PGFL, Placental Growth Factor-Like, SHGC-10760, D12S1900, PlGF-2, PIGF, Placenta growth factor, PlGF, PGF, Placental Growth Factor, Placental Growth Factor, Vascular Endothelial Growth Factor-Related Protein

KO Status

RenMab: Antibody Discovery

Drug Information

Launched drugs: 2
Drugs in clinical trials: 14
Latest Research Phase: Approved

Drug Name





Clinical Trials


BAY-865321, AVE-0005


Regeneron Pharmaceuticals Inc, Sanofi

Ovarian Neoplasms, Solid tumours, Ascites, Lung Diseases, Prostatic Neoplasms, Colorectal Neoplasms, Lung Neoplasms, Lymphoma, Neoplasm Metastasis


BAT-86-5321, BAY-865321


Regeneron Pharmaceuticals Inc, Bayer Ag

Diabetes Mellitus, Type 1, Macular Edema, Diabetes Mellitus, Type 2, Glaucoma, Neovascular, Retinal Diseases, Myopia, Degenerative, Diabetic macular oedema, Wet Macular Degeneration, Prostatic Neoplasms, Diabetes Complications, Colorectal Neoplasms, Retinal Degeneration, Diabetes Mellitus, Diabetic Retinopathy, Macular Degeneration, Retinal Vein Occlusion, Retinopathy of Prematurity, Neoplasm Metastasis

Aflibercept biosimilar (Mabwell)


Phase 3 Clinical

Diabetic macular oedema

Aflibercept biosimilar (Sam Chun Dang Pharm)


Phase 3 Clinical

Sam Chun Dang Pharm Co Ltd

Macular Degeneration

Aflibercept biosimilar (Momenta/Mylan)

M-710, MYL-1701P

Phase 3 Clinical

Mylan, Momenta

Diabetic macular oedema

Aflibercept biosimilar (CinnaGen)(阿柏西普生物类似药(CinnaGen))

Phase 3 Clinical


Macular Degeneration

Aflibercept Biosimilar (Boan Biopharma/Luye Pharma)

LY-09004, BA-9101, OT-702

Phase 3 Clinical

Shandong Boan Biotechnology Co Ltd, Luye Pharma Group Ltd

Wet Macular Degeneration, Macular Degeneration

Aflibercept biosimilar (Samsung Bioepis)


Phase 3 Clinical

Samsung Bioepis

Macular Degeneration



Phase 3 Clinical


Diabetic macular oedema



Phase 3 Clinical


Macular Degeneration





Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor

Maglione D., Guerriero V., Viglietto G., Delli-Bovi P., Persico M.G.,

Proc. Natl. Acad. Sci. U.S.A. 88:9267-9271(1991)

A heparin-binding form of placenta growth factor (PlGF-2) is expressed in human umbilical vein endothelial cells and in placenta

Hauser S.D., Weich H.A.,

Growth Factors 9:259-268(1993)

Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing

Cao Y., Ji W.-R., Qi P., Rosin A., Cao Y.,

Biochem. Biophys. Res. Commun. 235:493-498(1997)

Evidence of a novel isoform of placenta growth factor (PlGF-4) expressed in human trophoblast and endothelial cells

Yang W., Ahn H., Hinrichs M., Torry R.J., Torry D.S.,

J. Reprod. Immunol. 60:53-60(2003)

The DNA sequence and analysis of human chromosome 14

Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H., Weissenbach J.,

Nature 421:601-607(2003)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

The MGC Project Team,

Genome Res. 14:2121-2127(2004)

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR

Park J.E., Chen H.H., Winer J., Houck K.A., Ferrara N.,

J. Biol. Chem. 269:25646-25654(1994)

Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14

Maglione D., Guerriero V., Viglietto G., Ferraro M.G., Aprelikova O., Alitalo K., del Vecchio S., Lei K.-J., Chou J.Y., Persico M.G.,

Oncogene 8:925-931(1993)

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

Rolny C., Mazzone M., Tugues S., Laoui D., Johansson I., Coulon C., Squadrito M.L., Segura I., Li X., Knevels E., Costa S., Vinckier S., Dresselaer T., Akerud P., De Mol M., Salomaki H., Phillipson M., Wyns S., Carmeliet P.,

Cancer Cell 19:31-44(2011)

The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution

Iyer S., Leonidas D.D., Swaminathan G.J., Maglione D., Battisti M., Tucci M., Persico M.G., Acharya K.R.,

J. Biol. Chem. 276:12153-12161(2001)