OX40L

Synonyms

CD252, OX40 ligand, OX40L, TNFSF4, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, TNF Superfamily Member 4, TXGP1, Tax-Transcriptionally Activated Glycoprotein 1 (34kD), Tumor Necrosis Factor (Ligand) Superfamily, Member 4, Tumor Necrosis Factor (Ligand) Superfamily Member 4, Tumor Necrosis Factor Superfamily Member 4, Tumor Necrosis Factor Ligand 2B, OX40 Antigen Ligand, CD134L, OX-40L, TNLG2B, OX4OL, GP34, CD252 Antigen, CD134 Ligand, TAX transcriptionally-activated glycoprotein 1, Tax-Transcriptionally Activated Glycoprotein 1, 34kD,

Description

OX40L is the ligand for OX40,also known as CD134 or TNFRSF4,and is stably expressed on many antigen-presenting cells such as DC2s, a subtype of dendritic cells,macrophages,and activated B lymphocytes. It co-stimulates T-cell proliferation and cytokine production.

KO Status

F0

Drug Information

Launched drugs: 0
Drugs in clinical trials: 2
Latest Research Phase:Phase 2 Clinical

Drug Name

Code

Phase

Company

Indications

Clinical Trials

KY-1005

KY-1005

Phase 2 Clinical

Kymab

Autoimmune Diseases, Immune System Diseases, Dermatitis, Atopic

mRNA-2416

mRNA-2416, OX40L mRNA - Moderna Therpeutics

Phase 2 Clinical

Moderna Therapeutics

Ovarian Neoplasms, Lymphoma

anti-cancer mRNA therapeutics (Moderna Therapeutics)

MT 004, MT-377, MT-380, MT-513, MEDI-1191, mRNA-2095, mRNA-2752, mRNA-IL12-iTu-I-O

Phase 1 Clinical

Moderna Therapeutics, Astrazeneca Plc

Neoplasms

SCB-340

SCB-340

Preclinical

Sichuan Sanyecao Bio-Pharmaceutical Co Ltd

Neoplasms

Oxelumab

R-4930, RG-4930, Roche-4, RO-4989991, OX40L-huMab, huMAb-OX40L

Discontinued

Genentech Inc, Genmab

Asthma

Efizonerimod alfa

MEDI-6383

Discontinued

Medimmune

Neoplasms