles S.A., Martinez-Maza O., Rezai A., Magpantay L., Kishimoto T., Nakamura S., Radka S.F., Linsley P.S.,

Science 255:1432-1434(1992)

Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation

Mosley B., De Imus C., Friend D., Boiani N., Thoma B., Park L.S., Cosman D.,

J. Biol. Chem. 271:32635-32643(1996)

Crystal structure and functional dissection of the cytostatic cytokine oncostatin M

Deller M.C., Hudson K.R., Ikemizu S., Bravo J., Jones E.Y., Heath J.K.,

Structure 8:863-874(2000)

Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M

Malik N., Kallestad J.C., Gunderson N.L., Austin S.D., Neubauer M.G., Ochs V., Marquardt H., Zarling J.M., Shoyab M., Wei C.M., Linsley P.S., Rose T.M.,

Mol. Cell. Biol. 9:2847-2853(1989)