PGF

Synonyms

PGFL, Placental Growth Factor-Like, SHGC-10760, D12S1900, PlGF-2, PIGF, Placenta growth factor, PlGF, PGF, Placental Growth Factor, Placental Growth Factor, Vascular Endothelial Growth Factor-Related Protein

KO Status

RenMab: Antibody Discovery

Drug Information

Launched drugs: 2
Drugs in clinical trials: 14
Latest Research Phase: Approved

Drug Name

Code

Phase

Company

Indications

Clinical Trials

Ziv-aflibercept

BAY-865321, AVE-0005

Approved

Regeneron Pharmaceuticals Inc, Sanofi

Ovarian Neoplasms, Solid tumours, Ascites, Lung Diseases, Prostatic Neoplasms, Colorectal Neoplasms, Lung Neoplasms, Lymphoma, Neoplasm Metastasis

Aflibercept

BAT-86-5321, BAY-865321

Approved

Regeneron Pharmaceuticals Inc, Bayer Ag

Diabetes Mellitus, Type 1, Macular Edema, Diabetes Mellitus, Type 2, Glaucoma, Neovascular, Retinal Diseases, Myopia, Degenerative, Diabetic macular oedema, Wet Macular Degeneration, Prostatic Neoplasms, Diabetes Complications, Colorectal Neoplasms, Retinal Degeneration, Diabetes Mellitus, Diabetic Retinopathy, Macular Degeneration, Retinal Vein Occlusion, Retinopathy of Prematurity, Neoplasm Metastasis

Aflibercept biosimilar (Mabwell)

9MW0813

Phase 3 Clinical

Diabetic macular oedema

Aflibercept biosimilar (Sam Chun Dang Pharm)

SCD-411

Phase 3 Clinical

Sam Chun Dang Pharm Co Ltd

Macular Degeneration

Aflibercept biosimilar (Momenta/Mylan)

M-710, MYL-1701P

Phase 3 Clinical

Mylan, Momenta

Diabetic macular oedema

Aflibercept biosimilar (CinnaGen)(阿柏西普生物类似药(CinnaGen))

Phase 3 Clinical

Cinnagen

Macular Degeneration

Aflibercept Biosimilar (Boan Biopharma/Luye Pharma)

LY-09004, BA-9101, OT-702

Phase 3 Clinical

Shandong Boan Biotechnology Co Ltd, Luye Pharma Group Ltd

Wet Macular Degeneration, Macular Degeneration

Aflibercept biosimilar (Samsung Bioepis)

SB-15

Phase 3 Clinical

Samsung Bioepis

Macular Degeneration

CT-P42

CT-P42

Phase 3 Clinical

Celltrion

Diabetic macular oedema

FYB-203

FYB-203

Phase 3 Clinical

Formycon

Macular Degeneration

References


Title

Authors

Source

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

Maglione D., Guerriero V., Viglietto G., Delli-Bovi P., Persico M.G.,

Proc. Natl. Acad. Sci. U.S.A. 88:9267-9271(1991)

A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta

Hauser S.D., Weich H.A.,

Growth Factors 9:259-268(1993)

Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing

Cao Y., Ji W.-R., Qi P., Rosin A., Cao Y.,

Biochem. Biophys. Res. Commun. 235:493-498(1997)

Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells

Yang W., Ahn H., Hinrichs M., Torry R.J., Torry D.S.,

J. Reprod. Immunol. 60:53-60(2003)

The DNA sequence and analysis of human chromosome 14

Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H., Weissenbach J.,

Nature 421:601-607(2003)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR

Park J.E., Chen H.H., Winer J., Houck K.A., Ferrara N.,

J. Biol. Chem. 269:25646-25654(1994)

Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14

Maglione D., Guerriero V., Viglietto G., Ferraro M.G., Aprelikova O., Alitalo K., del Vecchio S., Lei K.-J., Chou J.Y., Persico M.G.,

Oncogene 8:925-931(1993)

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

Rolny C., Mazzone M., Tugues S., Laoui D., Johansson I., Coulon C., Squadrito M.L., Segura I., Li X., Knevels E., Costa S., Vinckier S., Dresselaer T., Akerud P., De Mol M., Salomaki H., Phillipson M., Wyns S., Carmeliet P.,

Cancer Cell 19:31-44(2011)

The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution

Iyer S., Leonidas D.D., Swaminathan G.J., Maglione D., Battisti M., Tucci M., Persico M.G., Acharya K.R.,

J. Biol. Chem. 276:12153-12161(2001)